4C2T


Conserved Protein Domain Family
UvrD

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COG0210: UvrD 
Superfamily I DNA or RNA helicase [Replication, recombination and repair]
Statistics
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PSSM-Id: 439980
Aligned: 628 rows
Threshold Bit Score: 257.171
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4C2T_A          7 PD----LLQAL--NPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHYGVHPGEILAVTFTNKAAAEMRERAGHL 80  
WP_014402856  185 dvpalpvapthppSDAQRLAAQAPERYVNVVAGPGTGKTTTLVHRVAHLI-ATGVPASRILVMTFTNRAAQELVERLTAG 263 
WP_012112794  191 ppvgvvatPRH--DPSQDRAAAHRDTPFQLQAGPGTGKTRTLVKRVLSLLA-DGIDPAAILVLTFSNRAAGELSERLIAA 267 
WP_011463506  185 vvlapeartqhppSLDQLLAIQAPERYVNVVAGPGSGKTSTLVHRIRYLIDEKAVDPSHILVLTFTNKAAFELVDRLRDA 264 
WP_013040333  185 vaaaetetierplnplqasaaaHRGEAFLLEAGPGTGKTQTLTARVEGLLA-EGVDPRRILLLTFSNKAAGEMAERIGRK 263 
WP_075336063    1 MNsfrvAAQELhpNKEQWQAYES-QGHLVVLAGPGSGKTKLLAVKLARIAEEELEPPHRIACLTYNNECVSEIRKRLVAV 79  
NP_797462     187 gtkegkseVIL--NEQQKHAADHRGKPYLLEAGPGTGKTQTLVKRVEGLLD-EGVDPRRILILTFSNKAAGEMAERLASK 263 
WP_010040968  187 gaeetrasdadepdaSQRTAIEAGDGPRQVRAGPGTGKTRTLVGRVVHLLRARNVPAGSILALTYSNLSAKDLAARIRAA 266 
WP_008250242  188 rtesaatpVGL--DDSQRNAALHRGSAFQLQAGPGTGKTRTLVHRIESLLE-DGVDPGVILVLTFSNKAAGELRERIAAK 264 
WP_084764649  208 aptvnaqkpkfgrddsqeaaagFADPALLLEAGPGSGKTRTLVKRIEHLLDFDEAVPNEILALTFSNKAAGELADRIATA 287 
4C2T_A         81 VP-G-AGDlWMSTFHSAGVRILRTY-GEHIG--LRRGFVIYDDDDQLDIIKEVMGS-IPGIg--A-EtQ---PRVIRGII 148 
WP_014402856  264 SA-PnAAQiWAGTFHSFGLEILRKH-HHLFN--LTPQIKIADLLQQVRLLAGELPN-LRLNyffRlRnPydwLPDVLKII 338 
WP_012112794  268 AP-DaAPKlWIGTFHAFGLDLVRRY-HDKLG--LTPNPALFDRSDAIAVLEEILPT-LPLVhyrNlWdPamvLRDIVAAI 342 
WP_011463506  265 NI-HrASDvWAGTFHAFGLDFLRKY-HQCFG--LESDLKVADRLNAITILNQELPK-VELThyrRvQdPydwLPDVVNSI 339 
WP_013040333  264 HK-VaAAAmWIGTFHAFGLDIIRRF-HIELG--LPKDPRMMDRTEAVELLEAEFPR-LGLNhyrNlYdPtqiIADMLAAI 338 
WP_075336063   80 -GvRlEERfYLGTVHSFCLSEIVRPfARLAGlrLPSPVRVAPEHIQEKCMQAAINRfGRgQ---D-------VAwFRPEI 148 
NP_797462     264 NK-EaVASmWIGTFHAFGLDLVRRF-YSELG--FEKEPRLLERTEAVEALEDEFPR-LGLEhfrNlYdPtehITNLLSAI 338 
WP_010040968  267 VG-DkATAvWSGTFHAFGLELLRKH-GHVLG--MEGPPKLLDRTDSLMFLEQLLPQ-LPLNhylDlYeParaLKDILNAI 341 
WP_008250242  265 FP-RaVATlWLGTFHSFGLDVVHRF-HDRLG--LSENPRVISRYEAIELLEDEIAR-LPLKhfrNlYdPtldLGDMLSAI 339 
