Conserved Protein Domain Family
DUF6049

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pfam19516: DUF6049 
Family of unknown function (DUF6049)
This family of proteins is functionally uncharacterized. This family of proteins is found primarily in Actinobacteria. Proteins in this family are typically between 695 and 823 amino acids in length.
Statistics
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PSSM-Id: 437348
Aligned: 43 rows
Threshold Bit Score: 237.272
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_009402672            22 RAMVTIAALLGVASLVALPLTVLPT-ARADQAPGTPltaradgisadispvastkpsapttpsesssaspsasagkssqg 100 Actin...
KHS50984                10 RFLTALLSTLLLLAGSVFAY----PlLNAAPAAASTda------------------------------------------ 43 
SNS97625                11 RAHRNRTGALVLIVVLATAMLLATPpAHSQP------------------------------------------------- 41 
jgi:Sked_37910          20 GLLTALVLACVLLGSAAPATATVLP-ATTTPSPSPStppt---------------------------------------- 58 
SKC61257                22 RLLTVLLLLAALLGAGALVALPVGP-ASASPGAVTA-------------------------------------------- 56 
WP_056654015            56 LVGGLLTAALALALVVVPSSPGGAReATASAAVGTSgaa----------------------------------------- 94  Oersk...
KGM13061                 6 RAAHLLGTVLALMATMV---------VLTAPAQATL-------------------------------------------- 32 
PRJNA247940:FB03_06530   4 GALAGAVAAWVPLSAIGLVGAQAEP-AQVGPAQNSLa------------------------------------------- 39 
WP_073452714             8 RLLASAAAVLSSAAMMI-----AGP-ALAAPVTPGIpsdrgeggapav----------------------------qalp 53  Actin...
SJM64352                16 RIFAPLPAALVVLAAFGCVVGSAPA-ASAASGPVVRa------------------------------------------- 51 
WP_009402672           101 tegsqapRAEAA-ANQVTMSIDAMApEVLHSDQDLVLTGSI---------TNGTGQVITGADLVTRVQRSTEVTSQSLKK 170 Actin...
KHS50984                44 ------nKDSDAnKNEVSITLDEVTpWI-DDKGTLTVRGTI---------SNTTKKAVEKPSLSLQMSTRKLDSESRLDS 107
SNS97625                42 -------------RDGIPVTIVSVApHIATPQSEVVIEVEV---------TNPATTDLNA-NVTLNISRVIMQERQQVSA 98 
jgi:Sked_37910          59 ---dsapVPATEpTAAPAVRLMTMSpEVVRPGDTMTVRAEV---------TNTTGETLTSPVATLTVSKYRFSTRDRLAA 126
SKC61257                57 ---------PAArDGAATVELVRSTpTLAVPGSTVTLTVRV---------TNGTDAALDGAALDLGVSWRPITSREDLSA 118
WP_056654015            95 ----gaaPAVVDePGAVSTTLVSMTpTTVGPGSTVTVVARI---------HNGTDEALTAPRATLGVNWRLLGTRSALAT 161 Oersk...
KGM13061                33 -------VDPEDpPHPVDVVLDELDpPVLEPGQDLRVHLTL---------TNTGATTLEEPRVVVHLDRGSFISRSSLDR 96 
PRJNA247940:FB03_06530  40 ------hVLPARpAAAPSVDIVDVGaPVLGADATLTLTATV---------TNSTTETRHLNSVSLYIQRYVPSSRSAVLS 104
WP_073452714            54 adsapgaAAPAItDGALTLAVDAMApEILHSGEDLRISGTI---------ANGTATNLSGASIVVQAQQTTEVSTENLSS 124 Actin...
SJM64352                52 ------aAEDEEqAPTLDLTLPDHG----LVSGEFTATVTIdypsdgnplTADAGDPLPSGRVVLERAVSPLKDADALDD 121
WP_009402672           171 WLTGideSG---------------------------LSDPVTVPLGRDLQPGEAAQFSITVpaDELPLSSA---DQWGPR 220 Actin...
