Conserved Protein Domain Family
PRK11905
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PRK11905: PRK11905 
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed
Links
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Statistics
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PSSM-Id: 237018
Aligned: 86 rows
Threshold Bit Score: 1720.86
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
89256175     9 GEyPISKEIMNI--YKYWLIDEKEAMTKLVEKAHMSSVQKAQVRERAYGLVEKVRKNRLKKSgIDAFMIEYDLSSEEGVV 86  
110679747    1 ---MISALRQSV--DEKTYADPDEIILEMISQTALTKTDRAQISAAAARLVDDIRNTTSPGL-MEVFLAEYGLSTDEGVA 74  
126461607    1 ----MLAAAVHP--TSSDTLDEAGLVARLIAEADLDPSARARIVARGADLVRRIRQGSRPGL-MEGFLAEYGLSTDEGIA 73  
119383694    1 MNrVNPTVRSDVfsAQAKFADEAELLSGLVAQAGLDDAQRAAITRRAADLVRRIRDEAKPTM-MEHFLAEYGLSTREGVA 79  
77462714     1 ----MLAAAVHP--TSSDTLDEAGLVARLIAEADLDPSARARIVDRGADLVRRIRQGSRPGL-MEGFLAEYGLSTDEGIA 73  
99081536     1 -MtRDMRLRDRI--DAGTYLDQANMRDALVALAALSEADRSAICASATQLVKDIRGHSSPGL-MEVFLAEYGLSTDEGVA 76  
146278361    1 ----MLAAVPQP--PLSDRPTEADLVARLIAEADLDAEARARIVARGASLVRRIRQGSRPGL-MEGFLAEYGLSTDEGIA 73  
56697843     1 ---MTHALRTHI--DSQTYADQSALLDQLVAQAALSEVDRAAICAAAAGLVRDIRSSTAPGL-MEVFLAEYGLSTDEGIA 74  
221638575    1 ----MLAAAVHP--TSSDTLDEAGLVARLIAEADLDPSARARIVARGADLVRRIRQGSRPGL-MEGFLAEYGLSTDEGIA 73  
294678169    1 ----MTDLSALG--PKAKFAPEAEVLQALVAQAALPQPQLDRIAARGADLVARIRAEAKPSL-MEHFLAQYGLSTREGVA 73  

89256175    87 LMCLAEALLRVPDKYTIDLLIKDKLTSAAWKNHVGMEKHLFVNAATWSLMLTGKILKD-PHRSYRKVFQNFLKKTSEPVI 165 
110679747   75 LMCLAEALLRVPDPETIDALIEDKIAPSDWGRHLGHSASSLVNASTWALMLTGRVL-DdSHPGPVRQLRAALKRLGEPVI 153 
126461607   74 LMCLAEALLRVPDAETMDALIEDKIAPSDWNRHLGRSASSLVNASTWALMLTGKVL-DdREPGVAGHLRGLVRRLGEPVI 152 
119383694   80 LMCLAEAMLRVPDRMTIDALIEDKIAPSDWGKHLGEASSSLVNASTWALMLTGKVL-DdDQAGIAGTLRRAVRRLGEPVI 158 
77462714    74 LMCLAEALLRVPDAETMDALIEDKIAPSDWNRHLGRSASSLVNASTWALMLTGKVL-DdREPGVAGHLRGLVRRLGEPVI 152 
99081536    77 LMCLAEALLRVPDADTIDALIEDKIAPSDWGKHMGKSTSSLVNASTWALMLTGKVLD--EEKSPVGALRGAIKRLGEPVI 154 
146278361   74 LMCLAEALLRVPDADTMDALIEDKIAPSDWNRHLGRSASSLVNASTWALMLTGKVL-DdREPGVAGHLRGLMKRMGEPVI 152 
56697843    75 LMCLAEALLRVPDADTIDALIEDKIAPSDWGKHLGHSSSSLVNASTWALMLTGKVL-DeRKASPVGALRGAIKRLGEPVI 153 
221638575   74 LMCLAEALLRVPDAETMDALIEDKIAPSDWNRHLGRSASSLVNASTWALMLTGKVL-DdREPGVAGHLRGLVRRLGEPVI 152 
294678169   74 LMCLAEAMLRVPDTATIDALIEDKIAPSDWGKHLGTAASSLVNASTWALMLTGKVL-DdGAGGIAGTLRGAMRRLGEPVI 152 

