1T5J


Conserved Protein Domain Family
ADP_ribosyl_GH

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pfam03747: ADP_ribosyl_GH 
ADP-ribosylglycohydrolase
This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.
Statistics
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PSSM-Id: 461037
Aligned: 641 rows
Threshold Bit Score: 31.0025
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1T5J_A              12 GSVFGAVIGDA-LGMPTEN----LTKE-EIKKLYGFVDsyv---------epkNYLAGKLNKGEWTDDTEQAICLIKSLT 76   Methanoc...
EPB86760            21 GLIFGAILGDS-LGLATEG----LSRS-EIQAIYGDGPirfgmde-dgvpfhrDEYRSKFEENDFGDDAEQVLLVMESLF 93  
EFX90358           286 GLIYGTVLGDT-LGVATEY----LMTD-EINFYYGGGRldhh-------sivqDEHRSHFPRGKTT-----CLLIFDSIL 347 
Q54PL0              16 GCIYGQCLGDA-YGLSTVC----KMKH-HVDRWYPKVNensfidfpnykiddyMEGGHTHDRGDWGIDSDNMILLLQSII 89   Dictyost...
jgi:SpiBuddy_1700    9 AILTGWYTGDG-MGSQTDG----MEAS-EVEVLCPEGIqe-----------lyTLEEVRPLCGMSSDVSDLPTLLGLSIA 71  
Q22C47              40 GCMMCSYIGDS-IGTVTEFtk-dLTEE-QIQKAIRME----------------GGGIHRVIAGQGTDDSELATSLGYGLI 100  Tetrahym...
EFN51316             2 ehalGALLGAAtVGAFLEFfp-rRPREaGVEQALALPG----------------GGCLNVGPGQFTDDTELALAGTEPGV 64  
Q22TC4             926 GCIFGSFLGDS-MGLFIR-----YKKQfSIKEIQQSInm------------eyQPSIILPNPAQLSEISELSLEIGYGLS 987  Tetrahym...
XP_008895946        16 GAFLGLLCGDA-AGATLEFspgvITET-DVSRAMAMPG----------------GGVFRVGKGQITDDSELALSLARGLL 77   Phytopht...
XP_001030788       179 GCLFGAFIGDS-MGSYLEFnkqqITNE-LVRQAYQLPG----------------GGIFNLTKGQLTDDGELAIMLAEGLL 240  Tetrahym...
1T5J_A              77 K--------------------------------------------EGIDI-KK-----------FANCLIawknknppdi 100  Methanoc...
EPB86760            94 En------------------------------------------gGHFLP-KD-----------FASRLYsygehgiknl 119 
EFX90358           348 Rw------------------------------------------sGVLDE-LE-----------LARRLIdysskglkdl 373 
Q54PL0              90 KvfqhtndvnsnnssssssnnndelffkvyrniflknkiwdyiriQ------EeeeeddailkiFIKKLKvyytkkgfqe 163  Dictyost...
jgi:SpiBuddy_1700   72 Sn-------------------------------------------KACDV-HH-----------VKASYRkyiqegdgps 96  
Q22C47             101 Es-------------------------------------------DENSIdLN-----------LITKYYvlwvkskpid 126  Tetrahym...
EFN51316            65 ----------------------------------------------PRQR-GR-----------TAVRLVvqasqpfdmg 86  
Q22TC4             988 Ck------------------------------------------yGVFDQ-KE-----------IAMNLIewvnsrppfn 1013 Tetrahym...
XP_008895946        78 Ghr-----------------------------------------pSEGFPlES-----------VAQQ-Yaawcnskpfd 104  Phytopht...
XP_001030788       241 E--------------------------------------------AKTNEpND-----------FMINILkkyhfwvnsn 265  Tetrahym...
1T5J_A             101 gltslmaid----------------------------klenndysgvdssscgaaMRIYPLGIVFHN--NLKKLKEEVIK 150  Methanoc...
EPB86760           120 hklptgmnatnqavlanp----------tyktspqqaaievwktrnnlrgangalVRAPLLGALKFW--DGTTVIENTTE 187 
EFX90358           374 ngeplitssvvnrllche---------rfsidphavasetaklfdeaicedlhalPMAIMSGLPQFY--NLTEVQSNATR 442 
Q54PL0             164 lgdwdknwfsfcrgrqttqlvv--rndeflkdpmmvskyyyliestkypndtgalMRSSIIPCMNFL--NEKQQLINTVN 239  Dictyost...
jgi:SpiBuddy_1700   97 ehvsh-----------------------------------ilqtepskadhslslTRSPIHGILKVSq-SQGKWLTFLKA 140 
Q22C47             127 igqttsnpfkllindqqinikm--nkdqvqekdlsniaisqaqidnqnsesnggcMRICSLIVYLSKlnDQEEIKKSVFS 204  Tetrahym...
EFN51316            87 nathnafgmrgwegi---------------adcaaqalqnvhneysaaskangalMRATPLAVWAHRl-GTDAIAACAKA 150 
Q22TC4            1014 idnkqfykvlrqvsnlqd---------dikpeelykqiqqkflfdqnednqvevlARVCFLAVFTSAvmDEDMIKIIKSL 1084 Tetrahym...
