Conserved Protein Domain Family
trp

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TIGR00870: trp 
transient-receptor-potential calcium channel protein
The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
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PSSM-Id: 273311
Aligned: 14 rows
Threshold Bit Score: 797.752
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAD42069   27 RG-------------PAYM---FNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESK----TLNFN-------CVDYMGQ 79   house mouse
P19334     16 RL-------------DYDL---MMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQgt-dKFNIN-------CTDPMNR 71   fruit fly
CAB02410   12 EE-------------NYNI---QFADEYVLTETEKTFILACERGDIASVKVIIEENKgapeKFNIN-------CVDPMNR 68   urban bluebottle ...
BAA23599   17 RI-------------PLRI---VRAES-ELSPSEKAYLNAVEKGDYASVKKSLEEAEiy-fKININ-------CIDPLGR 71   Norway rat
CAA06911   17 RI-------------PLQI---VRAET-ELSAEEKAFLNAVEKGDYATVKQALQEAEiy-yNVNIN-------CMDPLGR 71   rabbit
CAA11261    9 R---------------------------DLNNEERQFLGAVARGDVGSVKQALAEAEer--fIDIS-------CKDSLGR 52   northern European...
BAA78478   27 Kg-------------KNEP----PPMESPFQGEDRNFSPQIKVN---LNYRKGLG------PSQQD--------PNRFDR 72   house mouse
AAD26363   27 Rg-------------KLDFgsgLPPMESQFQGEDRKFAPQIRVN---LNYRKGTG------ASQPD--------PNRFDR 76   human
AAC53398   37 KPhifttrsrtrlfgKGDSe-eASPLDCPYEEGGLASCPIITVSSVLTIQRPGDGPAsv-rPSSQDsvsagekPPRLYDR 114  Norway rat
CAB40138    9 K----------------GP----------WAQLQKLLISWPVGEQDWEQYRDRVN------MLQQE----------RIRD 46   rabbit
AAD42069   80 NALQ-LAVGNEHLEVTELLLKKEn-----------lARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLspleqelr 147  house mouse
P19334     72 SALI-SAIENENFDLMVILLEHN-------------IEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYs------- 130  fruit fly
CAB02410   69 SALI-SAIENENFDLMIVLLEEG-------------IDVGDALLHAISEEYVEAVEELLQWEETHHKEGTPYs------- 127  urban bluebottle ...
BAA23599   72 GLLFsLAIENENLELIELLLSFN-------------VYVGDALLHAIRKEVVGAVELLLNHKKAQRREAGAS-------- 130  Norway rat
CAA06911   72 SALL-IAIENENLEIMELLLNHS-------------VYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPT-------- 129  rabbit
CAA11261   53 SSLV-IAIENENDDLVSLLLNYD-------------VDLEDSLLHAIREEYVVAVEMILTHQLKKFGEDY---------- 108  northern European...
BAA78478   73 DRLFsVVSRGVPEELTGLLEYLRrtskyltdsayteGSTGKTCLMKAVLNLQDGVNACILPLLQIDRDSGNPq------- 145  house mouse
AAD26363   77 DRLFnAVSRGVPEDLAGLPEYLSktskyltdseyteGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPq------- 149  human
AAC53398  115 RSIFdAVAQSNCQELESLLPFLQrskkrltdsefkdPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLk------- 187  Norway rat
CAB40138   47 SPLLqAAKENDLRLLKILLLNQScdf-------qqrGAVGETALHVAAL--YDNLEAATLLMEAAP-------------- 103  rabbit
AAD42069  148 dddFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIErphdYFCKCNECTEKQRKDSFSHSRSRMNAYKGLAS 227  house mouse
P19334    131 ---WEAVDRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPmphdVKCGCDECVTSQMTDSLRHSQSRINAYRALSA 207  fruit fly
CAB02410  128 ---WEAVDRSKSTFTPDITPLILAAHRNNYEILKILLDRGATLPmphdVKCGCDECVTSQETDSLRHSQSRINAFRALSA 204  urban bluebottle ...
BAA23599  131 ----HPPWQTFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPrpheVRCNCVECVSSSDVDSLRHSRSRLNIYKALGS 206  Norway rat
CAA06911  130 ----LMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPrphqIRCNCVECVSSSEVDSLRHSRSRLNIYKALAS 205  rabbit
CAA11261  109 ----LQIEFKSNTFTADITPIILAGHIDNYEIIKMLLDRGYRIPkphdLTCHCDDCLRGSLVDVLGHSRARINAYRALAS 184  northern European...