WP_084764649  288 RP-DaAADmWIGTFHAFGLDLIRRY-YELLD--LPSNVQLIDKAQAIELLEDQLPL-MGLNhyhDlRnPdqgLVKILSAI 362 
4C2T_A        149 DRAKSNLWTPDDLD-RSr------------------EpfiSGLPRDAAAEAYRRYEVRKKGQNAIDFGDLITETVRLFKE 209 
WP_014402856  339 HRLKEELIFPDQYA-AIvqalp-------------aveedVARERGDIVTLYRAYEAALRRDGWVDQPDLLVRPTLMARD 404 
WP_012112794  343 SRAKDELADPARYR-ALaqgmaa-------eavdeeAr-iAAAKCLEIADIYDLYEQALRKHGGVDFGDLIMRPARLLET 413 
WP_011463506  340 KRLKEEMVSPEAYR-LAiqglp-------------taepgRRECREDVASLYECYERALRERKMVDFVDLVAKPAKAIEQ 405 
WP_013040333  339 SRAKDEVVNEVRYA-ELaeamfv-------savtpeDr-eAAERAEEVARVYAAYEGLKRQAHCVDFGDLVSMPVRLLEG 409 
WP_075336063  149 DCYRRTHLNrDRPDwR--------------------------GEDSSLASIIEEYERLLRADGFVDFDDMVLLAVQILEK 202 
NP_797462     339 SRAKDEVVDHRDYF-RLaqemld-------sadteeSk-tAALKAKEVATVYEAYERLKRAKGCIDFGDLVLLPVKFLEN 409 
WP_010040968  342 GRAKDDLVTPERYG-ELahamla-------sasdpdAi-tRAEKALEVANVYSVYERELRSQWRVDFGDLVARPVELLRA 412 
WP_008250242  340 SRAKDEVVNATEYR-ALaeamleasrelplgddadkQr-eRAEKCLDVAELYQAYETVLQGTDSVDFGDLVSLPVRLVES 417 
WP_084764649  363 SRAKDELVTHAEFT-RRareala-------aavsaeQv-eVAERACEAARVYEIYADALGKAGAVDFGDLVMLPTLLMMR 433 
4C2T_A        210 VPGVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLA-SRDRNLLVVGDPDQSIYKFRGADIQNILDF-QKDYPDA------ 281 
WP_014402856  405 DRPTLAPFLEQFDHVLVDEYQDVNHVMVEFVKLIG-PIQRNLWVVGDIRQAIHHWRGASIQSLLKF-DEAYSTRrddasl 482 
WP_012112794  414 DEATRIAVQLRHRHVLVDEYQDVNRASARLLKLVA-GDGERLWVVGDARQSIYRFRGASSENMVRF-GRDYPGA------ 485 
WP_011463506  406 DRPQYSELADKFQHVLVDEYQDVTHAMVELISQLA-KNAKSLWVVGDVRQAIHHWRGASVHSLTKF-NERFEAQagsgki 483 
WP_013040333  410 NLEIRAHLQAQYDHVLVDEYQDVNRSSVRLITALR-SDGRNLWVVGDAKQSIYRFRGASSFNMTRFgTSDFPGG------ 482 
WP_075336063  203 HHVARRAVSAKYPTIAVDEYQDLGLPLHRIVELLCfQSASRLFAVGDPDQSIYGFTGARPEMLLEL-SRRI-GV------ 274 
NP_797462     410 NVELFKHFQSLYDHVLVDEYQDVNRSSIRLLMLLC-GEGENLWAVGDARQSIYRFRGASSVSMSRYcTQDFPTA------ 482 
WP_010040968  413 HPEVRDAVRDQYRHILVDEYQDMNRASAHFLKEIV-TPKAGPWVVGDVRQAIYRFRGASPLNMSRF-EQDFPGA------ 484 
WP_008250242  418 EPEVQQLLASRHKHILVDEYQDVNRASVRLIKAIA-GEGKRLWVVGDSRQSIYRFRGASSINMKRF-IEDFPGA------ 489 
WP_084764649  434 NDCVRAQVAQRHSMVLVDEYQDVNRASARLLMELY-REGARLWVVGDARQSLYRWRGASSANMAQF-ERDFSGG------ 505 
4C2T_A        282 KVYMLEHNYRSSARVLEAANKLIENnTER----LDKtLKPVKEA-GqPVTFHR-ATDHRAEGDYVADWLTRLH---GEGR 352 
