3SMT


Conserved Protein Domain Family
SET_SETD3
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cd19176: SET_SETD3 
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.
Links
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Statistics
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PSSM-Id: 380953
Aligned: 35 rows
Threshold Bit Score: 235.226
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site
Evidence:
  • Structure:3SMT; Homo sapiens SETD3 binds cofactor S-adenosylmethionine, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  # #                                                   
3SMT_A        79 PDLXKWASENGas--veGFEXVNFKeEGFGLRATRd--IKAEELFLWVPRKLLx-TVESAKNSVLGPLYSQDril-qaxG 152 human
XP_001745126  28 DELVDWLKQCGat--vdKVAVDHFNgMGQGLKATAe--AAPGETLLRIPEACMl-SEESARRSTLGAYMDSDtml-klmP 101 Monosiga brevic...
NP_727144    119 EAFSAWAKDGGvh--seGLEIAIFPgYQLGLRATRp--LAKDELVLSVPRKLIl-SEENNSDCRLFGKMTQA-------T 186 fruit fly
KRZ18429      69 EEFEQWCKKNSik--tfGVKPEAVEnCGIGMVATEd--IPQGKLLVLVPRKEMltTGSLQSCPAMRHLLKDDpil-stmS 143 Trichinella zim...
PAA71710      64 ELRQHVASASGgfv-rsCIGFANFGlQGVGLRAEEd--VKAGQLLLKVPRSQMltHTDALLCPAWRAVHLSDdpmcqrmP 140 Macrostomum lig...
CDS32960      69 EAKLKSLERRYkdyfecKISIQNSEsAGFGLRVEEp--IKKNTRLLHVPAEHM--LYIRNLTTQLPNFLESDpif-cgmN 143 Hymenolepis mic...
NP_497604     75 KTFLAWADGVGia--rnNVTIGSTKtAGLSLQATGp--IPKSHIVARVPRHAMitLDLAKKSSLLKKAFEKDpiv-ggmD 149 nematode
CEF67994      71 TTFKKWCKDEQif--fdKVDIIKIDdNNYGLVSTEd--VMDKQVLIKVPRKAIfsIDTIHENPIYKKIIVNDill-snmN 145 Strongyloides r...
KII70265     109 ETLFDDLVKSGan--lsKLRLEFVG-GEVRVIAKEn--IDPMTPLAMIPTSSIilADFFSQHEGLNHLVNKDpil-ssmH 182 Thelohanellus k...
GAU89072      72 GQLLEWLATSAgsa-vsRVTIACTGeRGYGVCVTEeipADDEEPLVKIPLTCCi-GPDVRSNFVIGQCISAFpl----pD 145 Ramazzottius va...

Feature 1                                   #                                                    
3SMT_A       153 NIALAFHLLCERAs-PNSFWQPYIQTLPs-eYDTPLYFEEDEVRYLqs-tQAIHDVFSQYKNTARQYAYFYKVIqthpha 229 human
XP_001745126 102 NVTLAFHLLLELHd-LDSFWRPYIACLPv-sYSVPLYWDLPDLMSLrg-sSLFVEAIRLYKHVCRQYGYLHNKLsvranp 178 Monosiga brevic...
NP_727144    187 HLNLAYDLVIEKIrgEFSEWRPYIDVLPa-kYNTVLYFTTKQMELLrg-tAAAALAMRQCRVIAKQYAFLYKYAhtmtep 264 fruit fly
KRZ18429     144 NVSLTMAILYELFlgKKSHWYEYLRFLPt-eYSVPLYFDEEAFSALkf-sAFFDQAVNVYASIVRQYSYFYQLLigrssp 221 Trichinella zim...
PAA71710     141 NACLALYLLHHLSlgPASPHSAYLKCLPtgiAPVCLSSTPTVYRRLsiqpTVRERILIELRNTCRQYLYFYRLFsqirst 220 Macrostomum lig...
CDS32960     144 NVALSMATLHELSlgEKSKFKEYISSLPs-tYSTVAYLSVDDFSVIdg-fPAAELISNTYRNICRQYAYFYLLFdrmege 221 Hymenolepis mic...
NP_497604    150 NVGLALFLACQWIqnEKSKWKSYISILPt-tFPTPLFYSEEQLLQLkp-sPIFEEAILFYRTISRQFCYFLLAIaknkiy 227 nematode
CEF67994     146 NVALVFFMCIERLn-KDSKWQDYFNILPt-kFTTPVNYTIEELELLkn-tVIYEESLKTFRHFARQYIYFLQKLydessk 222 Strongyloides r...
KII70265     183 NILLAYGLLIEFYrgQDSSFYNYIQALPd-cYENSYYYSLEDLKLLrg-sASFRDALNNWKSAVRQYAYFHLKIvetmeg 260 Thelohanellus k...
GAU89072     146 NLKMAAFLMSEASntEKSRWKAYLKSLPi-kHETILHLDAEAVAILqg-sLYFDDVIRRFCSVCKHYINCVAAIdlsdkf 223 Ramazzottius va...