XP_008895946       105 igntcatafgakphs---------------dgkyadvmtqtaavhcsaseangslMRIAPLAIWSMGq-PEETIAALART 168  Phytopht...
XP_001030788       266 pfdfgstmqnswmpmnfttykellqkyqnnelnllqsiqnnaaktsvnsqsngflMKQQPLGILLWNs-PIDVIFQFAEL 344  Tetrahym...
1T5J_A             151 ASKITHNNKT-AIAGALAIAFFVSSA-LKDRKDFSLLDEcynyikdideefakkl------------------------- 203  Methanoc...
EPB86760           188 CCRVTHPDPR-CMISCVIASTLIARL-LRGQDLEIEINHsptpsidqqhqpsfnyfidtlpvndrlqalvrnvvetnkpm 265 
EFX90358           443 VCRTTHNHER-VIKSTSLLASIIALI-LQGCEMDNIKEVvtnqnlvesefyys--------------------------- 493 
Q54PL0             240 FSKVTHYDPR-SVTCCIIQNNLITTI-LNYYYNNNNNNNnnnnnnnnnnnisnlllklikiiyedkkieklqnyyn---- 313  Dictyost...
jgi:SpiBuddy_1700  141 ENQITSSSDL-SLQAALLLSYGFASLlEQGYDQGLTFVTelqsfakrsrfderii------------------------- 194 
Q22C47             205 EQQITHPNII-SQYCTYIYVRACINL-IQNGDAKKAFEDinnyvenflnigviq-------------------------- 256  Tetrahym...
EFN51316           151 DAQLSHPNQA-CQDANAAYVMACASL-IRWPGDAGAALTaaeeraaanacrevqew------------------------ 204 
Q22TC4            1085 VLMFTHPSDQlLTNACLAICYCIKQI-INSNLDRKSIFEktmkfclthimdsqiiei----------------------- 1140 Tetrahym...
XP_008895946       169 EATLSHPNQV-CQDCNAVYCLMLEHL-LRVPGDFQGAVSrgerfvnncvnsvvrt------------------------- 221  Phytopht...
XP_001030788       345 DTKFTHSDQF-CLEVSKIYTYILAQLiKRGKQESFKIYCearklawenyfsnqmketfnyiemqfqg------------- 410  Tetrahym...
1T5J_A             204 ----------------------------leiknfnnldyiydyFGTGVKTDEVVPSAIATYLL----------------T 239  Methanoc...
EPB86760           266 liapqtdplfitpetdmnqmqkyyhqlvdycvpsslgdlalddSADCRDTFKCLSAALYCLTRevpl---------qseT 336 
EFX90358           494 -----------------------------------gnlayeenngmkdeLANVLSAALHCLEEk---------------E 523 
Q54PL0             314 -------ekngmfeneidkrrkigisnyliysardwghlnlerSLQGGFSLSGLSSSIYSLKKfnqyfnqekeklinsgC 386  Dictyost...
jgi:SpiBuddy_1700  195 ---------------------------tclqaainqkplplydAKQSTFVLTTLLVVMHTLIA----------------F 231 
Q22C47             257 ----------------------------qwwrenvlkekfsetKIYEVWIKHQFINVFIILKRiaegs-------esidS 301  Tetrahym...
EFN51316           205 ---------------------------laeardngamaaynahGASMGFVKHAFCLAFYHLRR----------------H 241 
Q22TC4            1141 ----------------------------lqhstnpimkvfdhltiQQQPLQFAVYMAFYFFYH----------------N 1176 Tetrahym...
XP_008895946       222 -----------------------------wfleesldisslvctRKVGHVRWAFVLATYFLRQ----------------N 256  Phytopht...
XP_001030788       411 ---------------iteqslrtgekfginqigfpnfyaiykaEKQIGWVRIAFSYSLYILIA----------------N 459  Tetrahym...
1T5J_A             240 dN--------FKEGMLKCINAGGDTDSLASMYGAMAGAYYGFKNIPKE 279  Methanocaldococcus jannaschii
EPB86760           337 eY--------FKKMLMDVVMQGGEADTNATAAGAMLGARFGYSQLPTE 376 
EFX90358           524 pH--------FETTLTNILFLGGQSRIYGAVCGGILGCRSGYAHMPAR 563 
Q54PL0             387 sDglinlsflFRKVLDELIREGGDNN--GASTGALLGSIIGYSNLPKD 432  Dictyostelium discoideum AX4
jgi:SpiBuddy_1700  232 dS--------YEAGMQALVMRGGNARLTCAVYGGLAAGLYGSQCIPER 271 
Q22C47             302 dL--------LPRVLKQIIRLHGDTDTAACIVGGMIGSLVGYQNIPSN 341  Tetrahymena thermophila SB210
EFN51316           242 sG--------FVEGLRHTLLCGGDTDTNACIVGGVLGARYGAAGIPPE 281 
Q22TC4            1177 fG--------FESSLQNIFSYGGDSCLFGSIVGCLIGAIIGFGNLPQT 1216 Tetrahymena thermophila SB210
XP_008895946       257 eS--------YERAIQQTLLKGGDTDTNAAIVGGLIGALHGVESIPSh 296  Phytophthora parasitica INRA-310
XP_001030788       460 lT--------VEQLYQGILSIGGDTDTNLCIAGAVYGAQNGIETFPSF 499  Tetrahymena thermophila SB210
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