4EA3,5DHG,5DHH


Conserved Protein Domain Family
7tmA_NOFQ_opioid_R
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cd15092: 7tmA_NOFQ_opioid_R 
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nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.
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Statistics
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PSSM-Id: 320220
Aligned: 7 rows
Threshold Bit Score: 475.896
Created: 15-Dec-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Structure:4EA3: Human nociceptin/orphanin FQ receptor in complex with a peptide mimetic antagonist (C-24), contacts at 4A
  • Structure:5DHG: Human nociceptin/orphanin FQ receptor in complex with an antagonist (C-35), contacts at 4A
  • Structure:5DHH: Human nociceptin/orphanin FQ receptor in complex with an antagonist (Sb-612111), contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #  ##           ###### ##
4EA3_A       126 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 205
P41146        52 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 131 human
EMC83480      50 ITIVVVYSIVCIVGLVGNCSVMYVIVRFTKMKTaTNIYIFNLALADTLCLMTLPFQGTDTFLGfWPFGNvlCKIAISIDY 129 chicken
NP_001089156  44 VTIVVVYLIVCVVGLVGNCAVMYVIVRYTKMKTaTNIYIFNLALADALVLVTLPFQGTDIFMGiWPFGNvlCKIAIAIDY 123 African clawed ...
NP_991152     44 ITIAVVYMIVCVVGLVGNCLVMYVIIRYTKMKTaTNIYIFNLALADALVLATLPFQGTDVFLGfWPFGNalCKVVVSIDY 123 zebrafish
5DHG_A       126 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 205
5DHH_A       126 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 205

Feature 1          #                                            # #####                          
4EA3_A       206 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 284
P41146       132 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 210 human
EMC83480     130 YNMFTSTFTLTMMSVDRYIAICHPikALDIRtPHKAKVVNVCIWALASVFGIPAMVMGsa-enENNEIDCLIklpspvDY 208 chicken
NP_001089156 124 YNMFTSTFTLTMMSVDRYIAICHPvkALDIRtPHKAKVINVCIWILASFIGIPVMVMGsa-emENDEIECLVqipppeHY 202 African clawed ...
NP_991152    124 YNMFTSVFTLTVMSMDRYVAVCHPvkALDMRtPHKAKVVNICVWVLASAIGVPAMVLGdveqdNGESIECILvlpdprSY 203 zebrafish
5DHG_A       206 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 284
5DHH_A       206 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 284

Feature 1         #  ### ### ##                                                   #  ## ##  #    
4EA3_A       285 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 364
P41146       211 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 290 human
EMC83480     209 WDPVFGICVFLFSFMIPVLIITICYSLMIRRLknvrvlsgskeKDRNLRRITRMVLVVVAVFIICWTPIQIFVLVQclga 288 chicken
NP_001089156 203 WDPVFGICVFLFSFVIPVLIITICYSLMIRRLkkvrvlsgskeKDRNLRRITRLVMVVVAVFIICWTPIQIFVLVQslga 282 African clawed ...
NP_991152    204 WDPVFGTCVFLLSFLIPVAIISVCYSLMVKRLrsvrilsgskeKDRNLRRITRMVLVVVAAFVVCWTPIQIMALAQslgf 283 zebrafish
5DHG_A       285 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 364
5DHH_A       285 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 364

Feature 1              ## ###  #  ##                     
4EA3_A       365 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 404
P41146       291 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 330 human
EMC83480     289 kaeselELAISCFCTALGYANSSLNPVLYAFLDeNFKACF 328 chicken
NP_001089156 283 kpdsdlKVAILHFCIALGYVNSSLNPVLYAFLDeNFKACF 322 African clawed frog
NP_991152    284 nlasvqTVVFMHFCIALGYVNSSLNPVLYAFLDeNFKRCF 323 zebrafish
5DHG_A       365 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 404
5DHH_A       365 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 404

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