1H3D,2VD3,1NH7


Conserved Protein Domain Family
HisG

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COG0040: HisG 
ATP phosphoribosyltransferase [Amino acid transport and metabolism]
ATP phosphoribosyltransferase is part of the Pathway/BioSystem: Histidine biosynthesis
Statistics
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PSSM-Id: 439810
Aligned: 791 rows
Threshold Bit Score: 211.101
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1H3D_A         6 RLRIAMQKsGRLSD----DSRELLARCGIKINL--HTQR-LIAM-AENMPI-DILRVRDDDIPGLVMDGVVDLGIIGENV 76 
AKV03687      14 ELRLALPK-GRMQD----GVFKLLADAGMPVRV---GPRaYRPA-FSLPNV-EAKLLKPQSIVEMLHNGSRDVGFAGADW 83 
AXN02481       1 -MIISVPK-GRIYS----FFYKFLKKKKIKIYN--KNNRkLILN--TNSNF-KIALLKQIDTMYYLKNNYVDFSIVGLDF 69 
WP_010936573   1 MLRVALPK-GRLLG----DTKALLEKSQWGLDGyvDKAKiYCFKsVSNPEM-SAKIFHEKDIPIQLAIGNYDLGVCGADW 74 
WP_012800788   2 ALKMVIPK-GKLYD----KVAELLSDIGLTLVG---DSRnYRPQ-LFGCDI-EVKLLKSQNIPEMVALGQHDIGFAGMDW 71 
WP_012955851   3 EITLGLPK-GSLNNvnrgNTYQLFVDAGYEVRGyePGNEsYEINiLNDSEI-KAFLTRPQSTPVELNRGMVDISIVGEDW 80 
WP_013644796   3 KIVLGLPK-GSLNNvnrgNTYQLFVDAGYEVRGyePGNEsNEIGiMNDPEI-KGFLTRPQSAPVELNREILDLAVIGEDW 80 
WP_013719509   1 MIDIAIPK-GSLQN----QTLQLFEQAGLEVK---RTEReYNAR-IDDPRIgKVKILRPQEIPGYVAKGYFDLGISGTDW 71 
WP_014586430   1 MINIAIPK-GSLQN----QTLQLFAQAGLEIK---RTEReYNAR-IDDPRVgKVKILRPQEIPTYVAKGYFDLGISGTDW 71 
WP_048060741   2 KIVLGLPK-GSLNNvnrgNTYRLFRDAGYEVKGyePGREeNEIEiTNDPEI-KAYLTRPQSAPVELNREMLDIAIIGEDW 79 
1H3D_A        77 LEEEllnrraqgeD------PR-----YFTLRRLDFGG-----CRLSLATPVDEAWDGPLSL--------NGKRIATSYP 132
AKV03687      84 VAEL---------G------AD-----LVELVDTGCDP-----VRVVAAAPPEIAAK--LES--------RPIRVASEYE 128
AXN02481      70 FLEK---------KmfnlikKD-----IIGIKKMDFFK-----CGLYLIRKKNXSYKr------------KKIIISTKYV 118
WP_010936573  75 LTELtsr----ypS------SS-----IVKLKNLGYGH-----GALYAATAVNSPYDSLAALsa----csTRIRIASEYP 130
WP_012800788  72 VLEQ---------E------AD-----VEVLEDLGFNP-----VRLVSCIPEEWDWNEVQQ---------RKIIVASEYK 117
WP_012955851  81 VKEE---------Svl--sdND-----IVKIGDLNYGE-----TRLIVAIPKESPYDSLSEFfranadreRPILVFTEYP 139
WP_013644796  81 VQEE---------S------VNykeklIKKVGDLDYGQ-----TRLIVGVPKEAEYKDLTDFfrknkdrkTPILCFTEYP 140
WP_013719509  72 IMES---------G------AI-----VTKVADLNYGKqgpgaVKLVVAVLESLQISSARMIk-------PGSRVATEYP 124
WP_014586430  72 VVES---------G------AV-----VVTVAELDYGKqgpgkVKVVVAVPEAQRAASAKDIl-------PGSRISTEYP 124
WP_048060741  80 VREE---------S------INsgngsIKKIGDLDYGQ-----TRLIVAVPQEEPYRSLEDFflknsgreRPLLCFTEYP 139
1H3D_A       133 HLLKRYLDQK-----------------------GI-SFKSCLLNGSVEVAPRAGlADAICDLVSTGATLEANGLREVEVI 188
