Conserved Protein Domain Family
Myelin_PLP

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pfam01275: Myelin_PLP 
Myelin proteolipid protein (PLP or lipophilin)
Statistics
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PSSM-Id: 460144
Aligned: 23 rows
Threshold Bit Score: 186.731
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4QQQ6         4 HDGCVRCMVGVPFASVIATVLCFAGVALFCGCGHEALSGTEKLIETYFS--KNYQEYEYLIHVINAFQYVIYGIAVFFFL 81  tropical clawed...
Q8UUT5         4 YDCCIRCLGAVPYTSLVATLLCYAGVGLFCGAGHEALTHTHTFVELHFA--RDVQDFTVMADFIKYFQYVIYGLASFFFL 81  zebrafish
EEC09141       7 KRPCARCLSRVPFATLVATVMCCAGVAIFLGAVLRAVASTMRMVEVVFKrpNPYGPAELQAAAI--------GTAVAMGL 78 
EFX77567       1 MGSCRDCLTRIPYATFIATVLCFIGIGVFCGTVYRGATLANLILLDVFH---------VQVEWIGIMRLLLIILGGIMAC 71 
OWR49416       2 GDSCQACLTRVPHATLIATIMCCLGVGVFCGTMYRGSSLSILMFDEVFH---------FRLMWIDALQMIFIVGSACMAA 72 
XP_008191691   1 MGFCDSCLTRIPYATLIATIQCALGVVIFCGTMYRGATLAVLMFSDVFK---------MQLFWVDAVKMTFVIIGACMGA 71 
KRG06394      66 ADCCQSCMARIPYATLIATLMCLLGVGIFCGTMYRGASLTVIMMDQVFH---------LRLIWIEAVQMIFVIIAAGMAA 136
Q16W23         2 GDCCKSCLTRIPYATLIATVMCLIGVAIFCGTMYRGTSLAIIMLDQVFH---------LRLLWIEAVQMIFVVIGASMAA 72  yellow fever mo...
XP_394320     42 RSICNDCMARVPYATLIATIMCCLGVGIFCGTMYRGVTLGSLMMDQVFH---------LRLGWLEAVQLIFATIGASMAA 112
KAE9426925     2 GSRCDECMARVPYATFIATIMCIIGVGVFCATMYRGATLSALMLDEVFH---------MRLSWLEAVQTSFVCIGAVMGA 72  Apolygus lucorum
Q4QQQ6        82 FGIILLAEGFYTTTAI-KHILGEFKppaikggliSTVTGGppkgrsprgrqpvhtielicrCLGKWLghpdklVGVTYVI 160 tropical clawed...
Q8UUT5        82 YGLLLLAEGFYTTSAV-KQTFGEFR---------STQFGR---------------------CISLTF------IILTYVL 124 zebrafish
EEC09141      79 LELCLVAVGFLTTGPT-RERLGA-R---------ARVGGR---------------------LSCGLL------IVLSYLV 120
EFX77567      72 LALIMLVVGCLATGSTrHTVYRAWK---------ARVGGR---------------------LSCAIF------LGMSYIL 115
OWR49416      73 LGFMLLCLGCLTTGATrQKVYRAWR---------ARVGGR---------------------ISCAVF------MIITYIL 116
XP_008191691  72 LGLMILTVGCLATGATrHKVYRAWR---------SRVGGR---------------------VSCAIF------MAITYIL 115
KRG06394     137 LGFMILFVGFLATGATrYKVYRAWR---------SRVGGR---------------------ISCAVL------MGITYLL 180
Q16W23        73 LGLMILFVGFLATGATrYKVYRAWG---------SRVGGR---------------------ISCAVF------MGITYVL 116 yellow fever mo...
XP_394320    113 LGFMILCVGCLATGATrHKVYRAWR---------SRVGGR---------------------ISCAVF------MTITYIL 156
KAE9426925    73 LGLMILFVGFLATGATrHRVYRAWS---------ARVGGR---------------------ISCAVF------MSITYVL 116 Apolygus lucorum
Q4QQQ6       161 TILWLLIFACAAVPVYIYFNTWVTCQSIAFPGkTttsvST---LCSDARMYGVLPWNAF---PGKVCGTS-LLAICKTSE 233 tropical clawed...
Q8UUT5       125 ALIWLIVFGFTAVPVLFFINMKSSCHTVNVLSeTtl-fNQqsrVCMDARMYGFLSWNAM---PGVVCGNA-LANICKAPE 199 zebrafish
EEC09141     121 LLVWLALALLLVTAALSVTLVGGMCNQLKQEY-----------QCLDFRQLDFPVYEANgkpAMQLCDVR-RKEFCKDWV 188
EFX77567     116 FYVWVGILVCLTMVTLIFTLFWGLCVDNQRRH------DR---PCISFVQFDWLFPNGTtidDLQVCGPEeLKLFCKDYV 186
OWR49416     117 TFIWLILLGFLVITTFLFTIFWALCSKPKNIE------LS---TCIDFTQFDFMFPSSVrqeDMKICEAHkIKLFCKDYV 187
XP_008191691 116 QLLWIVIFCFLVIATFLFTIFWKMCTNERVAT------FQ---DCIDFTQFYFMFPQGTkqeHMKVCGEHnVKVFCKDYT 186
KRG06394     181 NFVWTLILCFLVIVTFIYTMFWNMCASVEHSQ-----------SCIDLTQFHFMFPPNTkleDMKVCEKYeIKAFCKDGV 249
Q16W23       117 KIVWIVILCFLSIVTFMFTVFWNMCENPNVQS------HR---NCIDLTQFYFMFPAGVkqeDMNICEQSkVKAFCKDGV 187 yellow fever mo...
XP_394320    157 QLGWLLIFAFLVIIAWIFTIFWGLCSNPRVQS------LD---QCIDFTQFSFIFPNNTrieDMKVCGPQeVKLFCKDFV 227
KAE9426925   117 QLGWIVMFIFLIIVTVFYTIFWALCSSERVQN------K----QCIDFTQFDFMFPQGTrreDMEVCHPQeIKLFCKDYV 186 Apolygus lucorum
Q4QQQ6       234 FQMTFHLFIAAFVGAAATLVALLTYMVGASFNYAVLRVTGR 274 tropical clawed frog
Q8UUT5       200 FHVTYDLYICAFAGAGITLLALFVYMVATTYNYAILRFLGR 240 zebrafish
EEC09141     189 EQCGL-LLWLAGGAALLALLGLVKHLMCLAANYAHLRDQQK 228
EFX77567     187 EVAEV-SFILSTVASFVVSLALVHYLMCLASNYAYIRDQEK 226
OWR49416     188 EKAEF-MFILAMVSCLLVILSLVHYLMCLSANYAHIRDHEK 227
XP_008191691 187 EKIEI-MVILATVASVLVILSLVHYLMCLAANYAHIRDHEK 226
KRG06394     250 ENAEV-MFILATLSTLLVILSLVHYLMCLSANYAHIRDHEK 289
Q16W23       188 EKCEI-MFILATVSCLLIILSLVHYLMCLAANYAHIRDHEK 227 yellow fever mosquito
XP_394320    228 EKAVV-MFILATIAAMLVVLSLIHYLMCLSANYAHIRDHEK 267
KAE9426925   187 EKAEV-MFILASFACMLVILSLVHYLMCLSANYAHIRDHEK 226 Apolygus lucorum
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