WP_014402856  483 QRYTLDINRRSSPEILRLVQKAGTThVLQpi-qPLDqVFPSRAAsGlLPTLVR-TSSKPKQQSMVAAQVEQAR---SAGY 557 
WP_012112794  486 AVDQLGVNYRSTDQIVRSFVAVAPRmGAShg-mLALaLEADRGAaPsRPEICR-FETLDDEAAGLAASIRELE---GAGV 560 
WP_011463506  484 KTYPLAFNRRSSSEILELVKQAGKRhILEttslKLEnTTATSGPnGhPPTLVS-CFPFVSMPDAIAAGIHELH---SEGV 559 
WP_013040333  483 ARGRLKRNYRSADEVVQAFSAFAIRmKAGdq---dSgLESERGRcGaSPQLRT-VDQSPQQTVALADAIEEMR---QAGH 555 
WP_075336063  275 TPVRLKKNYRSGQSILAAAEVALGEsRGY----TGEk----KDV-Gr-LEARQcIGGIEEQCSAAIREIVPALmrlHPGL 344 
NP_797462     483 LQGRLKINYRSSEEIIRAYSKFAFDmSANig---sPeLIADRGEtGcLPEFKV-VEKADDQAVVLAETIKDMQ---ESGY 555 
WP_010040968  485 AVTDLTVNYRSGGKIVRAFEAFGQKmTAApl-aPNSgLTAHRGEtNgNVLYDV-AVSREAEAEGIAQAIKKRQ---SDGV 559 
WP_008250242  490 QVAGLDINYRSSGEIVDLYRHFSTSmKASeg-aLPLqLHAHHGSlGkRPELRV-ATTPDDEIAVLAAAIMEKK---SQGV 564 
WP_084764649  506 KRLPLDRNYRSTEHIVGLGRGFARDmRAGkn-gLAYnAKSAREEpGsATRLLV-GLDDRCEGELLAAEITSLK---QAGV 580 
4C2T_A        353 AwsEMAILYRTNAQSRVIEESLRRVQIPARIVGGVGFYDRR----EIRDILAYAR--LALNPAdDVALRRIIGRPRRGIG 426 
WP_014402856  558 RygSQGVISATNAQVDELALALEQAGIPVLHVG--DLSQRV----EVKEFMCFMQ--LLARRS-PSALLGLQRQPDFSMP 628 
WP_012112794  561 RlrDQAVLCRTNGRLNEIAAALEARGIPILHLG--SLFERE----EVRDLLCLLS--LAVDPF-GDAIVRVGAMPRYGLS 631 
WP_011463506  560 PfgKQAVLNRWNYELGMVAAGLRRVGIPVLHIG--ELAQRP----EVKTLLCLMQ--LMVERL-PRALVGLMGDARLAVD 630 
WP_013040333  556 TyrDQAVLCTGNEKLSELGQDLERLGVPVLFLG--SLFERP----EIKELLSLLT--ILTDRR-AMGLVRAACMSEFAMP 626 
WP_075336063  345 RlgNVAILYPSKKEGEYLAEACRASSVPFVRNDRGSPYSRTrlirWLEDAAAWVagrtLMTPRwEDLLDRWVSLC----G 420 
NP_797462     556 SyrDQAVLCSGNERLSQLAEQLELLGVPVLYLG--SLFERE----EVKDMFSFLS--LLTDSW-GSGLVRIGRWPEFELS 626 
WP_010040968  560 PfrHQVVLARSHTTLARLAGHLERSGVPCLYFG--DFFERP----EVRDLLSLLS--VVSEKR-GVGLLRVAQMPQYAVP 630 
WP_008250242  565 EykDQAILCTSNNRLSEIAASLEALGLPVLYLG--SLFERE----EIKDLLSLLS--LVTDRR-ATGLVRAATLPGYTVR 635 
WP_084764649  581 PlsQQAVLAPTNNRLDIVAGILAEHGIATTHLG--SFFERE----EVRDLLSVIA--LLAEAN-GGALVRVAALREIGVG 651 
4C2T_A        427 DTALQKLMEWARTH-HTSVLTACANAAEQNIL-DRGAHKATEFAGLMEAMSEAADnYEPAAFLRF-VMETSGYLDLLRQE 503 
WP_014402856  629 IADIQLLMGLSKQGfEHQRGRWLRTSAPVPGLsPKGQQVVQALRTLLQGNSRSS---RPWAFVCDlMFEQGHGMGS-LSD 704 
WP_012112794  632 LQDAYCVSRHLRSI-GKPALAGLAEASAAPGLsTAGRAGVERLAADLAGLRANA---SAWDFLATyLLDRTDLAKQLSQA 707 
