Conserved Protein Domain Family
PIG-S

?
pfam10510: PIG-S 
Phosphatidylinositol-glycan biosynthesis class S protein
PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear.
Statistics
?
PSSM-Id: 463126
Aligned: 96 rows
Threshold Bit Score: 264.909
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
KIS70396      18 ACFWVALLASIPWWLRLTTIQRLPLPAQQVRALQQFGSCPVTLQssLVIS-VDADILREagadadrDARTAFLKQVEQLV 96 
XP_012811796  22 SIALITAVLGLPLWWKTTETYRASLPYSDIRGLET-LQLHLTVP--IEII-FGKATLTA-------EQQRNVPSTGLKET 90 
XP_001507200  22 SFATVAIVVGLPLWWKTTETYRASLPYSQISQLGD-LRLQLTVP--ISVV-FAKGALPI-------EAQRKLP-YTDTQE 89 
XP_003770093  46 CFATMAVMLGLPLWWKTTETYRAALPYSQIGHLDS-MLLRLRVP--VSVV-FIQGSLPI-------VDQQKLPFTVVNER 114
XP_003996538  22 FFAAVAIVLGLPLWWKTTETYRAPLPYSEISGLNA-LQLRLMVP--VTVV-FTRESVPS-------DDQEKLP-FTVVHE 89 
XP_005056851  23 SFATIAVVLGLPLWWKTTETYRAALPYADIDGLGQ-QPVRLVVP--MAVV-FGPGSVPR-------DLSRSLP-FTDVQE 90 
XP_003227327  25 SFAAIAVVLGLPLWWKTTETYRASLPYAEIAELDT-LRFQLTVP--VSVV-FAKGSLPA-------KQERKLP-SRKMQD 92 
XP_006005796  22 SIAAIAILLGIPLWWKTTETYRASLPYSQIRELDT-LWFQLMVP--VEVI-FAKGTLRA-------EQQRQIP-FSQSRQ 89 
XP_002113280  17 AVGVVIIVLGVPLWWVTTEVYRAPLPYNRIAQLAF-LQPQSVVP--VEVVwLTKGEGVT-------EESTKLSELLKANL 86 
XP_002124261  25 ATGLIFVVLGVPIWWNTTKVYRANLPFTEIAELNQDAGLKVGIN--VNVV-VADNCDFE-------AVKSKLEDYFGNFG 94 
KIS70396      97 QQSLeikSqlpaaASLectrWKVQVQSSaSEVSPesfq----------------petGAYVVRIASEA-----SAESTSS 155
XP_012811796  91 ETVLn-aQ-----TSItr-hYEFKYRRTsVDEEEalglkslqdan-nalqklgetahGSITIFILPESsvllpKGIRVYI 162
XP_001507200  90 RKIPlnyK-----MTInc-lFEKSYRNTiDQEEValglanvqead-avlslvqespeGMLTVYVVPEAssllpQDVMGYV 162
XP_003770093 115 DVPLk-cK-----MKLkc-rFQLAYRMAgSHEEKafkkdtieeae-aalplpkedtlGSLNIFVIPEKssllpKDKMSYI 186
XP_003996538  90 REIPlkyK-----MKIkc-rFQKAYRRAlDHE-EealslgsmqeaetmlaepqeqaeGSLTVYVIPEHssllpQDMMSYI 162
XP_005056851  91 MEISvnlR-----TTVts-rYEMRYRSTtAQE-EaalfaatareadaalhplqdttmGSLTMYVVPETssllpQGINVYV 163
XP_003227327  93 VEIPlnpK-----TSVts-hYEMFYRRAtTQE-EmilaqksleevdsslrtteetsmGSITVYVVPQNslllpQDVAVFV 165
XP_006005796  90 KEAQlnsK-----TGFry-rYETKFRAAtAME-EtalalpgvqeaeetlsrlketpeGTVLVYIIPETslllpQGIKTYI 162
XP_002113280  87 KSASsdnM-----TIIdy-iITTRVGNEmEME-IvkenlialneldrklgalnpesqG-FRFYLLRPSqikspIN-RIYV 157
XP_002124261  95 GSVSak--------pIfv-kYNVTYspksvdl------------------glegevaGTIRVAVscg----nfDDFKINV 143
