Conserved Protein Domain Family
ASKHA_NBD_NTPDase5
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cd24114: ASKHA_NBD_NTPDase5 
nucleotide-binding domain (NBD) of ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase5) and similar proteins
NTPDase5 (EC 3.6.1.6), also called nucleoside diphosphate phosphatase ENTPD5, CD39 antigen-like 4 (CD39L4), ER-UDPase, guanosine-diphosphatase ENTPD5, GDPase ENTPD5, inosine diphosphate phosphatase ENTPD5, nucleoside diphosphatase, uridine-diphosphatase ENTPD5, or UDPase ENTPD5, hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP.
Links
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Statistics
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PSSM-Id: 466964
Aligned: 6 rows
Threshold Bit Score: 743.17
Created: 26-Jan-2023
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:
  • Comment:The catalytic residue Glu functions as a general base to deprotonate a water nucleophile for direct attack of the terminal phosphate group.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
O75356        47 TLYGIMFDAGSTGTRIHVYTFVQKmpgqlpiLEGEVFDSVKPGLSAFVDqPKQGAETVQGLLEVAKDSIPrshWKKTPVV 126 human
E1C1L6        47 TFYGIMFDAGSTGTRIHIYTFVQKspeilpeLEGEIFESVKPGLSAYADqPEKGAESVKRLLDMAIDAVPphlWKKTPVV 126 chicken
XP_007904221  47 IFYGIMFDAGSTGTRIHIYTFMQKssaepphLDNEIFESVKPGLSAYVDqPEQGAETVRGLLDMAKQTIPsthWSSTPVV 126 elephant shark
XP_005986626  52 TFYGIMFDAGSTGTRIHIYTFVQKspaeppqLDKEIFESVKPGLSAYADqPEQGAETVRELLEVAKHSVPpsqWKETPVV 131 coelacanth
TRY58357      74 TFYGIMFDAGSSGTRIHIYKFIQKdpaelpvLDNEMYHAVKPGLSAYADnPEVGGETIRQLLRVAKKTIPkeqWIQTPVV 153 Danionella tran...
KAE8585942    49 TIYGIMFDAGSTGTRIHIYRFKQRargshleLEGEVFESIKPGLSAFADqPKKGAATVRLLLDLAQKEVPstqWSHTPVV 128 tropical clawed...

Feature 1                                                     #                                  
O75356       127 LKATAGLRLLPehKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTVNFLTGqlhghrqeTVGTLDLGGASTQ 206 human
E1C1L6       127 LKATAGLRLLSeeKAQALLSEVKEVFEESPFLVPEDSVSIMDGSYEGILAWITVNFLTGqlsgqnqhTVGTLDLGGASTQ 206 chicken
XP_007904221 127 LKATAGLRLLPeqKAQALLSEVQELFEESPFLVPDECVSIMNGTYEGILAWVTINFLTGqlydqnqrTVGILDLGGASTQ 206 elephant shark
XP_005986626 132 LKATAGLRLLPeqKAQTLLSEVKEIFEDSPFLVPEDSVSILNGTYEGILAWITVNFLTGqlyn-ekrTVGILDLGGASTQ 210 coelacanth
TRY58357     154 LKATAGLRLLPqeKAKALLDEVKEIFDDSPFFVPDGSATIMNGINEGVLAWVTVNFLTGhlysrtkkTVGILDLGGGSTQ 233 Danionella tran...
KAE8585942   129 LKATAGLRLLPetQSDALLSEVREVFRESPFLVPENSVSIINGADEGIFAWITVNFLTGrlh--shrTVGILDLGGGSTQ 206 tropical clawed...

Feature 1                                                                                        
O75356       207 ITFLPqfektleqtprgyltsFEMFNSTYKLYTHSYLGfGLKAARLATLGALetegtdghtFRSACLPRWLEaEWIFGGV 286 human
E1C1L6       207 ITFLPrfeetlkesptdfltsFEMFNSTYKLYTHSYLGfGLKAARLATLGALntevadrqmFRSSCLPKQLEaEWHFGGV 286 chicken
XP_007904221 207 ITFLPqaestlkaasekyispFEMFNRSYKLYTHSYLGfGLKAARLAILGALggkd-esrmYRSSCLPPSLKaEWKFGGI 285 elephant shark
XP_005986626 211 ITFLPwsdetlkvapegfvtsFEMFNHTYKLYTHSYLGfGIKAARLAILGALasce-edqvYRSSCLPKTLKaEWKFGGI 289 coelacanth
TRY58357     234 ITFLPrlkktvqnapsdyiakINMFNSTYELYTHSYLGnGLFASRLATLGALgadglewkvFRSSCLPKKFSeEWTFGGL 313 Danionella tran...
KAE8585942   207 ITFLPltkntldqtphdflasVELFNSTYRLYTHSYLGlGLKLARLAVLGVSedndqqkqfFHSNCFLHGVKgEWSFAGV 286 tropical clawed...

Feature 1                                                                                        
O75356       287 KYQYGGnqegevGFEPCYAEVLRVVRGKLHQp-eEVQRGSFYAFSYYYDRAVDTDMIDyekGGILKVEDFERKAREVCDn 365 human
E1C1L6       287 KYRYGGnkegetGFKPCYLEVLKVVKGKLHQp-dEIRGSSFYAFSYYYDRAADTNLIDyeqGGVLEVRDFERKAKEVCDn 365 chicken
XP_007904221 286 NYKYGGmaeevtGFQSCYAEVLKVIREKLDQp-aEIRSRTFYAFSYYYDRAVDTGMIDgdqGGIILVKDFEMKANKVCEa 364 elephant shark
XP_005986626 290 NYKYGGnkegpmGFQSCYSEVRKLAKGKLHQa-dEMGDSSFYAFSYYYDRAVDTGLIDyekGGVIKVKDFEIKAKEVCNn 368 coelacanth
TRY58357     314 TYKVSGnpdgyaGYKLCYKEVLQVVKGIVHQpleVKGNSVFYAFSYYYDRANDTGLIDgarGGSVEVKDFKKKAKEVCNk 393 Danionella tran...
KAE8585942   287 TLKYEKksdgqsGFDACYSEILPIIQDKLHQv-pEMQHSPFYAFSYYYDRAADANLIDhmhGGVLQVYDFAKSAKEVCEr 365 tropical clawed...

Feature 1                                                                
O75356       366 lenftsGSPFLCMDLSYITALLKDGFGFaDSTVLQLTKKVNNIETGWALGATFHLL 421 human
E1C1L6       366 merfssASPFLCMDLTYITALLKEGFGFrDNTLLQLTKKVNNIETSWTLGATFHLL 421 chicken
XP_007904221 365 ltetntGSPFLCMDLTYITALLKEGFGFyDHTELQLKKKVNNIETSWTLGAAFHLI 420 elephant shark
XP_005986626 369 lhryssRSPFLCMDLSYITALLKEGFGFpDTTVLQLTKKVNDVETSWALGAAFHLI 424 coelacanth
TRY58357     394 mtkyrpISPYLCMDMTYITCLLIDGFGFkDNTVLQLTKKVNNVETSWALGAIFDHF 449 Danionella translucida
KAE8585942   366 teqsptHSHFLCMDLTFITALLKEGFGFeDNTSLQLTKKMYDVEMSWTLGAIFHVL 421 tropical clawed frog

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