Conserved Protein Domain Family
BRINP

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pfam19052: BRINP 
BMP/retinoic acid-inducible neural-specific protein
This entry represents the BMP/retinoic acid-inducible neural-specific protein (BRINP) family, including BRINP1/2/3. They are predominantly and widely expressed in both the central nervous system (CNS) and peripheral nervous system (PNS). They inhibit neuronal cell proliferation by negative regulation of the cell cycle G1/S transition.
Statistics
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PSSM-Id: 465961
Aligned: 12 rows
Threshold Bit Score: 775.453
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013994799 334 ESEEFQSFVGRLPTHYAVNTSVVEHLWRMDGGLLQRYRQLETTSGLLLDKARRAANKLFSLSKRCRHQPRIVLQRERPLR 413
XP_017334774 441 ESDEFKAFLTRLPQNFYLNASAIHHLWLLDGMFQRRYELLESTMKSLFRRAQRVVYKLFSLSKRCEKQPLIKLPHERPRS 520
XP_017326638 298 QSDEFQAFMVRLSTHAALNLSSVWRAWRSDAALQKRYRKLENDAVFLLNKAQGCAAKLFGLSRRCRSQPKIILPRERRLG 377
XP_018113970 317 ESVEFRSFLKNLPTDRFLNSSAVSKLWNADPALIRRYEQLRTSFKQLVTRSERQMRRLINLSKYCQRQPQYTLLRERSVD 396
EPQ07113     416 ESEEFQTLLKRLPDDRFLNSTTISQFWAMDAGLQHRYQQLGASLKMLFKKMHRIVSRLFNLCKRCHRQPRFRLPKERSLS 495
KFP65193     242 PAEEFQALVKRLPGDRFLNRTAISHFWAMDLDVQHRYQQLGTSLKLLSRKTHRLIRRLFNLSKRCHRQPRFKLPKERSLP 321
XP_014437159 267 krEELQALVRRLPEDRFVNVTTISQYWAMDLDVQHRYQQLGASLKLLLKKTRRIVQRLFNLCRHCHRQPRFRLPKERALP 346 Chinese soft-sh...
XP_006011953 240 EAEELNLFIKKLPTDRFLNSSTISHRWAIDSGLQRRHQQLEASLALLSKKAQRIVRRLFNLCKRCQKQPRFKLPRERSFR 319 coelacanth
XP_029687278 255 ESEEFQNFVGNLPTNHAVNISGVELLWRADANLPQRYRQLETSSNQLFAKARRTANKLFSLSKRCQKQPRIVLQRPRALK 334 torafugu
NP_001107909 314 ESEDFQNFVRRLPTFYALNTSAVQYFWKMDSGVQQRFQLLETNTQQLLSKAQRIVSKLFKLSKRCRTQPKISVPRERPLS 393 zebrafish
XP_015210925 305 DSEEFKMFLARLPQNYFLNISTIHHLWSMDTSFQRRYEQLENSMKGLLKRAQRVVYKIFSLSKRCQKQPQVILPRERPQI 384 spotted gar
XP_006634696 322 NSDEFKSFVKRLPLDHLLNMSTIFQLWSKDMSLQRLYEKLEGSMKHIYSKAQKMIQKLFNLSKRCDKQPQYRLPRERPLT 401 spotted gar
XP_013994799 414 YWLSYILSLLYCSENDHIGLYSVETRSCSCPYHHPPCQGPIPCSVGEGPRCTSCSSENRTRCSSCNPGFTLG-QGLCRPA 492
XP_017334774 521 YWLNYFQSLLYCSENNQMGFFSEELHTCICTYDQYSCQRPTPCSVGEGPACASCASDNYTRCGSCNTGYMLS-QGSCRPM 599
XP_017326638 378 YWLQHSLSLLYCSEAESPGIYSEVTHSCVCPGGHLSCQGLIPCSVGTGSRCASCSPENRTRCSSCNSGFALS-QGLCRPA 456
XP_018113970 397 YWLHRTQSFLYCSATLIPGTFLEASHSCTCTVQHSTCQGPIPCIQGPGPLCSLCSSVHHSQCASCNTGYILTaQGLCTPS 476
EPQ07113     496 FWWNRIQSFLYCGESTFPGTFLEQSHSCSCPYDQSSCQGPIPCALGEGSACAHCARDNSTRCGGCNPGYVLV-QGLCRPE 574
KFP65193     322 YWWSRAQSLLYCSETTVPGTFLEESHSCTCPSDQPSCQGSIPCALGEGPACASCAEDNSTRCGTCNHGYVLT-QGFCRPE 400
XP_014437159 347 YWWSRIQSCLYCSESSPPGTFLEDSHSCTCPSEPASCQGPIPCALGEGPACAACAEENSTRCGACNPGYVLS-QGLCRPE 425 Chinese soft-sh...