KHS50984               108 WKQGqaqHRtvadlehdgtearekakkdddsdsdddSESTLDTSFEDTIDPGTTAEFTFRVpaDDLDLSKSspvSSWGPR 187
SNS97625                99 WLAAaddD----------------------------DPGSPLVSEPVTIRGDDAVKVRLTVppGELGLLSSp--DGLGPR 148
jgi:Sked_37910         127 WADQgltAPf--------------------------GTVLESVDVPADLAPGDSAVVDFSVeaDSMGLLTSl--DFWGPR 178
SKC61257               119 WADDdgaG----------------------------TAASQVVEPVDRLAPGDSAQVQLELevDALGLSAD---NPWGPR 167
WP_056654015           162 WADEptsKR---------------------------SAEAMATEALDPIAPGQEATVTFDLdtDDFNLEPG---STWGPR 211 Oersk...
KGM13061                97 WRGAdpeGPl--------------------------GAAIVNHDLDEPLDPGASVEVVVDVpaTTVGLRTGq--ASWGPR 148
PRJNA247940:FB03_06530 105 FMRAepaG----------------------------LALYDTLTPDADIAPGTSTRVTFSIprERIP-------AEWGPR 149
WP_073452714           125 WLAGersTS---------------------------LVTAMDGALGSDVAPGASQRFSVTVkgSDLPLADT---DQWGPR 174 Actin...
SJM64352               122 WSGGaatGStv----------------------------qLAYVNTEEITSGQTLSVDITAdvSD---------DDDGVY 164
WP_009402672           221 GVAVRLESQGGSla------qdRSVLV--WDSGASV--TPVHLTAFIPVTA--------------SAQEMAVL--AGPRT 274 Actin...
KHS50984               188 GLAVQLGDETGLra------saLGFTT--WYPDPEF--DQTKISVLAPVTLpg----------hsEGGLIPSDrlDAAIA 247
SNS97625               149 GISVTVDGIVGDvshq--lgiaRTFLI--WQPQSSYevPIVDVAIAAPITG-------------------NPAalITDTA 205
jgi:Sked_37910         179 GIAVTLAGNGTSpatvdpvgtlRTFVL--WFPVEDSevTPVGTSVLVPVVGpav---------dpLDPASAEAslEAATS 247
SKC61257               168 EMSVALTRDGAAld------vlHTFLL--FAPEDTAp-DPVAVSVAAPVTGpav---------dpLDPDGYDLdlATDTA 229
WP_056654015           212 PLSITVTDGSARld------vlRTFLL--WEDAAAP--APVGLSLLAPVTGpplglttapdaegqEQTSVDVAavDGALG 281 Oersk...
KGM13061               149 GLGAQVVDVADParar--lgvvRTFLV--WLPVEDV--GTTYLSVATPLVGar----------pdGTAQAWVDelETLTG 212
PRJNA247940:FB03_06530 150 GVQVSAVVDGEta-------tdRSFIV--TAPGDDA--APAPISAIVPVTRsls---------dvGSAQALEEqvYTSLT 209
WP_073452714           175 GIQVTLAQNGSAla------qdRAISL--WDSGASV--DPSRVTVIIPVTA--------------SPAELALL--ADLGT 228 Actin...
SJM64352               165 PVVARFEPDTADttqe---ltdsAVLTraDDD------PA--VTVVVPITApa-----------sSRGVLTSDqlDVLTS 222
WP_009402672           275 QEREEA-------------------------------------------------------------------------- 280 Actin...
KHS50984               248 EGGSLDtia----------------------------------------------------------------------- 256
SNS97625               206 EEGRLSrvv----------------------------------------------------------------------- 214
jgi:Sked_37910         248 SDGRLTqvl----------------------------------------------------------------------- 256
SKC61257               230 SDGRLSrll----------------------------------------------------------------------- 238
WP_056654015           282 AEQPLGhll----------------------------------------------------------------------- 290 Oersk...
KGM13061               213 PEGRLRdvl----------------------------------------------------------------------- 221
PRJNA247940:FB03_06530 210 APSASPqppaaapapasspagtptpsaiapnvtsaadpaasaapsapsvsqgasspaapsaprkmptasapsspsgsaae 289
WP_073452714           229 TEQREAeqaaedaaekaakatgtptagptasasppspgtsps---gdpsagaaptatgspspsagpdsvppaspqdsaps 305 Actin...
