Conserved Protein Domain Family
Brme1

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pfam15710: Brme1 
Break repair meiotic recombinase recruitment factor 1
Brme1 (also known as Meiok21) is a component of meiotic recombination bridges involved in meiotic double-strand break repair. The C-terminal domain of Brme1 physically interacts with the N-terminal domain of HSF2BP. BRME1 facilitates the loading of RAD51 and DMC1 recombinases onto DSBs (DNA double-strand breaks) through interaction with MEILB2/HSF2BP and replacing ssDNA binding proteins. Brme1 is highly expressed in mice testes and fetal ovaries. Knockout of Brme1 results in male mice infertility.
Statistics
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PSSM-Id: 464816
Aligned: 8 rows
Threshold Bit Score: 753.297
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0VDD7         1 MTKRKKLRTS--GEGLCPPKPLKNPRLGDFYGD-PQSSMLGCLHHPEEPEGKLGPVPSTQQHGEEPGKAVS---SSPDEE 74  human
XP_021589581  39 MSKRKKLRTS--GEGVRPPKPPKNPRLGPSKGG-PESPDSGHLHHPEESEDSSGPAAFPELTGEEPRGAVS---SSPHEE 112
XP_005661300   1 MSKRKKLRTSggGEGIRPMKLPKISSLEDSDGV-PQSSKLGHLHHLEESEGRSGPAPSAEQSREEPEQVAS---SSPDTE 76 
XP_007640741   1 MNKKKQQRDS--GGDLPLSKPPKNPRLKDPHGS-PESSVLMQSQHSRESEDSSESAASVEPGGEEPQPAAS---SCPVED 74 
EHB14456       1 MSKRKKLRTA--GQGIHPPKPPKNPRPGDSNGG-SRSSKLGTLQHPNESEDISTPTTPTELSGQEPGPAVS---S--FSE 72 
XP_012033199   1 MSKRKKLRTSg-REGLHLRKLPKNPRIEDSDGAtSQSSLLDCLHHPEESEGGSGLTPSAEQSGEEPGQAAS---SSPDNE 76  sheep
XP_014321231   1 MSKRKKLRTP--GEGIRPPKPPKHPRLGDPDGD-PQSFQFGPLGHPEESKGSSGPVPSTEQSGEESGHEAS---SSPDKE 74  little brown bat
XP_017353152   1 ---mtkrklgtseEGICPSKPLKTPRIEDSDGD-LQSSTLGCLHHPEVLEGKLGPVPSTQQHGEEPGKAVSsspN---KE 73  
Q0VDD7        75 TGSPCRLLRQPEKEPAPLPPSQNSFGRFVPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVP 154 human
XP_021589581 113 TGAASRLLRQPEKEPTPLPPSQNSVGRFVPQFAKPRKTGTRKAETREEDAENGAVSSDTLPVPSAQQAGSLLLPESLGLA 192
XP_005661300  77 AAAPSRLLRQSEKEPVPFPLSQNSVGRFIPQFAKAKKTVTRQAERREEDPGGGAFSSETLPEPSVQQARNQPQEESPGLA 156
XP_007640741  75 TRAVSDLPGSPE-ELVSLPPSQNSVRRFVPQFAKSKKTITRKAKAWKEVPESCPGSQETWPELGALQAGSQPQKESLKFP 153