BAA78478  146 ---PLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANVH----IRACGRFFQKHQG-TCFYFGELPLSLAACTKQ 217  house mouse
AAD26363  150 ---PLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVH----ARACGRFFQKGQG-TCFYFGELPLSLAACTKQ 221  human
AAC53398  188 ---QFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQ----AAANGDFFKKTKGRPGFYFGELPLSLAACTNQ 260  Norway rat
CAB40138  104 ---ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVS----ARATGAAFRRSPH-NLIYYGEHPLSFAACVGS 175  rabbit
AAD42069  228 AAYLSLSSEDP-----VLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVN--LQVW 300  house mouse
P19334    208 SSLIALSSRDP-----VLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEpsHDIW 282  fruit fly
CAB02410  205 SSLISLSSRDP-----VLTAFELAWELKRLQAMESEFRAEYGEMRHGVQEFVTSLLDHARTSTELEVMLNFNHEasNDIW 279  urban bluebottle ...
BAA23599  207 PSLIALSSEDP-----FLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDn--SLI 279  Norway rat
CAA06911  206 PSLIALSSEDP-----ILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDh-sEEL 279  rabbit
CAA11261  185 PSLIALSSKDP-----ILTAFELSWELRNLSEMENEFRAEYEELGITCQNFAVDLLEQIRGSKELEVILNHDCRs-pDQD 258  northern European...
BAA78478  218 WDVVTYLLENPhqpasLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLtpLKLA 297  house mouse
AAD26363  222 WDVVSYLLENPhqpasLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLtpLKLA 301  human
AAC53398  261 LAIVKFLLQNSwqpadISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLtpLALA 340  Norway rat
CAB40138  176 EEIVRLLIEHGa---dIRAQDSLGNTVLHILILQP-----NKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLtpFKLA 247  rabbit
AAD42069  301 SDHHRPSLSRIKLAIKYE-------VKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAP 373  house mouse
P19334    283 CLGQRQTLERLKLAIRYK-------QKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAP 355  fruit fly
CAB02410  280 TPGQRQTLERLKLAIKYK-------QKTFVAHPNVQQLLAAIWYEGLPGFRRKKSSQQILEVIKLGCMFPINSMNYLMAP 352  urban bluebottle ...
BAA23599  280 EEQSGNDLARLKLAIKYR-------QKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAP 352  Norway rat
CAA06911  280 DPQKYHDLAKLKVAIKYH-------QKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISP 352  rabbit
CAA11261  259 EEKELKKLSRLKLAIKYK-------QKKFVAHPNCQQLLAAKWYEGLGNFRRKPILKQLTVAFGILFGFPILSGIYMIAP 331  northern European...
BAA78478  298 AKEGKIEIFRHILQREFSgly-qplSRKFTEWCYGPVRVSLYDLSSVDSWEKN-SVLEIIAFH-C--KSPHRHRMVVLEP 372  house mouse
AAD26363  302 AKEGKIEIFRHILQREFSgls--hlSRKFTEWCYGPVRVSLYDLASVDSCEEN-SVLEIIAFH-C--KSPHRHRMVVLEP 375  human
AAC53398  341 ASSGKIGVLAYILQREIHepecrhlSRKFTEWAYGPVHSSLYDLSCIDTCEKN-SVLEVIAYSSS--ETPNRHDMLLVEP 417  Norway rat
CAB40138  248 GVEGNTVMFQHLMQ-----------KRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSS----KKREARQILEQTP 312  rabbit
AAD42069  374 CSKLGQTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVktlp--netFTDYPkqifrVKTTQFSWTEMLIMKWVLGMI 451  house mouse
P19334    356 DSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITfellafpwmLTMLEdwrkhERGSLPGPIELAIITYIMALI 435  fruit fly
CAB02410  353 ESDAGKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITfellafpwmIEMLDdwrkhERGSLPGPIELGIITYISSLV 432  urban bluebottle ...