XP_006011953 320 YWLTYVQSQLYCSDNSLLGTFHEETHSCTCPYEQTLCQGPVPCVIGEGDACTTCAPDNTTRCGSCNPSYSLV-QGFCRPE 398 coelacanth
XP_029687278 335 FWLNYALSILYCSENNQVGVYSEENHSCSCPYVHPSCQVLIPCSVGDGQRCASCSSENRTRCSSCNPGFTLT-QGICRPA 413 torafugu
NP_001107909 394 YWLRYILSIMYCSENNQIGSYMEETRTCSCHYEHPSCQGVIPCSVGDGPHCASCSYENRSRCASCNPGYMLS-QGTCRNT 472 zebrafish
XP_015210925 385 YWLNHFQSLLYCSENNQLGLFSEETHTCICAYGQNTCQLATPCMLGEGLACATCAADNHTRCGSCNSGYVLS-QGACKHL 463 spotted gar
XP_006634696 402 YWLKKVQSLLYCSENNLSGTFNEELQSCACPMEQDSCQGILPCVVGDGASCSSCAQENPALCGSCNPGYVLI-LGSCRPE 480 spotted gar
XP_013994799 493 VPDPTDPYLGLESDrdLQDLELCYLLQHRDPRITLHGIFVSNDIRLNAWFDPSWRKRMLLTLKSNRYKSNRVHMLLGVAL 572
XP_017334774 600 VADSTDNYLGFETD--LQDLELRYLLQRSDRRLEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSNLVHMLLGISL 677
XP_017326638 457 APSPTKQYLGTEME--MHDLELRDLLEQRDAHLALSAIFVSSDVKLNTWFEPSWRKRMLLTLKSNKSKSSRVHMLLGISA 534
XP_018113970 477 VPESSEPYLGTEGT--LQDLEIKYLLLKRDGRLRAPAFFISGDLRLGVWFQMGGRKRMLLTCKSNKHWPRQLHMLLGLSL 554
EPQ07113     575 VAESLENFLGLETD--LQDLELKYLLQKWDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSL 652
KFP65193     401 VADSLEHYLGLETD--LQDLELKYLLQKRDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSL 478
XP_014437159 426 VADSLEHYLGLETD--LQDLELKYLLQKRDSRLEVHSIFISNDMRLGGWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSL 503 Chinese soft-sh...
