6EZN


Conserved Protein Domain Family
Ribophorin_I

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pfam04597: Ribophorin_I 
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Ribophorin I
Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC:2.4.1.119). OST catalyzes the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum. Ribophorin I and OST48 are though to be responsible for OST catalytic activity. Both yeast and mammalian proteins are glycosylated but the sites are not conserved. Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function Most family members are predicted to have a transmembrane helix at the C terminus of this region.
Statistics
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PSSM-Id: 428028
Aligned: 168 rows
Threshold Bit Score: 190.481
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EZN_A        32 ENVDYKRTIDVSNAYISETIEITIKNIaSEp-ATE------YFTAFeSgifskvsfFSAYftN--Eatf----------- 91   Saccharomyces ...
ESS32972     261 VIEKLERRLDMKRQ-VKVTIRTTVANHgASa-VEN------LAFLLpFheavqvgwMAAKqnGqtVsfdaiserprissf 332 
CAQ39702      56 VYEHITKNMHLKKNYVEVIIQGDLKNK-GDkcVDSfvfllpYHEAFqA--------STLRvrDqnQselryqvl------ 120 
O77351        56 IYEHVSKYINLKNNYVEIVIKGKLKNV-QDtlVENflfllpYHEAYqG--------TNLYalDdeGnvlkhni------- 119  Plasmodium fal...
XP_002142738  29 TQTNVIRNFYLTKRVVRVFLEISLRSN-NSsnIRDf----eYGIFFpTlvyskvgyISSGisPlnLniy----------- 92  
Q7RNU8        56 IYEFINKNVYLKNNYVEINVKGAIKNI-STtlVDKiifllpYHEAFqG--------ANLQikDekNselnykv------- 119  Plasmodium yoe...
EFN51949      22 VIEEAQRRIDISTFRSGHKTRLVIRNDgSAg-EDV------VVLCQaAglldkvaiTEVAlsGa---------------- 78  
Q9SFX3        28 VLSKVERRIDVTSQIARVTKTLKVVNSgSEs-VSE------FALTFpKflgnnlayLSVApsEgkGkskr---------- 90   thale cress
Q0DJC5        31 VVTRADRKVDLTSHIVRVLTSLKVENSgPEa-VSQ------FLLAFpNvqaknlaaIRAFgtE--Ekvkg---------- 91   Japanese rice
XP_006855653  26 VVLKVDRRVDLTSHIVRVTSTLKVENSaTRv-ASE------VLIALpNhqvqnlayLKASfqDgkGkak----------- 87  
6EZN_A        92 ---------------------lnsQLLANSTtApGDDgES-EIR--------------YGIIQFPNAISPQEEVSLVIKS 135  Saccharomyces ...
ESS32972     333 sphtpaslshdallveevdqalqvAAGVAADsPsGGRgGAnDLArstreegedecrplLLELHLRKPLEPQGRTHIEITY 412 
CAQ39702     121 -----------------qeprhdaREIQVDTfNeDYDlEQfQVK--------------AYRVTLKRRLHKDEKVSLHFGY 169 
O77351       120 -----------------lkdtkdiEEMNIDPfNdDVDlSHfNLR--------------VYEIILSRKLKLEENVLVKLSY 168  Plasmodium fal...
XP_002142738  93 ---------------------tinCEEFNKTnNkHFSnLSeDIY--------------VCKINIPELTKNLTTIY--IEY 135 
Q7RNU8       120 -----------------lrnvidiDKINIDKfNnDYDiELfNVK--------------IFEIYLNKKLKKNEKILINLSY 168  Plasmodium yoe...
EFN51949      79 ------------------------NLPWSAA-PpPAGvPA-GVG--------------CRSYKLPEALAPGARATLEAEA 118 
Q9SFX3        91 ---------------------tlvNLSVREA-D-QKGlPD-SIS--------------VYSVALPKPLSKGDTLTLEVVA 132  thale cress
Q0DJC5        92 ---------------------psmVLPIEVV-Q-PSGvPP-ELT--------------FFSASLSKPLEKGKTLHLDVLT 133  Japanese rice
XP_006855653  88 ---------------------gsvDLPIKMV-Q-PEGmAA-DVT--------------IYAVSLAKGINKGEIVNLEVFS 129 
6EZN_A       136 FYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAY-DT-KKASF------------TLIGSSSFEE-YHpp----------- 189  Saccharomyces ...
