2Z5L,2FR0,3MJC,2VZ8,3QP9


Conserved Protein Domain Family
PKS_KR

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smart00822: PKS_KR 
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This enzymatic domain is part of bacterial polyketide synthases.
It catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
Statistics
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PSSM-Id: 214833
Aligned: 1716 rows
Threshold Bit Score: 79.8337
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2Z5L_A        260 GTVLITGGMGAIGRRLARRLAAEGAERLVLTSRRGPEAPGAaelaeELRGHGCEVVHAACDVAERDALAALVTAY----- 334  Streptomyces ...
YP_334656    2139 GAYLVVGGTGGLGFASARWMVERGARRLTLASRSGELAVAArd---eiECWRATLGVAVDIVSCDVTDAAAVDAMiaaiv 2215 Burkholderia ...
ZP_03451904  1116 GAYLVVGGTGGLGFASARWMVERGARRLTLASRSGELAVAAr---dEIECWRATLGVAVDIVSCDVTDAAAVDAMiaaiv 1192 Burkholderia ...
ZP_04966561  2112 GAYLVVGGTGGLGFASARWMVERGARRLTLASRSGELAVAAr---dEIECWRATLGVAVDIVSCDVTDAAAVDAMiaaiv 2188 Burkholderia ...
YP_001060246 2139 GAYLVVGGTGGLGFASARWMVERGARRLTLASRSGELAVAAr---dEIECWRATLGVAVDIVSCDVTDAAAVDAMiaaiv 2215 Burkholderia ...
ZP_04901289  2139 GAYLVVGGTGGLGFASARWMVERGARRLTLASRSGELAVAAr---dEIECWRATLGVAVDIVSCDVTDAAAVDAMiaaiv 2215 Burkholderia ...
YP_001067508 2139 GAYLVVGGTGGLGFASARWMVERGARRLTLASRSGELAVAAr---dEIECWRATLGVAVDIVSCDVTDAAAVDAMiaaiv 2215 Burkholderia ...
ZP_02387463   357 AAYLVVGGTGGLGFASARWMVSRGARHLTLASRGGALAEPLcd---evERWRSELGVATHVVACDATDAAALARTmgeid 433  Burkholderia ...
CAJ87979     2104 GTYLITGGLSGLGAATAHLLADRGARHLALLSRSGSDTAGAq----SLLRELADRDVQATAHAADVTEEAALRRVldavd 2179 Streptomyces ...
AAK27473      990 GTYLVTGGTSGFGAAGARWLADRGVRRLALVSRRGPHAPEAa----GLLADLAARGVTATAYAADAADPDGMRRVirlid 1065 Streptomyces ...
2Z5L_A        335 ----PPNAVFHTAGILDDAVIDTLSPESFETVRGAKVCGAELLHQLTaDIKGLDAFVLFSSVTgTWGnAGQGAYAAANAA 410  Streptomyces ...
YP_334656    2216 rrdiPLKGVLHSAMAIDDGLVRNLDDARMAAVLAPKVAGAWNLHRAT-RSLPLDLFVVYSSATtYLGnPGQSNYVAANSF 2294 Burkholderia ...
ZP_03451904  1193 rrdiPLKGVLHSAMTIDDGLVRNLDDARMAAVLAPKVAGAWNLHRAT-RSLPLDLFVVYSSATtYLGnPGQSNYVAANSF 1271 Burkholderia ...
ZP_04966561  2189 rrdiPLKGVLHSAMTIDDGLVRNLDDARMAAVLAPKVAGAWNLHRAT-RSLPLDLFVVYSSATtYLGnPGQSNYVAANSF 2267 Burkholderia ...
YP_001060246 2216 rrdiPLKGVLHSAMTIDDGLVRNLDDARMAAVLAPKVAGAWNLHRAT-RSLPLDLFVVYSSATtYLGnPGQSNYVAANSF 2294 Burkholderia ...
ZP_04901289  2216 rrdiPLKGVLHSAMTIDDGLVRNLDDARMAAVLAPKVAGAWNLHRAT-RSLPLDLFVVYSSATtYLGnPGQSNYVAANSF 2294 Burkholderia ...
YP_001067508 2216 rrdiPLKGVLHSAMTIDDGLVRNLDDARMAAVLAPKVAGAWNLHRAT-RSLPLDLFVVYSSATtYLGnPGQSNYVAANSF 2294 Burkholderia ...
ZP_02387463   434 argtPLKGVLHSAMHIDDGLVRNLDDERFAAVLAPKVAGAWNLHRAT-RERALDFFVVYSSATtYLGnPGQASYVAANSF 512  Burkholderia ...
CAJ87979     2180 vtghALRGIVHAAMHMDDAVLSDLTDDRFAAVLAPKAAGATLLDHLT-ADRDLDLFLTYSSVSaSIGnPGQSAYAAANAY 2258 Streptomyces ...
AAK27473     1066 atghPVDGVLHCAMHLDDDPLADLTDERFAAVLTPKTTGAAVLERLL-ADRPLETFLLYSSDTtFLGnIRQAAYVAANLH 1144 Streptomyces ...
2Z5L_A        411 LDALAERrrAAGLPATSVAWGLWGG 435  Streptomyces fradiae
YP_334656    2295 LEALVEHrrAAGLPGTFMAWGPLED 2319 Burkholderia pseudomallei 1710b
ZP_03451904  1272 LEALVEHrrAAGLPGTFMAWGPLED 1296 Burkholderia pseudomallei 576
ZP_04966561  2268 LEALVEHrrAAGLPGTFMAWGPLED 2292 Burkholderia pseudomallei 406e
YP_001060246 2295 LEALVEHrrAAGLPGTFMAWGPLED 2319 Burkholderia pseudomallei 668
ZP_04901289  2295 LEALVEHrrAAGLPGTFMAWGPLED 2319 Burkholderia pseudomallei S13
YP_001067508 2295 LEALVEHrrAAGLPGTFMAWGPLED 2319 Burkholderia pseudomallei 1106a
ZP_02387463   513 VEALVEQrrEAGLPGTFMAWGPLED 537  Burkholderia thailandensis Bt4
CAJ87979     2259 LEALTRArrGAGRAGTALAWGPIGG 2283 Streptomyces ambofaciens ATCC 23877
AAK27473     1145 LEALARQrrQRGLPAQTLAWGAIDE 1169 Streptomyces verticillus
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