Conserved Protein Domain Family
COG5001

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COG5001: COG5001 
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms]
Statistics
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PSSM-Id: 444025
Aligned: 941 rows
Threshold Bit Score: 310.938
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_089418051   6 DASSDRERPTVLLVDDEPVNLALVSAALGQYGFDVTETHNGEDALHMLGEWVPDLVILDALMPGLDGFETCRRLRARRGL 85  
WP_114593019 184 VRWMMSAGFALEAIAIIVLPQSMTGGRYAEQAVGTSLMLGGGVLLVTVLWIVANGYRPEADREPRTLRWWAPMTVAIISY 263 
WP_014161110 283 DEDRALLVYVAQHILTAVDRRQAHDELEDRIQERTHELQRANRELQAEVIERKRAEKLQGALFRITDLANTSPTLEQFYA 362 
WP_014437030   1 ---------------------------------------------MRVLAIDDTPAILADYEKIFSRGTGVRSDPDGRQL 35  
WP_051085153 299 FGVALFDPSAAAGIARLSFAATVLAGIVLMFYLSFRRYDRAILLMPAWALIVAWLFAGYMAVTGRIDNDIIQPALDGGMV 378 
BAN03723       1 ----------------------MGLADEHSDGIDEHDERSKPATSTETPELDAWSAVVDAMPIPGALVSVDGEVLAANRW 58  
WP_096298642 247 LRRDGRVCGAIVVQSYDVPQRYSQEDRALLEFVAQHILTALDRKQAHAELERRVDSRTLELQEANIGLQAQIAERGRAER 326 
WP_012564455 281 WLVFLGALVGLALFDPAVASGIARISLLLIAAAGFVLIVTLSTQGFDRAVLLIPTWFLFLIWVIAAGMTVTGAVTNDIVG 360 
WP_084244618 304 LAGLVALVVIALIDASIASGIARLSLVGIALLGFGLVVYLSTHGYDRAVLLIPTWFLLLVWAIALVMTVTGSVQNDIIGP 383 
WP_007510846 275 RHDLELLNYVAQHVQTALERREAHLELGRRVTDRTAALREANRVLRQQVLQRQRGERLQAALFRIAELANTSDSLDKFYA 354 
WP_089418051  86 EDLPVLMLTGLDDDASIERAYRAGATDFIVKSSQWSLLAGRLHHMLRAARTHQELVRSRARLARAQDLARMGSFDWRYRP 165 
WP_114593019 264 VAHTGVRRFRPEAGFDPVELVLVTVAGLTLVLRVVRMVRTERLLSRRLDADRLQLETLLHDVQDNILIVDRDFVVVRQVG 343 
WP_014161110 363 AVHAVVDELIVARNFYIALLDEDGQALHFPYSIDERDPVRQSRQVSRGLTEYVIETGAPLLADPAVIATLTRSGKAVQHG 442 
WP_014437030  36 DAMEAALFGPEAGAVDAPAEADAVRVSVAGSGRDGLRLVEAAVRAGTPFDVAFVDMRMPGGWDGIETIRHLFAADPGLQV 115 
WP_051085153 379 LIVLLLGFTVIQHAFAGGVYQPGLFSDLERQALAFLGTDATVWDWDVGRDRIVTEPDFAPKLGLAPGALNGPARTWLQYL 458 
BAN03723      59 LDVAVGDPLFREEPLDHIVPLRSGVDGARWRARPIDERGDVLLATQEHEDAGDHLLRRFFANGDALFVVYDQAGLIIESN 138 
WP_096298642 327 LQRALYRISELSVAAGSIERFYADVHGIVGELLYAANFYIAMLSPDGQRLEFPYSVDERDAPRRPRARANGLTEYVIESG 406 