XP_006011953 399 VADSMEQYIGFEGE--LRDLEVKYLLQKRDSRIEVHAIFISNDVRLNSWFDPSWRKRMLLTFKSNKYKTNLVHMMLGLSL 476 coelacanth
XP_029687278 414 VPDPTDPYLGLESDrdLQDLELRYLlQRRDPRIGLHAVFVSNDMRINTWFDPSWRKRMLLTLKSNRVKSNRVHILLGIAL 493 torafugu
NP_001107909 473 IPDSTDNYIGFETD--LQDLELRYLLQKMDGRISIHAMFISNDVRLNNWFDPSWRKRMLLTLKSNKFKSSHVHMLLGISL 550 zebrafish
XP_015210925 464 VADSTENYLGFETD--LQDLELKYLLQKADRRLEVHAIFISNEMRLNSWFDPSWRKRMLLTLKSNKYKSNLVHMFLGISM 541 spotted gar
XP_006634696 481 VSDSPEHYLGLETD--FQDLEMKYLLQKHDSRIEVHAIFISNDMKLNSWFDPSWRKRMLLTLKSNKYRSNLVHMLLGLTV 558 spotted gar
XP_013994799 573 QVCLTKNSSLEPALSMFV-NPFGGSHSESWTMPIGQHGYPDWERTKLDI-PLDCYNWTLTLGNRWKSFFETVHFYLRSRI 650
XP_017334774 678 QICLTKNSTLEPALTLFI-NPFGGSHSESWLIPVNENKFPNWQSTKLDL-PLECFNWTLTLGNKWKTFFETIHIYLRSHI 755
XP_017326638 535 QICMTKNSTLELTLSVSV-NPFGGSHSESWTMPMNQNGYPDWEKTRLDT-PIDCYNWTLTLGNRWKSFFETVHFYLRSRT 612
XP_018113970 555 RLCLAGNGTRDPQVTIYV-NPFGGSHSESWLLPAGEPGYPSWEKTWDTDgGDRCQNWTLILGHRWRSFFETVHFYLRSSP 633
EPQ07113     653 QICLTKNSTLEPVMAIYV-NPFGGSHSESWFMPVNEAHFPDWERTNVDA-AAQCQNWTITLGNRWKTFFETVHVYLRSRI 730
KFP65193     479 QICLTKNSTLEPVMAIYV-NPFGGSHSESWFMPINEGSFPDWERTNVDA-SAQCQNWTLTLGNKWKTFFETVHVYLRSRI 556
XP_014437159 504 QICLTKNSTLEPVMAVYVaP----XHSESWFMPVKEGGFPDWERTNVDA-SAQCQNWTLTLGNKWKTFFETVHVYLRSRI 578 Chinese soft-sh...
XP_006011953 477 QICLTVNSTLEPVLAVYV-NPFGGSHSESWFMPVNEEHFPSWERTNFDL-ALQCSNWTLILGNRWKTFFETVHIYLRSRI 554 coelacanth
XP_029687278 494 QVCLTRNSTLEPALSVFV-NPFGGSHSESWTMPIGQHGYPDWERTKLDL-PLDCYNWTLTLGNRWKSFFETVHFYLRSRT 571 torafugu
NP_001107909 551 QICLTKNSTLEPLLSVYI-NPFGGSHSESWIMPIDQNNYPDWERTKLDI-PLDCYNWTLTLGNKWKTFFETVHIYLRSRV 628 zebrafish
XP_015210925 542 QICLTKNSTLEPVLSLYV-NPFGGSHSESWYVPVNENSFPDWERTKIEL-PLECFNWTLTFGNKWKTFFETIHIYLRGRV 619 spotted gar
XP_006634696 559 QICLTRNSTLEPVLSVYI-NPFGGSHSESWFLPISENHFPDWERTTLDG-FPQCTNWTLTLGNKWKTFFETVHIYLRSRI 636 spotted gar
XP_013994799 651 RDsvpgLAPGPevrghrnaSTVSLESPEGTVEPmvassSQSMGYMKINSMQLFGYSMHFDPDTIQDLILQLDYPYTQGSQ 730
XP_017334774 756 KT----SGPTA--------NESVYLEPLEMADP-----SRNLGYMKINSIQVFGYSMHFNPEAIRDLILQLDYPYTQGSQ 818
XP_017326638 613 QS----DGAQG---------NETVDSEVANRNA-----SQHVGYVKINSIQLFGYIVHFDPEAIRDLILQLDYPYTQGSQ 674
XP_018113970 634 LEd---EEEEE--------DSSEWTKKQTLDDK-----SEDPEYVRIDGLQAFGYSVPFDPEAIRGLAHQLEQP---GSR 694
EPQ07113     731 KS----LDDSS--------NETIYYEPLEMTDP-----SKNLGYMKINTLQVFGYSLPFDPDAIRDLILQLDYPYTQGSQ 793
KFP65193     557 KS----LDDSS--------NETIYYEPLEMADP-----SKNLGYMKINSLQVFGYSLPFEPDAIRDLILQLDYPYTQGSQ 619
XP_014437159 579 KS----LEDSS--------NETVYYEPLEMADP-----SKNLGYMKINSLQVFGFSLPFDPDAIRDLILQLDYPYTQGSQ 641 Chinese soft-sh...