BAA23599  353 KSPLGLFIRKPFIKFICHTASYLTFLFLLLLASSTS------------------------T----------------GFI 392  Norway rat
CAA06911  353 RSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIV------------RTDLH-----VQGPPPTVVEWMILPWVLGFI 415  rabbit
CAA11261  332 HSKFGKLCRKPFIKFLLHSASYLSFLVLLILVSQRIENPFfflfpmkeeKKISE-----LRGSPATIVELMILGYVIGLI 406  northern European...
BAA78478  373 LNKLLQEKWDRLIPR-FFFNFACYLVYMIIFTIVAYHQPS----------------------LEQPAIPSSKATFGDSML 429  house mouse
AAD26363  376 LNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPT----------------------LKKQAAPHLKAEVGNSML 432  human
AAC53398  418 LNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRP-----------------------VEGLPPYKLKNTVGDYFR 474  Norway rat
CAB40138  313 VKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLklr---ddnRTDPRd----ITILQQKLLQEAYVTHQDNIR 385  rabbit
AAD42069  452 WSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAqlyvdqyvqdvtlhnvslppevayFTYARDKW 531  house mouse
P19334    436 FEELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDlwfr-----------------gidPYFPREHW 498  fruit fly
CAB02410  433 LGELKSLYSDGLFDYIMDLWNIVDFISNMFYVTWILCRATAWIIVHRDlwfr-----------------dinPYFPREHW 495  urban bluebottle ...
BAA23599  393 WGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------------------ALNPRESW 446  Norway rat
CAA06911  416 WGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYN--------------------------GSRPREEW 469  rabbit
CAA11261  407 WSEIKQIWMQGALEYIHDMWNIMDLVTNSLYMATFTLRLLAWLQVRRErael-----------------npyAFEERKHW 469  northern European...
BAA78478  430 LLGHILILLGGIYLLLGQLWYFWRR--RLFIWISFMDSYFEILFLVQA------------------------LLTVLSQV 483  house mouse
AAD26363  433 LTGHILILLGGIYLLVGQLWYFWRR--HVFIWISFIDSYFEILFLFQA------------------------LLTVVSQV 486  human
AAC53398  475 VTGEILSVSGGVYFFFRGIQYFLQR--RPSLKSLFVDSYSEILFFVQS------------------------LFMLVSVV 528  Norway rat
CAB40138  386 LVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYA------------------------SLVLLTMV 441  rabbit
AAD42069  532 WPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVK-DIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYN 610  house mouse
P19334    499 HPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMII-DIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKN 577  fruit fly
CAB02410  496 HPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMII-DIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKN 574  urban bluebottle ...
BAA23599  447 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEETKGl 525  Norway rat
CAA06911  470 EMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYETRAID 548  rabbit
CAA11261  470 DAYDPNLIAEALFAGANIFSSLKLIYIFTVNAHLGPLQISLGRMVS-DIVKFISVYFLVLFSFACGLNHLYWYYAALRAE 548  northern European...
BAA78478  484 LRFVETEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILrDLLRFLLVYLVFLFGFAVALVSLSREARSPKAP 563  house mouse
AAD26363  487 LCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILrDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAP 566  human
AAC53398  529 LYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILrDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLP 608  Norway rat
CAB40138  442 MRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFgDLMRFCWLMAVVILGFASAFHITFQTEDPNNLG 521  rabbit
AAD42069  611 ----------------------PAFTTVEESFKTLFWSIFGLSEVisvvLKYDHKFIENIGYVLYGVYNVTMVVVLLNML 668  house mouse
P19334    578 kcyhlhpdvadfddqekactiwRRFSNLFETSQSLFWASFGLVDLvsfdLAGIKSFTRFWALLMFGSYSVINIIVLLNML 657  fruit fly
CAB02410  575 kcyhlhpdvadfddqekactiwRRFSNLFETSQSLFWASFGLVDLvsfdLAGIKSFTRFWALLMFGSYSVINIIVLLNML 654  urban bluebottle ...
BAA23599  526 sckgi-----------rcekqnNAFSTLFETLQSLFWSIFGLINLyvtnVKAQHEFTDFVGATMFGTYNVISLVVLLNML 594  Norway rat
CAA06911  549 epnnckg--------ircekqnNAFSTLFETLQSLFWSVFGLLNLyvtnVKARHEFTEFVGATMFGTYNVISLVVLLNML 620  rabbit
CAA11261  549 eceagit--------hscdikyRSFANLFEILQSLYWAVYGLVDLehahLDEPHKLTELIGKLMFGSYSMIAIIILLNLL 620  northern European...
