3S4E


Conserved Protein Domain Family
DSP_DUSP19
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cd14523: DSP_DUSP19 
dual specificity phosphatase domain of dual specificity protein phosphatase 19
Dual specificity protein phosphatase 19 (DUSP19), also called low molecular weight dual specificity phosphatase 3 (LMW-DSP3) or stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1), functions as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). It is an atypical DUSP; it contains the catalytic dual specificity phosphatase domain but lacks the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. DUSP19 interacts with the MAPK kinase MKK7, a JNK activator, and inactivates the JNK MAPK pathway.
Links
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Statistics
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PSSM-Id: 350373
Aligned: 13 rows
Threshold Bit Score: 238.407
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:x x C x x x x x RClick to see conserved feature residue pattern help
Evidence:
  • Structure:3S4E: Human Skrp1 binds a sulfate ion in the active site; contacts at 4A
  • Comment:based on the structures of some DUSP family members with bound phosphorylated substrates (peptide and non-peptide)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #                                            #                      
3S4E_A         3 QVGVIKPWLLLGSqd--aaHDLDTLKKnKVTHILNVAYGVe-NAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKr 79  human
NP_998144     65 QVGIITPFLLLCAasqdaaHDIDTLKKlKVTHVLNVAFGVe-NVFPELFTYKTVSMLDLPETDITAYFPECFEFITQARq 143 zebrafish
XP_002586446  61 QVAKIRPGLFLGSqd--vtVRPELLRSnNVTHVLNVAAGVetETFPDAFTYKHVPILDLPDTNITDFFPECFAFISAGVt 138 Florida lancelet
XP_002737637  61 QVACVRPWILLSSqd--vaADYDLLVEnKVTHILNVASLVd-NHFEDDFIYLKLEILDIPETDITRYFDQCFKFIDEAKs 137 Saccoglossus ko...
NP_001089209  65 QVGVVKPWLLLGSqd--vaQDLDILKKyKVTHILNVAYGVd-NVFPNEFTYKKISILDLPETDIASFFPECFNFLEKVKl 141 African clawed ...
XP_421855     63 QVGAARPWLLLGSqd--aaHDLETLRKhKVTHILNVAYGVq-NAFLNDFVYKTISILDLPETDITSYFPECFEFIEKAKi 139 chicken
XP_001200447  69 QIVQVRPYLYMSScd--vaYNLEILKYhNITHILNVANLN--NVYPDHFTYKNLPIWDLPEVKITKFFKYAIDFINQARs 144 purple urchin
NP_001121737  64 QVGYVKPYLLLGSqd--aaHDFATLRKyKVTHILNVAYGVe-NAFPDLFIYKTLSILDQPDTDIISHIKECAQFIDQAKn 140 zebrafish
ADO29089      63 QVGVITPFLLLSSqd--aaSDTETLRKfKVTHVLNVACGVe-NAFPGHFIYKTVPMMDLPETELTSYLPQCFEFIDEAKk 139 channel catfish
XP_005999735  64 QVGLIKPWLFLASqd--vaHDLETLKKhTISHILNLAYGVe-NAFPIDFTYKSISILDLPETDIVSYFQECFEFIEEAKv 140 coelacanth
Q8WTR2        65 QVGVIKPWLLLGSqd--aaHDLDTLKKnKVTHILNVAYGVe-NAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKr 141 human
XP_007888303  64 QVGVVKPWLLLSSqd--vaQDYETLKKfKISHILNVGYGIe-NAFPDVFTYKSISILDLPETRITSYFQECFSFIDQARt 140 elephant shark
KRX90233      59 SLAEILPHLLLSSqe--paTKLHLLQQhRVTHILDLASSFt-NRYADQFIYKRIEIFDCPMANIKRYFNECVDFIDEVRm 135 Trichinella pse...

Feature 1                #######                                             
3S4E_A        80 kDGVVLVHSNAGVSRAAAIVIGFLMNSEQTsfTSAFSLVKNARPsICPNSGFMEQLRTYQ 139 human
NP_998144    144 qDGVVLVHCNAGVSRSASVVIGFLMSELKMsfDEAFSVAKTSRPqIQPNPGFLQQLKTYN 203 zebrafish
XP_002586446 139 -SGGVFVHCNAGVSRAVSIVVGYLMTTEGLefEDAYRQVKEIRPsARPNDGFMKQLKEYK 197 Florida lancelet
XP_002737637 138 sNGVVLVHCNAGVSRSASIIIGYLMHTENIslEDCLETLKEIRPgIRPNAGFMSQLQGYE 197 Saccoglossus kowalevskii
NP_001089209 142 qNGVVLVHCNAGVSRAPAIAIGFLMYDEKInfARAFSIVKNARPaACPNPGFMEQLHKYQ 201 African clawed frog
XP_421855    140 qDGVVLVHCNAGVSRAAAIVIGFLMNSEGLsfASAFSLVKSARPsICPNPGFMEQLHKYQ 199 chicken
XP_001200447 145 tGGRVLVHCNAGRSRSTTIVVGYILADERAriSKTLEEIRVHRPcVRPNEGFMRQLEEYE 204 purple urchin
NP_001121737 141 eKGVVLVHCNSGVSRSVSVVIGYLMLKENQgfGDTFALVKSARPaSCPNPGFMEQLKNFK 200 zebrafish
ADO29089     140 qDGVVLLHCNAGVSRSASIAIAYLMAKEKIpfEDAFNRVRSARPsIRPNAGFLVQLTEYH 199 channel catfish
XP_005999735 141 qDKVVLVHCNAGVSRSASVVIGYLMYTDRLafREAYSVVKGARPaVCPNPGFMEQLKKYQ 200 coelacanth
Q8WTR2       142 kDGVVLVHCNAGVSRAAAIVIGFLMNSEQTsfTSAFSLVKNARPsICPNSGFMEQLRTYQ 201 human
XP_007888303 141 kDGVVLVHCNAGVSRSASIVIGYLMKVAGLsfEDAFSLVKNARPaSNPNAGFNEQLRKYQ 200 elephant shark
KRX90233     136 qNGRVLVHCNAGVSRSPTIVVAYLMKRENYtlENALSFVRAKRPcIRPNNGFMKQLKEFE 195 Trichinella pseudospiralis

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