1MNM,1HBX


Conserved Protein Domain Family
MADS_SRF_like
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cd00266: MADS_SRF_like 
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SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.
Links
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Statistics
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PSSM-Id: 238166
Aligned: 46 rows
Threshold Bit Score: 66.1295
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1MNM_B, interaction of the N-terminal and alpha 1 helix with the major and minor grooves of the DNA
  • Citation:PMID 9490409
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      # #             #  ###  #  ##                                                  
1MNM_B     17 ERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVSETGLVYTFSTPk---fEPIVTQQEGRNLIQAC 93  baker's yeast
BAB67991    2 ARRKIPIGLIAHRQKRAATYAKRKESLRKKAEELSTLCGVRVAFVCAGPVVPGGGGGAAg---kEEVWESEEGVLAEYRA 78  Oryza sativa (japo...
NP_200380   2 GRKMVKMTRITNEKTRITTYKKRKACLYKKASEFSTLCGVDTCVIVYGPSRAGDEMVMEp----ELWPKDGSKVREILTK 77  thale cress
NP_200697   2 VPKVVDLQRIANDKTRITTYKKRKASLYKKAQEFSTLCGVETCLIVYGPTKATDVVISEp----EIWPKDETKVRAIIRK 77  thale cress
NP_196268   2 ARKKVRAAWIRDDRMRRASLKRRLTGLIKKVNELSILCDMRASVVVFNREEEQLTAWPSpe-aaNSLIDNFYSLTDHERT 80  thale cress
NP_180256   2 TRKKVKLAWIENDNTRAISLRKRRVGLVKKVRELSILCDIKACTIVFSPNEAELMVWPSv----ERLMDIELFLNEKTNK 77  thale cress
NP_181550   2 TRKKVKLVWIENDKSRATSLQKMRVGLLKKVKELTILCAVRAIVIIFSPDKVGPLVWPSpq-atHGLLDEFFALPKSVQK 80  thale cress
BAB01791   17 NKTFFKKPNSAFSSSRATSLIKRQQTVFKKAKELSILCDIDVCVICYGSNGELKTWPEEre-kvKAIARRYGELSETKRR 95  thale cress
NP_198061  18 QTCFKKSSLSSSNAKKTTNLSMREQTMFKKALELSTLCDIEVCVIYYGRDGKLIKTWPEd----QSKILHDKKLSEKVLE 93  thale cress
AAB61064  434 TCFKKSSLSSSSTAKKTTNLSMREQTMFKKALELSTLCNIDVCVIYYGRDGKLIKTWPDdqskvRDMAERFSRLHERERC 513 thale cress

Feature 1          
1MNM_B     94 LNAPD 98  baker's yeast
BAB67991   79 LPPEA 83  Oryza sativa (japonica cultivar-group)
NP_200380  78 YRDTA 82  thale cress
NP_200697  78 YKDTV 82  thale cress
NP_196268  81 MKAVD 85  thale cress
NP_180256  78 VNEKL 82  thale cress
NP_181550  81 KKESN 85  thale cress
BAB01791   96 KGSVD 100 thale cress
NP_198061  94 MEDSL 98  thale cress
AAB61064  514 KKRTN 518 thale cress

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