Conserved Protein Domain Family
PRK05478

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PRK05478: PRK05478 
3-isopropylmalate dehydratase large subunit
Statistics
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PSSM-Id: 235490
Aligned: 609 rows
Threshold Bit Score: 794.324
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
121605930   1 MGRTLYDKIWDEHVVHTEEDGTSILYIDRHLVHEVTSPQAFEGLREAGRKVWRISSIVATADHNTPTTgwelgydgITDL 80 
292655656   2 SEGTLYDKVWEEHTVSELPTGQTQLFCGLHLIHEVTSPQAFGMLQERDLEVAYPNRTHATVDHIVPTSdqs---rpFRDD 78 
76801741    2 SEGTLYDKVWENHKVTTLPNGQDQLFVGLHLIHEVTSPQAFGMLRERDIEVARPDLTHATVDHIVPTAdqs---rpLDNE 78 
83814734    2 STGTLYDKVWNRHAVRELPTGETQLFVGLHLIHEVTSPQAFGMLEERDLSVAFPARTFATTDHIIPTAdle---rpFGDD 78 
222479303   2 SEGTLYDKVWDRHTVTKLPTGQDQLFVGLHLVHEVTSPQAFGMLKERDQEVAFPERTHATVDHIVPTGnrd---rpYRDE 78 
257051729   2 SQGTLYDKVWDEHKVTQLPNGQDQLFVGLHLIHEVTSPQAFGMLRERDIEVARPDLTHATVDHIVPTSdqs---rpYSDD 78 
284166032   2 SEGTLYDKVWDRHKVTTLPTGQDQLFVGLHLIHEVTSPQAFGMLRERDLEVAYPKLTHATVDHIVPTAdqs---rpYEED 78 
289580581   2 SEGTLYDKVWDHHKVTTLPTGQDQLFIGLHLIHEVTSPQAFGMLEERDLEVAYPELTHATVDHIIPTAdqs---rpYEED 78 
294508186   2 STGTLYDKVWNRHAVRELPTGETQLFVGLHLIHEVTSPQAFGMLEERDLSVAFPARTFATTDHIIPTAdle---rpFGDD 78 
300711467   2 SQGTLYDKVWDNHAVTELPTGQTQLFVGLHLIHEVTSPQAFGMLRERDLEVAYPERTHATVDHIVPTAdqs---rpYGDD 78 
121605930  81 VSKEQITTLDANIKEFGAAAfFPFMSKRQGIVHVIGPENGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVMATQ 160
292655656  79 AAEEMMAELEQNVREAGINF-SDPTSGEQGIVHVIGPEKGLTQPGMTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATQ 157
76801741   79 AAEEMMAELEENVREAGITL-DDPTTGNQGIVHVIGPEQGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATQ 157
83814734   79 QAETMLQVLERNTEAYDITF-FDPSSGAQGIVHVVGPEQGLTQPGMTIVCGDSHTSTHGAFGTLGFGIGTSQIRDVLATQ 157
222479303  79 AAENMMAELEANVRGSGIDF-SDPDSGNQGIVHVIGPEQGLTQPGMTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATG 157
257051729  79 AAEEMMSELEENVREAGIQF-SDPTTGDQGIVHVIGPEQGITQPGKTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATQ 157
284166032  79 AAEEMMAELEENVREAGIDF-SDPTTGDQGIVHVIGPEQGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATG 157
289580581  79 AAEEMMRELEENVREAGIEF-SDPDSGDQGIVHVVGPEQGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATG 157