SJM64352               223 SGGTLRnql----------------------------------------------------------------------- 231
WP_009402672           281 VTGIRSRVLGLLGMAGDGVVMAVDPALVEAlgvtptsleeaarnsgsqpaspdgatqapqgadssasavstaptsepsas 360 Actin...
KHS50984               257 -----------klLKHKELALAVDPRVIASfeaaiaeppaadapeeteepsagkgdetqsp------------------- 306
SNS97625               215 ----------saTVDFSGVSWLIDPALVAAaegtlpaaalpql------------------------------------- 247
jgi:Sked_37910         257 ----------asTEGVDDVAWAVDPALVPEtdgtpsaddtegaddagatada---------------------------- 298
SKC61257               239 -------daAAVTGTSPGMSLAVDPALVAAaagtddtdaqawatrltgapv----------------------------- 282
WP_056654015           291 ----------taTAGRPEVAWAVDPALVAAartsaes------------------------------------------- 317 Oersk...
KGM13061               222 ----------taTAEHTGVTWVVDPWLVDAtsgslagvt----------------------------------------- 250
PRJNA247940:FB03_06530 290 AGQLPHRLQTLNYFAHPGVSAAVDPLLIAGdpe----------------------------------------------- 322
WP_073452714           306 IHALRQRVTGMLDLAGDGVVLAIDPALIDAlgmtperlqaaaaagsgesgptadptpsavgpsd---------------- 369 Actin...
SJM64352               232 -----------daVDGNSAALAVDPAIPAAirvlgsaapasa-------------------------------------- 262
WP_009402672           361 agpsssasstppsssasatpsasagpsssapstktpddvtqlsaalmraIg------tGGLVALPWGDSDTAALAHLQQ- 433 Actin...
KHS50984               307 ------------------pvgapenddadssaaeleaaeeqrkrlgswyQdfveetqkHTVVALPYGDPDLSALRGTKI- 367
SNS97625               248 -------------------------------------qartsdetkqwaAtvrsdsglHSSYALEPFDADVTVIGSEPAp 290
jgi:Sked_37910         299 ----------------------------dstdspddaeagvddaagelsArivdgaagREVFALPHRDQDVTAYAAAGL- 349
SKC61257               283 ----------------------------tgdedatadatatsaslsstaAdaaasgepADVAVLPGFDPDLAAVAHADPs 334
WP_056654015           318 -------------------------------------------staawvSafdeasadRSIFALRPYDPDPAAYAQVGA- 353 Oersk...
KGM13061               251 -----------------------------------------qqharrwaLdlldaaegHEVDLLPYTDPDVAALAHAGA- 288
PRJNA247940:FB03_06530 323 ----------------------------------------------rtaLqtfasaagTSVFFGLGADVDAAALTHAGS- 355
WP_073452714           370 ----------------spgptaspsapptssrdlaeedltelagslyraLtgsgakgkGDVVVLPWGDADVSALTHLGA- 432 Actin...
SJM64352               263 -----------------------------------------------tewlddlmalpNDRFALQFGDADVATQISAGE- 294
WP_009402672           434 TSLIETAAQRTQESAIVKAG----------------------------------AP-----TSLAWLASSVLDSTTVGTL 474 Actin...
KHS50984               368 DRLSTFAQKQREIVK---------------------------------------DVfpdarTDIAWPVAGSATKNGLRAL 408
SNS97625               291 PSLSKSLRDTLDEITQYWg------------------------------------------SGITLPRENVPRRTLIERA 328
jgi:Sked_37910         350 -----PAPTQPALVGATStw----------------------------------------rTDLAWPEEAAPDAATLATV 384
SKC61257               335 RADVAAATGGEAALGGSW------------------------------------QRpedwdLTVAWPVG-RPDAATLAVG 377
WP_056654015           354 -----ALPAPSVPLPGGS------------------------------------TTdpswrTDLTLPGDEVPGRATVRTS 392 Oersk...
