4OMA


Conserved Protein Domain Family
MetC

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COG0626: MetC 
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]
Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Statistics
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PSSM-Id: 440391
Aligned: 863 rows
Threshold Bit Score: 259.211
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OMA_A         7 YGf-NTQIVHaGQQPDPSTGaLSTPIFQTSTFVFDSAEQGAARFAL--EESGYIYTRLGNPTTDALEKKLAVLERGEAGL 83 
WP_025228041   6 MGl-GTLLSHlGEE-EKVKGaVVSPIFQNSLFLFDTCDDLHKALTTdlEGPPFHYSRISNPSVAIAEKKIAALEGAEACK 83 
WP_011195132  10 dRa-ETLAAHaGDDPFRFLGaAAPPIFETSTFVFRTVADALAAFAD--EQEHYVYTRRRNPTVRVVEEKLAALEGAAECR 86 
WP_106890510   5 kDl-SYILTHlGEDRAQYFDaVIPPIVQSAMFAHPNVATMRTRVAD--EFSSHVYTRGQNPTVEIVAKKIAALEGAEAAL 81 
WP_127017522   5 kDifQTICIHeGEDYERFYGgVTPPIFENSLFSFPAYEEIDKAFAG--NSNRYIYTRGTNPTVEILERKITALEGTEATK 82 
WP_067646149   1 mDl-SYILNHlGEDRASYHGaVAPPLVQSSIFAFPSVADMRAGFRD--EYAQHMYTRGNNPTVAMLRRKLAALEGAEDCL 77 
NP_816881      3 vendENICCEvEKGMEKMYHpMVPELVQTSSFYFPTYEEFMAASID--EKNNYVYTRGTNPTTEILEKKIARLERGEKCK 80 
AEI48845       1 mHy-SHIINElAEDRERYFNaVSPPIVQTSNFVFNDFASLRAAFDD--EMSTYLYSRGVNPTVDILRQKLAALDEAEDCL 77 
WP_119054661   4 qDl-SYILNElGEEREQYFRaIAPPIMQSSNFAFKKVEDLRKVFED--EYSNYLYSRGLNPTVEILRKKLAALDGAEDCL 80 
WP_062542381   1 mDl-SYILNElGEDRATYFNaVAPPIIQSSNFACRTVAEMRFMLQH--EAEVHFYSRGNNPTVSMLEQKVAALEGTEHAI 77 
4OMA_A        84 ATASGISAITTTLLTLCQQGDHIVSASAIYGCTHAFLSHSMP-KFGINVSFVDAAKPEEIRAAMRPETKVVYIETPANPT 162
WP_025228041  84 LCGTGQGAIALAILSVVAAGAHVIAPDTCYGPVRSMLSEMLQ-RFGVSYTFVDGRDPVDFIDAIRPETTLIYLESPSSLL 162
WP_011195132  87 LFASGMAAISAAILSCVGAGDHVVCVDTAYGPARAFITGYLS-RFGISATLVDGCDPAEWEAAVRPNTRLFYLESPSSGL 165
WP_106890510  82 MFGSGAAAMAAAALSVLRAGDEVLCVDKPYAWTRTLVKSHLQ-RFGVNGRLLDARDPAEVEAAITDQTRLIILESPNSLT 160
WP_127017522  83 VFASGMAAISAAIMSVVKNGDHVVAVKNIYSPAYQFLTDYLAkKFAIDVTYVDGRETDEIANALKPNTSLIYLESPTSLN 162
WP_067646149  78 VFGSGAAAMAAGVIACVGQGDHVVCVARPYSWTRSLLQDFLP-RFGVGASFVDGTDSAAFEAALTPRTRLIVLESPNSMT 156
NP_816881     81 VFASGMGAISATLFTLLQQGDHVLMVNTIYGESVSFVQY-LE-KFGVSLTKVDVAETEELFQFVQENTKVIYFESPSSQK 158
AEI48845      78 VLNSGASAIFCAVMSNVQAGDHIVSVHKPYTWAWKLFDNILP-RYNVATTYVDGTMIENFEAALQPNTKVIYLESPNTLT 156
WP_119054661  81 VFNSGASAIFASVFANIQSGDHIVSVGKPYTWAQKMFDNVLP-RFGVATTYVDGTKIENFERAILPNTKVIYLESPNSWD 159
WP_062542381  78 AFGSGIAAVAAAVLSQVKAGDHVVCIKKPYTWTNKLMRYFLP-RFGVEVTMVDGTDARNFDLASKENTVLYYLESPNSFT 156
4OMA_A       163 LSLVDIETVAGIAHQQGALLVVDNTFMSPYCQQPLQLGADIVVHSVTKYINGHGDVIGGIIVGKQEFIDQARFVGLKDiT 242
WP_025228041 163 FRLQDVDAITKVARERGITTIIDNTYNTPIHYNPIKHGVDIVCHSASKYLGGHSDLTAGALCTTRERMNGIVRHELNY-I 241
WP_011195132 166 MKLQDLAAVTALARRHGIATICDNSYATMLLQRPLELGVDLVVYSCSKYFGGHSDVLAGAVLGPAERIRRIGDAEQPL-L 244