89256175   166 RQAMKQAMKIVGKQYVLGETIEEALKVSEAKVARGYSYSYDMLGEAAMTMDDAEYYYSQYLHAIHELAKYATNTEIKKNP 245 
110679747  154 RTAVSRAMKEMGRQFVLGENINAAMERAAGMEKKGFTYSYDMLGEAARTEADAKRYHLSYSRAISAIATACTDDDIRKNP 233 
126461607  153 RKAVARAMKEMGRQFVLGETIEGAMERAAELEAKGYSYSYDMLGEAARTEADARRYHLAYSRAITAIAAAAKSRDIRDNP 232 
119383694  159 RTAVGRAMKEMGRQFVLGQTIEAALERAAKREAQGFTYSYDMLGEAAMTGADAARYDRAYSDAIAAIAKACTRGSVEDNP 238 
77462714   153 RKAVARAMKEMGRQFVLGETIEGAMARAAELEAKGYSYSYDMLGEAARTEADARRYHLAYSRAITAIAAAAKSRDIRDNP 232 
99081536   155 RTAVGRAMKEMGRQFVLGETIESAMKRASNMEAKGYTYSYDMLGEAARTEADASRYHLAYSRAISAIASACTSTDIRENP 234 
146278361  153 RAAVARAMKQMGRQFVLGETIEDALDRAAELEGRGYSYSYDMLGEAARTEADARRYHLAYSRAITAIAAAARSRDIRDNP 232 
56697843   154 RTAVSRAMKEMGRQFVLGETIQSAMKRASGMEAKGYTYSYDMLGEAARTEADAARYHLSYSRAIAAIAEACTHGDIRANP 233 
221638575  153 RKAVARAMKEMGRQFVLGETIEGAMARAAELEARGYSYSYDMLGEAARTEADARRYHLAYSRAITAIAAAAKSRDIRDNP 232 
294678169  153 RAAVGQAMREMGRQFVLGETIEKALERAEKREAEGYTFSYDMLGEAALTAADAERYRLAYAQAITAIGKAATRGSIAANP 232 

89256175   246 GISIKLSALHPRYEVAKHQRVHTELYPKLLKLTQLAKDYNVGMNIDAEETERLQISLELVERLAHEPSLEGFNGIGIVVQ 325 
110679747  234 GISVKLSALHPRYEVAQQEAVMSDLVPRLRALALLAKSAGMGLNVDAEEADRLGLSLDVIDCVMGEPALRGWDGFGIVVQ 313 
126461607  233 GISVKLSALHPRYEVAKRARVLAELVPRVTALAGLARAAGLGFNIDAEEADRLDLSLEVIAAALAEPSLAGWDGFGVVVQ 312 
119383694  239 GISIKLSALHPRYEVAQESRVMTELVPVVLKLARQAKAAGMGMNIDAEEQDRLVLSLKVIEAVLSDPSLAGWDGFGVVVQ 318 
77462714   233 GISVKLSALHPRYEVAKRTRVLAELVPRVTALAGLARAAGLGFNIDAEEADRLDLSLEVIAAALAEPSLAGWDGFGVVVQ 312 
99081536   235 GISVKLSALHPRYEIAKEESVMQQLVPRLKALALLAKAAKMGLNIDAEEADRLSLSLEVIEEVISDPALKGWDGFGVVVQ 314 
146278361  233 GISVKLSALHPRYEVAKRARVMAELVPRVTALAGLARAAGLGFNIDAEEAERLDLSLEVIEAALSEPSLGGWDGFGVVVQ 312 
56697843   234 GISVKLSALHPRYELAQDARVMDELVPRLRALALLAKAAGMGLNVDAEEADRLSLSLQVIEAVMAEPALKGWDGFGIVVQ 313 
221638575  233 GISVKLSALHPRYEVAKRARVLAELVPRVTALAGLARAAGLGFNIDAEEADRLDLSLEVIAAALAEPSLAGWDGFGVVVQ 312 
294678169  233 GISIKLSALHPRYEVAQEARVMAELVPVVRDLARAAARAGIALHIDAEEQDRLALSLRVMAAVIADPETAGWEGFGAVVQ 312 