XP_006011953 555 KP----SEVNG--------NESVFYEPLELVDP-----SRNLGYMKINTIQVFGYSMHFDPEGIRDLILQLDFPYTQGSQ 617 coelacanth
XP_029687278 572 RD----FGVASg-------NKTMYYDSVEGAEQ-----SN-IGYMKVNSMQLFGYSVYFDPEAIQDLILQIDYPYTQGSQ 634 torafugu
NP_001107909 629 KT----ASPQG--------NGTVHFEPLEYMDS-----SRNLGYMKINSMQVFGYSMHFDPDAIQDLILQLDYPYTQGSQ 691 zebrafish
XP_015210925 620 KT----QSANS--------SDSIYYEPLEFLDS-----SRNLGYMKINSIRVFGYSMHFDPEAIRDLILQLDYPYTLGSQ 682 spotted gar
XP_006634696 637 KT----TNSNG--------NETTYYEPLELTDP-----SRNLGYLKVNSVRSYGFSMPFDPEAIRDLILQLDYPYTQGSQ 699 spotted gar
XP_013994799 731 DSALLQLVEIRYRVNRLSPPGAQPMDLFSCLLRHRLKLSSSEVTRILASLQAFSVRQPNSVEYEATKLCS 800
XP_017334774 819 DSALMQLQDIRDRVNRLSPPGQQPLDLFSCLLRHRLKLTVNEVMRIHSSLQAFSARLPNPLDYETTKLCS 888
XP_017326638 675 DSALQELMEIRYRVNRLSPAGPTPLDLFSCLLRHRLKLSTSEVSRILAALQAFGAKHRYYTEYEAVKLCS 744
XP_018113970 695 ESAVPEMQELRKRVNFLSPPGIRKLDLFTCLLRHRLKMSSNEVARIQGQLNSFSTQPPNISTYETTKLCS 764
EPQ07113     794 DSALLQLIELRDRVNQLSPPGKVRLDLFSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNAVEYETGKLCS 863
KFP65193     620 DSAMLQLLEIRDRVNRLSPPGKTRLDLFTCLLRHRLKLANNEVARIQSSLRAFNTKLPNAVEQEMGKLCS 689
XP_014437159 642 DSALLQLLELRDRVNRLSPPGKTRLDLFSCLLRHRLKLANNEVGRIQSSMQAYSAKLPSPVALTQRERGT 711 Chinese soft-shelled turtle
XP_006011953 618 DSALLQLLEIRDRVNNLSPPGKHRLDLFTCLLRHRLKLSTSEVVRIQASLQAFNAKLPNSVEYETTSLCS 687 coelacanth
XP_029687278 635 DSALLQLVELRYRVNRLSPPGAAHVDLFACLLRHRLKLSGADVTRILAALQAFSARQPNYVEYEANKLCS 704 torafugu
NP_001107909 692 DSALLQLLEIRDRVNRLSPPGQQPLDLFACLLRHRLKLSTTDVVRIQTALQAFSAKQPNSMEYETTKLCS 761 zebrafish
XP_015210925 683 DSALLQLLEIRDRVNKLSPPGQQRLDLFACLLRHRLKLTTTEVVRIHSSLQAFGARLPNSLDYETTKLCS 752 spotted gar
XP_006634696 700 HSALLQLLEIRDRVNMLSRQGKQRLDLFSCLLRHRLKLSASEVVRIRDSLQSFAAKLPHAVDYELAKLCS 769 spotted gar
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