2W5Q,2W8D,4UOP,3LXQ


Conserved Protein Domain Family
LTA_synthase

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cd16015: LTA_synthase 
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Lipoteichoic acid synthase like
Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Statistics
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PSSM-Id: 293739
Aligned: 496 rows
Threshold Bit Score: 132.036
Created: 21-May-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                               #                       
2W5Q_A     30 KNIIKIHLESFQTFLInkkvn--gkevtPFLNKLssgkeqFTYFPNFFHqtg-qgkTSDSEFTMDNSLYGLpqgsaf--- 103 Staphylococcus aureus
KFL35745  218 RNVHVVLIETAWDPLQlghfrfsrdpfdPRFRRAm----eQSKDSAVLVpgf-ggaTANAEFEALCGLPATrdqvaf--- 289 Arenimonas donghae...
EGW21570  236 RNIHIVLLESFWDPSVlkkakykqnplsPEFRELw----kSAEYSHALSpvf-ggfTANSEFEVLCGFPAVkdavkf--- 307 Methylobacter tund...
CCG07323  231 RSVVLVVLESFWDPSAlsaaglsddpldPRFRALw----rQAGDSRALVpvf-ggyTANSEFEVLCGFPVAedtvff--- 302 Rhodospirillum pho...
ENO88493  223 RNVHMIVLESFWDPLPlkaaglssdpldPEFRRLw----rAGGGASALSpvf-ggyTANAEFEALCGFPVHtdgvff--- 294 Thauera linaloolen...
EGJ09488  239 PDIVLLLSESFTRLPEql--------fgKPYGCLa-----AAPESRLVSpaw-ggfTANVEFELLTGYPYAmlppgsvpf 304 Rubrivivax benzoat...
AGF77337  223 RNVHFILLESFWDPLGlkaidfdrdpldPRFREMw----kATGNSAIMSpvf-ggyTANAEFESLCGFPVVyddvkf--- 294 Desulfocapsa sulfe...
ACR78442  210 PDIVVTLMESTLDPHCfdfa----aakiPDLKMFgr--qeDTVFSSPLRvhtfggaTWKSEFAFLAGVPSTdfgalasgv 283 Neisseria meningit...
EGF10408  222 PDIVVCLQESTFNPHRialq----shslPPMSMFap--qrDTRFAAPLRvhtfgggTWKSEFALLTGVPSTdfgalaggv 295 Neisseria bacillif...
NP_438444 211 PDIVVTLMESTLNPHQfafs----qqsiPPLSMFep--qnDTVFASPLRvhtfagaTWKSEFAFLAGVPSTdfgalasgv 284 Haemophilus influe...
Feature 1                                                                                     
2W5Q_A    104 -slkgdNTYQSLPAILDQkqgYKSDVMHGDYKTFWNRDQVYKhfGIDKFYDATYYDmsdkn---vvnlGLKDKIFFKDSA 179 Staphylococcus aureus
KFL35745  290 -ehtlaKPMPCLPRLLRQa-gYLATASHPYHAGFWSRDQAYPllGFERYYPVNAFElddl-----dgmFLADASTYRQVL 362 Arenimonas donghae...
EGW21570  308 -erqllNDVPCLPHLLADk-gYRTIASHPNVPVFWNRVNAYKrmGFQTYWSLEDFVqddm-----nreFMSDSTLYRQVL 380 Methylobacter tund...
CCG07323  303 -etrlhNDVPCLPRLFSDa-gYAATASHPNVPVFWNRVNAYRriGFDVYRSLADFTldem-----hgeYLSDASLYRQVL 375 Rhodospirillum pho...
ENO88493  295 -egrlrRDVPCLPRHLGEa-gYRSIASHPNAAPFWNRVNAYRrvGFDQYWSDRDFAlddm-----ngeFLSDASLYRQVL 367 Thauera linaloolen...
EGJ09488  305 qmylsrPVVSALPRVLRDr-gWRTQAVHTFHRDFFSRPQAYAalGIDDYAGLEDLPgaar-----rgqYVDDRVLFDQIL 378 Rubrivivax benzoat...
AGF77337  295 -errmsNDAPCLPDILKGy-gYDSVASHPNVASFWNRINAYRriGFDTYWSINDFNlddm-----nlgFLSDSSLYRQVI 367 Desulfocapsa sulfe...
ACR78442  284 fysvvpHLQTGFVRNLREh-gYFCVALSPFTKGNYNAKAAYDhfGFNLMFQPQDLGypapmgknlwhiSSEEMMQYARMI 362 Neisseria meningit...
EGF10408  296 fysvvpHMQGGLVKNLKAh-gYFCVALTPFTKGNYNAKAAYDhlGFDLVLQPQELGypapl--sknlwHIGSGEMLAYAR 372 Neisseria bacillif...
NP_438444 285 fysvvpHLQSGLVKNLKAq-gYFCVALSPFTKGNYNAKSAYDhfGFDLMLQPQDLGypapisknlwdiSSEEMMKYTRMI 363 Haemophilus influe...
Feature 1                               #                                                     
2W5Q_A    180 NYQAKMk-------sPFYSHLITLTNHYPFTLDEkdatieks-------------------------ntgdatvdGYIQT 227 Staphylococcus aureus
