Conserved Protein Domain Family
7tmA_D2_dopamine_R
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cd15309: 7tmA_D2_dopamine_R 
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.
Links
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Statistics
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PSSM-Id: 320435
Aligned: 5 rows
Threshold Bit Score: 371.675
Created: 28-Jul-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      ###########################                                                    
EMC78343   45 NYYAMLLTLLIFVIVFGNVLVCMAVSREKAlqttTNYLIVSLAVADLLVATLVMPWVVYLEVvgeWRFSrihCDIFVTLD 124 domestic pigeon
P24628     29 NYYAMLLTLLVFVIVFGNVLVCIAVSREKAlqttTNYLIVSLAVADLLVATLVMPWAVYMEVvgeWRFSrihCDIFVTLD 108 African clawed frog
P53453     33 NYYAMLLTLLIFVIVFGNVLVCMAVSREKAlqttTNYLIVSLAVADLLVATLVMPWVVYLEVvgeWRFSkihCDIFVTLD 112 torafugu
NP_057658  35 NYYATLLTLLIAVIVFGNVLVCMAVSREKAlqttTNYLIVSLAVADLLVATLVMPWVVYLEVvgeWKFSrihCDIFVTLD 114 human
NP_000786  35 NYYATLLTLLIAVIVFGNVLVCMAVSREKAlqttTNYLIVSLAVADLLVATLVMPWVVYLEVvgeWKFSrihCDIFVTLD 114 human

Feature 1                                                                                     
EMC78343  125 VMMCTASILNLCAISIDRYTAVAMPmlYNTRYssKRRVTVMIAVVWVLSFAISCPLLFGLnnt---denECIIaNPAFVV 201 domestic pigeon
P24628    109 VMMCTASILNLCAISIDRYTAVAMPmlYNTRYssKRRVTVMISVVWVLSFAISCPLLFGLnnt---gskVCIIdNPAFVI 185 African clawed frog
P53453    113 VMMCTASILNLCAISIDRYTAVAMPmlYNTRYssRRRVTVMISVVWVLSFAISCPLLFGLnntatrdqsLCFIaNPAFVV 192 torafugu
NP_057658 115 VMMCTASILNLCAISIDRYTAVAMPmlYNTRYssKRRVTVMISIVWVLSFTISCPLLFGLnna---dqnECIIaNPAFVV 191 human
NP_000786 115 VMMCTASILNLCAISIDRYTAVAMPmlYNTRYssKRRVTVMISIVWVLSFTISCPLLFGLnna---dqnECIIaNPAFVV 191 human

Feature 1                                                                                     
EMC78343  202 YSSIVSFYVPFIVTLLVYVQIYIVLrkrrkrvntkrsshgldsdtqaplkdkcthpedvklctvivksngsfqvnkrkve 281 domestic pigeon
P24628    186 YSSIVSFYVPFIVTLLVYVQIYIVLrkrrkrvntkrnsrgvavdahkdkcthpedvklcsvfvksngsfpadkkkvilvq 265 African clawed frog
P53453    193 YSSIVSFYVPFIVTLLVYVQIYVVLrkrrkrvntkpkqrlcqaadpdiptslkdkcthpedvrlctmivksngsfpvnkk 272 torafugu
NP_057658 192 YSSIVSFYVPFIVTLLVYIKIYIVLrrrrkrvntkrssrafrahlraplkeaarraqelememlsstsppertryspipp 271 human
NP_000786 192 YSSIVSFYVPFIVTLLVYIKIYIVLrrrrkrvntkrssrafrahlraplkgncthpedmklctvimksngsfpvnrrrve 271 human

Feature 1                                                                                     
EMC78343  282 veshieememvsstsplektt---------------ikpaapsnhrlvvpiastqgtnstlqapldspgkaeknghaket 346 domestic pigeon
P24628    266 eagkhpedmememmsstsppek-------------tkhksaspdhnqlavpatsnqcknasltspvespykaeknghpkd 332 African clawed frog
P53453    273 kvifikdgvnevegleldelnycggshkqpppqqqpralgdtpatshqllmstkanasptstpptppeegqrtekngdpt 352 torafugu
NP_057658 272 shhql-----------------------------------------------tlpdpshhglhstpdspakpeknghakd 304 human
NP_000786 272 aarraqelememlsstsppe------------------rtryspippshhqltlpdpshhglhstpdspakpeknghakd 333 human

Feature 1                                                                                     
EMC78343  347 priakvfeiqsmpngklrtsllkamnrrklsqQKEKKATQMLAIVLGVFIICWLPFFITHILNmhcd-cniPPAMYSAFT 425 domestic pigeon
P24628    333 stkpakvfeiqsmpngktrtsiktmskkklsqHKEKKATQMLAIVLGVFIICWLPFFIIHILNmhcn-cniPQALYSAFT 411 African clawed frog
P53453    353 keaqgnpapvvalrngktqtslktlskrkisqQKEKKATQMLAIVLGVFIICWLPFFITHILNthctrckvPAEMYNAFT 432 torafugu
NP_057658 305 hpkiakifeiqtmpngktrtslktmsrrklsqQKEKKATQMLAIVLGVFIICWLPFFITHILNihcd-cniPPVLYSAFT 383 human
NP_000786 334 hpkiakifeiqtmpngktrtslktmsrrklsqQKEKKATQMLAIVLGVFIICWLPFFITHILNihcd-cniPPVLYSAFT 412 human

Feature 1                              
EMC78343  426 WLGYVNSAVNPIIYTTFNieFRKAF 450 domestic pigeon
P24628    412 WLGYVNSAVNPIIYTTFNveFRKAF 436 African clawed frog
P53453    433 WLGYVNSAVNPIIYTTFNveFRKAF 457 torafugu
NP_057658 384 WLGYVNSAVNPIIYTTFNieFRKAF 408 human
NP_000786 413 WLGYVNSAVNPIIYTTFNieFRKAF 437 human

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