ESS32972     413 ILGRAYRPVPRAAPLGAVQSVLFVSTSAWPSPYpVLhGSSTAv-----------ALAPGTSLGP---------------- 465 
CAQ39702     170 VLGQPYFPFPVDISPEEGQKVMFYLSSKILLPYeVEeKEELKiflck---ncsiVRIEDDNFLRsFVkvnddtyvcekte 246 
O77351       169 TLGQPYFPYPLEIDFINKQNVLFYLSSKILLPYqVEkYERIEinlce---acdiVSLDDACFLKgLKkindkn------- 238  Plasmodium fal...
XP_002142738 136 YIGDPYKTLPDSIYINENQLVEFKDFQYFLTPY-KVeNEKTI------------IHFLLGTQIErFLpts---------- 192 
Q7RNU8       169 ILGQPYFPFPIDINLNEKQNVLFYISSKILLPYnVEnEEKIIihmce---dcilKEFDDVNYMNwFEkidtnk------- 238  Plasmodium yoe...
EFN51949     119 LFTHVLRPEPAKIRQSEPQRVVYQDSALLASPY-RVeKQSTEvgarlvprlrtrVVTGTSAVPS-FTd------------ 184 
Q9SFX3       133 AFTNVLQPFPEKITQGEIHLVMLQESAQYLSPY-AVeSQSLS------------IKLPNARIES-YTk------------ 186  thale cress
Q0DJC5       134 VFTHSVQPFPEEITQAESQLVVYQDSAQYLSPY-PVkVQTLS------------IRLPGGRVES-YTk------------ 187  Japanese rice
XP_006855653 130 VYTHSLKPFPEEITQADNQLVLYQDSAYYLSPY-DVkVQSLS------------IRVPSPRVES-YTk------------ 183 
6EZN_A       190 ----------ndESLLg----kANGNSf---EFG------PW-E--DIprfssnetLAIVYSHNAPLNQVVNL------- 236  Saccharomyces ...
ESS32972     466 -----------------------AGATrimkKYGfkqesqPDgPwmIVap-----gpTLPFEVGQPFVLHMPLplhlgyf 517 
CAQ39702     247 grtvgelprgveETFRddqkefVAKES----KLG------PF-MlgQK--------VLFYFRSNNHLGYFEQV------- 300 
O77351       239 ------yiieyeHNIE------S------------------F-NlgNK--------ILLYFVCDYNLGYFEKV------- 272  Plasmodium fal...
XP_002142738 193 --------------------mkrQDTKl---TYI------PK-NntDiqtp--esmLYVHFNLNNHLVIYKSV------- 233 
Q7RNU8       239 ------yvhtknNDIRns--ekFNKLN----NDN------RF-SlgNK--------VLFYFTSDYNLGYFEKV------- 284  Plasmodium yoe...
EFN51949     185 -----------vPPSK------KSGSSl---QYG------PY-Q--DTqpft-lkpISVHYENFAAFAHVPEL------- 227 
Q9SFX3       187 -----------fENTK------LQGSEl---KYG------PY-K--NLqsys-yspIVVHFESKAAFAVAEKL------- 229  thale cress
Q0DJC5       188 -----------yPNTK------LAESEl---KYG------PY-E--DLppfs-yspMVVHYENNNPFAVAKEV------- 230  Japanese rice
XP_006855653 184 -----------vERVK------FTDLEi---KYG------PY-E--NIrafs-ftpIVVHFENNQPFAVVKEL------- 226 
6EZN_A       237 ---RRDIWLSHWaSTIQFEEYYELTNKAAKLSKg------------------FSRL---ELMkq---------------- 276  Saccharomyces ...