89256175   326 AYQKRAPYVLDYLANLAKKTNRRFMIRLVKGAYWDAEIKHAQEQGLAGYPVFTRKYHTDVSYQACVKQLFENHQYIYPQF 405 
110679747  314 AFGPRAGIVIDTLYEMAKRHDRKIMVRLVKGAYWDTEIKRAQVEGVEGFPVFTQKAQTDVSYICNARKLLGMTDRIYPQF 393 
126461607  313 AYGRRAGEVLDRLYGMAVRLDRKLMVRLVKGAYWDGEVKRAQVLGLADFPVFTRKMATDVSYIAQARKLFSMSDRIYPQF 392 
119383694  319 AYGKRAGQVIDWLYETATRLDRRIMVRLVKGAYWDTEIKRAQVEGFPGFPLFTSKVATDVSYIANARKLIGYADRIYPQF 398 
77462714   313 AYGRRAGEVLDRLYGMAVRLDRKLMVRLVKGAYWDGEVKRAQVLGLDDFPVFTRKMATDVSYIAQARKLFSMSDRIYPQF 392 
99081536   315 AYGPRTGLAIDALYEMAEKYDRRFMVRLVKGAYWDTEIKRAQVEGMDGFPVFTSKALTDVSYIANARKLLSRTDRIYPQF 394 
146278361  313 AYGRRAGEVLDRLYGMAVRFDRKLMVRLVKGAYWDGEVKRAQVLGLEDFPVFTRKMATDVSYIAQARKLFAMSDRIYPQF 392 
56697843   314 AYGPRAGLVIDTLYEMAQRHDRKLMVRLVKGAYWDTEVKRAQVEGVDGFPVFTQKSATDVSYIANARKLLSMTDRIYPQF 393 
221638575  313 AYGRRAGEVLDRLYGMAVRLDRKLMVRLVKGAYWDGEVKRAQVLGLADFPVFTRKMATDVSYIAQARKLFSMSDRIYPQF 392 
294678169  313 AYGKRAGAAIDALAAMARAAGRRINIRLVKGAYWDAEMKRAQVEGHPGFPLFTSKTGTDVAYICLAAKLFGLNDCIYPQF 392 

89256175   406 ATHNAQTVAVVFELANGnrdFEFQCLHGMGDALYDNVVgkeGYEDIPCRIYAPVGGHKHLLAYLVRRLLENGANSSFVNR 485 
110679747  394 ATHNAHTVAAILHMADDpqaYEFQRLHGMGETLHTLVL---QQNKTRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 470 
126461607  393 ATHNAHTVAAILELAEGr-pFEFQRLHGMGERLHDLVL---TEEKTRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 468 
119383694  399 ATHNAQTVAAILEMAGEt-rFEFQRLHGMGERLHDIVL---RDHNGRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVHQ 474 
77462714   393 ATHNAHTVAAILELAEGr-pFEFQRLHGMGERLHDLVL---TEEKTRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 468 
99081536   395 ATHNAHTVSAILHMAEEgqaYEFQRLHGMGETLHQMVM---DQNKTRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 471 
146278361  393 ATHNAHTVAAILEMAEGr-pFEFQRLHGMGERLHDLVL---AEEGTRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 468 
56697843   394 ATHNAHTVAAILHMAKDgqpYEFQRLHGMGETLHNLVL---TANKTRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 470 
221638575  393 ATHNAHTVAAILELAEGr-pFEFQRLHGMGERLHDLVL---TEEKTRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 468 
294678169  393 ATHNAHTVAAVLEMAAGr-pFEFQRLHGMGARLHDIVL---RETGGRCRIYAPVGAHRDLLAYLVRRLLENGANSSFVNQ 468 

