Conserved Protein Domain Family
SCP_3
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pfam17844: SCP_3 
Bacterial SCP ortholog
This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.
Links
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Statistics
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PSSM-Id: 465530
Aligned: 92 rows
Threshold Bit Score: 122.626
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_022861508    34 DRSTVAMAVRYSLRLLEMKAPGGAVEVRVAPWGAVKILDGPRSDPHnlTPPDVIELDPTTWLRLASGMTRWDDERRRGAI 113 Bifidobacteri...
EFM46850        54 PRNTVAMAVRWTLQVLAERAPGHAVEVRVPPFGAVQVMAGTAHRRG--TPPAVVEMSPSTWLALAVGRLCWADALGANQI 131
WP_033518640    41 DRRAMAMAVRYTLAMMEIKAPGPGVELRVAPFGAVKILEGPASDPHnlTPPDVIELEPDVWLRLACGITDWGQEWHAGHI 120 Bifidobacteri...
WP_021617297    44 DRRGMAMAVRYSLYMLELRAPGPGVEVRVAPFAAVKILEGPQSDPHnlTPPDVIELDPAVWLRLVCGITSWSEEKNAGRI 123 Alloscardovia...
KFI82833        39 PRKDYAMAVRYSLYLLTLRAPGGAVEVRVAPWGAVKILDGPSSDPHnlTPPDTIELDPDVWLRVACGITSWSSERDSGHI 118
WP_022860198    41 DRRTMAMAVRFSLFVLERKAPGPGVEVRVAPFSAVKILDGPASDPHnlTPPDVIELDPPVWLRLATGITTWDEEREAGHI 120 Bifidobacteri...
jgi:Sked_34170  25 ERRTVTTAVRFTLEEIADVAPGHAVEVRVPPWGAVQCVEGPRHTRG--TPPNVVETDPETWLGLVCGLVTWQDAVRDGRV 102
KGM16178        27 DRADVRTAVRFTLEELAARAPGGAVEIRVPPDGAVQAVPGPGHTRG--TPPNVVETDPRTWLELITGRTAWVDAVRDGRV 104
jgi:Namu_5050   28 DRDRVAAAVRASLRWLAQAHPGKAVEIRVPPYAAVQAMGGLSHTRG--TPPNVIETDPATWLALVVGTVSWADALGDGRV 105
WP_055239093    24 DRNTTATAVRYTLEELAERVPGNSVEVRVPPFGVTQCIPGPRHTRG--TPPNVVETDAATWLALVTGDLSWADAVSAGKV 101 Arthrobacter ...

WP_022861508   114 AAMGERDDLSALLPL 128 Bifidobacterium minimum
EFM46850       132 SASGERADLSELLPL 146
WP_033518640   121 SAVGERDDLSMLLPL 135 Bifidobacterium cuniculi
WP_021617297   124 SAVGERDDLSGLLPL 138 Alloscardovia omnicolens
KFI82833       119 SAMGERDDLSRLLPL 133
WP_022860198   121 SAVGERDNLSALLPL 135 Bifidobacterium magnum
jgi:Sked_34170 103 SASGDRADISHLLPL 117
KGM16178       105 SASGLRADLGPALPL 119
jgi:Namu_5050  106 SASGTRADLSALLPL 120
WP_055239093   102 SASGLRADLSGCLPL 116 Arthrobacter sp. Edens01
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