Conserved Protein Domain Family
beta-trefoil_FGF14

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cd23330: beta-trefoil_FGF14 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 14 (FGF14) and similar proteins
FGF14, also called fibroblast growth factor homologous factor 4 (FH-4), may be involved in nervous system development and function. It interacts with SCN8A. FGF14 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 467016
Aligned: 5 rows
Threshold Bit Score: 288.103
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q92915        65 DPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECK 144 human
NP_990108     70 DPQLKGIVTRLYCRQGYYLQMHPDGSLDGTKDDSSNSTLFNLIPVGLRVVAIQGVKTGLYIALNNEGFLYTSELFTPECK 149 chicken
NP_001012382  65 DPQLKGIVTRLYCRQGYYLQMNPDGSLDGTKDDSSNSSLFNLIPVGLRVVAIQSVKTGLYIAMNGEGHLYTSELFTPECK 144 zebrafish
XP_007885222  66 DPQLKGIVTRLYCRQGFYLQMHPDGAVDGTKDDSTNSTLFNLVPVGLRVVAIQGVKSGLYVAMNGEGYLYTSELFTPECK 145 elephant shark
XP_005994553  70 DPQLKGIVTRLYCRQGYYLQMHPDGSLDGTKDDSSNSTLFNLIPVGLRVVAIQGMKTGLYIAMNGEGYLYTSELFTAECK 149 coelacanth
Q92915       145 FKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREP 209 human
NP_990108    150 FKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQVMKGNRVKKTKPAAHFLPKPLEVAMYREP 214 chicken
NP_001012382 145 FKESVFENYYVIYSSMLYRQQESGRAWFLGLNKDGQAMKGNRVKKTKPAAHFLPKPLEVAMYREP 209 zebrafish
XP_007885222 146 FKESVYENYYVIYSSMLYRQQESGRAWYLGFNKEGQIMKGNRVKKTKPAAHFLPKPLEVTMYREP 210 elephant shark
XP_005994553 150 FKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREP 214 coelacanth
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