Conserved Protein Domain Family
Ax_dynein_light

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pfam10211: Ax_dynein_light 
Axonemal dynein light chain
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organizms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Statistics
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PSSM-Id: 463000
Aligned: 68 rows
Threshold Bit Score: 94.9474
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESN93509      71 QDILNAMLP--PRE--WI----AN-EQQWI-QHVSSTPATRSDVVNIQELLDKKLQ---QRQARETGI-CPVRR------ 130
XP_003246751  44 NKVFEYIYP--PEE--WM----ED-GVKWR-RVASTEPADRNHVLALAEDLKSNLS---YWHARMHGV-CLVRR------ 103
XP_003247366  41 KSILEEIFP--PRV--WTrivnNNnKVITLrQTISREPSNRDGVQKMIVMLNHLEQ---FFRFKKKGI-CEIRN------ 106
CZT99740      80 FFNLSLLFP--IKV--FK----KT-DKTLI--QLISEDTNLSDL----ELIQAVLK--------------NIENnnmdkl 130
XP_001616752  68 NEPLYNMFP--LKC--VR----DK-KVDQI--SYVCRVTSEEDATACLKKIQDIVSkmyAQNM-------LIEK------ 123
CAM68828     268 SRVLSSATAaaARS--AA-------STPVMwRRADVAHLSRLDVVLLYKHLERRCA---CESARPRGVvCPNRE------ 329
Q4DXE3       141 RNTFCS-----TRE--FG-------ESKWM-KVAAIDHTSRLDCVHLQDHLNRRCK---EENARPSGVlCTIRE------ 196 Trypanosoma cruzi
Q389G1       155 ETLLYTLLP--PQRivCE----ET-GETIV-KSVSLEQPSRVEVAKLHERTLQQLQ---QRRAREWGI-CPLRR------ 216 Trypanosoma brucei
Q4DPW6       146 ERVLYTLLP--PRRtvCK----ET-GNTIL-QCVSTEPSSRVEVADLHERLTERLR---QRRARDSGI-CPIRR------ 207 Trypanosoma cruzi
XP_001582280  42 RDVLNSLFP--PIE--FE----QD-EIKYT-RSISTAPISKTDVTKLRTELDTLLH---KNKTKPKGI-DIIRS------ 101
ESN93509     131 ------ELYSQCFD---ELIRQVTINCAERGLLLLRVRDEIRLTLDAYQVLYESSVAFGMRKCL--QSE----QGKVDMI 195
XP_003246751 104 ------ELYTQCFN---ELIRQVCVNSIDRGQLLIKIRNEYNASIKAHKLLFESGLIFRIKHTT--LDD----HKDDVTE 168
XP_003247366 107 ------SVHNLFFD---EVLRQVIIMDEDLGAILFRIHNEFKNMIFILKCMYDKAV-------LtnNSN----RDSSNID 166
CZT99740     131 nffyveNIIFELLD---EIIRQVICEYPKRGFAVLLITNELQKNINYYKNLID----------IieHNNemntQGFKEMN 197
XP_001616752 124 ------DFLEDLLSvfmELCRQVSVTCFQRGSLLRQLFNYNSMLLFHYHKLVRSSLTFNLKKEI--KRShtmsELRQEME 195
CAM68828     330 ------CIYNDGLR---ELIRQVTLLCPERGLLLDELARRMRQAIETYDVLLDSANQYAVRKST--ERD----LHQYLFA 394
Q4DXE3       197 ------GIYTDGLR---ELIRQTTVLCPERGLLLAELATEMQQTTNKYDILFDSASQYAVRKAI--ERD----MRSYLFD 261 Trypanosoma cruzi
Q389G1       217 ------EIYTELFD---ELIREITLEEPARGVLLLRIRDEMNQTLAAHRALAERTLLFASKQRM--EPP----EDISALR 281 Trypanosoma brucei
Q4DPW6       208 ------EVYAEVFD---ELIRQITLEEPTRGILLLRIRDELYQTLAAHSSLAERAMYFASKQRE--EAG----EGMDELK 272 Trypanosoma cruzi
XP_001582280 102 ------ELYSQCFE---EVIRQVTIDSNARGRLLFRIRNHYKTLIQSYKDLNELALNFGANKNI--QVT----LGMDQLL 166
ESN93509     196 KQ----IEDLTREKAELERQVAEEKARCEQTERRYQEQKHLEEKKHSDEV------------QFLKKINQQLKVQLEG 257
XP_003246751 169 KD----IQDIEDAHVKLKKKLVDANNKYNKLKTDLKNELNNLKDANQHEL------------SFFNRNHEALKDQLKL 230
XP_003247366 167 PE-------LFTEVEELTRINNELKIKCRHSKQRHKERLKKKESGEDYKFlvslkmkyemlnNYIKRSTKQLKEQMNM 237
CZT99740     198 EKnnliLQDLLVEENKLKEKLIDVQTRLELLKEENKKKLQENKNKKEIQY------------DLLKHNESLLDKIKEI 263
XP_001616752 196 RK--------KEAINSLRSEILDTDRLIEEERANAEREMSEVNIIYQNKI------------DKLKKNNQRKRDEFTR 253
CAM68828     395 EK-----TDLETEVRRREHRVNEWRAKYAGLQKRFQEQQEADRKLHAEEI------------AYAKRANQQLVSEIKR 455
Q4DXE3       262 DK-----KSMESEVRRLENRVNELRAKRDGMIKRFEEQKQSEQNRHEEEV------------KYLKKANQQIISEIKR 322 Trypanosoma cruzi
Q389G1       282 QR----IKELEEEREELLVKRRMATVREEQIQSALLDENTARVKLWQDET------------CYYRRANRQVSQRIKT 343 Trypanosoma brucei
Q4DPW6       273 RR----IHELEEKRLELIVRKKAVQVREEQILRAIEQENNTRSKLRQDEL------------GYYRRANRQLTQRIKS 334 Trypanosoma cruzi
XP_001582280 167 DY----NKKLREKRRELELEANNLQIQLDGLEKRIQENKQIREKEFADEI------------AFLKKQGQSIKMIYDQ 228
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