6U62


Conserved Protein Domain Family
MAPKK1_Int

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pfam08923: MAPKK1_Int 
Mitogen-activated protein kinase kinase 1 interacting
Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer.
Statistics
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PSSM-Id: 462635
Aligned: 8 rows
Threshold Bit Score: 125.922
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6U62_F         3 DDLKRFL-YKKLPSVEGL---HAIVVSDRDGVPVIKVANDNA-PEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNT 77 
Q8WQG5         1 MNVQQEL-EELMLTYEGV---CAIFITDHDGGLILNIGLPSTlDNSRFRQQLIVSHVTTIPQIHKLDMGGHQTTFALYES 76  Caenorhabditis ...
XP_018645758   3 esacdYL-KRFLSEVDGI---LGIFVADKDGVVVASATMDDM-PDQARSPYVTAAFIVSLQQVNKLDLGDLEWMITSYQE 77 
Q29LB2         3 DDIKTYF-NGLLEKVSGL---HVIQITDRDGVPLLRVGQEKN-VDFALMPSFIPTFTTACDQASKLGLGRNKTIISMYSN 77  Drosophila pseu...
Q7QHZ1         3 DDVKRFF-HNIRKRVAGL---NCIIITDRDGVPLMKVGDDKS-LGMIMKPSFHTTFTMATEQSNKLGLGRNRNIISVYTG 77  Anopheles gambi...
Q4SSF5         3 DDLKRYL-YKQLQSVEGL---HAIVVTDRDGVPVVKVANDNA-PVPALRPGFLSTFALATDQGSKLGLSKNKSIICYYND 77  spotted green p...
OCA35458       3 EELRRFL-YKKLTSVDEL---HAIVVSDRDGVPVIKVANENA-PEHALRPAFLSTFALATDQGSKLGLSKNKSIICYYST 77 
Q86J23         2 EKVDEFLeYIKVSILDKSivdTSLILSDRDGFVLGKIIDKSSsADNVIDNSLISTFSSATDQASKLHAGNNKSIVSFFED 81  Dictyostelium d...
6U62_F        78 YQVVQFN-----RLPLVVSFIASSSANTGLIVSLEKELAPLF----EELRQVV 121
Q8WQG5        77 HQIAVHS-----IDKYYFIVHAGTNTNTGAMLSLREKLFPIG----SHMMSLC 120 Caenorhabditis elegans
XP_018645758  78 MVVCQFHftcqsALPLFLTVVGSSECNIGAIIALEPSIRPLL----NRLapea 126
Q29LB2        78 YQVVQMN-----KLPLILTFVGAENCNTGHILALEQQVDGYL----EDIKQAV 121 Drosophila pseudoobscura
Q7QHZ1        78 YQVVQMN-----KLPLLVTFIGTESCNIGHILALDQQIELVL----DEVKVAV 121 Anopheles gambiae str. PEST
Q4SSF5        78 YQIVQFN-----RLPLVISFIARSSANTGLIMSLENELAPLI----EELKQVV 121 spotted green pufferfish
OCA35458      78 YQVVQFN-----QLPLVVSFIASCNANTGLILSLEKELGSLF----KELRQVV 121
Q86J23        82 RIIVHIN-----VSNVILSIITDTESNVGLILGSQDDLIRSLtslsNSIQSDI 129 Dictyostelium discoideum
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