WP_012564455 361 PALLGGLVLIVMLIGFTVMQHAFAGGATTGIVSDVERRALALTGSGDLIWDWDVSADKVFTSPETEGLLGLKRGTLEGPA 440 
WP_084244618 384 ALLGGLVLIVMLIGFTVMQHAFAGGITHNIVTDVERRALALTGAGDMIWDWDVSADRIYTSPETEHLLGLKRGSLEGPAA 463 
WP_007510846 355 AMHQVISGLLYARNFYIALIDEENGHLTFPYSVDDMDSVRPPRAHGRGATEYVLRHAKPLLATPAEIDRLSALGEISLFG 434 
WP_089418051 166 RLPVIQGLEWSAEALHVFGYTSDEALSLHSLLRQMQPDDRRALLITLRRVLRHVFPVAMDVPMRRAPGGLRiihveaepe 245 
WP_114593019 344 HRLEEGPGLADIVLLDFVHPEDRESMWIDKAAAARAPGTSISREVRLVIDGQLRWIEGVMVDRFDTPSVGGlvvt----- 418 
WP_014161110 443 PAAHSWLGVPLLQGHETRGCVVVQSYSPQVRYTAHDQNLLTFVAHHIGNGLSRQRARESLRAAHLELERRVeertfelae 522 
WP_014437030 116 VVATAFSDRSLGEVGRSFRRNDQLLILKKPFDAVEVRQAAAALAAKRRMTKAAAERVEELDAKVAARTEQI--------- 186 
WP_051085153 459 HPADRDRFRSTLDLFLEWRRGRLKLEFRVRANDGHYHFMTIRARPVLSSDGEVIRCVGTLNDQTDHKVSTQ--------- 529 
BAN03723     139 AAWEELLGYTTEEIFGIDSWSLLPDDEVSDRERVERELREDGRSETCFQMRTADGSYRRVRWTLQFDISVGrcfg----- 213 
WP_096298642 407 VPLLARRENIEKLEASGRLQSRGTHAQSWLGVPLHRDGRTVGAIAVQSYAEQIGFAPSDQTLLTFVAHHIDialerkraq 486 
WP_012564455 441 ARWLEVLHPLDQDRFRAALDSVLDQRRGRLVQDFRLRTPDGHFMWFALKARPVVGSDGEVARVVGTLSDVT--------- 511 
WP_084244618 464 RWLDVLHVLDRDRFRAALDSVLEQRRGRLMQDFRLRTPEGNYLWFALKARPVVGSDGEVVRLVGTLTDVTE--------- 534 
WP_007510846 435 ARSVCWLGVPLIWGGKAMGVLALQSYSPEHTYNERDQELLTFVSYHIANALQRKQAATALKQAYAGLERRVtertralal 514 
WP_089418051 246 fgdl---------------gqclgytgiiqdVTERHLAEDSIRRLANKDSLTQLPNRRQLQWRAEKALEQ-AR-R----- 303 
WP_114593019 419 ----------------------------frdITDRRIAQEDLRRRAMYDQLTGLASRDTLRSVAAELLQG-A--T----- 462 
WP_014161110 523 -----------------------anaklmaqIGERLRAEQRLTYQATHDALTGLPNRALLLDSLAEAIAR-AG-Ag---- 573 
WP_014437030 187 ------------------------------------------RRMSLQDALTGLPNRQALLERLGVLVEE-ERaRreaag 223 
WP_051085153 530 ----------------------------------------RLLQDAVIDNLTGLPNHTILIDRLQSLIAL-SR-A----- 562 
BAN03723     214 ---------------------------igrdVTEEDMVTAELEHRATHDELTGVANRSQLVAHLDEVIDA---------- 256 
WP_096298642 487 ealkaahtelefrvdartreleeanrelraqIGERVRAQQRLVHQARHDPLTGLPNRVQLLERLNTALAS-SE-S----- 559 
WP_012564455 512 ---------------------------------EIKNAEERMLHDSVHDNLTGLPNRQLFIDRLTALAGF-IK-T----- 551 