KIS70396     156 QPPHIPTIYIPAISedseslplVPDTLSAAVIAELVHLRGDKpltD--DDtstsTIAVTE--------QdPRVIQYSKHV 225
XP_012811796 163 GKHRIALVRCALSTslg--sedIANTVYKKVEHVIQTMSFTD---EavTAalsdRIPIGKfskedfenS-RRAFKSSAGY 236
XP_001507200 163 GKRRGAVVRGARGQq-------ALALVEQRVQQVIQATSVTD---DvlAAaladRLSGDKws----sdR-RRPLKSSLGY 227
XP_003770093 187 GPKRTAFV-RGTQVr------qGPTGMGQRILQVAQSMSLTD---EvlAAalgdRLPEDKvs----ldK-RRPLKSSLGY 251
XP_003996538 163 GPERTAVVRgim-------hreAFNIVGRRVIQVAQAMSLTE---DvlAAaladHLPEDKws----sdK-RRPLKSSLGY 227
XP_005056851 164 GKHRSALVRav----------gSLAALQARLREVTQVMSFTA---SsiAAalsdRLPSRQlg----pdA-RRNLKSSLGY 225
XP_003227327 166 GKHRSAVLRspln------aedALTKVDAHVQRVAHAMSFTP---DslAEaladRVLIGQpg----aeW-KRPVKSSLGY 231
XP_006005796 163 GKRRTAVLR--AVLsqshrmedTLDEISPQVQRVVQTMSFTD---DviASavsdRIPIGKfnketyadN-MKALKSSLGY 236
XP_002113280 158 GSYYSTFIV----LndgeryesFATKIQLVVKDIYVNEKVLR---NtvTSilgfRekka------dveS-MRAIRSTDSY 223
XP_002124261 144 ETNREISAQIGRkt-------eNLDEFGKILVEVLKQGVVGE---EmlEEvv-anIRKEGgsgrkdeeL-MKMVPPSSEF 211
KIS70396     226 RLVFSIMNQDITDg-tAYDSRllrNLADGnasadnPISKLTRALSQLHDFHIETQVQWFAPLHFQPTMeqlEEVvemeve 304
XP_012811796 237 EITFSLLNPDPKShdlNWNIS---SASDQ------YIQPFLDKLQNVANFSMDSQTLYYAMLGVTPRFe--KST------ 299
XP_001507200 228 EITFSLLNPDPRShdvRWAIE---GAVRH------YVQPFLDKLRPAANFSVDSQILYYAMLGVTPRYd--TAS------ 290
XP_003770093 252 EITFSLLNPDPKShevHWDIE---GAVEN------YVQPFLSLLSVVGNFSMDSQILYYAMLGVTPRFd--AAS------ 314
XP_003996538 228 EITFSLLNPDPKShdvHWDIE---GAVRR------YVQPFLSALSAAGNFSVDSQILYYAVLGVNPRF---DPAs----- 290
XP_005056851 226 EITFSLLNPDPKShtvDWDIE---GAVNR------YVKPVLDKLSLVANFSVDSQILYYAVLGVTPRY---DKEs----- 288
XP_003227327 232 EITFSLLNPDPRShdvHWDIE---GAIRR------FVKPMLEKLSPVAEFSVDSQILYYAALGVTPRF---DPAs----- 294
XP_006005796 237 EITFSLLNPDPKShdlHWDIE---NAVNY------YIQPFLGKLSSMANFSMDSQILYYAILGVTPRH---DKAs----- 299
XP_002113280 224 QLSFTLINPEPHNliaKWKIA---DAIRI------YLDPFLKALKDFSSFTIDSQVLYYSGLSIRPSQ---DSAt----- 286
XP_002124261 212 EVIFTLLCPDAEKm--TWDVE---RAILE------HITPILEELKPIFHFHISSQVLYSTKLRVRPKI---MKNstt--- 274
KIS70396     305 eevmvdqeiqeeVDVEvddvadvadvsqdkvsasethptagdqhelasngadaeaaeverqlsyvpqikrtrtlkqvrkr 384
XP_012811796 300 ------------SSYI---------------------------------------------------------------- 303
XP_001507200 291 ------------ASYV---------------------------------------------------------------- 294
XP_003770093 315 ------------SSYT---------------------------------------------------------------- 318