WP_011463506  631 FEDFQKLMELCEEDpLLQRGAWLDDLP--EDLsPQSRSVLVTIARLLNGQWRRS---NPWGFVCDlLLEHRFGYPP-RAD 704 
WP_013040333  627 LSDVDALFDHLRAV-DSIPGAWLGELGGITGLsETGSVALGAVAAAMRGFDQSA---SPWTVLATlLLDRTRITARIGGS 702 
WP_075336063  421 HG--GRLEH----Q------KAIa-L-------------RQRVARFLWRNRM--PgMPLCEWI-A-VLIE-GFEAELSE- 468 
NP_797462     627 LEDLDVILNHLRTE-RCEDKGWLLDSQDITGIsSSGKEALSKLGWTFEGIDKTD---HPWKVLATlIFDKTRIAARLSSS 702 
WP_010040968  631 PADIIKVVEWRREQ-AISMLSALRRADEICDLtDVGRAGIKLLVFDTRHWSWTV---SPHRFLTEyLFGSGEHVRLLLAG 706 
WP_008250242  636 LEHITALQQHLREA-DPDPLSWGVLIDEVPGLdEQARESLKRLSAVLGDVPTNA---NPWPVLASlVIDRLGWARQAAMA 711 
WP_084764649  652 ASDIGVIVRAAQAA-RVPLLSLLATASTLTGMsPTGGEALEQLGLQMAGLDQFT---PAFEVAASwLLDRSDYLRDLAVA 727 
4C2T_A        504 -GQEGQVRL-ENLEELVSAAEEWsqDean---vggSIADFLDDA---ALLS-SVDD-----MrtkaenkgaPEDAVTLMT 569 
WP_014402856  705 dSVAAQIRR-LAIWQFLYGV-RN--Tdgvg--sqaTLSKYLIRKdfqRYIGqRSGErvlppEa-------aAIDAVRVMT 771 
WP_012112794  708 dSLTAQMRA-VAIWQFLNFV-RE--Qvpvg--gglPIQRTLDRVrqlVLLAeERDLrqvpaAa-------lHLDAVRLMT 774 
WP_011463506  705 vSIEAHSLR-IALWQFAYAT-RT--Gdger--kfpTLPRFLLRQqlrQRIGeTYSErelpaEv-------aAIDAVRLLS 771 
WP_013040333  703 nDIAERTRG-LAIWQFMNFL-RV--Qpgg---qglPIVRLLDRVrrlVRLGdDRDLrqlpaAa-------qGLDAVRLMT 768 
WP_075336063  469 ----MKLNApDDVASLVGL-KEL------------ALNGFLQGC---TVLGfa-------fAg-------gSPDTLNLLT 514 
NP_797462     703 eVVSDKNRS-IAIWQLMNFV-RT--AisaetasglPVTRLLERVrrlLRLGdDKDLrqlpaSa-------qSIDAVRLMT 771 
WP_010040968  707 nTVQDQQRR-LAVYQLLQFAFAF--Kppe---kedPKHAFLNHVrrlTILDeEKQLrqlpaAa-------gDIDAVRLMT 773 
WP_008250242  712 nDLQSQMKG-VALWQLLSFV-RN--Sing---sglPIDRLLSRIrriVLLSeDREMrqlpqAa-------hSINGVRLMT 777 
WP_084764649  728 pDASGSLSR-AALLALLGFLDQR--Elgg---qplTPARALKRMrstVLLAdDRDLrdatlGa-------dA-DAVRLMT 793 
4C2T_A        570 LHNAKGLEFPVVFIVGVEQGLLPSK-G--------AI----A-----Eg---PSGIEEERRLFYVGITRAMERLLMTAAq 628 
WP_014402856  772 VHGSKGLEFDVVHMANVELSRYGAEpPawsn-erqGLllppEalnstPqmrsEGEAIERNNLLYVGLSRAKNLLRVYCGp 850 
WP_012112794  775 VHGSKGLEFEAVHIPGLTVASFPSSnRgqrcppprGMvegaGdlspaDea-kRAHDDEEECLFFVALSRARTHLRLYHAr 853 
WP_011463506  772 IHGSKGLEFDSVHVNNVNTDDYGPKgRywespseaSRlvppEvlrssQetwnFEATVERNNLLYVALSRARKRLFMYQNg 851 
WP_013040333  769 IHGAKGLEFPVVHVPGLNGDTIPRTpQappcpppdGMvegaEgr-alDvf-rAGHAEEQECLFYVALSRARDRLFLYAPt 846 
