7LOW,5H9U,3S82


Conserved Protein Domain Family
MetK

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COG0192: MetK 
S-adenosylmethionine synthetase [Coenzyme transport and metabolism]
S-adenosylmethionine synthetase is part of the Pathway/BioSystem: Methionine biosynthesis
Statistics
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PSSM-Id: 439962
Aligned: 609 rows
Threshold Bit Score: 452.94
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7LOW_A        11 KHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWV---D---IEEITRNTVREI 84 
YP_002344489   1 MYLFTSEVVSAGHPDKCADIIADTIVDILLKNDKNSRVASEVFVAGNKVVIGGEVKSNHKLskaD---YDNLVKDVLKNI 77 
WP_012082446   1 MYLFTCESVSPGHPDKCADIIADSIVDALLEIDPNARVATEVFVAGNHVVIGGEVKLDKEL---QkefFVEKAMEALEYI 77 
WP_011981136   1 MYLFTSESVSAGHPDKCADLIADTIVDSLLQRDPNAKVATEVFISGKHIIIGGEVKTSTAV---DnvfYEECAQKALEKI 77 
WP_013134511   6 EYLFTSEVVSPGHPDKCADIIADTIVDKLIIGDSKSRVASEVFVAGKHVVIGGEVTSATNLseqD---YKDLVIEALAKI 82 
WP_013326271   1 MYYFVSEAVSAGHPDKCADIIADSIVDRLLQLDSTAKVATEVFISGKHIIIGGEVKTAALV---DtsfYEEIAREALKQI 77 
WP_013651745   3 NFIHTSESVTRGHPDKLCDLISDTVVDAFLAAETPAPVNAECALASGIAFLAVRCAGDPKT---D---LAALVRRSIAEA 76 
WP_014769855   6 HYLFTSEVVSPGHPDKCADIIADSIVDALLISDKNSRVASEVFVAGKHIIIGGEVNTKQILsfsD---YEKIVKDALAKI 82 
WP_041927184   4 DMIFTSESVTPGHPDKLCDQISDAAIDALLREDDRARATVECALATGVVFLAARYAADALV---D---LPALARTVMQEA 77 
WP_099558660   1 -MIFTSESVTRGHPDKLCDQISDAVVDAFLRQDPKARITAECAIATGVVFVAARFSGEASV---D---IPQLARRVIAEA 73 
7LOW_A        85 GYVHsdMGFDANS------CAVLSAIGKQSPDINQGVDRA-----DPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRL 153
YP_002344489  78 GYDGa-GHFSKEQclhpdeVDVMVFLNEQSPDINQGVDQE------DGETGAGDQGIMFGFASCEAEEYMPAAISYARML 150
WP_012082446  78 GYPE--AGFSKEEtlypkdLNYHIFVNRQSPDISQGVDKP-------EELGAGDQGIMIGYATSERGDFMPYATMMAREL 148
WP_011981136  78 GYPE--GGFKRGEtffpdeAEIEVYVSKQSPDITMGVVKE------GNEIGAGDQGMMFGYATCERDDYMPSAFAYAREI 149
WP_013134511  83 GYNGh-PHFTKEEclhpddVNVQVLLNRQSPDINQGVDQV------DGETGAGDQGIMFGYANSETANFMPSAITYARML 155
WP_013326271  78 GYPE--IGFKKDEtlfpdeTDIEVYISRQSPDITMGVVKE------DDEIGAGDQGMIFGYATSEREDCMPTAFSYARQI 149
WP_013651745  77 GYTG--PGFNADS------CTIMTSVSKDLSFIGHGPG---------DPLHVQHSATVFGYACRHTAELMPLPIVAAHRL 139
WP_014769855  83 GYDGk-SAFTKEQclhpdeVKVQVLLNQQSSDINQGVDQV------SGEIGAGDQGIMFGFASCETADFMPAAITYARML 155
WP_041927184  78 GYAA--GSFDARN------CSILTSFMELPLEAREPPLQEldddaAIGRRVAHEQANVFGYACRDTPEFMPAPISLAHRV 149
WP_099558660  74 GYEK--HVFDAQR------ASILTSFSEVESPAGPLHP----------QSPADEQVNAFGYACDDCETLMPLPIDLAHRF 135
7LOW_A       154 VQRQAEVRKNGTLPWLRPDAKSQVTFQY------DDGKIVGIDAVVLSTQHSE--EIDQKSLQEAVMEEIIKPILp-AEW 224
YP_002344489 151 CDRVYAYAKANP-HELGVDIKTQVTIDYgtkanfENCKPQSIHTIVVSAPCVE--SMKIEDLRSLVMKLILDSNLp-KEL 226
WP_012082446 149 RDILYHNAKLNP-DKYGVDIKTEVVLDYgnkanfEANRPQRVDKIIVAQSHVR--DFDQKSLQNQIRELIEQKCSf-NVF 224
WP_011981136 150 RDALYAYALEHP-DTFGVDIKTEVVMDYgskenfDSCRPEHIAKIIVAIPCIS--SVEPDEVEVRVKKIIKEEVQfeAGH 226
WP_013134511 156 MEKVYAYALANP-DVLGVDIKTQVTVDYetkenfENCLPKHIHTIVVSAPCVS--TMNIDTVRKLILGLIKDTDLp-KEL 231
