Conserved Protein Domain Family
TFP_LU_ECD_Ly6K

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cd23550: TFP_LU_ECD_Ly6K 
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins
Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Statistics
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PSSM-Id: 467080
Aligned: 16 rows
Threshold Bit Score: 117.029
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q17RY6        41 VWCHVCERENTFECQNPRRCKWTePYCVIAAVKIf-----------------------pRFFMVAKQCSAGCAamerp-- 95  human
Q9CWP4        21 LTCHVCEAQNSYACSNPSQCPGEkKFCLLAVTRIf-----------------------eRFFYVSKQCTRRCPtpvvspp 77  house mouse
XP_008581400  51 INCHICEQENSFDCKNSQVCGADdQYCNIVVISIf-----------------------pRFFLVAKSCSQYCPviemp-- 105 Sunda flying lemur
EHB18004      35 LKCYICEGENSFDCATQQTCGEApKYCALTVIKIf-----------------------aRFFLISKQCVVFCPavvnl-- 89  naked mole-rat
XP_006830919 137 LNCHVCERENTFVCTNPVKCENAdRYCVVAATKIf-----------------------aRFFIMSKQCSQYCPvvemp-- 191 Cape golden mole
OBS64271       2 LTCHVCEQENSFNCTNPQICTNNkRFCTLAATQFf-----------------------eRFYIASKQCTRTCAipprqlp 58  desert woodrat
XP_012880610  21 VLCHVCELENDFGCLNQRNCTVGeSNCIIVAMKIf-----------------------pRFYIVSKQCVSACPtmevali 77  Ord's kangaroo rat
XP_006879503  30 LKCHSCEAENNFKCLNPVNCSSAeTYCITTAINLssteagvpsgenytyccpvageifaRFYLVSKQCSLSCPvverpa- 108 Cape elephant s...
XP_008251303  30 LRCHVCEKENDFSCQNAQDCAQRdTYCALAAIKIf-----------------------pRFYYVSKQCTPYCPliiip-- 84  rabbit
KFO26813     100 LMCHICESENNFGCSNRGNCAVHeKYCVIVVTKIl-----------------------rRFFIVSKQCVAYCPavqtf-- 154 Damara mole-rat
Q17RY6        96 -----------kpeeKRFLLEEPMPFFYLKCCKIRYCNLEGP 126 human
Q9CWP4        78 s-------tnppsepKEFLIEKPMPFLFYKCCQWDSCNGEGP 112 house mouse
XP_008581400 106 -----------rpkaKPFILLKPLPFLYVKCCTENLCNEAGP 136 Sunda flying lemur
EHB18004      90 ----------ghetpKQFLLEKPMPFVHIRCCTESLCKMEGP 121 naked mole-rat
XP_006830919 192 -----------apslQRFILLKPTAFLYAKCCEDSLCNEYGP 222 Cape golden mole
OBS64271      59 gt----evrsgppepKSFVIEKPLPFLFLKCCKWNLCNEKGP 96  desert woodrat
XP_012880610  78 mttptptwslyragaKVYTLQEPTPFIFIRCCNEDLCNEEGP 119 Ord's kangaroo rat
XP_006879503 109 ----------anlqpRRFLLEKPTPFLYIKCCEHTLCNEVGP 140 Cape elephant shrew
XP_008251303  85 ----------adspgRSFVILKPLPFVYIKCCKHPLCNDNVP 116 rabbit
KFO26813     155 ----------asepaKPFLLEKPMPFLYIRCCTESLCNMEGP 186 Damara mole-rat
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