Conserved Protein Domain Family
CPDase
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pfam07823: CPDase 
Cyclic phosphodiesterase-like protein
Cyclic phosphodiesterase (CPDase) is involved in the tRNA splicing pathway. This protein exhibits a bilobal arrangement of two alpha-beta modules. Two antiparallel helices are found on the outer side of each lobe and frame an antiparallel beta-sheet that is wrapped around an accessible cleft. Moreover, the beta-strands of each lobe interact with the other lobe. The central water-filled cavity houses the enzyme's active site.
Links
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Statistics
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PSSM-Id: 311669
Aligned: 7 rows
Threshold Bit Score: 203.46
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P53314   1 M-AIALWYCPPQGSVAYETLQMLI-FSFQTLFPDS----------------PVFEPHVTVTSHLVCN-----SKDDVNKI 57  Saccharomyces cerevis...
Q6FTX0   1 M-SIALWYCPAPGTLDYEVLKTLI-NSLQLLVPGS----------------PSFEPHLTVVTHLQVQ-----NRGDVSKV 57  [Candida] glabrata CB...
Q758H6   1 M-AVALWYCPPANSPCYDTVNSLI-LSLQTLFPDA----------------VLFEPHVTITSQLRCD-----SADDAAAV 57  Eremothecium gossypii...
Q7S724   1 MpGSSLWLIPPPSHPLYPILSFLIsQHLPSDFPSEagaad------arlipEFFAPHMTLSSGISPDl----YGDDPQRW 70  Neurospora crassa OR74A
Q6CGD3   1 M-GTSLWLQPPRNSPIWQQLATTI-QGLKPIFSDS----------------ENFEPHITLTSNISVN-----TQGQVDFV 57  Yarrowia lipolytica C...
Q5KJ43   1 M--------PSA--NEKLHYQHLI-NRLSKLYNETicqkdedegrtrgsasPSFEPHITLFAFIPLDtpvgeISNTLRQV 69  Cryptococcus neoformans
Q6CXV0   1 M-GISLWLCPYGHSPEYETFKTLI-ESLQTLFPNS----------------PVFEPHVTVCSGLSCE-----NMEEVHKV 57  Kluyveromyces lactis ...

P53314  58 LTS-CVAAIQSIRSHQtakkgrkgqvshavaaPLVSFNGCSVGKQYFKKIVLECNKNKILYGVAQVMREMYVEIDPETRs 136 Saccharomyces cerevis...
Q6FTX0  58 LQS-CSSCLKTIPKGH----------------SLIKYSNWSINKQYFKKIVLECEKDKYLLSLAQLMRELYVEIEDQKR- 119 [Candida] glabrata CB...
Q758H6  58 LAA-ACAALRACRPQLdar-----------gsPVVRFDAVAVGRRYFDKVHLACAHDRFLYGVAQVIRELFVQDPPDPA- 124 Eremothecium gossypii...
Q7S724  71 LDSiPWPSADEV---------------------QVRFEGISSQDTYYRRCYARVKLDEGIKKIAGLARARGVNGEDDAKg 129 Neurospora crassa OR74A
Q6CGD3  58 LDR-AVAAAKCVPQGF-----------------QIHLSSVKYGSRFFKKVYLQVEPTPELLSLARICREDFVYMPEAMSq 119 Yarrowia lipolytica C...
Q5KJ43  70 VARvTGSGLSSLGGGGh---------------FALGLLPAQSGRSYFQSVLAPVQPTAELLSLYDQTVAAFPPASPSSSp 134 Cryptococcus neoformans
Q6CXV0  58 LEM-AHHAINAVKSKVds------------enALVEFDGFNIGKKYFEKCRLECKPNPMLYSLAKLIRSMFVGEL----- 119 Kluyveromyces lactis ...

P53314 137 --------------------sRAATWVHEEFHPHVSLLYSDiHPVSQ--ASLRVVQQRIEDALDVQLVprekrkgsgnad 194 Saccharomyces cerevis...
Q6FTX0 120 ---------------------RAEHWVIEEFQPHVSLMYND-SQITK--ATEMVVRQRIHDAMQLFSN------------ 163 [Candida] glabrata CB...
Q758H6 125 ---------------------AAADWVHSSFRPHLSLVYSDlYHVDQ--ALLRVLRQRIGDALGAALLphppapg----- 176 Eremothecium gossypii...
Q7S724 130 ak-----------------tqEWLEWWRKEFGPHVSLMYGDvPISDDrlKEVAKVVEEAGVKLAEPEG------------ 180 Neurospora crassa OR74A
Q6CGD3 120 arnyqamsaeerqkidtqvgqRAAEWTRNEYDPHVSLVYSDlYPVED--ADRRTIETRLEDTFGSGYD------------ 185 Yarrowia lipolytica C...
Q5KJ43 135 ---------------------DEKKKKKGGYFPHLSLFYGDcSLAKR--DEIAAIANGEDPCL----------------- 174 Cryptococcus neoformans
Q6CXV0 120 ---------------------NIDTWLFEEFHPHLSLAYSDiYPMDQ--AMIRLIRQRIEDLFDVTTEeieshsr----- 171 Kluyveromyces lactis ...

P53314 195 gsnevqmrwdfdVSSSLSWNipgTFKVVNCVGPVQEWEVLGRVDV 239 Saccharomyces cerevisiae S288C
Q6FTX0 164 ------------NPSSKSWR---TFKVVSCEGPVEEWQVLGSVTL 193 [Candida] glabrata CBS 138
Q758H6 177 -----lqalwalQPPLDGWSipgSFKVVRCEGPVRDWHVLAAADL 216 Eremothecium gossypii ATCC 10895
Q7S724 181 ------------NVEGNGWNg-gVVWLVPTDRDIRDWKPIAKRVL 212 Neurospora crassa OR74A
Q6CGD3 186 -------------ESGLGWKn-gRFALVRCEGPVDEWEVLGVRDF 216 Yarrowia lipolytica CLIB122
Q5KJ43 175 -------------GSGQATVtinELGIVKCAGEVEEWQLVESIVL 206 Cryptococcus neoformans
Q6CXV0 172 -----dqdayklQHTLKGWSfplTFKVVRCEGPVEEWEVLSEVTV 211 Kluyveromyces lactis NRRL Y-1140
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