89256175   486 IVDENLPIEELIEDPVKKAIDHGCGQHPNIPYPKDIV-SPRLNSQGHNTNDFAVLADMYKQIEKYTHKnTYKAKPIVSGI 564 
110679747  471 IVDEDVPAEVVAADPFEKVITEPV---AQIPSGPDLFaPERCNSRGFDLTHSQTLEALFEARDGFAKS-AWQAAPLLVSG 546 
126461607  469 IVDESVSPEAVAACPLTAMERTEPVRNPVLRAGTDLF-PGRRNSRGFDLAAAEDLALIESARSPHRTA-LFDARPILAES 546 
119383694  475 IVDESVSPEEVARDPFAALAEAR--PPLGLITPDALFgASRRNSTGFDLTDEETLARIYTARDVAIPD----AMPLTVSE 548 
77462714   469 IVDESVSPEAVAACPLTAMERTEPVRNPVLRAGTDLF-PGRRNSRGFDLASAEDLALIESARSPHRTA-LFDARPILAES 546 
99081536   472 IVDEDVPPQVVAADPFQEVDDLTT----DIPTGPNLFqPERINSKGFDLRHAPTLAAIEKARAPFREA-TWDAVPLIAGE 546 
146278361  469 IVDESIRPEAAVACPLTAMEGMTPVPNPVLRTGSDLF-PGRRNSRGFDLASEADLALIDSARAPHQTA-LFDARPLLAGS 546 
56697843   471 IVDENVPPEVVAADPFETVKA----PAKPLKRGPELFaPERPNSMGFDLGHQPTLDAIDAARDPFRSH-RWQAGPLLAEE 545 
221638575  469 IVDESVSPEAVAACPLTAMERTEPVRNPVLRAGTDLF-PGRRNSRGFDLASAEDLALIESARTPHRTA-LFDARPILAES 546 
294678169  469 IVNESVPPAEVAACPFAALPTAR--APRGLLAPADLFgAGRVNAQGFDLSDPEVLARIEAARDVTLPD----AAPIVAGP 542 

89256175   565 DLDKTIt-ESVINP-NTNEVIGSVINADAKIAKRALKNAQSafeeWSNTPATKRADILEKFADLLEQDTNKFIAIAMIEA 642 
110679747  547 ETANDAptEAVLNPaDPSDRVGSVVWATAADVEAAFATATP----WAA-PPTERRRVLLQAADLLEADHAQLFTLLTREA 621 
126461607  547 LAGGQR--AEVTDPaT-GARVGNVLPASLPDVETALHHAVP----WEARP-EDRAEVLRRAADLYEASFGPIFALLAREA 618 
119383694  549 PTGKMQ---DVLNPaT-GEKIARVMMVDADTAARAIADARI----WDA-SAAERAAVLRRAADLYEDHYGPIFGILGREA 619 
77462714   547 LAGGQR--AEVTDPsT-GARVGNVLPASLPDVETALHHAVP----WEARP-EDRAEVLRRAADLYEASFGPIFALLAREA 618 
99081536   547 AQPEAR--VAVTNPsDLSEI-GSVSQSSAEDVELALASANT----WDA-PAEERAAALNKAADLYEAHYGELFALLAREA 618 
146278361  547 LAGGQR--REVANPaT-GARVGNAIPASLPDVEAALHHAVP----WEARP-EDRAEVLQRAADLYEQAFGPIFALLAREA 618 
56697843   546 ASPEAE--EAVVNPaDPHDVPGSVAPASAADAELSLARAQP----WQA-PAAERAAVLNRAADLYEAHYGELFALLHREA 618 
221638575  547 LAGGQR--AEVTDPsT-GARVGNVLPASLPDVETALHHAVP----WEARP-EDRAEVLRRAADLYEASFGPIFALLAREA 618 
294678169  543 VSGTLR---PVRNPaT-GAVVAQVTEADAATVALALDAAQV----WSA-PAATRAAVLCRAADLYEENFGPIFAALAQEA 613 