294508186  79 QAETMLQVLERNTEAYDITF-FDPSSGAQGIVHVVGPEQGLTQPGMTIVCGDSHTSTHGAFGTLGFGIGTSQIRDVLATQ 157
300711467  79 AAEEMMRELEENVREAGIEF-DHPDTGDQGIVHVIGPEQGITQPGMTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATG 157
121605930 161 TLLAKKAKNMLIKVEGAVTKGVTAKDIVLAIIGKIGTAGGTGYTIEFAGSAIRALSMEGRMTVCNMAIEGGARAGLVAVD 240
292655656 158 TVAMEKKKVRKIEVTGELGPGVEAKDVILEIIRRLGTEGGVGYVYEYAGEAIEDLDMEGRMSICNMSIEGGARAGYVNPD 237
76801741  158 TIAMEKKDVRKIEVTGELGEGVTAKDIILTIIRRLGTDGGVGYVYEYAGEAIENLGMEGRMSICNMSIEGGARAGYVNPD 237
83814734  158 CIAMEKQDVRRIQVDGALGEGVYAKDIILKIIGELGVEGGIGYVYEYGGPAIKGLSMEGRMSICNMSVEGGARAGYVNPD 237
222479303 158 CIAMEKQQVRKIEVTGELGEGVTAKDVILTIIGKLGTDGGVGYVYEYAGEAIEDLGMEGRMSICNMSIEGGARAGYVNPD 237
257051729 158 CIAMEKQKVRKIQVDGELGPGVEAKDIILEIIRRLGTDGGVGYVYEYAGEAIENLDMEGRMSICNMSIEGGARAGYVNPD 237
284166032 158 TVAMEKQKVRKIQVDGELGEGVEAKDIILEIIRRLGTEGGVGYVYEYAGEAIESLGMEGRMSICNMSIEGGARAGYVNPD 237
289580581 158 TVAMEKQKVRKIQIDGELGDGVEAKDVILEIISRLGTEGGVGYVYEYAGEAIENLGMEGRMSICNMSIEGGARAGYVNPD 237
294508186 158 CIAMEKQDVRRIQVDGALGEGVYAKDIILKIIGELGVEGGIGYVYEYGGPAIKGLSMEGRMSICNMSVEGGARAGYVNPD 237
300711467 158 TVAMEKQKVRKIEVTGELGDGVEAKDIILEIIRRLGTEGGVGYVYEYAGEAIESLGMEGRMSICNMSIEGGARAGYVNPD 237
121605930 241 AKTIEYL-KGRLLAPgtdsvtgkfvGGPEWDMAARYWATLHSDADATFDAVVELDASQILPQVSWGTSPEMVLSIEDRVP 319
292655656 238 ETTYEWL-KETEYFQe---------NPERFDELKPYWESIRSDEDAEYDDVVTIDGSELEPVVTWGTTPGQGVGITQPIP 307
76801741  238 ETTYEWL-RETDAFAd---------DPERFEELKPYWESVRSDPDAEYDDVVTIDGSEIEPVVTWGTTPGQGIGITEEIP 307
83814734  238 LTTFEYM-KGRPHAP----------SGAAWERAVDCWQQIQSDPDATYDDTVTFDGSAIEPMVTWGITPGQALGISEPIP 306
222479303 238 ETTYEWLaETDAFAD----------DPEKFERLKPYWESIRSDADAEYDDVVTIDGSAIEPTVTWGTTPGQTAGITEPIP 307
257051729 238 ETTFEWM-QNTDYFQe---------NPEAFDELKPYWESIRSDADAEYDDVVHIDASELEPVVTWGTTPGQGIGITEPIP 307
284166032 238 ETTYEWL-EETDYFQe---------NPEKFEELKPYWESIRSDEDAEYDDVVHIDANELEPVVTWGTTPGQGVGVTEPIP 307
289580581 238 ETTYEWL-EETDYFQe---------NPEKFEELKPYWESIRSDDDAEYDDVVHIDADELEPVVTWGTTPGQGIGITDPIP 307
294508186 238 LTTFEYM-KGRPHAP----------SGAAWERAVDCWQQIQSDPDATYDDTVTFDGSAIEPMVTWGITPGQALGISEPIP 306
300711467 238 ETTYEWL-AETDAFEn---------DPEKFERLKPYWESVRSDPDAEYDDVVTIDGSSLEPVVTWGTTPGQGVGITQPIP 307
