Conserved Protein Domain Family
7tmA_GPR55-like
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cd15165: 7tmA_GPR55-like 
G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.
Links
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Statistics
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PSSM-Id: 320293
Aligned: 12 rows
Threshold Bit Score: 373.979
Created: 15-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                   #  ##            ####
Q9Y2T6        21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKnrwpdyaaTSIYMINLAVFDLLLVLSLPFKMVLSQvqsp---fpsLCTLV 97  human
EMP26376      16 SLQLVISIPTFIVGLILNLIALWVFHSWKKqt-----eSSIYMINLALADLLLLFSLPFKMYDSKkeq----nrlLCNFI 86  green seaturtle
EMP26375      12 LFQITVYIPTFVLGLLFNAMALWFVFCKIRkl----teSTIYLVSLITLDTLLLFTLPFKIISYGsqnkwnvgsaFCSFL 87  green seaturtle
EMC87308       3 LFQLIMYAPTFSLGLLFNVMALSFLFFKVKkl----seSTVYMIALIFLDTLLLFTLPFKIISYHlqnnwnlgsvFCSTL 78  domestic pigeon
NP_001035080  15 WFQRCVYVPILVFGIPLILGSLWQLLFRVRrw----seSTVYLINLIINDSLLMLSLPFKIHAYKkvwt--lgrtFCSLL 88  zebrafish
XP_006011984  16 SIQLVVYIPTFILGVTLNSLAIWVFCCFLKkw----seSTIYMTNLAMADLLLLISLPFKMHFSKhpwi--lskyLCSFV 89  coelacanth
XP_002933415  18 NVELGIYIPTFILGCILNIFALWIFFFSIKkw----teASIYLINLAILDLFLLLSLPFKMYSSIqieqi-vdrhLCTFA 92  western clawed ...
XP_007887800  83 IIQLVVYIPTFILGVPFNLIALFFFWFKIKrr----teSVIYMSNLALADILLLLSLPFKMYYSSsrkwp-fhmaFCSFV 157 elephant shark
XP_006637693  12 WIQWIVYIPTFVVGLVFNLSALWILLFKIRkc----teSTVYLANLILNDSFLLFSLPFKIHSYKynwv--lgntLCSFL 85  spotted gar
CDQ70765       8 YVQWIVYVPTFVVGLPLNLATLWLLLFRIRrw----teSTVYLSSLIINDSLLIFSLPFKIYAFGrtwg--lsmgFCTFL 81  rainbow trout
XP_006637694  15 SLQLVVYIPTFALGLILNSLALFVFCIQLRkw----teSTIYMTNLSLMDLLLLLSLPFKMHASQnewsv-nkkmFCTFL 89  spotted gar
XP_005163624  15 KLDLVIYVPILVFGLALNIMALVVFCRLLRkw----teSSIYMTNLALMDLLLLLQLPFKMHAAHhewae-dkklLCSFL 89  zebrafish

Feature 1        ## ##  #                                            # #####                     
Q9Y2T6        98 ECLYFVSMYGSVFTICFISMDRFLAIRYPllVSHLRspRKIFGICCTIWVLVWTGSIPIYSFHgkv-------ekYMCFH 170 human
EMP26376      87 EALYFVNMYGSIFIVVCISLDRYIAIRHPlkAKAFRspKQAIIVCCCVWVIVWLSSIPIYDFHnn--------dkVKCFH 158 green seaturtle
EMP26375      88 ESLYFVNMYGSILISACICVDRYIAIRHPflAISLRstRKAAMVCSIICMGVWAGTSFTYQFHds--------tnTTCFY 159 green seaturtle
EMC87308      79 ESLYFVNMYGSILISLCICVDRYITIRHPftAPTLRstKKAALVCAVICLGTSAGTVSTFQLHgeg------hniSSCFH 152 domestic pigeon
NP_001035080  89 ESLLYVNIYGSILLSVCIAVDRYIALQFPfiALRLRspRKSVIICLILWILVFACSTPIYKLHdepvn---ktdkVYCFQ 165 zebrafish
XP_006011984  90 ESLYFVNMYGSIFLITVISLDRYIAIRHPfkAKELRskKVAICFCIGIWIFVWLGSIPVYSFHdhs-------pnFRCFH 162 coelacanth
XP_002933415  93 EILYFANMYGSIYIITFISLDRYIAIKHIfwAKRLRspKKTTSICFFIWVFVWIVGGSIFKKEd----------nNRCFH 162 western clawed ...
XP_007887800 158 ESLYFVNMYGSIFFISAISVDRYLAIIHPlrARVYRspRNSGLVCLAIWMFIWLGSIPIYNFHdspg----sngsIICFH 233 elephant shark
XP_006637693  86 ESLLYVNMYGSILLITCISVDRYIALRHPflAKTLRspQKAAVACFTIWIVIFGASVEVYNLHek--------naTYCFR 157 spotted gar
CDQ70765      82 ESLVFVNIYGSIVLIVCISGDRYVSLRFPfnGKRLRspRKAALVCLAVWVTVFAFTTPVYELHnknttslhnnneTRCFE 161 rainbow trout
XP_006637694  90 ESLYFVSTYGSIYTIMCISIDRYIAIKHPfkAKVLRspKKALIVCAVIWVVVWTGTSPVYSFHkdkd-----anlLRCFH 164 spotted gar
XP_005163624  90 ESLYFVAMYGSIYTIACIALDRYFAINHPfrAKQLRskRNALIICVFIWLFVMGATSPIYTFRrek------tgnFTCFH 163 zebrafish