WP_075336063  515 LHSSKGLEFEVVVMVGLDEGVIPRY-K--------AS---------------ARGVAEARRLFYVGLTRAMRHVVFVYSg 570 
NP_797462     772 MHGAKGLEFKVVHLPGMSQGTLPRTyQkpaceppfGMitgeDdt-svTml-kAEHEKEQECLFYVSMSRAQDKLFMYAPa 849 
WP_010040968  774 VHASKGLEFPVVHLVSLAKTIFPLGnRsdpcpppaGMiaadDll---------taTAEEESLFFVGMSRAKDVLHL--Sr 842 
WP_008250242  778 IHASKGLEFKVVHLPGMIATGLPGSnRpprcvppdGLidgtEgltglEai-tAGHEEEEECKFFVATSRAQEGLLLYASs 856 
WP_084764649  794 IHGAKGLEFPAVHVVGLHDQCLPGAfRrddsplppGLv--------ePet-rEGHLEEEECLFFVAISRAEDHLRLYHSe 864 
4C2T_A        629 nr-mqFGkTNAAEDSAFLEDI-E-GlFDTVD-------PYGQpie-----yrAKTWKQYRPTVPAATTAVKNTSPLTAEL 693 
WP_014402856  851 d--------dSTVPRSLLDPA-------VIArytgaliPAVPepaprhrplvTPASISYAALDGFMTCPLQYHYGYELNF 915 
WP_012112794  854 kq--rnGs--GRSASPFLGWIpA-TlLDEISnpptlplP-------------AGASTSQPIAIAWPADWSVTDSRLGSYE 915 
WP_011463506  852 e--------dTRKGAPQLSPPsA-Pv-RALSfngtvtaPAGQapi-----prPPLTEPLPFDEFETFVRCPLQHWYRFEL 916 
WP_013040333  847 qk--snGh--NRPLSSFLDRVgS-GlART-KvnpaktlPP------------APEAGDVTLVVDGALRFTGAQIALYERC 908 
WP_075336063  571 ftvdqWGrKHRNGPSRFVRELlGrSlVEVRR--------D---------------------------------------- 602 
NP_797462     850 kk--snNs--QWKHSPFISRIqD-KvRTS-NvvetynlPR------------IDLDTDMDIAVDRDFIFESNHLGLYQQC 911 
WP_010040968  843 se--tnGa-vKRGPSSFLEHVtA-HlPKAVDaaag-------------wknlGHQAKGRPRLAAAAVTGAWSYYAIETYD 905 
WP_008250242  857 vq--anGn--NRKPSKYIDRIaS-ViQQQ-NsptrlslNS------------VELEVLSLDEEALLISEQQLSLYDRCPR 918 
WP_084764649  865 l---anVr--GRKPSPFLGRLgA-LeRRHl--------PAAAtaa-----gaAGSPLSPISTDRINLFDVRDFDSCPLRI 925 
4C2T_A        694 AYRGGEQVKHPKFGEGQVLAVAGVGERQEVTVHFASAGTKKLMVKFA 740 
WP_014402856  916 PAEQEMDVSMRAIKSVLVGLEYFYRDGMAPDQAFSQAWQEKSLPTFQ 962 
WP_012112794  916 KCPRRFFYTHVLGLGGARKPTAFSRTHDCLYDLLRWLADTRRTAEPT 962 
WP_011463506  917 RLAGEQGVDIAIKARWAVMAALKALAQKPGSSPKEAFMAEWESRKLP 963 
WP_013040333  909 PRRFFYTHVLQVGGRRTATAFMQMHEAVRTVFQTVIADARIIGGEGD 955 
WP_075336063      -----------------------------------------------     
NP_797462     912 PRRYLYTHLLKTGGKRTKTSYVKLHDAVRFVVQRHMEEGFDESELKS 958 
WP_010040968  906 ECPRRYYYDHALALNARDEEGPYLQFQSALHASLAWLRSVPQAAERS 952 
WP_008250242  919 RFLYTHALALAGKRSESAFMQMHSAVHEVLDWLGQEHSESTPSAGEL 965 
WP_084764649  926 AYRRFFGVEGRRHETPYLKTSGVLYALVDRITEVSGPGVEERLQVLL 972 
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