XP_003996538 291 -----------sS-YY---------------------------------------------------------------- 294
XP_005056851 289 -----------sS-FL---------------------------------------------------------------- 292
XP_003227327 295 -----------sS-YR---------------------------------------------------------------- 298
XP_006005796 300 -----------sS-YI---------------------------------------------------------------- 303
XP_002113280 287 -----------gS-YY---------------------------------------------------------------- 290
XP_002124261 275 ---------nevKYHY---------------------------------------------------------------- 281
KIS70396     385 tiqvpriqrirkqkrtplpprhVvEWDDLKVFVNSQEWSLTSTVppcSSSPSeraydvlsqthdLHFLLYIPSKSHSPLM 464
XP_012811796 304 ----------------------L-NLHNLPHVINPVEARLGSSAa--SLYPV------------LNFLLYVPEYSHSPLY 346
XP_001507200 295 ----------------------L-PVHSLPHVINPVEARLGSSAa--SLYPV------------LNFLLYVPDRSHSPLY 337
XP_003770093 319 ----------------------L-AAYSLPHVINPVEARLGSRAt--SLYPV------------INFLLYVPERAHSPLY 361
XP_003996538 295 ----------------------L-AAHSLPHVINPVESRLGSSAa--SLYPV------------LNFLLYVPELAHSPLY 337
XP_005056851 293 ----------------------L-SAHSLPHVINPVEARLGSSAa--SLYPV------------LNFLLYVPERSHSPLY 335
XP_003227327 299 ----------------------L-SVHSLPHVINPVEARLGSSAa--SLYPV------------LNFLLYIPEDLHSPLY 341
XP_006005796 304 ----------------------L-SAESLPHVINPVEARFGSSAa--SLYPV------------LNFLLYVPDYAHSPLH 346
XP_002113280 291 ----------------------L-TPRLLPRVINSIESRLGSHAt--N-NPA------------ANFILYVPETKFKNLH 332
XP_002124261 282 ----------------------L-QGNQLSNIINSIESRLGSHL---STFPT------------LNFVLYLTDISNNPLY 323
KIS70396     465 IRDTVhGGvkedvgGWLIPQWGGVVIVNVDHEEKQStglvkldqkldrggVEELAEIaVAEAMALFARQLEILLGLSdg- 543
XP_012811796 347 IQDKDgSRip--tnAFHSPRWGGIMIYNVDYGN-LGel----------qfPVHIDID-MVRVMEVFLTQLRLLLGITkaa 412
XP_001507200 338 IQDKDgAPva--tnAFHSPRWGGIMIYNVDLSA--Snat---------elPVRVEVD-MVRVMEVFLAQLRLLFGISqaq 403
XP_003770093 362 IQDKDgARva--tnAFHSPRWGGIMVYNVDPSAYNTtk-----------yPVKVDVD-MVPVMEVFLSQMRLLFGIPppq 427
XP_003996538 338 IQDKDgAPva--tnAFHSPRWGGIMVYNVDPK---Ayna--------sklPVRVEVD-MEQVMEVFLAQLRLLFGIAqpq 403
XP_005056851 336 IQDKDgAPvs--tnAFHSPRWGGIMVYNVEVP---Aspq--------aslPLHVDVD-MARVMEVFLAQLRLLFGLSree 401
XP_003227327 342 IQGKDgSAvp--tnAFHSPRWGGIMIYNVGPD---Tane--------tsfPKRVDVN-MVAVMEVFLAQLRLLFGVSqtp 407
