1F4R


Conserved Protein Domain Family
AAG
?
cd00540: AAG 
Click on image for an interactive view with Cn3D
Alkyladenine DNA glycosylase catalyzes the first step in base excision repair
Alkyladenine DNA glycosylase (AAG), also known as 3-methyladenine DNA glycosylase, catalyzes the first step in base excision repair (BER) by cleaving damaged DNA bases within double-stranded DNA to produce an abasic site. AAG bends DNA by intercalating between the base pairs, causing the damaged base to flip out of the double helix and into the enzyme active site for cleavage. Although AAG represents one of six DNA glycosylase classes, it lacks the helix-hairpin-helix active site motif associated with other BER glycosylases and is structurally distinct from them.
Links
?
Statistics
?
PSSM-Id: 187726
Aligned: 91 rows
Threshold Bit Score: 172.323
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
DNA bindingactive site
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1F4R_A; Homo sapiens alkyladenine DNA glycosylase (AAG) bound to double-stranded DNA; contacts at 3.5A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #      # #    # # #             #  #  #
1F4R_A     11 FFDQPAVPLARAFLGQVLVRrlpn----gteLRGRIVETEAYLGpEDEAAHSRGGRQTPRnRGMFMKPGTLYVYIIYGmY 86  human
YP_473785   6 WLSKPAPLVAPTLLGMVLVRqfad----glqVRAQIVETEAYTA-GDPACHAYRRKTRRN-QVMFGPPGHLYVYRIYGlY 79  Synechococcus sp. ...
NP_874657  25 FFCRPSEEVAPDLIGCLLVKresn----kklLWGAIVETEAYSQ-SEPACHGFTRKTSKN-KTLFGNPGRLYVYLTYGsY 98  Prochlorococcus ma...
Q9HX17     21 FFDRDALLVARELLGKVIRHrqg-----nlwLAARIIETEAYYL-EEKGSHASLGYTEKR-KALFLDGGHIYMYYARG-G 92  Pseudomonas aerugi...
NP_880981  20 FFNRDAQQLARDLLGKVVRHrvd-----glwLSARIIETEAYYL-AEKGSHASLGYTHKR-RALFMDGGVVYMYYARG-G 91  Bordetella pertuss...
NP_970499   7 FYFEDTTLVAQSLLGKVLNIrtd-----sgiQKARIIETEAYLGiEDPACHTFEDRRTERtKSMYLDGGHSYVYMIYGmY 81  Bdellovibrio bacte...
ABO13236    9 WFQRETSEVAYDLIGCVLCKrqpd----gqvIRCTISETEAYLGvRDKACHSYNGKRTARtEVMYRHGGTIYVYLIYGmY 84  Acinetobacter baum...
Q93FQ6      9 FYKQKSLDVASSLLGKMLLFn---------qHKGIITETEAYIGqDDQAAHSFHGYTKRT-AVMFGNPGFSYVYLIYGmY 78  heartwater rickettsia
Q1QEF7     15 WFARPTCVVAADLIGKVLCReltdsdgqqkiLRMRISETEAYIGeGDAACHAHAGTRTPRtEIMYHIGGVFYVYLTYGiH 94  Psychrobacter cryo...
Q68X22     11 FFARDTNLVSTELIGKVLYFq---------gTTAIITETESYIGnDDPACHAARGRTKRT-DVMFGPAGFSYVYLIYGmY 80  Rickettsia typhi s...

Feature 1        #            # #                                #                     ####   
1F4R_A     87 FCMNISSQg--DGACVLLRALEPLeglet------------------mrqlRSTLRkgtasrvl--kdrelcsGPSKLCQ 144 human
YP_473785  80 HCLNIVTEaegIASAVLIRAAQLDclpewi----------------pankrLKPARva--------------aGPGLLCQ 129 Synechococcus sp. ...
NP_874657  99 YCVNIVTHkkdYANGVLLRAIAIP---------------------------NENERia--------------aGPGLLAN 137 Prochlorococcus ma...
Q9HX17     93 DSLNFSAGg--PGNAVLIKSGHPWldrisd---------------htalerMQSLNpdsqgrpr--eigrlcaGQTLLCK 153 Pseudomonas aerugi...
NP_880981  92 DSLNFSAAg--PGNAVLIKSGHPWvdevsg---------------pralacMQRLNpdaqgqpr--pparlcaGQTLLCR 152 Bordetella pertuss...
NP_970499  82 FCLNFVTRthqHPEAVLIRAVEPLp-------------------------aQENLRkkdl----------ktnGPGKLCK 126 Bdellovibrio bacte...
ABO13236   85 EMLNIITQtegVPEGVMIRSAFLNsa------------------------sTKKEYkl-------------laGPGKLTR 127 Acinetobacter baum...
Q93FQ6     79 HCLNVVTEpegFPAAILIRSIILLs-------------------------kNTPHTkv--------------nGPGKICK 119 heartwater rickettsia
Q1QEF7     95 HMLNLVSGpteSPEAVLIRAGFLIegsarlm-------------neqlldvNRQLNhik-----------qlaGPGKLTK 150 Psychrobacter cryo...
Q68X22     81 HCLNFVTEdegFPAATLIRGVYVIshndlytiytakvksqitdektqsiiiSEDRRstkfdipnleesnlylnGPGKLCK 160 Rickettsia typhi s...

Feature 1          #                                     ##                       
1F4R_A    145 ALAINKSf-DQRDLaqd----eaVWLERGplepsepAVVAAARVGVghageWARKPLRFYVRGSPWVS 207 human
YP_473785 130 ALRIDGSh-NGWRLepvaagqegIWLEGSpaweaqfPIVQTTRIGIt---rGVELPWRWYIKGHPAVS 193 Synechococcus sp. JA-3-3Ab
NP_874657 138 RFGLNRS--HDNSLisv---engLWIDKGlsgskmnSIIQTKRIGIs---kAKDLPWRWYLQNSRSVS 197 Prochlorococcus marinus subsp....
Q9HX17    154 AMGLKVPewDAQRFdp-----qrLFVDDVger--psQVIQAARLGIpk-grDEHLPYRFVDAAFAAFC 213 Pseudomonas aeruginosa
NP_880981 153 ALGLKVPqwDAKAFdp-----rrFFVEDVgvr--ldRLVRTTRLGIpa-grDEHLPYRYVDPAYAAFC 212 Bordetella pertussis Tohama I
NP_970499 127 YYGITRKh-DGLKLwkk---ssdLYVTDEdfkvskkQIIPTARVGVdyageAAKWPLRFYLRDHLFVS 190 Bdellovibrio bacteriovorus HD100
ABO13236  128 YLGIDRTl-KGQTLgee----sgLWIEAAtt---qpEVVLTPRIGIdyaeeAKDWPERYCWKDHPSLS 187 Acinetobacter baumannii ATCC 1...
Q93FQ6    120 TLHITKEh-NNIDMtan----hsFCICNTnln--idDYICTPRIGIs---kATDKFWRFVIPDVTSLQ 177 heartwater rickettsia
Q1QEF7    151 GLQIDRTl-YGKPItpa----skVWVEDDgc---qpLVSLRPRIGIdyagdAKEWLLRYIWTDHPSLS 210 Psychrobacter cryohalolentis K5
Q68X22    161 YLGINTTh-NKCDLinn----kdFFVSDIgl---nlPYSTTKRIGIt---kGTDKLWRYIVTDNKNAL 217 Rickettsia typhi str. Wilmington

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap