1WWH,4LIR


Conserved Protein Domain Family
RRM_Nup53

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cd12722: RRM_Nup53 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in nucleoporin Nup53
This subgroup corresponds to the RRM of nucleoporin Nup53, also termed mitotic phosphoprotein 44 (MP-44), or nuclear pore complex protein Nup53, required for normal cell growth and nuclear morphology in vertebrate. It tightly associates with the nuclear envelope membrane and the nuclear lamina where it interacts with lamin B. It may also interact with a group of nucleoporins including Nup93, Nup155, and Nup205 and play a role in the association of the mitotic checkpoint protein Mad1 with the nuclear pore complex (NPC). Nup35 contains an atypical RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a C-terminal amphipathic alpha-helix and several FG repeats. This RRM lacks the conserved residues that typically bind RNA in canonical RRM domains.
Statistics
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PSSM-Id: 410121
Aligned: 17 rows
Threshold Bit Score: 150.694
Created: 7-Mar-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
homodimer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:1WWH; mouse Nup35 forms a homodimer, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # ##                            ###                  # #   ##### #    
1WWH_A        23 DDTWVTVFGFPQaSASYILLQFaQYGNILKHVMSn-tGNWMHIRYQsKLQARKALSKDGRIFGeSIMIGVKPCID 96  house mouse
XP_002107889 125 DECWVTIFGFPPsAATYILEQFsHYGVIVKHVMLa-nSNWMHIQYQfKIQAKKAISKSGRIFGnGIMVGVRPCID 198 Trichoplax adhaerens
XP_002596749 165 DETWVTVFGFPPaATSFILQQFsQYGNIVKHVIAs-nGNWLHLHYQsKMQAKKALSKNGKVFGgSIMVGVTLCID 238 Florida lancelet
XP_001624092  91 SQCWVTVFGFPPaATSYILQQFaQYGNIIRHEVVa-nKNWMHIQYQsKLQAKKALSKNGKVYSsNIMIGVMPCIE 164 starlet sea anemone
XP_007888305 164 DDTWITVFGFPPaSASYILLQFaQYGNILKHVMSn-nGNWMHIQYQsKLQARKALSKDGKIFGeAIMVGVKPCIE 237 elephant shark
PIK41976     204 DQTWVTIFGFPPsAASYILQQFsQYGNIQKHVVAs-nGNWMHLQFSsKLQAKKALSKNGKIFGgNIMIGATPCID 277 Japanese sea cucumber
PVD34006     135 DETWVTIFGFPPgATSFILQQFsQYGNILKHVLSa-eGNWMHVHFQsKLQAKKALSKNGKVYGgRMMIGVLPCID 208 Pomacea canaliculata
XP_013408984 199 DETWITVFGFPPnTASFILQQFsQYGNITRHVIAn-eGNWMHIHYQsKLQAKKALSKNGKVFG-NIMVGVTPCID 271 Lingula anatina
ELT94444     201 DETWVTIFGFPPaASSFILQQFsQYGNITKHIISp-dGNWMHLHFQsKLQAKKALSKNGKVFGnSIMVGVTACID 274 Capitella teleta
XP_018670857 180 DDTWVTVFGFPPsSASFVLQRFsQYGSILHHQMAadnGNWMHIHYEsRLQVKKAMSRNGKVVGtNVMIGVVPCID 254 vase tunicate

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