1FX8,1FQY


Conserved Protein Domain Family
MIP
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cd00333: MIP 
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Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.
Links
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Statistics
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PSSM-Id: 238204
Aligned: 27 rows
Threshold Bit Score: 170.897
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Asn-Pro-Alaamphipathic
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:Asn-Pro-Ala signature motifs
Evidence:
  • Comment:located at the segment interface between helices M3 and M7
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                ###  
1FX8_A      9 GQCIAEFLGTGLLIFFGVGCVAALkvag----------asfgQWEISVIWGLGVAMAIYLTAg------vSGAHLNPAVT 72  Escherichia coli
1168480    40 RAAIAEFIATLLFLYITVATVIGYkketdp-------casvgLLGIAWSFGGMIFVLVYCTAg------iSGGHINPAVT 106 four-winged saltbush
135858     24 RATLAEFLSTFVFVFAAEGSILSLdklywehaahagtntpggLILVALAHAFALFAAVSAAIn------vSGGHVNPAVT 97  thale cress
1FQY_A     12 RAVVAEFLATTLFVFISIGSALGFkypvgnn-----qtavqdNVKVSLAFGLSIATLAQSVGh------iSGAHLNPAVT 80  human
135860     21 KAALAEFISTLIFVVAGSGSGMAFnklteng-----attpsgLVAAAVAHAFGLFVAVSVGAn------iSGGHVNPAVT 89  thale cress
CAA94770   45 TKCVAEFLGDLTFVYVGTMQASLFqya-------------dgILHAAFAHGFTIFILVTAFGhirmfpnySGGHFNPAVS 111 Caenorhabditis ele...
728874     11 RAVFAEFLATLLFVFFGLGSALNWpqa------------lpsVLQIAMAFGLGIGTLVQALGh------iSGAHINPAVT 72  human
586102     53 RAGIAEFMATFLFLYITILTVMGLkrsdsl-------cssvgIQGVAWAFGGMIFALVYCTAg------iSGGHINPAVT 119 tomato
135859     21 RASLAEFASTFIFVFAGEGSGLALvkiyqds-----afsageLLALALAHAFALFAAVSASMh------vSGGHVNPAVS 89  Phaseolus vulgaris
127102     11 RAICAEFFASLFYVFFGLGASLRWapg------------plhVLQVALAFGLALATLVQAVGh------iSGAHVNPAVT 72  cow

Feature 1                                                                                     
1FX8_A     73 IALWLFACFDKRKVIPFIVSQVAGAFCAAALVYGLYYNLffdfeqthhivrgsvesvdlagtfstypnphinfVQAFAVE 152 Escherichia coli
1168480   107 FGLFLARKVSLLRALVYMIAQCAGAICGVGLVKAFMKGPynqfgggan-----------------svalgynkGTAFGAE 169 four-winged saltbush
135858     98 FGALVGGRVTAIRAIYYWIAQLLGAILACLLLRLTTNGMrpvgfrl---------------------asgvgaVNGLVLE 156 thale cress
1FQY_A     81 LGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLtgnslgrn------------------dladgvnsGQGLGIE 142 human
135860     90 FGAFIGGNITLLRGILYWIAQLLGSVVACLILKFATGGLavpafgl---------------------sagvgvLNAFVFE 148 thale cress
CAA94770  112 WAIAGAGKMPIFHLPFYVVSQLLGGICGAFLTAAVLSQEqltsceaga----------------tllspgsqwWQGLIAE 175 Caenorhabditis ele...
728874     73 VACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADirgdlavn------------------alsnsttaGQAVTVE 134 human
586102    120 FGLFLARKLSLTRAVFYMVMQCLGAICGAGVVKGFMVGPyqrlgggan-----------------vvnpgytkGDGLGAE 182 tomato
135859     90 FGALIGGRISVIRAVYYWIAQLLGSIVAALVLRLVTNNMrpsgfhv---------------------spgvgvGHMFILE 148 Phaseolus vulgaris
127102     73 FAFLVGSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAvrgnlaln------------------tlhpgvsvGQATIVE 134 cow

Feature 1                                                          ###                        
1FX8_A    153 MVITAILMGLILALTDdgngv---prgpLAPLLIGLLIAVIGasmgplTGFAMNPARDFGPKVFawlagwgnvaftggrd 229 Escherichia coli
1168480   170 LIGTFVLVYTVFSATDpkrsardshvpiLAPLPIGFAVFMVHlatipiTGTGINPARSFGAAVIynkk----------rv 239 four-winged saltbush
135858    157 IILTFGLVYVVYSTLIdpkrg---slgiIAPLAIGLIVGANIlvggpfSGASMNPARAFGPALVgwr------------- 220 thale cress
1FQY_A    143 IIGTLQLVLCVLATTDrrrr----dlggSAPLAIGLSVALGHllaidyTGCGINPARSFGSAVIthn------------- 205 human
135860    149 IVMTFGLVYTVYATAIdpkng---slgtIAPIAIGFIVGANIlaggafSGASMNPAVAFGPAVVswt------------- 212 thale cress
CAA94770  176 TVVTFFLVHTILITAAdtd------tvtLAPLAIGLTLSIDIlstgsiTGASMNPARSLGPSIIgsifatq----ktsfy 245 Caenorhabditis ele...
728874    135 LFLTLQLVLCIFASTDerrg----enpgTPALSIGFSVALGHllgihyTGCSMNPARSLAPAVVtgk------------- 197 human
586102    183 IIGTFVLVYTVFSATDakrnardshvpiLAPLPIGFAVFLVHlatipiTGTGINPARSLGAAIIynde----------ha 252 tomato
135859    149 VVMTFGLMYTVYGTAIdpkrg---avsyIAPLAIGLIVGANIlvggpfDGACMNPALAFGPSLVgwq------------- 212 Phaseolus vulgaris
127102    135 IFLTLQFVLCIFATYDerrn----grlgSVALAVGFSLTLGHlfgmyyTGAGMNPARSFAPAILtrn------------- 197 cow

Feature 1                              
1FX8_A    230 ipYFLVPLFGPIVGAIVGAFAYRKL 254 Escherichia coli
1168480   240 wdDHWIFWVGPFVGALAAAAYHQYV 264 four-winged saltbush
135858    221 whDHWIYWVGPFIGSALAALIYEYM 245 thale cress
1FQY_A    206 fsNHWIFWVGPFIGGALAVLIYDFI 230 human
135860    213 wtNHWVYWAGPLVGGGIAGLIYEVF 237 thale cress
CAA94770  246 wnNHYIYWAGPLLGSTIALCIYKLF 270 Caenorhabditis elegans
728874    198 fdDHWVFWIGPLVGAILGSLLYNYV 222 human
586102    253 wnDHWIFWVGPMIGAALAAIYHQII 277 tomato
135859    213 whQHWIFWVGPLLGAALAALVYEYA 237 Phaseolus vulgaris
127102    198 ftNHWVYWVGPVIGAGLGSLLYDFL 222 cow

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