KGM13061               289 WDLLDLARDHAAGRAADG------------------------------------YLppeavVSVAWPVD---PLPDLATA 329
PRJNA247940:FB03_06530 356 --ADKLALARQDAVQAAQ------------------------------------TSgfaarSDIAVTAL-GVDRATARAL 396
WP_073452714           433 TDLMSTANARASGSLLAGAS----------------------------------AS-----TSLAWPAGP-LDAQTLSAL 472 Actin...
SJM64352               295 EELLAPTSLAPYIAGAGDVDdagvggdgsepdpsptpsvdpvdmtldelldigdAT-----DDVYWPNP--------DLV 361
WP_009402672           475 PQS-TSTVIASPtSLPAaDELTYTPSGLGA-------------------------------------------------L 504 Actin...
KHS50984               409 KKSgNSTAIISDsQQPSiTGIHDDAHSQTTitd--------------------------------------------dgE 444
SNS97625               329 WTAgSTTVIARR-NYQAvDPDDVSPGGVTTvq---------------------------------------------haN 362
jgi:Sked_37910         385 AAAgASTVVTAPgSLSPsTALSYTPTGRTTvp---------------------------------------------taS 419
SKC61257               378 RAApVDQVVVAAgLAPTdGAPASARTAVETp------------------------------------------------S 409
WP_056654015           393 VQAgSPLVVVRGdGLTPvDSVSYTPTGLATve---------------------------------------------tdA 427 Oersk...
KGM13061               330 AFVgADPLVVAPgALPTpGILTYTPTGRTTit---------------------------------------------aqG 364
PRJNA247940:FB03_06530 397 RDAgAAALITT--DVDAeHASWLSPSGRVNiplaadgsdtcslsdargdaedsgagaaggsgadgasadgatdvngtagA 474
WP_073452714           473 PES-ASVVVASPgDMGVtEPLTYTPSGVAS-------------------------------------------------F 502 Actin...
SJM64352               362 GSQtVEGIDAMD-GVPLvPSTRTRAGANGApva--------------------------------------------anA 396
WP_009402672           505 GDRAVLLPEQSLSETLTGEASQT--GASDQNgaatqathdtrspqtaqtdqaAELDTRQLLRGDSAILVRQA-PAL--ER 579 Actin...
KHS50984               445 STIDTLISDTKLTDMSAEAIADD-----------------------------NPAGALSELVAESAVIQSEA-PYR--TR 492
SNS97625               363 GASTVLVADPILSKTLTNPRSSS------------------------------PAAAAQEVLAQLVVIARNN-PDR--RR 409
jgi:Sked_37910         420 GDVAALVPDTVLSAQLTAPTDAS------------------------------PAAARQRLLAETAVVSRER-PAE--AR 466
SKC61257               410 GKVSALVADAGLSAGFAALTDGDsa--------------------------pSAAEASTRILADAALLALQQqDAGtqDL 463
WP_056654015           428 GPATALVSDAALTEAFSAGTRASga--------------------------gSTADATQRLLAETAVIASER-PAD--SR 478 Oersk...
KGM13061               365 RDVTVLTPDLRLSRAVQDGSMAW--TPADDTtg-----------------tlSPAAAAQDLLAETAVITRER-PAD--PR 422
PRJNA247940:FB03_06530 475 DEAAALRADGVLSALVQGYLPSSdeANVLASgggeglp-------eaagsrlSAIDARQTALALSAATYREL-PAA--PR 544
WP_073452714           503 EDRTILLPDAPLSAGVAG-SLET--QASTQSl--------------------SEIDTRQYLRALTAILTRQA-PNL--GR 556 Actin...
SJM64352               397 GD--ALVYDAGLSSDISEAAAVE--DSAARS------------------------DALEKAVASLWLTSDEL-D----GA 443
WP_009402672           580 DVVVAMPR----------RAASTAdp------saVHERVAALRSASWIRPQSLGDLQEHTRAEVEATDEGTSHversepp 643 Actin...