AKV03687     129 RLTAQWIQRR-----------------------GL-DARFVRSFGATEVFPPED-ADCIVDNAASGATLAVNGLVVVDEL 183
AXN02481     119 NITNRYYKNF--------------------------NKEIININGSNELAIKFKiSDFIIDIVDTGKSLKDNKLKKIYRL 172
WP_010936573 131 NIAEAFAMQL-----------------------RLkNFSIFPLWGSAEAYP-PDtAEVVILPRKSEADLAKKNLRSIAKV 186
WP_012800788 118 KISAKYLDKL-----------------------GV-KYQLLRAYGATEVFPPED-ADMVIDNTSTGSTIRANRLKIVDTV 172
WP_012955851 140 NLTRKHIMENeayqeiygdavpfvqvrglrdgdNK-KVQVINSDGATEVYIAKG-ADLIVDNTQTGSSLRKAGLKELETI 217
WP_013644796 141 NLTRQFFENNegykevfgetkpfvqvrglrdgdNM-MVQIINSDGATEVYIAKG-ADLIVDNTQTGSSLRKAGLKELETI 218
WP_013719509 125 NLTRAYFSNL-----------------------GI-PVDIQFSFGATEAK-VPElTDVVVDLTETGSTLKKNGLKIIDVM 179
WP_014586430 125 NLTRKFFADL-----------------------GI-PVEVENSFGATEAK-VPElADAVVDLTETGSTLVKNGLKIVDVI 179
WP_048060741 140 NLTRDFFMKNpgyrelfgdskpvvqirglrdgdNE-MVQIINSDGATEVYIAKG-ADLIVDNTQTGSSLRKAGLKIIDTI 217
1H3D_A       189 YRSKACLIQRDGEMEes-kQQLIDKLLTRIQGVIQARESKYIMMHAPTERLDEVIALLp----GAERPTILPl--AGdqq 261
AKV03687     184 MTSTTRLYASRAALDrpelRTRIEDLTLLVRSVIEARSRVMIELNVAAGELEAVVAILp----CMREATIAPlhgNG--- 256
AXN02481     173 FDIFPVIIYLKKNIN-------IKKISFFYEN--N--------------------------------------------- 198
WP_010936573 187 LDFKAYLIANSQSLEekdlSGAISSVMANISRYVEPKAEDI--------KIEPVNGCQp---sFLDMP-------DD--- 245
WP_012800788 173 MESSTQLIANKDIMNdpakRQQIDDLLLLMRGVLNGRKRVLLEMNCSEESIDRVVDLLp----AMRAPTVSQlynAD--- 245
WP_012955851 218 LHSSAGLYAGVSCTEe--kMVKAKMIYEQLLGAVTARKYFDVKFNIANEDIEKVSNYLienkfCSHEPTVNHg--SS--- 290
WP_013644796 219 MESSAGLYAGPSCTGe--kEKKAKMIFDQLFGAINARKFFDVKFNISTLKVDDIKEFLlknkyCSDEPTVVEg--KT--- 291
WP_013719509 180 LESTSELVANKKSFAdkekHDDISAVQTLLLAVMRARGKTLLKMNVPEAALDAVISMLp----SMKRPTLSKlysTD--- 252
WP_014586430 180 LESTSELIANKNSWAdpekREEIEAIETMLFAVTRARGKVLIALNVPEDRIEEVIALLp----SMKRPTVSKlynSG--- 252
WP_048060741 218 MESSAGLYAGPSCTGe--kLEKAEMIFKQLYGATKARNYFDVKFNIANHRADDVVEFLvrmkyCSDEPTVVRg--RE--- 290
1H3D_A       262 RVAMHMVS----SETLFWETMEKLKALGASSILVLPIEKMM 298
AKV03687     257 GFSVRAAV----PRAELPRIVPAVKARGGTDVVVFSPAQIV 293
AXN02481         -----------------------------------------    
WP_010936573 246 --TVRLALpdghQQPHVRKILDAagiaiedypsatgnhrpa 284
WP_012800788 246 GFAIKAAI----ERKLIKDLLPKLITAGATDILETPIRKVL 282
WP_012955851 291 FSQINVLI----PKNIFPEMLDGIKELGASSIIRSDVKQYV 327
WP_013644796 292 YSQVNVLI----PKTKFPAMVKGIKNYGASAIVRENVKQYI 328
WP_013719509 253 YYAIETVV----DRSQVNLLIPLLKKSGAEDILELAISKIV 289
WP_014586430 253 FYAVQSVV----DRSGINLLIPLLKKAGAEDIIEVAISKIV 289
WP_048060741 291 FSQVNVLI----DKSRFPEMLEEIKGFGASAIVRENVKQYI 327
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