1J46,1J47,2GZK


Conserved Protein Domain Family
HMG-box_SoxA_SRY
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cd22034: HMG-box_SoxA_SRY 
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high mobility group (HMG)-box found in sex-determining region Y protein (SRY) and similar proteins
SRY, also called testis-determining factor, is a transcriptional regulator that controls a genetic switch in male development. It promotes DNA bending and is also involved in pre-mRNA splicing. The SRY HMG box recognizes DNA by partial intercalation in the minor groove. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY is the only member of group A SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438843
Aligned: 6 rows
Threshold Bit Score: 137.458
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1J46; Homo sapiens SRY binds DNA, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           # ## #####  ##  ##  #   ######  ##  #  ##      #   #      #          ####### 
1J46_A         1 MQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKA 80  human
1J47_A         1 MQDRVKRPINAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKA 80  human
Q05066        56 VQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKA 135 human
AAB58342      56 VQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKA 135 papaya
2GZK_A         1 VQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRKGETK 80  unidentified
XP_006195462  57 MKDRVKRPMNAFIVWARDQRRKVALENPKMQNAEISKRLGYQWKLLTEAEKRPFFEEAQRLRAIHRDKYPDCKYQPRQKT 136 Wild Bactrian c...

Feature 1        #    
1J46_A        81 KMLPK 85  human
1J47_A        81 KMLPK 85  human
Q05066       136 KMLPK 140 human
AAB58342     136 KMLPK 140 papaya
2GZK_A        81 KKFKD 85  unidentified
XP_006195462 137 EGLPR 141 Wild Bactrian camel

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