KHS50984               493 SLFVPLPR----------AAASAN----------WEQTVEELSSAPWIAPTGVDEILDSGSEsrgllrt----------- 541
SNS97625               410 NVLISLPR----------SWEPDVtt--------arAQLTALESADFVNSVSLDEFAAFGDDGTPRNTPRTSAtes---- 467
jgi:Sked_37910         467 QLVITVPR----------DWAPep--------avARAQLEALGSAPWTRLRPVSTILGAEAAEVDRTGPAEAPaae---- 524
SKC61257               464 HVLAALPR----------GWSPdp--------alVGTVLDDLDGASWADVVPLTETVAAPASRVPRDGPARAGrsg---- 521
WP_056654015           479 HLLIALSR----------GFDPdp--------aaFDAVLDALDAASWVTLTPVDDLLSAPVP----------Dversalp 530 Oersk...
KGM13061               423 HLLVTTTR----------DWHPdp--------avTRAQLTALEAAPWVVLEPLGTLVGASDA----------Pvdrgtlp 474
PRJNA247940:FB03_06530 545 AQVVLVDR----------PESGALaragalpdrdIGAALGALTSAPWLAPTGAGDLLDKPAAgcaqlpe----------- 603
WP_073452714           557 DAVVAIDR----------RTASTTsp------tvLGARVDALRQTSWTRPSGLADLSADADRQ----ASQDDEpgraglp 616 Actin...
SJM64352               444 NLLVALERtggvlvdedeDAPATTrp--------agAVSDVVTTIADVSKTTLRSLTTSDRHGAKYVSAAGP-------- 507
WP_009402672           644 ekvidddeLPADLLTAASGTAATLQSVSSVLSDPPAllgDYTGLESVVASASWRADPATRSAQVPAAEAAGTGVTSSLAA 723 Actin...
KHS50984               542 --dsdaphIRKRAVKSLGETRANQEDFNSVFSDRESadiRLDRELLTCTSAAWT-LGRNANICAGQAREQSEKLMDSLRL 618
SNS97625               468 -----dfrLTPSQWSDLVELADKSKTFAQIATDPSAiagPIADAVWQLTSVQWLDNENARNDIANQLNDQVDRLLASQSV 542
jgi:Sked_37910         525 ------gtISAAQLSELDGALEDIRSFAQVVPDQTAltaPVEDAVRAATSVAWRVDPAGRSTAVADVVTHVDATRASVSV 598
SKC61257               522 -----dgeLAPPSVRRLLDSHRDLSAFSTVASDPVElsgDTDQALVAPLAVAARTAPDTRDHAVDLAVERSDALQQGIGV 596
WP_056654015           531 etdggegvLPAPEMSSLQRARSEVSTFSTIATDPAAivqEAEPALVVPTAVAYRAAQDERTAAVQAAIADADRLRSSVAV 610 Oersk...
KGM13061               475 ermrhpaqIPADQLALVSGAVDERERYASMLEDPETllaATAVERLAPASAAWREDPVGRSEMIARTTSATATLRDSVTV 554
PRJNA247940:FB03_06530 604 -ervlpgeISAAMLARGDAHVTTISTTAALTPVPASitgPVTHHAAQLAGVALRDHHAQREELSAQLTQLAEEMAGAVTV 682
WP_073452714           617 piqitdseLSDPELARAQAAAQRVGATSSVLHDPTAimgTRAQLVSSVSASAWRADAAGRTALITGADAAADSVVSALQV 696 Actin...
SJM64352               508 --------LRIDMSAALAEYGSPLEEISSVLSDPQLlmgRTRAERLQLLSVAWEAHPDAWRESFDSHLASLGALSEAVGL 579
WP_009402672           724 VPS-STINLISSEAQLPVRITSSLDQDVTVQVYLVSDNKRLQVPRTTTVKVPANQQAKVTVPIRAV-GSGDVGLTVQVLA 801 Actin...
