3J0L,1IQV,4KZZ


Conserved Protein Domain Family
uS7_Eukaryote

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cd14867: uS7_Eukaryote 
Click on image for an interactive view with Cn3D
Eukaryota homolog of Ribosomal Protein S7
uS7, also known as Ribosomal protein (RP)S7, is an important part of the translation process which is universally present in the small subunit of prokaryotic and eukaryotic ribosomes. Eukaryotic RPS7 (also named RPS5) have variable N-terminal regions that affect the efficiency of initiation translation process by impacting small ribosomal subunit to function. The ribosome small subunit is one of the two subunits of ribosome organelles that use mRNA as a template for protein synthesis in a process called translation. The small subunits of bacteria and eukaryotes have the same shape of head, body, platform, beak, and shoulder. RPS7 is located at the head of the small subunit which is a primary ribosomal RNA (rRNA) binding protein that assists in rRNA folding and the binding of other proteins during small subunit assembly in all species. RPS7 is also involved in the formation of the mRNA exit channel at the interface of the large and small subunits. Some ribosomal proteins have extra ribosomal functions in cell differentiation and apoptosis.
Statistics
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PSSM-Id: 271246
Aligned: 64 rows
Threshold Bit Score: 256.712
Created: 26-Nov-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:rRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Ribosomal protein S7 directly interacts with ribosomal RNA during the assembly of the small ribosomal subunit.
  • Structure:4KZZ; Rabbit RPS7 interacts with ribosomal RNA at 4A
  • Comment:Ribosomal protein S7 plays a critical role in controlling of rRNA folding.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          # #   ####  #       #  # #####                
3J0L_T         4 KLFGKWNYDEvkIQDPCFQNYIActttksqVFVPHTAGRYQVKKFRKTQCPIVERLIGTLMFHGrn-------------- 69  rabbit
4KZZ_F        18 KLFGKWSTDDvqINDISLQDYIAvke-kyaKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGrn-------------- 82  rabbit
EET89613      41 QLFDKYSYDVk-VEDLSLRNYINlk----pLAFPSTFRRTSKKMFSKAGMNIVERLENAMMRGGtgkkigghvirtkgrl 115 uncultured eury...
WP_018036371  13 LLFRKWDVSEieIQDVGLKTAISlk----eTILPMSFGRSALKRFNKADVNIVERLVNKMMHFGkkyakn------tgrm 82  alpha proteobac...
YP_001031043  11 LLFNKWDMSEvvVKDAGMVRYVTit----sTEVPSSCGRLTQQQFTKSEMAIVERLINRLMQQEyn-------------- 72  Methanocorpuscu...
O28386        11 LVFGKYDPSEvqISDPALESYICle----pKYVPHNHGRHANVPFAKQKVFIVERLINKVMRKGhn-------------- 72  Archaeoglobus f...
P14037        10 KLFGKWDSTSvtVKDPSLKSHISln----pVLIPHTAGRNSKKMFDKNKMHVVERLANKLMATQvn-------------- 71  Methanococcus v...
CBH36965       9 RIFDEWPISDvaVVDIGIEKHINl-----qPVSALHTGGRHAKQSYESKVCVVELLINKLMRREkn-------------- 69  uncultured arch...
ABZ08569       7 LLFRKWDISQieIKDVGLKTAIClk----eTILPMDFGRSALKRFNKADVNIVERLVNKMMHFGkkyakn------tgrm 76  uncultured mari...
Q8TRC2         6 KIFGKWDPTEveVKDLGIKRYVSlt----pVIVPHSSGKHARQQFNKSEISIVERLANNLMRTEtn-------------- 67  Methanosarcina ...
Feature 1         #####  #                                       ### #         #      #      #  #
3J0L_T        70 aGKKALCIKVVKNAFEIIHLVTgrnPLEVFVGAVQNAGPREDSTRIGTAGVVRKQAVDVapMRRVNLAIYFIIKGCRESA 149 rabbit
4KZZ_F        83 nGKKLMTVRIVKHAFEIIHLLTgenPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVspLRRVNQAIWLLCTGAREAA 162 rabbit
EET89613     116 qGKKIKVMHVIESAFDSVHRDTkenPLQLLIMALENSAPIEDTTRIRQGGTVSNIPVDIsaSRRLDIALRNIATASIIGA 195 uncultured eury...
WP_018036371  83 aGKKFHTFNVVKTAFEIIHHKTgknPIEILVRAVENSAPNEDTTRIVYGGTVYHVSVDVapIRRVDLALRFIADGVKEAT 162 alpha proteobac...
YP_001031043  73 tGKKMMCTKMVMDAFDVINKKTkqnPLQVLVDAVANAGPREETVRLKYGGINVPKSVDSapIRRVNTALRYIALATWKGS 152 Methanocorpuscu...
O28386        73 tGKKILAYNIVKEAFEIIEKKTkknPIQVLVDAIINAGPREEVVRLKYGGIAVPKAVDTssSRRVDIALRNIAEGARRAA 152 Archaeoglobus f...
P14037        72 tGKKNEVLSIIEEALTIVENRTkenPIQVVVDALENSGPREETTRISYGGIAFLQSVDVspSRRLDTAFRNISLGASQGA 151 Methanococcus v...
CBH36965      70 tGQKQKTYKIVKNAFELVYQDTkknPFQVFVDAIQNAGPMEETIRLRFGGILVPKAVDVssQRRVEHALRFIVQGAQKCA 149 uncultured arch...
ABZ08569      77 aGKKIHAYNVVKTAFEIIYQKTgknPVEILVRAVENSAPNEDTTRIVYGGTVYHVSVDVppLRRVDLALRFIADGVKEST 156 uncultured mari...
Q8TRC2        68 tGKKQVTLRAVEEAFDIVNKKTkqnPIQVLVDAIANAGPREEVVRLKYGGISVPKAVDTapQRRVDTALRYISMGTNAAA 147 Methanosarcina ...
Feature 1             ##                                    
3J0L_T       150 fksmrSIAETLADEIINAEKnntqssWAIRKKDEIEKVAKGNR 192 rabbit
4KZZ_F       163 frnikTIAECLADELINAAKgss-nsYAIKKKDELERVAKSNR 204 rabbit
EET89613     196 fgskkTISEALANELILAAKndi-nsYAIKRKNEIERMARSAK 237 uncultured euryarchaeote ARMAN-2
WP_018036371 163 fsnpkAIEEYLAEHLILSANndt-aaPSVKKKNELERIAQASR 204 alpha proteobacterium SCGC AB-629-F11
YP_001031043 153 hktkkPAYLVLADELIMAAKgda-kcFSVGKKEEVERIAKSAR 194 Methanocorpusculum labreanum Z
O28386       153 fkskrSIAQCLADEIIAAANnes-rsFAVAKKEEVERVAKSAR 194 Archaeoglobus fulgidus
P14037       152 hkskkSIAQCLADELVAASKadmqksFAVKKKEEKERVAQSAR 194 Methanococcus vannielii
CBH36965     150 fkskrSMARCLADELIAASRna--kcHSIGKKEEKERVARAAR 190 uncultured archaeon
ABZ08569     157 fsnpkAIEEYLAEYLIISANndp-aaPSIKKKNELERIAQASR 198 uncultured marine crenarchaeote HF4000_APKG3E18
Q8TRC2       148 fkskrSVAECLATELIGAANrdt-ksFSINRKDAKERVAKAAR 189 Methanosarcina acetivorans

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