89256175   643 GKTLANAIDEVREAVDFCRYYAAQARKEfnGPIELPalsdhlkqieftgRGAMVCISPWNFPLAIFLGQITAVLAAGNTV 722 
110679747  622 GKNLPDCVAELREAVDFLRFYASQATDAp-------------------cAGIFTCISPWNFPLAIFLGQISAALAAGNAV 682 
126461607  619 GKTLPDAVGELREAVDFLRYYAAEGEALt----APP-------------LGTVVCISPWNFPLAIFTGQIAAALMAGNAV 681 
119383694  620 GKSLADAVAELREAVDFLRYYAAEGEASpgAP-----------------RGIVGAISPWNFPLAIFTGQIAAALMAGNAV 682 
77462714   619 GKTLPDAVGELREAVDFLRYYAAEGEALt-APP----------------LGTVVCISPWNFPLAIFTGQIAAALMAGNAV 681 
99081536   619 GKTQMDAVAELREAVDFLRYYASRIPDAa------P-------------AGIFTCISPWNFPLAIFTGQVSAALATGNAV 679 
146278361  619 GKTLPDAVGELREAVDFLRYYAAEGAALd-GAP----------------LGTVVCISPWNFPLAIFTGQIAAALMAGNAV 681 
56697843   619 GKTLPDAVAELREAVDFLRYYAANIPDAa-------------------sAGIFTCISPWNFPLAIFSGQIAAALATGNAV 679 
221638575  619 GKTLPDAVGELREAVDFLRYYAAEGEALi----APP-------------LGTVVCISPWNFPLAIFTGQIAAALMAGNAV 681 
294678169  614 GKTLGDAVSELREAVDFLRYYAAEGA----ADTRPP-------------RGAVVAISPWNFPLAIFTGQVAAALMAGNAV 676 

89256175   723 VAKPAEQTPIIAYKAVKLLFKAGLPKNVLQFTPGDGATVGSALVKSPVCKGVIFTGSTEVAAIINQTLANKsSEIVPFIA 802 
110679747  683 LAKPAQQTPLIAHRAITLMYEAGVPRSALQLLPGAGD-IGALVTSDARIGGVAFTGSTATALRIRSAMAENcRPGTPLIA 761 
126461607  682 LAKPAEQTPLIAALAVELLHRAGVPATALQLLPGEGGTVGAALTRDPRVGGVVFTGSTETARAIRQSMADHlDPAAPLIA 761 
119383694  683 IAKPAEPTPVIAAYAIGLLHQAGVPKAALQLLPGAGRVVGTALSSDPRVSGLVFTGSTGTAQTIARTMAANlAPGTPLIA 762 
77462714   682 LAKPAEQTPLIAALAVELLHRAGVPVTALQLLPGEGGTVGAALTRDPRVGGVVFTGSTETARAIRQSMAAHlDPAAPLIA 761 
99081536   680 LAKPADQTPLVAFRAVELLHEAGVPRDVLQFLPGRGSKVGAAITGDARINGVAFTGSTATAMRIRSAMAEHcAPGTPLIA 759 
146278361  682 LAKPAEQTPLIAALAVELLHRAGVPTTALQLLPGEGGTVGAALTRDPRVKGVVFTGSTETALAIRRSMAEHlDPSAPLIA 761 
56697843   680 LAKPAPQTPLIAHRAVQLLHEAGVPRDALQLLPG-GPAVGAALTSDPRVSGVAFTGSTATAQKIRAAMAANmRPGTPLIA 758 
221638575  682 LAKPAEQTPLIAALAVELLHRAGVPATALQLLPGEGGTVGAALTRDPRVGGVVFTGSTETARAIRQSMAAHlDPAAPLIA 761 
294678169  677 LAKPAEQTPIIAALAVRLLHQAGVPETALQLLPGDGPTVGAALTRDPRVAGVVFTGSTETAQIIARAMAAHlAPGTPLIA 756 