Feature 1               #  ### ### ##                                                  #  ## ##  
Q9Y2T6       171 NMSddtWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILlgrrd--htqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFL 248 human
EMP26376     159 NMSeqaWGIPVILSVEVFGFLIPLTLMIYCSVQIIQTLwrrkn--qgqkwAEQAASVWIILGNLMVFVVSFTPFHLGMFL 236 green seaturtle
EMP26375     160 GFSnktWGNPAVPIVLETAFFGSLIAMIFCTVQIIICLkrsrr--pddplTDTSKSVKIVMANLATFVVCFTPFHVMFFL 237 green seaturtle
EMC87308     153 NFSkstWENTGLLVALEIAFFSSMAAMTFCTVQTVRCLrkhrk--pynpqTHTSRAEKIVLTNLVAFLVCFTPYHVAYLL 230 domestic pigeon
NP_001035080 166 QFSnktWSKSWIVVSMETVFCSSTIVMVFCSVRVVQILhsmrarnpgdpkLRSNKSLKIVLSNLGVFLACFIPYHIAALI 245 zebrafish
XP_006011984 163 GISkssWNVVLILLVEVFGFLIPTTVVVYCSIKSIQTLldssl--tenikEKRKTCIRIIVANLTVFIISFTPNHLGIFL 240 coelacanth
XP_002933415 163 KMSnkiWSPSIIICLELFGFLMPMIVIMGCSIQIVRKLgdhrgi-seqdhGQKTTVRRIIISNLVVFLLSFLPSHLGIFL 241 western clawed ...
XP_007887800 234 KFSdksWNFWLIAYVEFFGFVTPLAIVVFCSFSIIRKLlqkqip-varehQTVDSCVRIVTANLVVFIFCFAPTHLGILL 312 elephant shark
XP_006637693 158 GFSnrtWEKVHIVVVMETVYTASALIMIFCSIQVIRTLrtmrkrkaevqtLKNNKSVKIVLSNLVTFLVCFTPYHIAALV 237 spotted gar
CDQ70765     162 GFSretWGKKWIIVAMETVFTISTVTMLFFSVRVMQILsdmrrrnpldkkVRDNKSVKIVLSNLVAFMLCFIPYHVAAVV 241 rainbow trout
XP_006637694 165 GFSeesWNPAVIINLEIFGFLIPMLVMVFCSIQIIRTLkqsqr---npdmQNNKTCIRIIYANLFVFLVSFTPSHLGIYL 241 spotted gar
XP_005163624 164 GFSdkgWSTALIVCLEVFGFLLPAAVLVVCSIQSIRTLkatk-----nsnRKKQAGVRIIYSSLAAFLVPFTPCHIAIFL 238 zebrafish

Feature 1        #                  ## ###  #  ##                     
Q9Y2T6       249 QFLvrnsfiv--ecrakqsISFFLQLSMCFSNVNCCLDVFCYYFVIkEFRMNI 299 human
EMP26376     237 QFLvrqhiiv--dctvkqsISLFLQVAMCLANVNCCLDAICYYFATeEFRKKS 287 green seaturtle
EMP26375     238 YYLvkkevit---snlqqiIRSFVQISLCWANLNCCLDAICYYFVLkEFLKSP 287 green seaturtle
EMC87308     231 YFLvknniih---tsfqqvLRDTIQVTLCWANLNCCLDGVCYYFVLrESLEVP 280 domestic pigeon
NP_001035080 246 YFHaktnnwn---edtishLRYFVHVSICFSNVNILADGACYYFILkENLESA 295 zebrafish
XP_006011984 241 QFLvrnhiit--dcvskqnISLFVQLAMCFANVNCCLDALCYYFVTeEFREST 291 coelacanth
XP_002933415 242 QFLvkqdiia--ncshkqsIILFLRLSLCLANVNTCLDAACYYFAVkEFRKMS 292 western clawed frog
XP_007887800 313 QFLvrrdiigehlcstrqnISLFIQTAMCLANVNCCLDAICYYFIAkEFRDQG 365 elephant shark
XP_006637693 238 YFIakkkvt-----esiqpLRDFVHLSICLTSINCLFDAICYYFIFkENWISA 285 spotted gar
CDQ70765     242 YFLakngten---pdvidpLRDFVHISTCLGSVNCLTDGVCYYFILkENLLTA 291 rainbow trout
XP_006637694 242 QFLvrqnyfk--ecnttekISLFVQITMCLANITCCLDAICYYFITkELRSSS 292 spotted gar
XP_005163624 239 QYLvrndhil--dckkkqdIALFIQVSINIANVTCCLDALCYYFIAkEVRSTK 289 zebrafish

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