1H0C,2HUF,2CH1,2DR1,1VJO,2YRI


Conserved Protein Domain Family
AGAT_like
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cd06451: AGAT_like 
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Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Links
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Statistics
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PSSM-Id: 99744
Aligned: 16 rows
Threshold Bit Score: 408.988
Created: 1-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1HOC_A; catalytic residue (lys) and cofactor (PLP)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1H0C_A     24 LLLGPGPSNLPPRIMAAGglqmIGSMSKDMYQIMDEIKEGIQYVFqt---rnPLTLVISGSGHCALEAALVNVlep---g 97  human
2DR1_A     22 KLFTAGPVACFPEVLEIMkvqmFSHRSKEYRKVHMDTVERLREFLev---ekGEVLLVPSSGTGIMEASIRNGvsk---g 95  Pyrococcus horikos...
2YRI_A      2 LLLTPGPTPIPERVQKALlrpmRGHLDPEVLRVNRAIQERLAALFdpg--egALVAALAGSGSLGMEAGLANLdr----- 74  Thermus thermophil...
NP_295073  11 VLLTPGPTPIHPRAQKALirsmLGHMDPEVFALNSEIQRDLREMYgte--peGFTALLAGTGSLGMEAGFANLvea---g 85  Deinococcus radiod...
NP_178969  11 HLFVPGPVNIPEPVIRAMnrnnEDYRSPAIPALTKTLLEDVKKIFkt---tsGTPFLFPTTGTGAWESALTNTlsp---g 84  thale cress
O08374      6 HLFIPGPTNIPDAVRMAMnipmEDMRSPEFPKFTLPLFEDLKKAFkm---kdGRVFIFPSSGTGAWESAVENTlat---g 79  Hyphomicrobium met...
NP_772679  24 FLQIPGPSPVPERVLRAMdmpvIDHRSAEFGELGRTVLEGSQKIFqt----aGPVVIFPSSGTGAWEAAIVNTlsp---g 96  Bradyrhizobium jap...
NP_247954   9 LLMIPGPTMVPPEVLNAMalpvIGHRTKDYSNLLEDTIEKLKKVFit----eNDTFLITGSGTAAMDMAISNIikr---g 81  Methanocaldococcus...
NP_342398   1 MMLIPGPVNVPYSVLQASln-lVNHRSEKFRETVKTLEFLMNKHFg-----sTRVALLSGSGTLAVESMVYSLvkr---e 71  Sulfolobus solfata...
NP_116623   7 TLLIPGPIILSGAVQKALdvpsLGHTSPEFVSIFQRVLKNTRAVFksaaaskSQPFVLAGSGTLGWDIFASNFilskapn 86  baker's yeast

Feature 1                                                                                     
1H0C_A     98 dSFLVGANGIWGQRAVDIGERIgARVHPMTKdp-ggHYTLQEVEEGLaq---hkPVLLFLTHGESSTGVLQPLDGfgelc 173 human
2DR1_A     96 gKVLVTIIGAFGKRYKEVVESNgRKAVVLEYep-gkAVKPEDLDDALrkn--pdVEAVTITYNETSTGVLNPLPElakva 172 Pyrococcus horikos...
2YRI_A     75 gPVLVLVNGAFSQRVAEMAALHgLDPEVLDFpp-gePVDPEAVARALkr---rrYRMVALVHGETSTGVLNPAEAigala 150 Thermus thermophil...
NP_295073  86 dEVLVCANGSFGRRMAEMAARYgAKVRLVTApl-geAIKPADVAAHLdd----dISMVAVVHGETSTGVLNPVPEiaelv 160 Deinococcus radiod...
NP_178969  85 dRIVSFLIGQFSLLWIDQQKRLnFNVDVVESdw-gqGANLQVLASKLsqdenhtIKAICIVHNETATGVTNDISAvrtll 163 thale cress
O08374     80 dKVLMSRFGQFSLLWVDMCERLgLKVEVCDEew-gtGVPVEKYADILakdknheIKAVFVTHNETATGVSSDVAGvrkal 158 Hyphomicrobium met...
NP_772679  97 dRVLMVETGHFATLWRQMAGRFgIEVDFVPGdw-rrGADPAVIEAKLtedkaraIKAVMVVHNETSTGATSRIAEiraai 175 Bradyrhizobium jap...
NP_247954  82 dKVLNIVTGNFGERFANIVKAYkGEAIRLDVew-gdMAEPEAVKEILdky--ddIKAVTVVHNETSTGARNPIKEigevv 158 Methanocaldococcus...
NP_342398  72 eKVITFPYGEFGHRLEESLIRRgAKVISYQKkl-geSFTVEEIKKAIeen--kdATTVALVHNETSTGIAFRDLKkiadv 148 Sulfolobus solfata...
NP_116623  87 kNVLVVSTGTFSDRFADCLRSYgAQVDVVRPlkigeSVPLELITEKLsq---nsYGAVTVTHVDTSTAVLSDLKAisqai 163 baker's yeast