89256175   803 ETGGQNAMIVDSSSLPEQVTADVIRSAFDSAGQRCSALRILCLQEDIADNYIKMIVGAMKELKIGDSKYIDTDVGPVIDK 882 
110679747  762 ETGGLNAMIVDSTALPEQAVQAIIESAFQSAGQRCSALRCLYVQEDIAPEFTKMLLGAMQCLTVADPWHLSTDVGPVIDA 841 
126461607  762 ETGGLNAMIVDSTALPEQAVRDILASAFQSAGQRCSALRCLYLQEDVAESVLEMLCGAMDELQAGEPWDLATDLGPVIDA 841 
119383694  763 ETGGLNAMVVDSTALPEQAVRDIVNSAFRSAGQRCSALRCLYVQEDVAPHLVEMIKGAMDELRLGDPWDLTTDVGPVIDP 842 
77462714   762 ETGGLNAMIVDSTALPEQAVRDILASAFQSAGQRCSALRCLYLQEDVAEGVLEMLFGAMDELQAGEPWDLATDLSPVIDA 841 
99081536   760 ETGGLNAMIVDSTALPEQAVQAVVESAFQSAGQRCSALRCLYLQEDVAEDVLTMLKGAMELLDLDDPWHLATDSGPVIDE 839 
146278361  762 ETGGLNAMIVDSTALPEQAVRDILASAFQSAGQRCSALRCLYLQEDVAEGVLEMLFGAMDELRLGDPWDLATDVGPVIDA 841 
56697843   759 ETGGLNAMIVDSTALPEQAVQAVIESAFQSAGQRCSALRCLYLQEDIAEDVLTMLKGAMDALNLGNPWALSTDSGPVIDE 838 
221638575  762 ETGGLNAMIVDSTALPEQAVRDILASAFQSAGQRCSALRCLYLQEDVAEGVIEMLCGAMDELQAGEPWDLATDLGPVIDA 841 
294678169  757 ETGGLNAMVVDSTALPEQAVRDVVASAFRSAGQRCSALRCLYVQDDIAPHLIGMLKGAMEELVSGDPARLSTDVGPVIDA 836 

89256175   883 EAADNLNAYIEEKKSQFKLIYQSQPNqdtQKGTFVMPTAFEIDKISDLGREQFGPILHILRFKANQLDKLINDINATGYG 962 
110679747  842 AARDGIAQHIAQARAEGRVIAETTAP---ATGTFIAPTLISVPGIAALEREIFGPVLHLATFKAHQLDAVIDDINATGYG 918 
126461607  842 EAQAGIRDWIAAARAEGRVLKQMAVP---ARGTFVGPTVIRVGSIREMDREIFGPVLHVATFRATEIDRVIAEIDATGYG 918 
119383694  843 GAQKEIADYIAA--NANRVLHKLAAP---SRGWFIPPTMLKVSGIADLEREIFGPVLHVATFRGDQLDQMIADINARGFG 917 
77462714   842 EAQAGIRDWIAAARAEGRVLKQLAVP---ARGTFVGPTVIRVGSIREMDREIFGPVLHVATFRATEIDRVIAEIDATGYG 918 
99081536   840 GSRAKILAHIDEARAEGRVLKEMQAP---QSGTFVAPTMISINGISDLKEEIFGPVLHVATFKSRELDAVIDAINATGYG 916 
146278361  842 EAQAGIRDWIATARAEGRVLKELPTP---EGGTFVGPTVIRVASIREMGREIFGPVLHVATFRASGIDRVIEEIEATGFG 918 
56697843   839 AARKIITDHVAGARAEGRVLKELALP---PEGTFVAPTLIKVAGIGALEREIFGPVLHVATFRSNELDQVIAAINATGYG 915 
221638575  842 EAQAGIRDWIAAARAEGRVLKELAVP---ARGTFVGPTVIRVGSIREMDREIFGPVLHVATFRATEIDRVIAEIDATGYG 918 
294678169  837 EAKAGIETYLAANKA--RILHRSTAP---EGGHFVAPALLQVGGIADLEREIFGPVLHLATFAAEDLPAVIAAINARGYG 911 