Feature 1                                                 ##                             #####   
3SMT_A       230 n-------------------klplkdsFTYEDYRWAVSSVXTRQNQIPTedg---------srVTLALIPLWDXCNHTN- 280 human
XP_001745126 179 scscf------------pltlglspeaFTFEDWRWAVATVMTRQNSIPQagpd------gqmkPTLALIPLWDMINHAN- 239 Monosiga brevic...
NP_727144    265 stgnrsh--------pgerglfftqhgLCYKLYRWAVSTVMTRQNLVPSekqes----edgpkLISALIPYWDMANHRP- 331 fruit fly
KRZ18429     222 fr-----------------gtpfketnFTFENFRWAASTVMTRINFIPLqeelsev-gvatamNEPALIPMWDLFNHEV- 282 Trichinella zim...
PAA71710     221 ssda-------------nllplaksgcFTYAAYRWAVSMVMSRNNAVPKpgnngdglsnngtgTELALVPLWDMGNHRF- 286 Macrostomum lig...
CDS32960     222 tv------------------lpnymksFCFKDYQWAISTVMSRNNMIPEne-----------gEVLCLIPLWDMINHKQ- 271 Hymenolepis mic...
NP_497604    228 eaaqrrkdarnametpifynvpfnvanFTPKLYFWAVGVVTTRVNMVPSenqvge---dgnpvIIPALIPVLDMANHENv 304 nematode
CEF67994     223 dys----------------klsirledFTFDLFLWAANNVTTRINHIPSend---------qkSIPCLIPLLDFSNHSDd 277 Strongyloides r...
KII70265     261 gedlkd---------rqymekfqiasrFCFEDYRWAVATVAAKSLSIPSlgp---------hsINLALIPIIDLLKHSN- 321 Thelohanellus k...
GAU89072     224 sks----------------eknkfadaFTFNLFRWALDIVMTRGNALPLnpegql--sngttsATVALIPFLDMLNHQQn 285 Ramazzottius va...

Feature 1                                                   #           # # #
3SMT_A       281 --------GLITTGYNLEd----dRCECVALQDFRaGEQIYIFYGtRSNAEFVIHSGFFF 328 human
XP_001745126 240 --------HPMSTQFDSEr----eCLEFVCPAPAKpGSQITMWYGdRNNGQFLLHQGFFF 287 Monosiga brevicollis MX1
NP_727144    332 --------GKITSFYATVs----rQLECTAQEAVNtGEQFFIYYGdRSNTDLLVHNGFVD 379 fruit fly
KRZ18429     283 --------QALCSDYDTDt----dYGRVFSVKSWSaGDQVFIHYGdRGNYELFIGGGFVV 330 Trichinella zimbabwensis
PAA71710     287 --------GQMSTDYSQEd----sCLVFYAMEDAPaGSQLYFMYGrRSNADFFLYSGFSL 334 Macrostomum lignano
CDS32960     272 --------GQMTTDFDPAs----rSLLFYATESYEkGDEIFMDYGrRTSTEFLLYSGFVP 319 Hymenolepis microstoma
NP_497604    305 ltdvltepIEDLVCYSPEe----eCAVITSHCDVKaGNEVTIFYGcRSKGEHLLHNGFVP 360 nematode
CEF67994     278 --------SKNIVDFSIEd----nCAETIAGNALKkGNNITIVYGnRNNYSLFLANGFCL 325 Strongyloides ratti
KII70265     322 --------TVTSFNYESQe----rLLVVSNGFEMLsGEEVSIFYGaRTNSQFVLNHGFFY 369 Thelohanellus kitauei
GAU89072     286 as----kfGVVETRTADGptsafcELRLLSGQSLHsGQEVFMNYSaLSVKERFLNHGFLT 341 Ramazzottius varieornatus

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