Feature 1                                          #                                          
1H0C_A    174 --hrykCLLLVDSVASLGGTPLYMDrQGIDILYSGSQKALnapPGTSLISFSDKakkkmysr-ktkpfsfYLDIKWLANF 250 human
2DR1_A    173 --kehdKLVFVDAVSAMGGADIKFDkWGLDVVFSSSQKAFgvpPGLAIGAFSERfleiaek---mpergwYFDIPLYVKY 247 Pyrococcus horikos...
2YRI_A    151 --keagALFFLDAVTTLGMLPFSMRaMGVDYAFTGSQKCLsapPGLAPIAASLEarkaft-----gkrgwYLDLARVAEH 223 Thermus thermophil...
NP_295073 161 --rgsgALLTVDAVTTAGMEPFHMQqWGVDYAYTGAQKCLsapPGLAPVAISERafsrfaar-rtqtplwYCDFEGLRDY 237 Deinococcus radiod...
NP_178969 164 dhykhpALLLVDGVSSICALDFRMDeWGVDVALTGSQKALslpTGLGIVCASPKaleatkt---skslkvFFDWNDYLKF 240 thale cress
O08374    159 daakhpALLMVDGVSSVGSLDMRMGeWGVDCCVSGSQKGFmlpTGLGILAVSQKaldinksk-ngrmnrcFFSFEDMIKT 237 Hyphomicrobium met...
NP_772679 176 drtdhpALLMVDTISSLGSVDYRHDeWKVDVSVSCSQKGFmlpPGLGFNAISEKarvaakt---nkmprsYFDWEEMLKP 252 Bradyrhizobium jap...
NP_247954 159 --kdydALYIVDTVSSLGGDYVNVDkFHIDICVTGSQKCLaapPGLAAITVSEKawevikk--nddkvgfYLDLLAYKKY 234 Methanocaldococcus...
NP_342398 149 -vkgvgLKLLVDSVSGFAAYPLYVNqWKIDCVVTGSQKALasiPGVGFAALSEEgvnelv----esdlpsYLDLSFHLKF 223 Sulfolobus solfata...
NP_116623 164 kqtspeTFFVVDAVCSIGCEEFEFDeWGVDFALTASQKAIgapAGLSISLCSSRfmdyalndsknghvhgYFSSLRRWTP 243 baker's yeast

Feature 1                                                                                     
1H0C_A    251 Wgcddq--prmyhHTIPVISLYSLRESLALIAE-QGLENSWRQHREAAAYLHGRLQAlGLQLfvkdpalRLPTVTTVAVP 327 human
2DR1_A    248 Lkeke-----stpSTPPMPQVFGINVALRIIEKmGGKEKWLEMYEKRAKMVREGVREiGLDIlae-pghESPTITAVLTP 321 Pyrococcus horikos...
2YRI_A    224 Werg------gyhHTTPVLLHYALLEALDLVLE-EGVAARERRAREVYAWVLEELKArGFRPypk--asPLPTVLVVRPP 294 Thermus thermophil...
NP_295073 238 Wvnh------tyhHTVPVNLHFAFHAALRAALE-EGLEARQARVRLMGRVIERTLAPlGFSHyvrrpedRLPTVLALRLP 310 Deinococcus radiod...
NP_178969 241 Yklgt-----ywpYTPSIQLLYGLRAALDLIFE-EGLENIIARHARLGKATRLAVEAwGLKNctqkeewISNTVTAVMVP 314 thale cress
O08374    238 Ndqg------ffpYTPATQLLRGLRTSLDLLFA-EGLDNVFARHTRLASGVRAAVDAwGLKLcakepkwYSDTVSAILVP 310 Hyphomicrobium met...
NP_772679 253 Nakg------ffpYTPATNLLYGLREAIAMLLE-EGLDNVFARHQRLAAATRAAVNHwGLEVlcqepseFSPVLTAVLMP 325 Bradyrhizobium jap...
NP_247954 235 Yeekk-----qtpYTPSVNLTYALNVALDLVLE-EGIENRVKRHERLAKATRAGLEAmGIELfak-eraRSVTVTSAKYP 307 Methanocaldococcus...
NP_342398 224 Qdkg------etpFTPTVGAFFASRRAAELLDK-EGIENRWKRHEACARYLREVMLEmGFKLlgn-dtnFSNTVVAAFPP 295 Sulfolobus solfata...
NP_116623 244 ImenyeagkgayfATPPVQLINSLDVALKEILE-EGLHKRWDLHREMSDWFKDSLVN-GLQLtsv-sryPSNMSAHGLTA 320 baker's yeast

Feature 1                                                                  
1H0C_A    328 ag-ydWRDIVSYVIdhf-diEIMGGlgps-tgkVLRIGLLGcnaTRENVDRVTEALRAALQ 385 human
2DR1_A    322 pg-ikGDEVYEAMRkr--gfELAKGygsv-kekTFRIGHMGy-mKFEDIQEMLDNLREVIN 377 Pyrococcus horikoshii OT3
2YRI_A    295 eg-vdADRLVRALYae--gvAVAGGigpt-rgqVLRLGLMGegaRREAYQAFLKALDRALA 351 Thermus thermophilus HB8
NP_295073 311 eg--fDDAGLRQALrqr-eiSVTGGlgpt-agvIWRLGLMGesaRPGPYHRLMTELEDLLG 367 Deinococcus radiodurans
NP_178969 315 ph-idGSEIVRRAWqry-nlSLGLGlnkv-agkVFRIGHLGn-vNELQLLGCLAGVEMILK 371 thale cress
O08374    311 eg-idSNAITKTAYyry-ntSFGLGlnkv-agkVFRIGHLGm-lDEVMIGGALFAAEMALK 367 Hyphomicrobium methylovorum
NP_772679 326 pg--hDADQFRQIVlenynmSLGSGlskv-agkVFRIGHLGe-cNALTLLGALTGVEMGLS 382 Bradyrhizobium japonicum USDA 110
NP_247954 308 eg--iEDSKFRGILsnkyniVVAGGqkhl-agkIFRIGHMGi-cGEKEVLATLACVELALK 364 Methanocaldococcus jannaschii
NP_342398 296 i---pLDTFMSELKkr--niEISKGmgel-rdkIVRIGILGvvdDRAIRRLVGSMGEILKK 350 Sulfolobus solfataricus
NP_116623 321 vyvadPPDVIAFLKsh--gvVIAGGihkdigpkYIRIGHMGv-tACNKNLPYMKNCFDLIK 378 baker's yeast

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