KFL35745  363 ARLEQEsd-----prPQFNYVVSLSSHYPYERAAhrpdriav-------------------------tpqaplleAYANA 412 Arenimonas donghae...
EGW21570  381 EKISGSmda----kqPVLDYIVTYFGHWNYPLSEsrpnkiss-------------------------pspieevsAYANT 431 Methylobacter tund...
CCG07323  376 ETLKPVqes----gtPSFTYILTFFGHLDYPLDDalvrvrat--------------------------sadplveRYAST 425 Rhodospirillum pho...
ENO88493  368 ERIGPDldg----gpPLFNYVLTYFGHLDYPLNEarpdiida-------------------------kadnvlvrAYANT 418 Thauera linaloolen...
EGJ09488  379 KRLDAPga------ePRLVHAVSMMAHLPYDWEGrfplepglaarl-----------------pagldddalaltQYASM 435 Rubrivivax benzoat...
AGF77337  368 DKLDNRndp----dkPVLSYIITYFGHWAGGKLYpmnqsrpqvvr-------------------ceegcetpeieSYANA 424 Desulfocapsa sulfe...
ACR78442  363 LEKRHPdlen--vrqPMFVYVLTMKEHGPYRTDTdnvfdldvpd---------------------lnaktvsalnDYIGR 419 Neisseria meningit...
EGF10408  373 QILEKRhpalagieqPLFVYVLTMKEHGPYRSDApnryslvsdglsdkaigslndyaariadlntateafnqwlqQRADG 452 Neisseria bacillif...
NP_438444 364 LEKQHPalen--vdqPMFVYVLTMREHGPYELGMentfnlqmpn---------------------lgaksisalnDYTQR 420 Haemophilus influe...
Feature 1                                      ##                                             
2W5Q_A    228 ARYLDEALEEYINDLKKkgl---ydNSVIMIYGDHYGISenhnnamekl---------lgekitpakfTDLNRTGFWIKI 295 Staphylococcus aureus
KFL35745  413 IAYSTQAFMDYVQEVQArd-----pDALVVGFGDHAPVLgqapdpyelsgivlptrrdsvaepplmalPALARVPLLVFD 487 Arenimonas donghae...
EGW21570  432 VYYKSRELMVFINEMRKrd-----pEGIIVVFGDHLPFLgenfagyaesgvl----tanrreftptmfKAYVSTPMLIID 502 Methylobacter tund...
CCG07323  426 VLEKSRSFMDFLEELQArd-----pEALVVAVGDHLPFLgpnfggyresgvl----aadradfddrmfRDLVATPLLIID 496 Rhodospirillum pho...
ENO88493  419 VHYKSRELMAFLRELRQrd-----pDAIIVLFGDHLPSLgwnyggyaesgll----aadrsefddamfKTLVATPLVVIN 489 Thauera linaloolen...
EGJ09488  436 LYDHERAFCGFLEQLKSrp-----rRTLVLFYGDHYPSFgslavyerlnrv------lhgadaplnleRDFSKPPLALFD 504 Rubrivivax benzoat...
AGF77337  425 MYYKSKELMDFVEDLRVrd-----pDGIIVAFGDHLPFLgggyrgfveaetl----tgtrdqftpemfLTYVTTPLIVID 495 Desulfocapsa sulfe...
ACR78442  420 IADLDKAVESFDRYLHErg-----kPFVFGYFGDHQVPFegvsvr-----------------kkwdyaQPDYVTQFAVRS 477 Neisseria meningit...
EGF10408  453 FQTASDNAASTFQAASGknsipkkrDYVFAYFGDHQPNFehftpp-----------------iqtdhpHPDYLTQCAVRS 515 Neisseria bacillif...
NP_438444 421 IVALNDAIEGINNYLHErk-----kPFVLGYFGDHQVAFdnaipp-----------------kkgdyaQPDYVTQFVVRS 478 Haemophilus influe...
Feature 1                                
2W5Q_A    296 Pgks-ggINNEYAGQVDVMPTILHLAG 321 Staphylococcus aureus
KFL35745  488 Grk--gvVPVGEIPMFAISDLVLSRLG 512 Arenimonas donghaensis DSM 18148 = HO3-R19
EGW21570  503 Gkr--gpLKIGSLPLYQVPKLLLDLLN 527 Methylobacter tundripaludum SV96
CCG07323  497 Gpr--gaLPVGTLALYQVPGLIRTLAG 521 Rhodospirillum photometricum DSM 122
ENO88493  490 Gr-----RGPVRTGDLPIYALPALILD 511 Thauera linaloolentis 47Lol = DSM 12138
EGJ09488  505 Srdg-fvTLPDEVAAYNLGALVLQQAG 530 Rubrivivax benzoatilyticus JA2 = ATCC BAA-35
AGF77337  496 Grr--gpLDMGTIPLYQLPGKIVKLLG 520 Desulfocapsa sulfexigens DSM 10523
ACR78442  478 NiaggfvQRQDFLDLAFAGGVLMEAAG 504 Neisseria meningitidis
EGF10408  516 Slph-tpAPHRLLDLALFGSVILETAG 541 Neisseria bacilliformis ATCC BAA-1200
NP_438444 479 NcasqfkQEQKFLDLAFAGGVLMNVAG 505 Haemophilus influenzae Rd KW20

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