121605930 320 DPEkEKDANKRGAIERALTYMGLEPGKALNDLYIDKVFIGSCTNSRIEDMREAAAVVKhiGQKVAKNVkLAMVVPGSGLV 399
292655656 308 APE-DLPEEKQETARMAQEHMGVTPGETMEGYEIDVAFLGSCTNARLPDLRRAAGVVK--GRQVADSV-RAMVVPGSQRV 383
76801741  308 APE-DLPADKQDTARRAQDHMGVEPGETMAGYNIDVAFLGSCTNARLPDLRSAAEIIK--GREVHDSV-RAMVVPGSQRV 383
83814734  307 DPA-RMDSGDRATAEKALDHMDLRPGRTMEGVNVDVAFLGSCTNARITDLREAASLLErlGRPVADDV-RAMVVPGSQGV 384
222479303 308 DPD-DLPEEDRDTAKRAQKHMRVEPGDTMEGYDIDVAFLGSCTNARLKDLREAAAFVE--GREVDDDV-RAMVVPGSQRV 383
257051729 308 HPE-DLPADKQDTARRAQEHMRVEPGETMAGYDIDVVFLGSCTNARLPDLRRAADIVE--GREVDDSV-RAMVVPGSQRV 383
284166032 308 APE-DLPEDKQDTARRAQEHMRVEPGDTMEGYDIDVAFLGSCTNARLPDLRRAAEIVE--GRQVDDDV-RALVVPGSQRV 383
289580581 308 APE-DLPEDKQDTARRAQEHMRVEPGETMDGYEIDVAFLGSCTNARLPDLRRAARIVE--GRQVADDV-RAMVVPGSQRV 383
294508186 307 DPA-RMDSGDRATAEKALDHMDLRPGRTMEGVNVDVAFLGSCTNARITDLREAASLLErlGRPVADDV-RAMVVPGSQGV 384
300711467 308 HPD-DLPEDKQDTARRAQEHMRVEPGDTMEGYPIDVAFLGSCTNARLPDLRRAAELVE--GREVPADV-RALVVPGSQRV 383
121605930 400 KEQAEREGLDKIFIAAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQG-AGGRTHLVSPAMAAAAAVHGHFVD 478
292655656 384 KAAAEAEGLDEVFKEAGFEWREAGCSMCLGMNEDQLEGDEASASSSNRNFIGRQGsKDGRTVLMNPRMVAAAAVTGEVTD 463
76801741  384 KAAAEDEGLDSVFKEAGFDWREAGCSMCLGMNDDQLVGDEACASSSNRNFVGRQGsKDGRTVLMSPEMVAAAAVTGEVTD 463
83814734  385 KQQAEDEGLADTFREAGFDWRGAGCSMCLGMNQDQLEGRELCASSSNRNFIGRQGsKDGRTVLMSPAMVVAAAVEGEVTD 464
222479303 384 RDAAEAEGIDEIFIEAGFDWREPGCSMCLGMNDDQLVGDEASASSSNRNFVGRQGsKDGRTVLMSPIMVAAAAVTGEVTD 463
257051729 384 QRAAEEEGLGDIFREAGFEWRNAGCSMCLGMNEDQLEGDEASASSSNRNFVGRQGsKDGRTVLMNPQMVAAAAVTGEVTD 463
284166032 384 QEAAAEEGLKDIFEEAGFEWRNAGCSMCLGMNEDQLEGDEASASSSNRNFVGRQGsKDGRTVLMNPQMVAAAAITGEVSD 463
289580581 384 QEAAEEEGLKDIFEDAGFDWRNAGCSMCLGMNEDQLEGDEACASSSNRNFVGRQGsKDGRTVLMNPRMVAAAAITGEVTD 463
294508186 385 KQQAEDEGLADTFREAGFDWRGAGCSMCLGMNQDQLEGRELCASSSNRNFIGRQGsKDGRTVLMSPAMVVAAAVEGEVTD 464
300711467 384 QRTAEEEGLKDVFEAAGFEWRNAGCSMCLGMNEDQLEGDQACASSSNRNFVGRQGsKDGRTVLMNPRMVAAAAVTGEVTD 463
121605930 479 IRKFV 483
292655656 464 VRELK 468
76801741  464 VRELP 468
83814734  465 VRRLM 469
222479303 464 VREME 468
257051729 464 VRELP 468
284166032 464 VRELK 468
289580581 464 VRELP 468
294508186 465 VRRLM 469
300711467 464 VRELE 468
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