7PKT,6NU2,8A22


Conserved Protein Domain Family
NUDIX_MRP_L46
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cd04661: NUDIX_MRP_L46 
Mitochondrial ribosomal protein L46
Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the NUDIX hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the NUDIX hydrolase superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the NUDIX motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif.
Links
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Statistics
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PSSM-Id: 467546
Aligned: 85 rows
Threshold Bit Score: 111.165
Created: 6-Dec-2006
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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modified NUDIX
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:modified NUDIX motif [structural motif]
Evidence:
  • Comment:G[X5]E[X7]REUXEEXGU, where U is a bulky aliphatic residue (usually Ile, Leu, or Val).
  • Comment:The NUDIX motif contains many of the active site residues of NUDIX hydrolases.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
7PKT_G     51 PIIAACVLQRLPlvrprlttgeqaqlalerqralqtgelkdyp---------------------------qnmavtgkdd 103 Chlamydomonas rein...
JAA71456   48 QLVGAVALERKPvitrdfneferrylemlrtmeveasllsdhelqvkaes------------qrkasaeegsgikiqtan 115 castor bean tick
ADY42433   35 DIFAGVALLREPiiapvmtdaerrytevlrrieeegsllsdfelkhikdtkllakraqleaegrelsaldeqigvtaeaq 114 pig roundworm
AEE62479   31 DLLTAVLIERKPvtspeltgiekdfkeylsaveferslkndteinlekerai---------ttqkkeiedldlkstrttq 101 mountain pine beetle
EFO26460   27 DIFASVALVRPPftappmsdiekryhdfmlqreledslrcdfelrqlrderllker-arlklggeeanpeeeigilasvd 105 Loa loa
NP_647661  27 DLYAGVLVERLPvvskslnplekqfqdllwrveyenslksdhelkhereivqae-----likqgkiqvdledagskqtaq 101 fruit fly
BAH71691   25 DIMAGLCLQRKPiitkpltdtevnfqnilqeiefekslksdhelrhekdvkrme----klkngkvidfddmdqasnqsaq 100 pea aphid
NP_499994  20 EIFASVVLSRAPvvappmsevesrfhrlqmaeeqekslmcnyelktkqdekmvar--raqliadgkelseldeeigvtna 97  nematode
BAM19634   18 DIITGVCVERLPvvtpplndiqkkykellwtievekslksdheirhendkiqa------ellksdthdvdidavskitaq 91  Papilio xuthus
EFX87716   15 ELLGAICLERTPiivppmteieqqisemiekfdnmrslksnhelrheedkklqk-----maadgnqddsnpdaatrqtaq 89  common water flea

Feature 1                                                                  ###################
7PKT_G    104 agskqqqqdlrafdpvpattAADSNgDVSTMRRRLADSLYLVVRGGpaag-ggggEWAFPQAVNTAEESISDTAQRALYG 182 Chlamydomonas rein...
JAA71456  116 diaeewnkkakefqpasrltDADAKgDKRSTERLLDHPLLLVVNQRlgn----ghRWILPQTVHAAGETMRQTAERALAE 191 castor bean tick
ADY42433  115 rddwmkkgetsrkrfaigdlSKVEEnKDTSLRRKLQEKLILVVKQRfsrddgyssPWILPQTANRCDENLKETAERCLSN 194 pig roundworm
AEE62479  102 dfidackeefakfkpaekttAADQTnEVKSLQRKLSKHLIFVQNQKigd----qsFYILPQGIREDGETLRQCAERVLQE 177 mountain pine beetle
EFO26460  106 eenwrkeagrirkklaigdlTKFSKaDTRSLQRKIDEFLVLIVCQKfgrkdgyrsPWHLPQLRILPGESLKQTSERCLKE 185 Loa loa
NP_647661 102 dlkdayveelkkfqlgsrttPDDQAnRTTSTDRCLDDTLYLLVQQKlgq----qeHLILPQGKREEGESMRQTAERVLRE 177 fruit fly
BAH71691  101 dyvdknkeellnfkfasrltEADTInDTKSLKRKLDDNLVLIVKQKlgh----edYWVLPQGLWKDGETLRETSERILKE 176 pea aphid
NP_499994  98 vreddwkkaaedldkkfkfgEFPPKnELKSVERELQRKLVLIVKQKlgek-gyssPWILPQMKHRDGETLRQTAERCIGE 176 nematode
BAM19634   92 dmedaateelsqfkfgsietEADKKgDKTNSDRCLQRHLVLVAPVKlgt----dvRTILPQGKWQEGETLRQTAERVLEE 167 Papilio xuthus
EFX87716   90 dfedacneeflkfkpaprttAEDLSgDQKSTNRKLDKHLLFVVQEKek------kVWKLPESRWREGETLRETAERALRE 163 common water flea

Feature 1     ####                                                                            
7PKT_G    183 AIGRsh-pVYFIGNAPMGHVral------------pagTSFFMLAQVvddpwdtq---llpgaaqELAWVTKQELLgsyl 246 Chlamydomonas rein...
JAA71456  192 VCGSgl-eVRFLGNAPAGFYkyrypaef---rkdgivgAKVFFFKAQlqggslsadslmkldranDFEWLTQTELEs--r 265 castor bean tick
ADY42433  195 IFEGal-hATVSGNAPFSVYsyrypsglkrsetnnsvgAKVFFFSALispfhnfk---vnvkevsDYKWVTADEFSkt-i 269 pig roundworm
AEE62479  178 KCGDqv-kAQIFGNAPCGFYkykypkav---rsetsvgAKVFIYFARyasgqi-------agsesDFKWLDKSELKe--v 244 mountain pine beetle
EFO26460  186 LFSIei-hGKGINSAPFSVYfycypaqlrqrlkthsrgAAVFFFKALymnrvplv---ankdevaDYKWVNAEEFAasvr 261 Loa loa
NP_647661 178 SCGQel-qVLFYGNAPVGFHkykyprn----qrtetvgAKVFFYRASlrsgqv-------penltKFEWLPKEALNek-l 244 fruit fly
BAH71691  177 SCGNni-nVRFYGNAPCGFYkykypkqk--reqfnvegAKIFFFKAKlldgnve-----ekgtwtDYEWSTVQELNk--r 246 pea aphid
NP_499994 177 LSGTdl-sADISGNAPFGVFthryptpi--sqktgargAKIFFYTANlstiptef--qvnpddvtDYQWVNREEFWk--t 249 nematode
BAM19634  168 YCGKdl-kVQFLSNAPCGFYkykypqss---qtdnsigAKVFFYYANyqggav-------dgkekNFNWLTRNELKe--l 234 Papilio xuthus
EFX87716  164 YVKTpdtsVRVLGNAPWGVHtikypssv--rqklgftgVKVFFFKAQllssct-------tcsdiEYNWLGREELRn--s 232 common water flea

Feature 1                 
7PKT_G    247 SDARLRELVSKM 258 Chlamydomonas reinhardtii
JAA71456  266 MLPKYCQSVKSF 277 castor bean tick
ADY42433  270 RSKPYRNSVSTL 281 pig roundworm
AEE62479  245 LPASYSRSVLPL 256 mountain pine beetle
EFO26460  262 HKMSYLRALSTL 273 Loa loa
NP_647661 245 TNTAYAQSVKKF 256 fruit fly
BAH71691  247 LIQPYMKNVKLF 258 pea aphid
NP_499994 250 VPGTEYKKAAKF 261 nematode
BAM19634  235 LPPRYNKSVQEF 246 Papilio xuthus
EFX87716  233 LEPEYLRSVSKF 244 common water flea

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