89256175   963 LTAGVHSRINEVMNYVKNNLKAGNIYVNRNIVGAVVGVQPFGGQGKSGTGPKAGGPYYMHRLANEklsgvgaveeiynpe 1042
110679747  919 LTFGLHTRIDDRVQHVCERIAAGNVYINRNQIGAIVGSQPFGGEGLSGTGPKAGGPHYLTRFLQAdrk------------ 986 
126461607  919 LTFGLHSRIDDRVQALVGRLRVGNIYVNRNQIGAVVGSQPFGGEGLSGTGPKAGGPAYLARLVSRpa------------- 985 
119383694  918 LTFGLHTRIDSRVQEVSDAIHVGNIYVNRNQIGAVVGSQPFGGEGLSGTGPKAGGPRYVPRFFAP--------------- 982 
77462714   919 LTFGLHSRIDDRVQALVGRLRVGNIYVNRNQIGAVVGSQPFGGEGLSGTGPKAGGPAYLARLVSRpa------------- 985 
99081536   917 LTFGLQTRIDDRVQHVCDRIHAGNIYVNRNQIGAIVGSQPFGGEGLSGTGPKAGGPNYLARFCAP--------------- 981 
146278361  919 LTFGLHSRIDDRVQTLVGRLRIGNIYVNRNQIGAVVGSQPFGGEGLSGTGPKAGGPSYLARLRARpa------------- 985 
56697843   916 LTFGLQTRIDDRVQHVTEAVHAGNIYVNRNQIGAIVGSQPFGGEGLSGTGPKAGGPNYMARFCAP--------------- 980 
221638575  919 LTFGLHSRIDDRVQALVGRLRVGNIYVNRNQIGAVVGSQPFGGEGLSGTGPKAGGPAYLARLVKRpa------------- 985 
294678169  912 LTFGLHSRIDARVETVAETIRAGNIYVNRNQIGAVVGSQPFGGEGLSGTGPKAGGPLYLNRFYAP--------------- 976 

89256175  1043 kiaeyekqtnklikdkytitnivagekakkdkytnlkaangktigkkyvasvntvdnaieiaskeveiwNHVNAEQRAAT 1122
110679747  987 ------------------------------------------------------------------evsEQWSQPQATLA 1000
126461607  986 --------------------------------------------------------------------pDCAGSEAPAQP 997 
119383694  983 ------------------------------------------------------------------------------AA 984 
77462714   986 --------------------------------------------------------------------pDCAGSEAPAQP 997 
99081536   982 ------------------------------------------------------------------------DRRQVDAA 989 
146278361  986 -------------------------------------------------------------------ppSIGAGADHEAG 998 
56697843   981 ------------------------------------------------------------------------DRQQAAAD 988 
221638575  986 --------------------------------------------------------------------pDCAGGEAPAQP 997 
294678169  977 -----------------------------------------------------------------------EPVVAVGGW 985 

89256175  1123 IEKFLELLEKER-----YLIASSLVVESNisvedahiqidktiqqvayyclqAKKEFAHPQLLPGPTGEIDELSLKGRGV 1197
110679747 1001 PLTMDAPVTPHS-----------------------------------------------SLSLPGPTGESNRLSTLPRPA 1033
126461607  998 AAEVQAALDRLAp---------------------------------------KAGELIGTRALPGPTGESNRLSLLRRPP 1038
119383694  985 PSAVPGTWQGEGdearlRGALADASPKKI-----------------------------DERLMPGPTGELNRLTAHARPP 1035
77462714   998 AAEVQAALDRLAp---------------------------------------KAGELIGTHALPGPTGESNRLSLLRRPP 1038
99081536   990 WKDTMGEIPAAR----------------------------------------GQAGHPETTSLPGPTGESNRLTVSARPP 1029
146278361  999 EAEVQAALDRLAd---------------------------------------EVGLSLSTHVLPGPTGESNRLSFLRRPP 1039
56697843   989 WAAPMATLPRAT----------------------------------------GTPAPVRVQSLPGPTGESNRLSEMARPP 1028
221638575  998 AAEVQAALDRLAp---------------------------------------KAGELVGTRALPGPTGESNRLSLLRRPP 1038
294678169  986 TEAATPILPE------------------------------------------ARETQLDEIFLPGPTGELNRLTRHQRGP 1023