ESS32972     518 lsaERFVEVSHF-GNIFFHEWYRLHNDAAKLEGsydaitaaalqgiqpgaprFSRH---MKKd----------------- 576 
CAQ39702     301 ---TKDIKLSQL-GFVYEREEYILRNDAGRIHT-------------------FDRYllsDYEnrhtseekgn-------- 349 
O77351       273 ---IKNINISSL-GYIYEKEEYFLKNNAAKINK-------------------FDRYilsDYEsrytspggsntgeaings 329  Plasmodium fal...
XP_002142738 234 ---NRTIEVSHW-GNVYIKEEYAGKNQAATHKGe------------------FNRK---EIMllagqg------------ 276 
Q7RNU8       285 ---VKDIKISQL-GYIYEQEEYILKNNSAKINK-------------------FDRYllsDYEnkytseedrekngq---- 337  Plasmodium yoe...
EFN51949     228 ---EREIEISHW-GNVYFEERYHLRHAGAKITGe------------------WSRY---DLM------------------ 264 
Q9SFX3       230 ---VREIEVSHW-GNVQVTENYNVVHRGAQLKGe------------------FSRL---DFQ------------------ 266  thale cress
Q0DJC5       231 ---IREIEISHW-GNVQITEHYNIAHGGAKLKGe------------------FSRI---DYQ------------------ 267  Japanese rice
XP_006855653 227 ---VREIAISHW-GNVQVTEHYNLAHGGAQTKGg------------------FSRI---EYQ------------------ 263 
6EZN_A       277 ---------------------------iqTQn-MRQTHF--VTVLDMLLPEGATDHYFTDLVGLVSTSHAERDh------ 320  Saccharomyces ...
ESS32972     577 ----------------------------eVNdpREPPAShmLTHLVAALPKRAFSLEVFDQIGNVSSTRAARVgpeaq-p 627 
CAQ39702     350 ------------------------gtdtdtdtdDQSTTI--IYSMKSKINYDIYDYEYFDDLGKIYLIQAEEIfdrkkrk 403 
O77351       330 dnigfinmenkndtvnnipiknnskshfpRNktDKHNSI--IYSLESKIDYNIYDYNYFDDLGKIYLIRGEEIyddekkk 407  Plasmodium fal...
XP_002142738 277 ------------------------farmrNPgsVLPQNThiCFQMDHILPYRAIGLEYYDKIGNISYSHASKVnsr---- 328 
Q7RNU8       338 ----------------kkqtkltkqakltKHnnKNHSSI--IYSMQSKINYNIFEYNYFDELGKIYLIRAGEFydthkkk 399  Plasmodium yoe...
EFN51949     265 -----------------------------TRpnDFARGA--IAAVGATLPPTAHSLYYRDAIGNISSSEARFGres---- 309 
Q9SFX3       267 -----------------------------ARpnPRGASA--FRHLLARLPPRAHSIYYRDDIGNISTSEMKSDskk---- 311  thale cress
Q0DJC5       268 -----------------------------SRpyIRGVSS--FRHLIARLPPRAHSIYYRDEIGNISTSHLWSDskk---- 312  Japanese rice
XP_006855653 264 -----------------------------GRptSRGASS--FRHLLAKLPPRAHSIYYRDHIGNISTSHLWGDlrk---- 308 
6EZN_A       321 ----FFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSgsDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFD-IDSP 395  Saccharomyces ...
ESS32972     628 iyteLELYPRFPLLGGWNTDFQVQYNLPARTVMVKHAd-AHRYTLNLTLAPPFRDIYTEDVFLNIALPSGAQNVT-VTSP 705 
CAQ39702     404 shiqFDLRPRYPLLGGWRAHFFNAFYHESNLYRIKNK--ENYYAYRIDISPSIKSFFIKQLKVRISLPPFSDDVAvVSRD 481 
O77351       408 nilkFDVKPRYPLLGGWKFHFFNTFYHFSNLYKIKNK--RNVYAYKVDISPTIKSFYIKQLIINICLPSYSYDVL-INND 484  Plasmodium fal...