WP_084244618 535 ----------------------------------FKTAEERLLHDAVHDNLTGLPNRQLFIDRLEAVMAF-AK-S----- 573 
WP_007510846 515 -----------------------anrdlreqIAERERVERRLKYETLHDSLTGLPNRTLLLQRLEQAMQRyAA-N----- 565 
WP_089418051 304 ---------M-GH-RMALLLIDLDRFKKVNDTLGHTAGDELLIEVAHRLRSC-VRHSDqiidgnidmagvrlhrmleAVG 371 
WP_114593019 463 ---------S-TC-PVSMLYCDLDRLKVVNDSLGHHVGDEVISAVAERWNAL-LPPRA-------------------TLS 511 
WP_014161110 574 ---------Q-GG-HFAVLFMDLDRFKLVNDSIGHAAGDELLIEVARRITSQ-VRDGD-------------------LVA 622 
WP_014437030 224 agsprgetaD-GR-GFALLFLDFNRFKLINDSLGHAVGDRLLLSITRRIHAL-ERSFQ-------------------AgA 281 
WP_051085153 563 ---------A-PHlHPTLIVADIDRFKEINETLGFAAGDNILIALTRRIQRL-LKPED-------------------TLS 612 
BAN03723     257 -----------GG-HPSLLFCDLDRFKVVNDSLGHLAGDQVLAQLAQRIDSLdLGDDA-------------------LVS 305 
WP_096298642 560 ---------R-QE-PFAVLFLDLDRFKLVNDSAGHTAGDAMLVEIAQRISAL-LGPQD-------------------MAA 608 
WP_012564455 552 ---------ApNL-RPTVMVIDLDRFKQVNDSVGIAVGDSILLTLARRLTRI-LKPQD-------------------TLA 601 
WP_084244618 574 ---------DaNI-RPTVVVIDLDRFKQVNDSVGIAVGDSILLTLARRLGRL-LKPQD-------------------TLA 623 
WP_007510846 566 ---------P-GE-QFAVLFIDLDRFKVINDSVGHLVGDDLLFQVGGRIRAC-LKTRD-------------------VVA 614 
WP_089418051 372 ------------------RLGGDEFVALLPEIRQDSDAERVAQRMLHALRAPVSIDGQDLIATASIGVALYPRDG-HSVA 432 
WP_114593019 512 ------------------RFGGDEFVICYPHERGRLDALEFAEALLRDLRTPLRIADNELTVSASIGVTTITAGG-TTID 572 
WP_014161110 623 ------------------RLGGDEFAMVIHYHTDALEVTEFAARLLEALNRPIWVAGRELFPAASIGIATWHPRY-TGGE 683 
WP_014437030 282 aeaaagctmpiggpltgyRLGGDEFVLLLERVPCLGAASEVALAAIDLFAEPHELRPHACVSTASIGLATSFREH-LDAG 360 
WP_051085153 613 ------------------RIWGSSFAIILQSQNDPDAIAEFTDALTAAIDVPITFENREIALTAAIGIASWHDDH-ETAE 673 
BAN03723     306 ------------------RFGGDEFIVMLDDGGE-ARARLVAARLLDCLERPFEALGRTVHLTMSIGICFQNKENlRTVD 366 
WP_096298642 609 ------------------RLGGDEFAVVLGGVDDPGDADAMAAALLETLSRPMWVAGRELYPSASIGIALSH-PG-ADAG 668 
WP_012564455 602 ------------------RIGGDQFGLLLTSEHEPARITALAETIRKTIRAPIAFNEREIFLTASIGLALSDPQA-PLTD 662 
WP_084244618 624 ------------------RLTGDQFAMIVLSERDPTRLIAFAETIRRTLRAPITFNDREIFLTASIGLALGDGQP-SRTE 684 
