1RI6,6IGB,3SCY,3FGB


Conserved Protein Domain Family
Lactonase

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pfam10282: Lactonase 
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Lactonase, 7-bladed beta-propeller
This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.
Statistics
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PSSM-Id: 431196
Aligned: 58 rows
Threshold Bit Score: 249.832
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RI6_A         6 TVYIASPES----QQIHVWNL----NHEGALTLTQV--VDVPGQVQPMVV--SPDKRYLYVGVR-----PEFRVLAYRIA 68  Escherichia coli
Q8A8P5        36 FLLVGCYMKpd-eEGVRMYRFd---GQTADVDYPCG--LRGISNPAFLTS--DSTGNRIYAIGDde--gKSSTANALLFD 105 Bacteroides the...
XP_001582328   3 TAVVGTYTDng-sKGIYSLKIs---QNDGSFSFLES--V-EVDNPSYVIL--NRNNTRVYAVSEmh--nEKAALVALEFE 71 
3SCY_A        15 TXLVGTYTSgn-sKGIYTFRFn---EETGESLPLSD--A-EVANPSYLIP--SADGKFVYSVNEfs--kDQAAVSAFAFD 83  Bacteroides fra...
O59681         2 KLVIGTCTD----GPVLVFDM-----ETKSITEKLE----GVSSPTWVEW--EKKSKRLYVANEi----EEGYVAVFEWD 62  Schizosaccharom...
Q2H0R7        32 TLWVTTYPIgdgaGELLTLKL-----EGSKLSSVATs-DTCGPFPSWLTQ----VDDVLYCVNEaw-ggQNGDLAALQIG 100 Chaetomium glob...
Q7S9K3        24 ifatsmgTStd-pGFLSTIKY-----ADGKLEVINKqlGICGNNPSWLEF----VGDHIYCLDEaw-ssITGSLYNFQVP 92  Neurospora crassa
Q4WHI9        16 TLYATHYS-----GAVYTLSLth-rNGKYNLSLASDm-TTCGGMPSWLTLdrDTTTSTLYCSDEtgdatTNGTLTSYAVG 88  Aspergillus fum...
XP_001272673  15 HLYATHYS-----GSLSTLTLdraaNGSYALSIAASe-VTCGGMPSWLTL--DATTRTLYCSDEtgdasTTGSLSTYTVG 86 
Q7S6A9        22 TLLVSHFS-----GPVYTLSLtt-sGTTGKLSITSQa-GGCGTTPAWLEY--YNDTKTAYCFDEsw--tGSGVITQYNVG 90  Neurospora crassa
1RI6_A        69 PDDGALTFAAESA---LPGSLTHISTDHQGQFVFVGSYNAGNVSVTRL-ED-GLPVGVVD-VV------------EGLDG 130 Escherichia coli
Q8A8P5       106 KESGLLSLLNSQSt--DGELPIYITLSPKEYFVLTANYKGGSITVFSQdKK-GKLQRDTK-IIrfagng-pnkkrQEQSH 180 Bacteroides the...
XP_001582328  72 KISGQFKVINSQLt--HGMDPCHLLL--GDGFVVTANYSSGSITVFPLdSN-GGIQEASQ-VIkfegtg-pdksrQEMPH 144
3SCY_A        84 KEKGTLHLLNTQKt--XGADPCYLTT--NGKNIVTANYSGGSITVFPIgQD-GALLPASD-VIefkgsg-pdkerQTXPH 156 Bacteroides fra...
O59681        63 N--GKFSLVDRFTi--DGHSPTSLCVLENGS-VLTANYNSASISR-------SKAKDEKPhVWhhegks-lhperQTSSH 129 Schizosaccharom...
Q2H0R7       101 AD-SSFTVLSSGKt--VGGPVSTIVYGNEGRGLAVADYAGGGIDTFDIsDP-AAIKTLVSkVFpgrdd--gaappQEQAR 174 Chaetomium glob...