XP_002142738 329 -ytlIQAEPRSPVMGGWNFDYVIEYNLPLENVVFYDYe-KKTYMLNITLTPSAKGIYAENVTTHIRLPPGSSEIQ-FLLP 405 
Q7RNU8       400 niikFDLKPRYPILGGWKTQFCNSYYHSSNLFKIKNK--KNYYAYQVDISPSIKSFYIKEMHINIYLPPYSNNIS-INNN 476  Plasmodium yoe...
EFN51949     310 --vdVKLTPRFPLFGGWALQFLFGWSMPLQECVRKLP--SGRLLFEAPIGPSVHNLVVDKLTVKVVLPEGARDVR-LVSA 384 
Q9SFX3       312 --teLLIEPRFPLFGGWKTFFTIGYGLPLTDFLF-AS--EGKRFLNISFGSPILDLVTEKLIVQVVLPEGSKDIS-VTTP 385  thale cress
Q0DJC5       313 --tqLEVEPRFPLFGGWQTTFTIGYGLPLQDFVF-NS--DGKRFLNITFGSPVEEILIEKLIVKVVLPEGSKDID-ISVP 386  Japanese rice
XP_006855653 309 --teLQIEPRYPMFGGWRTAFTIGYGLPLHDFLF-ES--DGKRFLNISFGSPLDEVAIDNLVIKVILPEGSKDMS-VSIP 382 
6EZN_A       396 vp------ftNVSI---ETQK----SYFDLnKGHVKLTFSYRNLISqVANG---QVLIKYDYPKSS-FFK--KPLSIACY 456  Saccharomyces ...
ESS32972     706 rkv-----dwNMNE---KLH-----SWLDVfTFRPLLKLHFPSSFVpDRNIlqfKVQVSYDYPPFL-AVEvfKQLQICLL 771 
CAQ39702     482 -----------DRV---NVQTskqkGWLDLfSFRNVVEIQIEKFFPpMDENyyqDFLVMYKYKFFN-LFW--KPLLVILI 544 
O77351       485 n--------lKNYV---HVQTtkkkEWIDFfSERNVVTLQIYKFFPsSDEKymnNFLVMYNLPITH-IFI--KPLMLIII 550  Plasmodium fal...
XP_002142738 406 knrnipslkkQEDL---SYYY----GWLDIfKPRPVIIYSAHSMYIpEQHIlnfKGQVYYQIKSEFlLKY--KLFVIPGI 476 
Q7RNU8       477 n---------LKEM---SVKNgkakDWLDLiSHRDTIQIQIQKIFPqHEENnykNFIVMYELKFFN-IFL--KPLIIILI 541  Plasmodium yoe...
EFN51949     385 sgl------glAQDpafETKY----TYLDV-VGRPVLVLRADNVVD-EMNV---PFKVEYSYSPMG-LLQ--KLLLLVAA 446 
Q9SFX3       386 fa-------vKQSQ---EIKY----SHLDI-AGRPVVVLEKNNVVP-DHNQ---HIQVYYKFSNIN-LLS--EPLMLISG 443  thale cress
Q0DJC5       387 fp-------tKQEQ---EVKY----SHLDI-SGRPVVVLEKLDVIP-EHNL---YFQVYYRFNNIS-LLR--EPMMLITG 444  Japanese rice
XP_006855653 383 fp-------tEQRQ---EIKH----LHLDT-IGRPVVVLEKKNVVP-EHNV---YFQVYYKFNSLS-MLR--EPVMLIIG 440 
6EZN_A       457 IFTALMGVFVLK 468  Saccharomyces cerevisiae S288C
ESS32972     772 VFVLFLLLILSr 783 
CAQ39702     545 TFAAILLLCFLR 556 
O77351       551 TFFIIILSFVMK 562  Plasmodium falciparum 3D7
XP_002142738 477 IFISLLLFVLIR 488 
Q7RNU8       542 TFIVILFFYFIN 553  Plasmodium yoelii yoelii
EFN51949     447 FGALFAAAIMLN 458 
Q9SFX3       444 FFILFITCIIYT 455  thale cress
Q0DJC5       445 FFLLFMACIVYM 456  Japanese rice
XP_006855653 441 FFLFFLTCIIYM 452 
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