WP_007510846 615 ------------------RLGGDEFAVLLEGIVETGKATLIAERIISELQTPFRLGTKEIFTSASIGIALARPHY-RQPE 675 
WP_089418051 433 ELMRAADVAMYAAKERGRN----SCVTYTPLLSERGREKLELESALYKAIGRQQLILHYQPKIDIHTNAMVGVEALMRWD 508 
WP_114593019 573 EALRDADAALYEAKGAGRN----QIKEFDPAMRRSALERLHLEQELRRALRAGDVVVHLQPIVDLATGLPESFEALVRWH 648 
WP_014161110 684 EMLRDADAAMYRAKAQGRD----RSAVFDEAMREVAMKSLDLEADLRRAIKGRDFSPHYQPIVRLSDGQVIGHEALLRWH 759 
WP_014437030 361 ELLRDSDLAMFAAKAQGREtgrpACVAYEGAMHAAAQRRLTLENDLRTALDGSALDLRYQPILDSGDGRTVGVEALLAWT 440 
WP_051085153 674 AFLEDARLAMLRAKRMGGN----TVETYRPALRMLDDERKQLQGDLGRAIDRQEMTVLYQPIVKFDGQKLAGFRCSLNWK 749 
BAN03723     367 EMLRDADRAAYEAKSLGRK----RCVIFDEGLRDEAERRFEIEAGLRRAFDHGEIVAHFQPIVSVPDGEIVGAEALVRWQ 442 
WP_096298642 669 GLLRDADAAMYRAKACGRD----RSERFDEAMRAEATRLLDLEADLRRAILQDAFEPYFQPIVRLADGVVIGHEALLRWR 744 
WP_012564455 663 EIIKDAELAMYHSKRLGGD----RIDVYKPPMRSRKTDRLTLESDLRRAIERQEIAILYQPIMRLEDRTVAGFEALARWD 738 
WP_084244618 685 ETLKDAELAMYHAKRIGGD----RIELFKPAMRARKTDRLTLESELRRALEREEITLVYQPIVRLEDRSVAGFEALARWD 760 
WP_007510846 676 ELLRDADAAMYNAKDGGRH----RAAMFDDRLRREALSLLDMESDLRHALSRNEFEPFYQPIVELADGRITGYEALLRWH 751 
WP_089418051 509 RgSDGGLVPPGEFIPLAEETGLIITLSEWALGEAARQAAVWRDQ--FGf-DGAVAVNMPSRMFLRQDLAQLIDKTLEPYG 585 
WP_114593019 649 T-EDRGWVPAPTIISLAEETGLIVPLGEQVLDLACEAIARIRRLt-Ga--PIRVAVNTSAMQLLRPGFGDTVRATLERHG 724 
WP_014161110 760 H-EHRGLLLPAQFIALGEDSGLIEQVDWLLYEQVAERIAH------GV--DGYVSVNVSPRHLRSPDFAERMLALFERAG 830 
WP_014437030 441 H-PRLGRIGNAEILGVAEEAGLINDLGRWVRRSALEAAGAIARAp-GIagAPPVHVNVSRRELLSPGFAAGVQIEAQEAG 518 
WP_051085153 750 H-PQRGDVSAGEIFELSRESSRSAELILYTVRQAANDLAGWQQSv-ANa-RPFVMVELSCNEMLKTSTLIELESIVRESE 826 
BAN03723     443 T-PEq-LVLPGEFLDVAADAGLLPRVSRLVISATVAAAERLAAG--Gr--PLQMSINVSDPELHIAGFAADLIDRVARAD 516 
WP_096298642 745 H-ELHGLLPPSEFIGVGEDTGLIEQVDWLMYRKVIGMMAS-R-----Yp-TGYVSINVSPRHFRAGDFAERLLQLVDDAG 816 
WP_012564455 739 H-PRLGRMSPSEFISIAEEIGLIVDLGLFVMDATAKQLSTWQRAtrTRv-PLFASVNVSSRQLLRHDLIHDVRGVLSRSA 816 
WP_084244618 761 H-PKMGRMSPSEFISIAEEIGLIVDLGLFVLERTARQLGAWQRQvrTRe-PIFCSVNVSSRQLLRHDLIHDLRTVLSRSG 838 