EHB14456      73 ETAAASLLEQLEKEASFFPDSQTSLGRFVPQFAKPGKIVTRKAKTMEEDTERRAVSLEALPNPSA----PWQLEGSLG-- 146
XP_012033199  77 ADAPSRLLGQPEKEPAPLPPSQNSVGKFVPQFAKPRKTVTRQAERREERLGMGVFSSGTLPEPSAQQTRSQPQEESPGLA 156 sheep
XP_014321231  75 AGAPSRSLSQPEKEPIPFPPSQNSDRRFVPQFAKPRKAVTRLAATREEDLGSGAFSLETPPEPSAQQAGSQSWQESPELT 154 little brown bat
XP_017353152  74 TGAPCRLLHQPEKEPAPLPPSQNSVGRFVPQFAKSRKTVPKTGGMKDEDLGSGPFSLETLPESSAQQAGCQPLVETLGLP 153 
Q0VDD7       155 LQEATELGDPTQADSARPEQSSQSPVQAVPGSGDSQP----DDPPDRGTGLSASQRASQDHLSEQGA---DDSK------ 221 human
XP_021589581 193 LQEARGPGEQTQADSPSTEQSGQNLEISVPGRGDSQP----LFSPEVGTGPSHPERASQNRLLEQSNsvmAGGNlgnsrp 268
XP_005661300 157 LQEARDPEDQIQADSTYPKLNSQSPM---PGSGDPQPsastSPSSECGSVPLASERTSQDHLSEHRRnmpDDGS------ 227
XP_007640741 154 FHDARRPEDQAWADGTCSKERTISPDTGSPGNSDFEM---------------------------QRTtvqDSDS------ 200
EHB14456     147 ------PRAQMPADNPHLEQSGQKPGTPVPGEG---------------TGSCNSEMASQDPVSEQGTstsDGGNlws--s 203
XP_012033199 157 PQEARDLGHQTQADGTCTKPSGLSPMTPGPSDADPQPsvstNTSPELGTVPSASERADQDYLSEPGTnvpKGGS------ 230 sheep
XP_014321231 155 ILEAWEPGDQTQTDGTHSEHSVQNAVTPVSSRGDSQPevsnDISSEWGMVPLVSESASQDCLLKQGTnlpDAGS------ 228 little brown bat
XP_017353152 154 LQEATEPGDPMQADGAHPKQSSQSPVKAVSSSGDSQP----EDPPGRGTGWSTSQRASQDHLLEQGT---DDSR------ 220 
Q0VDD7       222 -PETDRVPGDGGQKEHLPSIDSEGEKPDRGAPQEGGAQRTAGAGLPGGPQEEGDGVPCTPASAPTsgpapgLGPaswcle 300 human
XP_021589581 269 eTEMAWVPGDRGQKGHLPGSDAGGQGSDRGAPRGGGAQGRSGAELPPVPKDEGASRPHTAAPAPAvglaqeLSPatphlk 348
XP_005661300 228 -TEDDWAPGDHSQHKHLPGKAVEEKEPDQGAFQERDARGGAGADLPEGGQEEGFAA------------------------ 282
XP_007640741 201 ------------QGRHLSDGDAEGRQADSRAPQEGDAQEGGTGAQQSGEPQEGEDTLYISASAPA--------------- 253
EHB14456     204 gPERSQVPNDLAPKRNHPCSGAEGMKPARGAPQEGGAQNGT--------PEEGGGITNGLVSAPT------LA------- 262
XP_012033199 231 -TEEGWAPGNHSQKGRLPGSDTGEMEPEQGAPQQGGARALAGADLLEGLQEEGGSL---------------LGP------ 288 sheep
XP_014321231 229 -TEGGRIPGDLSQKGHLPSSGAEKKEPDQGVPQEEGVQGGTGTD-----QEKGDSI---------------LGLvtqgse 287 little brown bat
XP_017353152 221 -PETERAPGDRGQKEHLPSSDSEGKEPDRGAPQEGGAQRTGGAGLPGGPQEEGGDVPCAPASVPTsgsalgLGPtswcle 299 