KHS50984               619 RKGsSVLLVTGEKTTIPVTIVNDSPAEATLRIRMKPNTPQLRAQETETVKVPAAETMRVDVPVEGL-ANADVPTTIEMVT 697
SNS97625               543 VLG-SDVNLIAASSALPITVANSLDQPVTVGVRLVADHPRLKSTEIDPVEVAPHSEVSVDIPVTAV-GSGDVDVLVRLLS 620
jgi:Sked_37910         599 VTA-RNFNIISTGSQIPVQVVNDLDQPVTLKIALDPDDPRLVAEKSVTVTIGPGEEVREQIPVRAV-GSGDVTVTAQIMA 676
SKC61257               597 ADR-SNITLVSDTGKLPVTVSNELPVDATVTVVLRPDASRLVVESRPTVVVPAGTSTNVHVPVRAI-GSGDVDLQVEVLA 674
WP_056654015           611 VRRgSGVLLINTSGNIPVRVQNTLDQEVTVQVALRPDNARLKVVSFPVGPIPPGTEVDFKVPVRAY-GSGNVRVEVELLA 689 Oersk...
KGM13061               555 VAG-GPINLISPTGDLRLRVTNAWPEPVTVRVGLRPDDSRLRADTDVEVTVPGSGETTAAVPVHGI-QTADVVTTVELRT 632
PRJNA247940:FB03_06530 683 QPS-STINIISENADLPVHVHNSLPVPVGAVVELRAEDFRIVPSDPVAATIPPAASVTVAVPVQAS-GSGNVTVTAAVTD 760
WP_073452714           697 APS-STINLISDKAQLPIRVSSSLKQDSTVVVEVISGSPRLQTKETVSVVVPAGGQAVASVPVTAV-GSGNASLTVRILS 774 Actin...
SJM64352               580 VPP-SDVNLLSSEAPLPVWVRNDLPYPVTVTVFSYPDDVRLSMDTSTEVVAQASSNTRVQLPVEATlGSGDVDIRISLQS 658
WP_009402672           802 -ADGTTVGRPTTVDMRVRADWESRGTGIIVGLLVSIVVIGTVRTVRRGRRta---------------------------- 852 Actin...
KHS50984               698 -ADEVVLPKHESLMVRVRADWENIGTAAIGLALAVVFVIGLIKTISRGRPk----------------------------- 747
SNS97625               621 -ADGTVVSTPASFTVRVRADWESRGTIIIGALLTLMLIAGIWRTIKRGRAstrtsqg----------------------- 676
jgi:Sked_37910         677 -LDGTVLGSAESFEVRVRADWENMGTAVVAGLLVVLLGAGIWRTVHRGRSdrrvsad----------------------- 732
SKC61257               675 -PSGAVVAGPTSFAVRVRAGWETAGTAVVAALVALLFLGGIWRTVRRGRSsarttdegvaddaadpqgpddadpphtdpa 753
WP_056654015           690 vPSGTVVAPSSDFSVRVRADWETVGTAVFAGLVALLMIGGLWRTIRRGRSprrv-------------------------- 743 Oersk...
KGM13061               633 -PTGDVIDDSTVMTVRVRAEWEGIGTAVIGVLLGLGLVIGVIRTVRRGRTgtr--------------------------- 684
PRJNA247940:FB03_06530 761 -PVGTAIGAVQDINVRVRAGWETTGTYIIGALLGVLLLGGIARSLRSGRRsggvdpe----------------------- 816
WP_073452714           775 -SDGTEVGTPARLRMRVRADWEGRGTRIVAGALVVLLAAGIYRTVRRGRRavp--------------------------- 826 Actin...
SJM64352               659 -PTGVLIGPEESMHVTVRADWERYGIAGLAVLIVGLVVFGTIRTIRRRMKrnap-------------------------- 711
WP_009402672           853 ---------------------vaPAA 857 Actinomyces sp. oral taxon 170
KHS50984               748 ----------------------iPEQ 751
SNS97625               677 -----------------ptpqepAAQ 685
jgi:Sked_37910         733 -----------------avglvePAD 741
SKC61257               754 avprdgahddqpnaphdpgggapPAA 779
WP_056654015           744 -------------------aeltPAS 750 Oerskovia sp. Root918
KGM13061               685 ---------------------aePQS 689
PRJNA247940:FB03_06530 817 ----------------khlhnlrEAS 826
WP_073452714           827 ---------------------daPLA 831 Actinomyces
SJM64352               712 -------------------depvPDE 718
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