WP_013326271 150 RDVLYQYALKNP-KIFGVDIKTEIVMDYgskenfDNCKPQRIAKIIVAIPHNS--SVEAEEVQVLVKKIIAEEVNfkAGH 226
WP_013651745 140 TRALEAARADGR-DHLSPDGQSQVAVEF------RDRRPARLHNIGLTVAVDGrtQIPARDIEEDLRETVIVPALq-GLG 211
WP_014769855 156 CDKVYNYALKHN-HKLGVDIKTQVTIDYgtkqnfEECKPQKIHTIVVSAPSNE--AMSIEEVRTLIKGLIDDTGLp-TEL 231
WP_041927184 150 ARALDAARRDG-FSSLSPDAKTQVSIEY------REGRPARIHGVSLTVAFDGa---AMDDDKFDRLRAIALDALs-AGD 218
WP_099558660 136 ARRLDDARN--ECPDLGPDGKVQVSVQY------KDGRPVAIADIAVTSALLQ--QLAPSDHEAIIRDLVLAPPLpgGHP 205
7LOW_A       225 L--T-SATKFFIN--PTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGL 299
YP_002344489 227 F--DpNKTRILIN--PTGKYVNHSSLHDSGLTGRKLIVDSFGGYSPIGGGAQSSKDYTKVDRSGLYAGRWLAKNIVAAGL 302
WP_012082446 225 I--D-EKTEFIIN--GTGKFVIHGPIADSGLTGRKIVVDNYGPYVPIGGGAQSSKDYTKVDRSAHYAARWIAKHIVASGL 299
WP_011981136 227 F--DaDKTVFYIN--NTGRYVTHSPIADSGLTGRKVVCDTYGGYAPIGGGAQSSKDYSKVDRSALYAARWLAKHIVAAGL 302
WP_013134511 232 F--DlEKTIIHIN--PTGKYVSHSSLHDSGLTGRKLIVDSFGGYAPIGGGAQSSKDYTKVDRSGLYAGRWIAKHIVASGI 307
WP_013326271 227 F--NeDSIVFYIN--NTGRYVTHSPIADSGLTGRKVVCDTYGSYAPIGGGAQSSKDYSKVDRSALYAARWLAKHIVAAGL 302
WP_013651745 212 TeaD-AATRVVIRqvPAG---GDGLAGHSGLTGRKSANDGYGGYARQSTAGMSGKDPSRIDRTAAYAARHIAKCIVSQGL 287
WP_014769855 232 Y--DpNNTIIHIN--PTGRYVNHSSLHDSGLTGRKLIVDSFGGYAPIGGGAQSSKDYTKVDRSGLYAGRWIAKNIVAAGL 307
WP_041927184 219 MrpD-VRTTVHVN--AGEPFEIGGPARHAGLTGRKNGIDAYGEIARQSGSALSGKDPSRIERAGAYAARHAAKNIVAAGL 295
WP_099558660 206 VrvT-AATRLHVN--PGGSFLYGGPAHHAGLTGRKTGIDTYGDFARQSGSALSGKDIGRIDRTGAYMARLAAKAIVAAGL 282
7LOW_A       300 ADRCEIQVSYAIGVAEPTSIMVETFGTE--KVPSEQLTLLVREFFDLRPYGLIQMLDLLH-P-------IYKETAAYGHF 369
YP_002344489 303 AKKCIVQLSYAIGVAKPTSVSVDCMGTNt-SVNDDVLSDFVMQNFSLTPNWIRDKFHLDK-Pske--tfLYADVAARGQV 378
WP_012082446 300 SKKVQVALSYVIGRAKPLQVTVDTFGTG--RLDDEKLSALIADRYELSPYWIMQKFSLHK-Pqg----fSYKETAAKGQV 372
WP_011981136 303 AKKALVQLSYVIAEPRPISVTVDTQHTAltDMKDEVLSQMIADKFVLSPKWIMHKFGLDK-Pske--hfLYAEIAAKGQI 379
WP_013134511 308 AKKAIVQLSYAIGVAKPTSISVDTCGTCidGLNDDILSTFVHDSFSLTPNWITKKFNLDK-Psvd--tfLYADVAARGQV 384
WP_013326271 303 AKKALVQLSYVIAEARPIAVTVDTQHTSliKMKDEELSQIIADKFSLSPKWIMQKFHLNK-Pske--sfLYADIAAKGQV 379
WP_013651745 288 SDECEVQLSYCAGEDRPISLEIDSFGTG--RYPDAEISASVFRHFDLTPAAIATRYRLWQlPger-ggrFYADLATYGHM 364
WP_014769855 308 AKKCSVQLSYAIGVAKPVSISVDTFGTYt-SVSDDELSEFVIHTFSLTPRWITEKFGLDK-Psed--tfLYADVAARGQV 383
WP_041927184 296 AERCEVHLAYAAGQAEPISLSVETFSTG--YLADEKIARRLAALLEFRPASIVRRFGLRAaPqmcgpagFYLPLATYGHF 373
WP_099558660 283 ARRAEVHLAYAIGEAEPSSLAVNCFGTS--QVAEAEIGRRLSALLDFRPGAIAERFAFAErVaragtegFFRPLACYGHM 360
7LOW_A       370 GRE--HFPWEK-TDKAQLLRDAAG 390
YP_002344489 379 GQK--DYPWEK-LDALEQFKKLL- 398
WP_012082446 373 GYE--NYPWEQ-LDEIEWFQSL-- 391
WP_011981136 380 GYP--EYPWEK-LDGLDWFRYVRD 400
WP_013134511 385 GQE--DYPWEQ-LDELDKFISLKK 405
WP_013326271 380 GYA--QYPWEQ-LDELNWFKSLKE 400
WP_013651745 365 GRTeiDPPWEN-TSDIIDLTS--- 384
WP_014769855 384 GQS--DYPWEK-LDAVELFKTLKK 404
WP_041927184 374 GRAdlDLPWEA-TDVAEALKG--- 393
WP_099558660 361 GRAdlDVPWEDaVDLAEALRR--- 381
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