Q0VDD7       301 pgsvaQGSPDPQQTPSRM----GREGEGTHSSLGCSSLgmvviadlSTDPTELEERALEVAGPDGQasaispASPRRKAA 376 human
XP_021589581 349 twsvgQDLPDPRQIPGGS----GGEAGQSHSSPGCTSL--------SVDPTEVDQRTPEVAGPGGQ------AFPSRQAP 410
XP_005661300 283 -----QGPPDPMQTPSRT----GGEAEWSCSSPRHSPLgpvviadvNIDPTEPEQRTLKVAGPGREvntrvpASPSGKAP 353
XP_007640741 254 ---------SDPTVPVPThklsSTGAAPSCSSPAHASLtdsvltdvSLDPSLLQQRAPEVAALp--------GSLNGQTP 316
EHB14456     263 ----------TPETPTGA----GRQAECSCGGPVCACLgsavmentSTDAPETEQRTLRVAGPDVQpdtqppASPGKH-- 326
XP_012033199 289 ------EPPSAALVPPRClqtlGREAEWSWSCPRCPPLgaivitdvNTDPAEPEHKALRVAVPDREvsarvpASPSGKAP 362 sheep
XP_014321231 288 lgsaaQAPPDPLQILSRV----GKEAGGSCSSPRHSSLrisvitdvVTDPTKSEQRALELTGPDEKantqapASPSGKAP 363 little brown bat
XP_017353152 300 prsvaQGSPDSQQTPSRM----GREREGTHSSLECSSLgmgvitdlSTDPTELEEKALEVAGPDRQvcamspASPERKAA 375 
Q0VDD7       377 DGGHRRALPGCTSLTGETTGESGEAGQDGKPPGDVLVGPTASLALAPGSGESMMGAGDSGHASPDTGPCVNQKQEPG--- 453 human
XP_021589581 411 GRGCSAAKLDCAPLAEDTTAGRGDLGLEGGPQGDMPSSPLGFLAPASGNQTSTVCAKDSGHLALEMGPDVGQVPRPS--- 487
XP_005661300 354 DGGRSRALPVCMPLAGEITGGKGEARNEDKPPGDVPGVLGASLALAQEIQEPPIGAENSGPLALEMGSGVGQTQVPG--- 430
XP_007640741 317 GGGCSGTLLGYTPLTEETTAGREEARLEEGSPSDTLTSLIE--AAVPGKEEPMVGAGDPGHIEQEMSPAVKTKDSGSdgq 394
EHB14456     327 ------TLQGCRSLAEETTGDRGEAEPEHEPPSDTLRNPEAFWAVVLGNQEPTRDAKNPGNPVPDVGPGVHQ---PG--- 394
XP_012033199 363 NAGRSRALLSCAPLTGVTSGGRGEAQREDEPPGDILGCFAASLPLPHETQEPTLVAGDPSLSALEMGPDVGQTQVPG--- 439 sheep
XP_014321231 364 DGGHSGALLTGLPLAGETTESRGEEGWEADSPGDVSRGPAASLVLAHETQEPSVGAGCSSPIASEIDPVVGQTQVPD--- 440 little brown bat
XP_017353152 376 DGGHGRALPGCSPLTGETTGGRGEAGQDDNPPDDVPVGPAASLVLAPGSGQPMMGAGDSSHPALDTGPRVGQKQEPG--- 452 
Q0VDD7       454 -PAQE------------------EAELGGQNLERDLEGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTSELAGQRD 514 human
XP_021589581 488 -PVQEgpgrmct-----qpvdrrAAGLGSQGREQVLKELSLSPGASGLLELRDTVGDPPPETGAPLGSPEPSVEAAGQPQ 561
XP_005661300 431 -QGQEeiggvcspplpsqpesekAAKLGSQGCKQDFKGLSLSFGASAPLVYREAVAGPPQDAGTHQGSPDAPAGLAGQPE 509
XP_007640741 395 lPEEIgtlplea-----qpmsqkVVELSSLNCHQDVESLSLSPDTSSQLEHSHAASDLPQRTKASHSSPGIPIDLTEQQQ 469