BAA78478  564 ensnttvtek---ptlgqeeepVPYGGILDASLELFKFTIGMGEL----AFQEQLRFRGVVLLLLLAYVLLTYVLLLNML 636  house mouse
AAD26363  567 tgpnatesvqp-megqedegngAQYRGILEASLELFKFTIGMGEL----AFQEQLHFRGMVLLLLLAYVLLTYILLLNML 641  human
AAC53398  609 mestphkc------rgsackpgNSYNSLYSTCLELFKFTIGMGDL----EFTENYDFKAVFIILLLAYVILTYILLLNML 678  Norway rat
CAB40138  522 ef--------------------sDYPTALFSTFELFLTIIDG-------PANYSVDLPFMYCITYAAFAIIATLLMLNLF 574  rabbit
AAD42069  669 IAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSpksf--yylIMRIKMCLIELCqskAKRCEnDLEM 746  house mouse
P19334    658 IAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPN---------MKMLRKTLGRKR---PSRTK-SFMR 724  fruit fly
CAB02410  655 IAMMSNSYQIISERADVEWKFARSQLWMSYFEDGGTVPPPFNMFPS---------VKLMRKVFGKQR---PKRSR-SFML 721  urban bluebottle ...
BAA23599  595 IAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSpksl--wylVKWIWTHLCKKM---MRRKPeSFGT 669  Norway rat
CAA06911  621 IAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSpksf--lylGNWFNNTFCPKRdpdGRRRRhNLRS 698  rabbit
CAA11261  621 IAMMSNSYQLIYSQADEEWKFARSRLWISYFAEGATVPPPFNIIPSpksf--tnmMTLFKSLILSHT---AEQKQaKWTN 695  northern European...
BAA78478  637 IALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRR-KRHRAGrll-------kvgTKGDGIPDerwCFRVEeVNWA 708  house mouse
AAD26363  642 IALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCR--KKQRAGvml-------tvgTKPDGSPDerwCFRVEeVNWA 712  human
AAC53398  679 IALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR-KAFRSGkll-------qvgFTPDGKDDyrwCFRVDeVNWT 750  Norway rat
CAB40138  575 IAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGyeyglgdrwFLRVENHHDQNPlrvLRYVEaFKCS 654  rabbit
AAD42069  747 GMLNSKFRKtryqagmrnsenltanstfskptrYQKIMKRLIKRYVLKAQVDRE-NDEVNEGELKEIKQDISSLRYE 822  house mouse
P19334    725 KSMERAQTL------------------------HDKVMKLLVRRYITAEQRRRD-DYGITEDDIIEVRQDISSLRFE 776  fruit fly
CAB02410  722 KSRVKAQSL------------------------HERVMKLLIRRYITAEQRHRD-DFGITEDDIIEVRQDISSLRFE 773  urban bluebottle blo...
BAA23599  670 IGRRAADNLrrh-------------------hhYQEVMRNLVKRYVAAMIREAKtDEGLTEENVKELKQDISSFRFE 727  Norway rat
CAA06911  699 FTERHADSLiqn-------------------qhYQEVIRNLVKRYVAAMIRNSKtNEGLTEENFKELKQDISSFRYE 756  rabbit
CAA11261  696 VRSTVKNINkre-------------------irYQYVIRNLISRYIMNKQRPQK-DEMVSQDDINELKQDISTFRFE 752  northern European squid
BAA78478  709 AWEKTLPTLse--------------------dpSGAGITGYKKNP----TSKPG--KNSASEEDHLPLQVLQSH--- 756  house mouse
AAD26363  713 SWEQTLPTLce--------------------dpSGAGVPRTLENPVLASPPKED--EDGASEENYVPVQLLQSN--- 764  human
AAC53398  751 TWNTNVGIInedpgncegvkr-tlsfslrsgrvSGRNWKNFALVPLLRDASTRD--RHATQQEEVQLKHYTGSLKPE 824  Norway rat
CAB40138  655 DKEDGQEQLsek-------------------rpSTVESGMLSRASVAFQTPSLS--RTTSQSSN--SHRGWEILRRN 708  rabbit
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