Conserved Protein Domain Family
BEX
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pfam04538: BEX 
Brain expressed X-linked like family
This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.
Links
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Statistics
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PSSM-Id: 461346
Aligned: 62 rows
Threshold Bit Score: 61.504
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001503090   1 MERVDKENEGKPE-NQGNSENEG-KPEDevdtedegksdeegkpavegqpghqgkpqnegqpddeaqpedegkqdkqgks 78 
XP_005614429  14 MKNTNQENEKK-D-EKEQDANKG-EHLAl--------------------------------------------------- 39 
XP_012013576  14 MENANEENEKKd--EKEQDANKG-EP-Lal-------------------------------------------------- 39 
XP_003435428  14 MENTDQENKKYd--EKEQSTNKG-EP-Lal-------------------------------------------------- 39 
XP_006163610  14 VENGNKEDEGKd--EKEQDANKG-EP-Mgr-------------------------------------------------- 39 
XP_006166113  14 MENAQKANE-----EQEQVANKG-EP-Vtl-------------------------------------------------- 36 
XP_012668634  14 MENAQKKHEGKe--EKDQVANKGeEP-Lal-------------------------------------------------- 40 
Q9BXY8        14 VENVNQENDEKd--EKEQVANKG-EP-Lal-------------------------------------------------- 39  human
XP_003802562  14 MDNTNQENEEKa--EKEQDANKG-EP-Lah-------------------------------------------------- 39 
ELK17708       1 MEKANQENRKKKKdEKGQDANKG-EP-Lg--------------------------------------------------- 27 

XP_001503090  79 edegkpqggegkresqakpeserraaekrpAEDYVPRKAKRKTDRG-TDDSPKDYQEDLQERHLGSEEMMREcGDMSRAQ 157
XP_005614429  40 -----------------------------pLETGECGVPRGNRGQIhVRQSILQYRWDMIQRLEEPQARMRE-ENMERIG 89 
XP_012013576  40 -----------------------------sLGAGEYCIPRGNRRWFrVRQPILHYRWDMTQRLGKPRARMRE-ENIERIG 89 
XP_003435428  40 -----------------------------pLETGEYCVPRVNRRRFrVRQPILQYRWDVFQRLEEPQGRMRE-ENMEKIG 89 
XP_006163610  40 -----------------------------pLEAGEHCVPRGNRRRFrVRQPVLQYRWDTLHRLGVPQARMRK-ENMERFG 89 
XP_006166113  37 -----------------------------pLEAREHCVPRGNRRRFrVRQPILQYRWDLMHRLGEPQARMRE-ENMGRFG 86 
XP_012668634  41 -----------------------------pLETGEYCVPRGNRRRFrARQPILQYRWDMMHRLGEPQARMRE-DNMERIG 90 
Q9BXY8        40 -----------------------------pLNVSEYCVPRGNRRRFrVRQPILQYRWDIMHRLGEPQARMRE-ENMERIG 89  human
XP_003802562  40 -----------------------------pL---EYSVPRGNRRRFrVRQPILQYRWEVMHRLGEPQARMRE-ENMERIG 86 
ELK17708      28 -----------------------------iKEAGGYYVPRGNSRQFpVRHPILQYRWDVIQRFGEPQARMRE-ENMERIG 77 

XP_001503090 158 EELRKK-QKMGGFHWMQ--------RDVQDPFAPR 183
XP_005614429  90 EEVRQLrEKQLSHSLRAvs----tdPPHHDHHDEF 120
XP_012013576  90 EEMRQLmQKLREKQLSHslravstdPPHHEHNDEF 124
XP_003435428  90 EEMRQLmQKLKEKQFSHslqavstdPPHRDHQDEF 124
XP_006163610  90 EEVRHLmEKLREKQLSHslqavsldPPHHGHRDEF 124
XP_006166113  87 EEVRHLmEKLREKQLSHslravsldPPHHGHRDEF 121
XP_012668634  91 EEVRQLmEKLREKQLSHslqavstdPPHHDHHDEF 125
Q9BXY8        90 EEVRQLmEKLREKQLSHslravstdPPHHDHHDEF 124 human
XP_003802562  87 EEMRQLmEKLREKQLSHslravstdPPHHDHRDEF 121
ELK17708      78 EQMRQLmRKLRVKQLSHslpavstdLCHHDHHNKF 112
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