WP_007510846 752 H-PERGLLPPHDFLLIAEECGCAEAIDWQIFEQVCTQAVRLI----Gt--DGFISINVSGRHFRSADLDLRLLALFDQYA 824 
WP_089418051 586 IPSHMLVLEITESSLMQDLERILPILQNLNDRGVQISVDDFGTGYSSLQYLTELPISELKVDRSFVENMAVK---PKAVE 662 
WP_114593019 725 LPSDALVLEVTESILLDEEGLARGTLRDLHVQGVSISLDDFGTGYSSLSYLGTFPLDQLKLDRALVTGTAET---ATGAA 801 
WP_014161110 831 ANPAQLRVEITETALLDDAPRTLHMLQLLREHGALAQLDDFGTGFSALSYLHRFPISALKIDRSFISGISSEy-rPESVG 909 
WP_014437030 519 LPLHRLVLEVSEVGIDRQSEPVSVAIRELHAAGLAVVLDDFGRERSPLAFLAGLPLRAVKIDRFFISGLGGD---TARFQ 595 
WP_051085153 827 VAPRQIVFSIPEDIVQEAPEQAKLALQYLRTIGVGVTLSGFGNGHGSLTLLKSFRFDATYVDSAIFK--YNQ---EPQAE 901 
BAN03723     517 LDPSMFLIEVTESMVLT-TGRAIEVLGELRAAGFRIALDDFGTGFSSLAHLRELPVDVVKVDRTFVADLLDD---EVAYA 592 
WP_096298642 817 ADATRLRIEITEVALLDDAPRALRMLNTLRERGVLAMLDDFGTGFSALSYLHRFPIRALKIDQSFVQGLGSDl-hAESLA 895 
WP_012564455 817 VARGSLKLELTESLVMENPEHAAQMLQRIKELGTGLSLDDFGTGHSSLSYLQRFPFDTIKIDQSFVRT-TRN---GARPT 892 
WP_084244618 839 LARGSLKLELTESLVMENPEHAAQLLTRIRELGAGIALDDFGTGHSSLAYLQRFPFDTIKIDQSFVRT-NNK---GTRPV 914 
WP_007510846 825 VPTRCIRIEVTEHALLENPTQVKQMLQNLRSHGVGIALDDFGTGYSSLSYLHQYPFETLKIDRSFITELPPDdaeTQGLA 904 
WP_089418051 663 VINLIVSLARSLNLRVVAEGVETLPQASLLRSLDCNIMQGYLFSRPLPGD-K-L-A-E--W-AMT----HL-Q 723 
WP_114593019 802 VLAGIIRITQNLGLPVVAEGLENLADVKRLRGLGATLGQGWHYARAMAPQ-D-A-L-D--WaLARvtdgQRtE 868 
WP_014161110 910 LVRAILALAGTLGIQTVAEGVETSEQLQALRGLGCDYAQGYLLGRPGPVLgE-----K--V-L---------- 964 
WP_014437030 596 VLQAIIGFARAMGLATLACGVETPEQLAGVQGIGLDHVQGNLTGPPVTLE-E-L-C-SgpeaLTR----RS-A 659 
WP_051085153 902 IVKAFSELAERLGTAIGISDLDNEADAKAFAEAGCTYATGPIYGAAVVSS-A-A-I-R--L-VRE----NG-A 962 
BAN03723     593 VTTSLVTLCDALGLDVIMEGIETPLQASAVELIGCRLAQGFLYHHAMPIS-E-L-E-R--L-VGS----TElq 654 
WP_096298642 896 LVRAILALAGTLGIDAVAEGIETQAQRDMLGELGCQYGQGYLYGRPAPp------------------------ 944 
WP_012564455 893 LLKSIIAMAHDLGMEVVAEGAETDSDAVELYQLGCQYAQGFAFGEPMDAA-S-A-T-R--L-LTG----DK-T 953 
WP_084244618 915 ILRSIISLAHDLGMDVVAEGAETDSDAVELYQLGCEYAQGYVFGEPMSPE-A-A-R-K--L-LQS----EH-L 975 
WP_007510846 905 LVRAIQVLADSLRMKVIAEGIEEESQRQALLRVGCRYGQGFLFAEAQPAS-TwLgAdKplL-L-A-------- 966 
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