Q7S9K3        93 RDGTNLTLINKLDt--LGGPVSSVRYGQNLKGLAIAAYAGGGFQSFDIsNP-AAPKALQNsTFtispkp-gsdpqQKTSH 168 Neurospora crassa
Q4WHI9        89 KD-GSLTQLAKVVdvgGGVHSVVYEGEGGAKYIAIAHYSGSAVSTFALpLEsGDEPLQ---ILryqtpp-gplpqQDSSH 163 Aspergillus fum...
XP_001272673  87 RD-GALTQTAKVVdvgGPVNSIVYEGVRGEKYLAIAHYTGSAVTTFSLpIQpSSKPHQ---VLrytlphpgprpeQDSPH 162
Q7S6A9        91 SD-GRLTQSGQTRtsgNTVHGKVYGGSDGKGFIATAQYSPSTITTYKLpLGqGQVQLEKF-TMsqrg----pnsrQDVPH 164 Neurospora crassa
1RI6_A       131 CHSANISPDNRTLWVPALKQDRICLFTV----SDDGH---LVAqdPAEV-TTVEGAGPRHMVFHP---N----------- 188 Escherichia coli
Q8A8P5       181 LHCVTFTPDGKFLLATDLGTDCIYLFPIgkrpEAGKAhslLDEsrVVRI-QMDSGSGPRHICFHP---N----------- 245 Bacteroides the...
XP_001582328 145 AHHVYFTPDRKFLLVNDLGTDKIHKFKVn---SQAPF---LSEt-YEDI-NVQPESGPRHSVFTK---N----------- 202
3SCY_A       157 LHCVRITPDGKYLLADDLGTDQIHKFNInpnaNADNKekfLTKgtPEAF-KVAPGSGPRHLIFNS---D----------- 221 Bacteroides fra...
O59681       130 PHQV--TAHKHLVCSVDLGLDRFSIFDAe---DTSSD--------PVVVvNVPAGYGPRHIVFHK---T----------- 182 Schizosaccharom...
Q2H0R7       175 PHEAILDPTGEFLVFPDLGADLIRVLKVd---KATLE---YTE--KPSY-EFARGTGPRHGAFYQsgdN----------- 234 Chaetomium glob...
Q7S9K3       169 PHEVVLDPTGNFIAAPDLGADLIRIFKVd---KNTLS---YVE--SKTV-PTPDLSGPRHGAFVKl-dS----------- 227 Neurospora crassa
Q4WHI9       164 PHQIILDPTGSFILVPDLGTDQVRVYAId---KQSGQ---LNT--CPSL-NYTPGSGPRHGLFWS---Shhshrdglriq 231 Aspergillus fum...
XP_001272673 163 PHQVILDPTGAFILIPDLGADQVRVYAId---KHTGQ---LDA--CPSL-EFTPGSGPRHGVFWSsadAvqrgsrs---- 229
Q7S6A9       165 PHETQLDPTGKFMLVPDLGADLIRIFKId---ASTGR---LTA--CPAG-QASPGDGPRHAQWWKsadG----------- 224 Neurospora crassa
1RI6_A       189 --------EQYAYCVNELNSSVDVW--ELK-DPHG--NI-ECVQTLDMMPE--N-FSDT---R---WAADIHITpdGRHL 245 Escherichia coli
Q8A8P5       246 --------GRFAYLISELSGKITVF--SYN---EG--KL-ERLQTIVCDP-----FVAE-------GNADIHVSsdGKFL 297 Bacteroides the...
XP_001582328 203 --------GKYMYLINELNGHVNAF----V-NQNG--TL-SMFQSIICD----S-VSAR-------GSADIHLSpdGKFL 254
3SCY_A       222 --------GKFAYLINEIGGTVIAF--RYA---DG--XL-DEIQTVAAD----T-VNAQ-------GSGDIHLSpdGKYL 273 Bacteroides fra...
O59681       183 --------LPVCYLICELANRILVY--DTN-------TF-ECLQDVSTLPPsmT-LEKDpkfPqppSAAEVAVVhdGPFL 243 Schizosaccharom...
Q2H0R7       235 ---------TYFYVVCELSNLLQGFsvAYN--EDSslTF-TQLYNATTHGAtdAlPEET-------AAAEIFLApnSNFL 295 Chaetomium glob...