EHB14456     395 -PAAHvlpsla------qlgdrqVAESGSQCLEGGCTGLSLALCALCPPEHRAATNGPLWEARAQQGSLEAPTDPPGPLQ 467
XP_012033199 440 -PDQEglggvcsqprlsqpagekAAELGSPSLKPDLQGLSLSLRASAAPMYQEAAGGPPQDAGAGRGSPDTPTGPVGQPW 518 sheep
XP_014321231 441 -LDQEglegvcalsllsqpsgekAAELGSQSHEQDFGGFSPSLGASVPPLHRETVVGPPLDARAHQGNPDAPAGPAGQPK 519 little brown bat
XP_017353152 453 -PAQE------------------AAESGSQNLEQDLEGLGLSPQASVLLEHKAAADGPLQEPGTQQGGPDTTLDLAGQRD 513 
Q0VDD7       515 HLPHSADqgtwadslaVELDFLLDSQIQDALDASDFEAPPEQLFPSGNKPGPCWPGPSSHANGD-PVAVAKAQPRTFVGI 593 human
XP_021589581 562 QPPTSSD---------LEVGFLPDSQIREALEGASFEAPPEQVSPAGSESGLCWPDPSPRARGD-LVMMAQVQPRPGVGV 631
XP_005661300 510 QPPDSSEqafwgespaMELDFLPDSQIQNALESPGFEAPPEQLFPAGSGLGPCCPGTSPCADGN---PFAEAQLRTRAGI 586
XP_007640741 470 SAPSTRDeaawqesstMELDFLPDSQLQDVLDAPNLKALSEQGFPAGNEPGHGGPVPNPDVIGGsPKAVAKSQPRPPMGT 549
EHB14456     468 HSLDSLSqagwpesltMELDFLPDSQLRDALDAPDLEAPLEQDASTENESGLCWPCPSLSAGGGnRVPVVEAQPSGGRPA 547
XP_012033199 519 RPTDSSKqaiwegspaMELDFLPDSQIQDALEAPGFEAPPEQLFPAGGELDPCRPGTGPRADRG---SCAEAQARTRVGI 595 sheep
XP_014321231 520 H-PDPADqa------aLELDFLPDSQIQDALEALNLEAPPEQ-FPAGSGVGPCWPGTSLSTEGG---PLIESQPSAHKGI 588 little brown bat
XP_017353152 514 HLPHSADqatwadssaVELDFLPDSQIQDALDASDFEAPPEQLFPLGSKPGPCWPGPSPHASED-PVAVTRAQPRTFVGI 592 
Q0VDD7       594 QASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAFKRLN-YRKTKLGGKAPLPYPSKgpGNIPRGDPPWREL 668 human
XP_021589581 632 QAPEAPRMEDATGTVQGLVVELSNLNRLIMSAHRDLEAFRRLH-SRKAKPPGKAPSLYPPK--GSLSRGEQAWRDL 704
XP_005661300 587 KTCEAARMEDATETVRGLVIELSNLNRLIMCAHRDLEAFKRFNyYRKAKPAGKAPTPHPPKwaGT-PRGEQSWRDL 661
XP_007640741 550 WAQEAFRMQDATDTVRGLVVELSSLNRLIMSTHRDLEAFKR----RKAK-----PLPYLTKglGSLARGDQGWREL 616
EHB14456     548 CSLPSLRIEDASDTVHGLIVELSNLNRLIMSAHRDLEAFKRLS-SRKAR-----PLPWPPKgaGAVSRGEQPWRDL 617
XP_012033199 596 KTCEATGIEDATDTVRGLVMELSNLNRLIMSAHRDLETFKRLNyYRKAKPAGKAPTPYTAKgaGTLPRGEQSWRDL 671 sheep
XP_014321231 589 KPREATRMEDATDTMRGLIIELSNLNRLIMNAHRDLEAFKRLN-YRKAKPAGKAPMPYTSKgaGALPRGEQPWRDL 663 little brown bat
XP_017353152 593 QACEAPRMEDATNIVRGLIVELSNLNRLIMGTHRDLEAFKRLN-YRKTKPGGKxPLPYPSKgpGDVPRGDQPWREL 667 
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