Conserved Protein Domain Family
RFamide_26RFa

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pfam11109: RFamide_26RFa 
Orexigenic neuropeptide Qrfp/P518
Qrfp/P518 has a direct role in maintaining bone mineral density. Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice. The c-terminal 28 residues are the functional 26RFa.
Statistics
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PSSM-Id: 431659
Aligned: 14 rows
Threshold Bit Score: 135.205
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017951848  14 YGMSVLVLLSLGYTFALQDSREQSDPWERIRLlRMMADGEENSAGALWYPLAPRQRKSTDPASLFSVAKELQGFGKERAG 93 
XP_007475223  10 HSLSCLLFLTLGACFPPSDKREIGDPVDGMGKvQMRGAKMAEGHWPGFLKGTPKWKRFQDPSSLFVMAKKLQGLGKERAG 89 
XP_003407599   5 YPLSYLLLLPLGVCFPLADREESGDTLGGIRA-KTSWAHLAQWHRPNFRWGSSWQPRAPQPLALLVVAKELQTSGKERAG 83 
P83862         5 YSLPYLLFLPLGACFPVLDTEEPVDAVGGTGR-EMSWMDPARGR--PFPWGSPGWPRAPYPHALLVTAKELRASGKARAG 81  cattle
XP_003122292   5 HSLPFLLLLPLGACFPVLDRDVPVNAMDVVGG-GRSWANLAGGR--HFLWGSPGWQRAPHPGAWLIMAKELQAVGRARAS 81 
XP_023602403  45 HLLSCLLLLPLAACFPLPDREAPMDTTGDTGG-GMSWADLAGGHVAHFP----RRLRAPHPQALLAMAKELQMSGRARAG 119
XP_012914087   5 RALPCLLLLPLGACLPLLDREEPAATVGGVRG-GMSWADLPGGYRMLPPRGSPGWPGAPQPHGLLVMAKELQVSGQRRPG 83 
XP_850751      5 RSLSCLVLLPLGACFPLLDREEPVAAMSGVGG-EMSWANLPGGHRAPLPRGSSRWLRAPHPHGLLVTAKELQMSGRQRAG 83 
XP_003794941   5 YSLAYLLLLPLVNCSPLRDRRGPTNALSSFAA-RVGWSIPAEGLRPHFMWGSSRWSRAPWPQALLVKAKELQTLGRVYAG 83 
EGW00429       5 HTLPYLLLLPLSTCFPLLDRRGPTD-IDDIRA-KMSWANPVEERRPHSVQDPFLWLRVPQPQALLVVAKELQSSHREHTG 82 
XP_017951848  94 FRFRFGRQEEGNEFEDFEQQDEEKRGGtALGSLAEELNGYNRKKGGFSFRFGR 146
XP_007475223  90 FRFRFGRQEEDSKATNIYPASEEKQNS-LLGSLAEELSGYIRKKGGFSFRFGR 141
XP_003407599  84 FRFRFGRQDDGDEATRFLPADGEKTSG-PLGSLAEELTGYSRKKGGFSFRFGR 135
P83862        82 FQLRLGRQDDGSEATGLLLGEAEKVGG-LLGTLAEELNGYSRKKGGFSFRFGR 133 cattle
XP_003122292  82 FGLRFGRQDNGSEAAGFLPGDGEKASG-LLGTLAEELHGYSRKKGGFSFRFGR 133
XP_023602403 120 FGLRFRRQDDGLGEAGSLLADGKKAGS-QLGTLADEISGHNKNKGGFHFRFGR 171
XP_012914087  84 FTFRFGRQDDGSKATGFLPADGEKASG-PLGTLAEELSSYSRKKGGFSFRFGR 135
XP_850751     84 FRFRFGRQDDGSEATGFLPADGEKAHG-PLGTLAEELSSYSRKKGGFSFRFGR 135
XP_003794941  84 FRLRFRRQDEGSEGTSFLPVDGEKASG-LLGNLAEELNGYSRKKGGFSFRFGR 135
EGW00429      83 F--PPGRRDRSSQAAGFLPTDAEKASR-PLGTLAEELSSYSRRKGGFSFRFGR 132
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