Q7S9K3       228 --------GTYFYVVTELSNEIIGWkvTYN-SNGLdlDFgKELFIIPTHGP--G-STGIgntT---RASELVISpdNKFL 292 Neurospora crassa
Q4WHI9       232 ktaaltapHTILYTVSELSRHFHAFavSYL-PSGCl-GF-RETQDFVPYPGg-E-ITEG---A---SLAELQQA--GSNL 298 Aspergillus fum...
XP_001272673 230 -rrpghaaETFLYTVSELSRHFDAFavSYP--AAGclAF-HRTQDFIPYPGgeT-PQGA-------SLAEIRLA--GHNL 295
Q7S6A9       225 --------VLRLYTLNELGNSVSSWnvVYPtDSNGclAL-SRAQTLSTYAPgkKgGPTT-------KAAEIRVA--GNFL 286 Neurospora crassa
1RI6_A       246 YACDRT-------------------ASLITVFSVsEDgSVLSKEGFQPTETQ---PRGFNVDHSGKYLIAAGQKSHHISV 303 Escherichia coli
Q8A8P5       298 YASKHLk------------------EDGIIVYSIdSQkGTLVQIGFQPT-GLy--PRSFAISPDGCYLAVVCRDANCIQI 356 Bacteroides the...
XP_001582328 255 YASNRLk------------------QDGICIYKIdSSsGYLSKVGYQIT-GIh--PRIFDITPNGKFLYVCCRDSNCIEV 313
3SCY_A       274 YASNRLk------------------ADGVAIFKVdETnGTLTKVGYQLT-GIh--PRNFIITPNGKYLLVACRDTNVIQI 332 Bacteroides fra...
O59681       244 VASNRYlnh--------------gqCDSLWAARLdPVtGKVIEGTEMQIMLHgicPRHFMFNRGASLLAVAMQDDDLVHV 309 Schizosaccharom...
Q2H0R7       296 TVSSRFerelsytv----angtevaSDPLITFSI-DAeGQLTHVQTAPAGGIn--PRHFSFNSDGSRVASALQSDGRVVI 368 Chaetomium glob...
Q7S9K3       293 LVSSRFdektfdipdpednaagrikSDSIINYAI-EAdGTLSLHQIFAAGGIn--PRQFSLSKDGSLVVSALQNSGHVAL 369 Neurospora crassa
Q4WHI9       299 YASIRSdha-------------fsgNDSLATLNR-SQnGTVTFQELTSSYGLv--PRTFVINRAGTLVAIGDQSSSNVAI 362 Aspergillus fum...
XP_001272673 296 YASVRSdha-------------fkpNDSLVTLTR-AHnGTVALRELTSAYGTv--PRTMVINKAGTLVAVGDQASANVAI 359
Q7S6A9       287 YASNRAdqtf------------gsnQDSVAIYTIdHQtGGIAWKEAANSYSYy--PRTFDINKDGTLVAFGGQTSSNVAI 352 Neurospora crassa
1RI6_A       304 YEIVGEQGLLHEKGRY-AVGQGPM 326 Escherichia coli
Q8A8P5       357 FERNRNTGLLKNTGKN-IRLERPA 379 Bacteroides thetaiotaomicron
XP_001582328 314 YQRSLESGLLRKDSE--IKLPHPV 335
3SCY_A       333 FERDQATGLLTDIKKD-IKVDKPV 355 Bacteroides fragilis NCTC 9343
O59681       310 YRREPKSMCLHLLFT--IPAPKPT 331 Schizosaccharomyces pombe 972h-
Q2H0R7       369 FERDVTTGKIGKVVAEtDVAGMPN 392 Chaetomium globosum CBS 148.51
Q7S9K3       370 IKRNVQTGNLTEFIGAvHLGGQPT 393 Neurospora crassa
Q4WHI9       363 VSRDSASGKLGDLVAN-LQVGEPG 385 Aspergillus fumigatus
XP_001272673 360 IARNPKSGKLGDLVAS-VQVGEPG 382
Q7S6A9       353 VSRDPATGKLGNLVAN-LQVGNKG 375 Neurospora crassa
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