WP_106890510 161 FEQQDLVAIARIARARGIFTLLDNSFATPLGQSAIELGIDLVAHSATKYLNGHSDVLAGVVAGSEKLIRDLFHGPYMT-L 239
WP_127017522 163 FHLQDIRAVAQLAKEQNIITIIDNSYSTPYYQRPFEMGVDLIVHSATKYLNGHSDVVAGVVTGRKDLIEKIQENELSL-F 241
WP_067646149 157 FEQQDLAAVAALARRHGIRTLCDNSHATPLNQSPIALGIDLVAHSATKYLNGHSDVVAGALCGEAALLRAVFKGPYMT-L 235
NP_816881    159 FELLDLEKITALAQKIGAYTVIDNTWASPLFQHPLCHNVDLVIHSCSKYIGGHSDIVAGAVIGKAALVDQIFEHGHQA-L 237
AEI48845     157 FDLQDLEAVAQLAKSRGIVTVIDNSYCSPLFQKPHRFGIDLCLQSATKYIGGHSDTVAGVLTGSKAMIKQIFDREALN-T 235
WP_119054661 160 FALQDLRAIAELARAEGIITICDNSYCTPLYQRPIEMGIDMVLQSATKYIGGHSDVVAGVLTGTREMMKKIFDNELLN-M 238
WP_062542381 157 FELQDIARVTSYAKGRNICTIIDNSFASPLFQNPAAMGVDLVVHSATKYIGGHSDAMGGIVCGTRERINRIFEAEFMT-L 235
4OMA_A       243 GGCMSPFNAWLTLRGVKTLGIRMERHCENALKIARFLEGHPSItRVYYPGLSSHPQYELGQRQMSLPGGIISFEIA-G-G 320
WP_025228041 242 GSILHPFTAWLLTRGLRTLPLRLKRHESTGNIVARWLETRPEIdRVHHISLDSFPQRELFLKSFSGSGGLFSFEPKvQ-D 320
WP_011195132 245 GGVVGPFEAWLIGRGLRTLPLRLRQHQQSAGRVAEFLAGHPRVaRVHYPGHPSHPQHGLALRQMRGASGLLSFELDtG-D 323
WP_106890510 240 GAILSPHDAWLLLRGLRTLPVRLKQIAETTDTVLRYLERHPKVaRVHSPWAQSYSQFGLTQQQLRHGSGLLSIELK-A-D 317
WP_127017522 242 GGIIGPFEAWLIIRGLRTLGIRMERHTKSALKVANFLEQHLKVkKVNYPGLESFPQKELADRQMSGWGGLLSIEVE-G-D 319
WP_067646149 236 GAILSPHDAWLLLRGLRTLEIRMQRVAASTREVLAWLERQPRIrRVWSPQAADNPQLGLSERQLRGASGLVTIDLD-AaD 314
NP_816881    238 GAVNSPFNSWLALRGIRTMPVRLAHQSQAIQTVLLALQKDPRIsRLYHPFVGNQQQQALAEKYLTGYGSLFAIDLKdT-D 316
AEI48845     236 GAFVSPFNGWLLLRGLRTLPVRLRHISESTQKVVAFLKNHPAIeRVYFPLDPDFPQYELAKKQMTGACGLLTIALNvT-R 314
WP_119054661 239 GNGVSPFNAWLLIRGLRTLPLRLERITVTTRKVIDYLKQHPSVeEVIFPLDDSFPQLELARQQMTGACGLLTIVMKaE-K 317
WP_062542381 236 GAVLSPHDAWLLLRGLRTLPLRMERVAKTTRQVVAYLQQRDEVaEIIWPFLPEHPQYYLAKKQMRNNTGQFTIRLA-AeS 314
4OMA_A       321 -LEAGRRMINSVELCLLAVSLGDTETLIQHPASMTHSPVAPEERLKAGITDG--LIRLSVGLEDPEDIINDLEHAIRKA 396
WP_025228041 321 -PIKIKAFCDSLSLFGRGVSWGGFESLVV-PLPIT----------ASGVPDGrwFIRLFCGLEEPGDLVSDLERAMHLL 387
WP_011195132 324 -LKQVSRFVDALRLFRLGVSWGGYESLVWLPVIGAMHRAPEEQWP----NPG--LVRIHVGLEDVDDLLEDLDRALRAL 395
WP_106890510 318 rVEQVDQFVDRLDRFLIAASWGGYESLVFPVAGVR---NWPSLDFPASVPVG--LIRFSIGLESSDVLIADLEQAFQAI 391
WP_127017522 320 -IEGISRMMNHLKYFSIGVSWGGFESLVFHPYISLKHKFTLEEMAEWDLSPQ--LIRLFIGLEDPAVLIQDLAEALEQL 395
WP_067646149 315 -VAAVERFCDGLERFLMTVSWGGYESLAFPVCAVFPP--GAPLRPAAGLPLS--LVRLSIGLEDPGILIADLEQALTRL 388
NP_816881    317 -FERLKTFVNALTLVTIGVSWGGFESLALPVFK----GNNLAAVQKRGLSPA--HIRMYVGLEEPTSIIEDIQQALDQA 388
AEI48845     315 -YEQIEQFAKNLKHFLLAVSWGGHESLIMPKCA----GLRPDQFDPTDREHR--LVRLYIGLEEVEYLMEDLGRALDKL 386
WP_119054661 318 -MEEIVTFCESLRHIMMAVSWGGHESLAIPRCA----SLQPSAFNAAEKEHR--MIRIYVGLEEAGYLIADMEQAFAAV 389
WP_062542381 315 -LEEVERFCDSLQHFLMAASWGGYESLIFPVAA-SYRD----GNFRSSMPFT--LIRFYIGLEDPEYLIKDLEQAFTKM 385
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