XP_006005796 347 IRDHHgAQvt--tnAFHSPRWGGIMVYNVKHK---Nsne--------tlfPIRVDID-MVRVMEVFLTQLRLLLGIQkve 412
XP_002113280 333 IRTSKnDSrm--tySFISPRWGGFII---DSK---Ahna--------lntSKVYEVD-LKEAMDIFVAHLKLLLGIPkis 395
XP_002124261 324 IQKGDgSPsk--snNFLLPRWGGMTIYNPQEG---Ar-----------------EVD-LDSVMPTFLTNLRTLVGLRnny 380
KIS70396     544 ----rSASAslsetQDRLqrrvQLSTLKQRRILELSREATSTLIAITRLVDRIENLGVGAHVKSDVEAALHIMHSLRNSS 619
XP_012811796 413 vpedyQLESp----GNEGltdwELDSLLWSRVVENIATVTTTLTSLAQLLDQIGNIVINDIVASEVYHAVSSVQTALSEL 488
XP_001507200 404 vpadfQLENp----GNEGlaawELDRLLWARTVENIATVATTLTSLAQLLDKIGNIVIKDDVASEVYQAVEAAQSAAAEL 479
XP_003770093 428 mpenfLLGDp----PREGlrswEVDRLVWARTVENVATVVTTLTSLAELLDKIGNIVIKDNVASEVYRAVDAIQEAVVEL 503
XP_003996538 404 lpvkcLFSGpk--sEGlt--twELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYRAVAAVQKAAEEL 479
XP_005056851 402 vppefLLESpg--nEGla--dwELDHLLWAHTVENIATVSTTLTSLAQLLDKIGNIVIKDDVASEVYQAVASVQSAVTKL 477
XP_003227327 408 lpegaLLANpg--nAGlc--dwELDRLLWARTVENVATVSTTLTSLAQLLGKIGNIVIKDDVASEVFHAVESAQGALQEL 483
XP_006005796 413 tpadvLLQSpg--nEGit--dwELDRLLWVRTVENIATATTTLTSLAQLLDQIGNIVINDHIASEVYSSVASVHATLSEL 488
XP_002113280 396 msgdkRLEFgk-sdVGls--kwEYSCLLRRRTLENVASANQTLTSLAKLLEEITNIVISDRIKELINLSIEELHKSLDFM 472
XP_002124261 381 pnidkQVIFkpptwPGit--gwETDYLLRLRSVENVATSTNTLGSLEKLLHQIDNIIINDDVADSVFQSVAAIVEAKQAI 458
KIS70396     620 sN-AHLDELLDRAAQAYALSNRAFFNPDMLGLLYFPDEHKYAVYTPLFAPLLVPLFVTTLKLIKQLVAR 687
XP_012811796 489 -EaGRLESAFQASKEAISSSEKAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPIFLSLIKIAKEYKQS 556
XP_001507200 480 -EaGRLGPAFQASRTAVTSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKILREARQA 547
XP_003770093 504 -SaGNLELAFRYSREAVTSSEKAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPIFLSMIKIIVENQKA 571
XP_003996538 480 -AsGHLASAFTASQEAVTSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKIFLETRKS 547
XP_005056851 478 -SlGHLQAAFQASKEAVTSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLAKIVRETRLR 545
XP_003227327 484 -EaGQLEAAFLASKAAVTSSERAFFHPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSMAKILRESRAA 551
XP_006005796 489 -EaGRLSSAFHASKQAITSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPIILSLLRIASDFRQA 556
XP_002113280 473 -KsGDNARAFAHSKTAVTNSEKAFFDASLLELLYFPSDQKFAVYVPLFLPISLPILQSLYHAIRFLYRQ 540
XP_002124261 459 -SvGNLTRAMSSSRDAFVSSQSAFFHPSLLELLYFPEDQKFAIYVPLFLPISLPVLVSLVFVYKRYKNK 526
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap