2LPB


Conserved Protein Domain Family
GCN4_cent
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cd12192: GCN4_cent 
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GCN4 central activation domain-like acidic activation domain
GCN4 was identified in Saccharomyces cerevisiae from mutations in a deficiency in activation with the general amino acid control pathway. GCN4 encodes a trans-activator of amino acid biosynthetic genes containing 2 acidic activation domains and a C-terminal bZIP domain, comprised of a basic alpha-helical DNA-binding region and a coiled-coil dimerization region.
Links
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Statistics
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PSSM-Id: 213399
Aligned: 28 rows
Threshold Bit Score: 30.0563
Created: 6-Sep-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:2LPB: Saccharomyces cerevisiae GCN4 central acidic activation domain bound to Gall11, contacts at 4A
  • Comment:GCN4 and Gall11 form "fuzzy" complex with multiple possible binding orientations
  • Comment:Gall11/MED15 is a general cofactor of RNAP II-dependent transcription
  • Citation:PMID 3062377
  • Citation:PMID 1406662
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ## ##              ## ### ##    ###
2LPB_B         1 STDSTPMFE--YENLEDNS---------KEWTSLFDNDI-PVTTDD 34  Saccharomyces cerevisiae S288c
AAH42363      47 IADQTPTPTrfLKNCEEVGl-------fNELASSFEHEFkKAADED 85  human
NP_990235     47 VADQTPTPTrfLKNCEEVGl-------fNELASPFENEFkKASEDD 85  chicken
XP_448878     98 STDSTPMFDy-DDNQLAGNtvsgssdnpENWTSLFDDDV-EIKVED 141 Candida glabrata CBS 138
NP_001079255  47 VADQTPTPTrfLKNCEEVGl-------fNELASPFENEFkKASEED 85  African clawed frog
AAI63094      47 IADQTPTPTrfLKNCEEVGl-------fNELASSFEQEF-PKAQED 84  zebrafish
CAR24307     104 SADSTPLFE--LDAVESDP---------QGWNSLFDDDI-AVSVSD 137 Lachancea thermotolerans CBS 6340
NP_984085    113 SSDSTPLFE--FEGLGKTAd-------pKTWSSLFDDDI-PVTLED 148 Ashbya gossypii ATCC 10895
AET39536     118 SSDSTPLLG--LDGVDHSSn-------hKEWSSLFDDDI-PVTIED 153 Eremothecium cymbalariae DBVPG#7215
CCE94153      47 HDGLTPMFD--SDPALSAVsg-----eeSKWGSLFDDEI-PINPAD 84  Torulaspora delbrueckii

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