3TER


Conserved Protein Domain Family
SOAR
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pfam16533: SOAR 
STIM1 Orai1-activating region
SOAR is the Orai1-activating region of STIM1, where STIM1 are calcium sensors in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region, which runs from residues 340-443 on UniProtKB:Q13586, forms a dimer, and is essential for oligomerization of the whole of STIM1.
Links
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Statistics
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PSSM-Id: 465164
Aligned: 22 rows
Threshold Bit Score: 118.897
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3TER_A        30 QAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVLSSLKLATGaaSTSDQVDSKIFALKSRMEKI 109
EKC35432     385 SVPPDLQPWLQLTYETEQMYFHIKKREAERQLDQAREECRRIQKKRGTLFGPLRMAPS--NTIDEFDNKIECARQALDEV 462
XP_009031508 307 IPLFELQIWLQLTYEVEKRYFESKREAAQNQLLAARQMWDKIRKQKSKFLGSIRVAHT--TSLDETDQQIMHVRNALDIV 384
KJE88479     405 VQSDELRILLQRTFAIEMQQHTIRRQSAELELKAAHEALENVTRKNKNFMGSFRVAHG--GSLDSLNDAVHSALQTLSHM 482
XP_003387480 361 QNRLALKQLLIETCLQEKYYLDANKRTAENEVMRAQKMCDKIKRKRASVIGAFRLANS--STLEDAGLMITKAVNKMQMV 438
XP_018673097 334 SPPTRLLTCLKTTYQVEMKLHEVKRHTAHKKVEQAKAQFQKMKKK-VSIFSSVQFIHS--RQVDSFDLEVQAAKDALREI 410
CDS35874     364 APITELALLLQMTHELELRHYWEKRSAAAKQLMAAKEACDRVRRKRSSLVGSVRLIHS--DNLDDVDSKLNAARRVLENV 441
XP_001641745 281 KAPEELAQWLHITYTKESRHFQMKRTQALKQMTEAKDACDRIRKKRNSFIGSFRMAHD--LTIDEVDQQILAARAALADV 358
Q16IM6       291 TPPQGLQNWLQLTFELENKQHIRKRVMAEKQLMQAREACEKLKKKRSSLVGAFVSTHG--KSIDDVDRSIVEARNALNDV 368 yellow fever mo...
XP_002028377  59 APPPQLQSWLQYTYELESKNHQKKRASAEKQLQSAREACEKLRKKRSSLVGAFVSTHG--KSIDDVDRSIVEARNALGEV 136

3TER_A       110 HTLTRETQERWLQIESLCGFPL 131
EKC35432     463 RKCLTEKSQRWHHIEQLCGFSI 484
XP_009031508 385 KVELQERMTRWHEIEKLCHFSI 406
KJE88479     483 RKESEEMSLRWQQIEDVLSVTV 504
XP_003387480 439 TEHFESFQKRWQSIEQIFGFPI 460
XP_018673097 411 QRDSHEHRKRWMELETI----L 428
CDS35874     442 TADMQERKHRWSRIEDLTGLIL 463
XP_001641745 359 TNEMEERQRRWYQIEALSGLPI 380
Q16IM6       369 TNDLQERMHRWKNIENLLGFSI 390 yellow fever mosquito
XP_002028377 137 TNELQERLHRWKQIETCLGINI 158
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