5USR,5WLW,5WGB


Conserved Protein Domain Family
Complex1_LYR_LYRM4
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cd20264: Complex1_LYR_LYRM4 
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins
LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.
Links
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Statistics
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PSSM-Id: 380759
Aligned: 76 rows
Threshold Bit Score: 63.6925
Created: 4-Apr-2019
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Comment:the cysteine desulfurase complex consists of a catalytic subunit (NFS1), a LYR protein (ISD11), and an acyl carrier protein (ACP)
  • Structure:5USR; Human LYRM4 in complex with human NFS1 and E. coli ACP, contacts at 4A
  • Structure:5WGB: Human ISD11 in complex with human cysteine desulfurase (NSF1) and E. coli ACP1; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  ##  ##       ### ##  ## ##  #  #                        #  ##  #    
5USR_B         8 QVLALYRAMLRESKRFSaYNYRTYAVRRIRDAFRENKnv----kdPVEIQTLVNKAKRDLGVIRRQVHIGQLY 76  western lowland gorilla
AYU82120      67 SVDRLRGQMIRTARRFRdYNFRQYFVQHVKDDFAALAkl----seEEQRKFLATEGRDKLRQLQRMALVNQMY 135 Leishmania donovani
EJY87705      40 QLHYLFQEMIQTSSQIKdYNFRNYFVRRSNEEYEKVKdlek-tisEEELNKQLELNHEKLEQLKRIKIVQNMY 111 Oxytricha trifallax
ANM86761       9 LIDELQKKVVANAKLFAdKNFRAYFLRIGKMDFDALRge----kdPVKQAELYREQEGVAEMLKRQGMINAMY 77  Stygiella incarcerata
Q8IEK7         8 QLKKLYRHILNEASKFEnINYNVYFSNKAKEKFREFCsdt--nfeSEKLKTFQNECWDYLNMLKRQTIIHNLY 78  Plasmodium falciparum 3D7
XP_012650964   7 QVLQLFKETLRAGFGFKdYNFRNYIVRRAKEDFRKYSal----tdQNEIAKQIQFAKEQLELLQRQKIIQNLY 75  Tetrahymena thermophil...
VDQ06857       7 RMQSLSSKLLKEAQKFTdYNIRSYFIRKIDRTFKKLGei----kdQGVLEAELKKNEDLLEVLKRQAILSNMY 75  Trichobilharzia regenti
TBU11368       5 DPSVLYANLLKIISKFKsQNFREYFSRKANEDFEFLQselekgknTCAIKKYMEEQNNLMDVLKRQTKIYNLY 77  Hamiltosporidium tvaer...
CBY35018       4 QLINILKQSVKTSQKFNdYNFRSYFVRKYSNELAAVEsn----egMTVTQELLEQAQRDLALVERQTVVQGLY 72  Oikopleura dioica
XP_018985141   2 SAVSLYKNLLATAAKFDnYNFRSYFVRRINETYAANRtv----tdAAELNAIFTKANLDANTLNRQASISQMY 70  Babjeviella inositovor...

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