89256175  1198 VVSMCSSSDLLIRfvgQTAAALLAGnTVVAKPAYTGNLTAYNIVKLMlkagidskvlhlvlsddeeITSALLfnskvalv 1277
110679747 1034 LLCMGPGAQAAKE---QARLVRALG-GVALEAQGKIDPAALRDGPEY--------------------GGVLW-------- 1081
126461607 1039 LLCLGPGPAAARA---QAEAVQALG--GLAVEAPGLAPEALATLRGF--------------------AGALY-------- 1085
119383694 1036 VLCLGPGAEAVAA---QVAAVQALG-GQAVGADGALPPEALTRLPQL--------------------STVLW-------- 1083
77462714  1039 LLCLGPGAAAARA---QAEAVRTLG--GLAVEAPGLAPEALATLRGF--------------------AGALF-------- 1085
99081536  1030 LLCAGPGAEAVSE---QAKLVASLG-GIAIEADGMVDLHRLAHMDGI--------------------SGVLW-------- 1077
146278361 1040 LLCLGPGAEAARA---QAEAVRALG--GLAVEAPGLPTTALGRLGGF--------------------SGALH-------- 1086
56697843  1029 LLCLGPTAATVAT---QAQAVEALG-GTAIRATGALAAEALETVEGI--------------------SGVIW-------- 1076
221638575 1039 LLCLGPGAAAARA---QAEAVQALG--GLAVEAPGLAPEALATLRG--------------------FAGALF-------- 1085
294678169 1024 ILCLGPGAEAASA---QAAAVVALG-GQAVQASGAVSPKALETLTPL--------------------AGVLW-------- 1071

89256175  1278 sfSGSVSAVKqvHQALVLRRGAIIPFVAesiakngkctslaietaSpLYLRRFVVEKTVSVDTTASGGNASLMSLEE 1354
110679747 1082 --WGDAATGRaiEVAFAARQGPIIPLIP-----------------GaPDVARVLAERHVCVDTTASGGNAALLGAAA 1139
126461607 1086 --WGGAGDARprAQALASREGAILPLIG-----------------GlPDEAHVAVERHLCIDTTASGGNAELLAAAS 1143
119383694 1084 --WGDEAQGRahAQALAAREGEIVQLIT-----------------AmPDLAHIAHERHLCVDTTAAGGNAALLAG-- 1139
77462714  1086 --WGGAGDARprAQALASREGAILPLIG-----------------GlPDEAHVAVERHLCIDTTASGAMPNFSPRPP 1143
99081536  1078 --WGDADTGReiEQSLAKREGPIVPLIP-----------------GaPDRARVLAERHVCVDTTAAGGNAALLGGNA 1135
146278361 1087 --WGGAEAARphALALAGRAGPILPLIG-----------------GlPDDAHVAVERHLCIDTTASGGNAELLAAAS 1144
56697843  1077 --WGDEETARayELALSRRSGPILPLIP-----------------GlPDGARVLAERHVCVDTTAAGGNAALLGGMG 1134
221638575 1086 --WGGAEDARprAQALASREGPILPLIG-----------------GlPDEAHVAVERHLCIDTTASGGNAELLAAAS 1143
294678169 1072 --WGAAEMGRayAQALAVRPGPLVPLIT-----------------AkPDLAHVAHERHLCVDTTAAGGNAALLAG-- 1127
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