1VFP,3TLM


Conserved Protein Domain Family
P-type_ATPase_SERCA
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cd02083: P-type_ATPase_SERCA 
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sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Links
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Statistics
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PSSM-Id: 319778
Aligned: 24 rows
Threshold Bit Score: 1527.61
Created: 20-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
1VFP_A          5 HSKSTEECLAYFGvsettGLTPDQVKRHLEKYGHNELPAeegksLWELVIEQFEDLLVRILLLAACISFVLAWfeege-- 82   rabbit
CAA76764       11 HAYPLEKVVGAVQtnlqkGLTKVEAEARLTKYGPNELEKeekesIWEKIKEQFEDNLVRILLLAAVISFVISQfedhed- 89   Paramecium te...
O23087         10 WSWSVEQCLKEYKtrldkGLTSEDVQIRRQKYGFNELAKekgkpLWHLVLEQFDDTLVKILLGAAFISFVLAFlgeehg- 88   thale cress
CAB65295        5 FAKPVDEVLSTFGvdpttGLSDEQVAQSRAKYGRNAIPEepptpIWELILEQFKDQLVLILLGSAAISFVLALfede--- 81   Neurospora cr...
Q9SY55          5 YARSVSEVLDFFGvdptkGLSDSQVVHHSRLYGRNVLPEekrtpFWKLVLKQFDDLLVKILIVAAIVSFVLALange--- 81   thale cress
BAA37143        5 HTKSCEEVLEYFNve-tdGLSEEQVKTNTEKYGPNELPTeegkpLWELILEQFDDLLVKILLLAAIISFVLAWfeese-- 81   Yesso scallop
AAC72756        5 FSKTVDEVLHHFEsdpenGLSDEQIKKQTAKFGPNELPAeeskaIWQLVLEQFDDLLVKILLMAAIISFVLALfeene-- 82   Schistosoma m...
EAL17724        6 WTFTPQDALGYFGtnpdtGLTEEQVKRNREAYGENSLPEsapnsLFKLILAQFQDQLVLILLGSAVVSFILAIfedsaep 85   Cryptococcus ...
P54209         28 YSSEVQEVAAFYHvdldrGLSDRDVQQARIKYGRNQMEAeqstpLWKLILKQFDDLLVKILLGAAIVDFIIAIsege--- 104  Dunaliella bi...
NP_001032719    5 HTRTREEVLQHFDvkegiGLSPHVVTQRIAKYGYNELPAeegkpLWQLVLEQFDDLLVKILLLAAVISFILALfeede-- 82   purple urchin

Feature 1                                                                                         
1VFP_A         83 --etitAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPemGKVYRadrksVQRIKARDIVPGDIVEVAVGDKVP 160  rabbit
CAA76764       90 -shavpPWVEPCVIFTILILNAAVGIWQDLDAERAIEALKDLQSphAMVLRdg--eWTQIEAKDLVIGDIVEIKQGDRIP 166  Paramecium te...
O23087         89 sgsgfeAFVEPFVIVLILILNAVVGVWQESNAEKALEALKEMQCesAKVLRdg-nvLPNLPARELVPGDIVELNVGDKVP 167  thale cress
CAB65295       82 --ggwsAFVDPAVIITILVLNAVVGVSQESSAEKAIAALQEYSAneANVVRng--qITRIKAEDLVPGDVVDIAVGARVP 157  Neurospora cr...
Q9SY55         82 --tgltAFLEPFVILLILAANAAVGVITETNAEKALEELRAYQAniATVLRng--cFSILPATELVPGDIVEVTVGCKIP 157  thale cress
BAA37143       82 --eqvtAFVEPFVILTILICNAVVGVWQEKNAEDAIEALKEYEPeiAKVVRkgqrgVQKIRASLLVPGDIVEISVGDKIP 159  Yesso scallop
AAC72756       83 --esisAFVEPLVILLILIANAVIGVWQERNAESAIEALKEYEPeiAKVFRkshygIQRIKARELVPGDIVEVSVGDKVP 160  Schistosoma m...
EAL17724       86 ggswmtAFVEPLVILLILVANAAVGVIQETNAEKAIDALKEYSPdeALVLRng--rLSRVSASSLVPGDIISVHVGDRIP 163  Cryptococcus ...
P54209        105 --siqsGLIEPMVILLILVANATVGVVTERNAEKAIEQLKSYEAddATVLRng--qLQLIPSADIVPGDIVELAVGNKVP 180  Dunaliella bi...
NP_001032719   83 -dekvtAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPeiAKVVRqdkngVQRIRARELVPGDIVEISVGDKIP 161  purple urchin

Feature 1                                                                                         
1VFP_A        161 ADIRILSIkSTTLRVDQSiLTGESVSVIKh-tEPVPDpra--vnQDKKNMLFSGTNIAaGKALGIVATTGvsTEIGKIRD 237  rabbit
CAA76764      167 ADLRMVELkTITLKTDQSiLTGEVNPVNKv-tDSVQKdka--avQDKINFLFSGTLVSnGTAIGVVCNTGmrTEIGKIQK 243  Paramecium te...
O23087        168 ADMRVSGLkTSTLRVEQSsLTGEAMPVLKganLVVMDdc---elQGKENMVFAGTTVVnGSCVCIVTSIGmdTEIGKIQR 244  thale cress
CAB65295      158 ADCRLISIeSNSFAVDQAiLTGESESVGKdfqAVVSDdka--vlQDQVNMLFSGTTVVtGHAKAVVVLTGsnTAIGDIHE 235  Neurospora cr...
Q9SY55        158 ADLRMIEMsSNTFRVDQAiLTGESCSVEK---DVDCTlttnavyQDKKNILFSGTDVVaGRGRAVVIGVGsnTAMGSIHD 234  thale cress
BAA37143      160 ADIRILHIySTTLRIDQSiLTGESVSVIKh-tDPIPDpra--vnQDKKNILFSGTNISaGKCKGIAFGTGlnTAIGKIRD 236  Yesso scallop
AAC72756      161 ADMRIIKImSTTLRVDQSiLTGESVSVIKf-tDAVPDpra--vnQDKKNILFSGTNIAaGKARGIVVSTGlmTEIGKIRN 237  Schistosoma m...
EAL17724      164 ADCRILSFsSSSFRVDQAmLTGESMSVGKt-dAAIKDdsa--vkQDMTNMLFSGTIVVnGAAKALVVLTGsrTAIGAIHS 240  Cryptococcus ...
P54209        181 ADTRVSHIyTTSLKIDQSlLTGESQAVEKh-tEVVHNeqa--vyQDKLNMLFSGTLVVaGRARGIVVGTGsnTAIGKIRD 257  Dunaliella bi...
NP_001032719  162 ADVRITIIkSTTLRVDQAlLTGESVSVMKq-vEEIPDpra--vnQDKKNILFSGTNIAaGKCSGVVIGTGlsTEIGKIRT 238  purple urchin

Feature 1                                                                                         
1VFP_A        238 QMAATeq----dkTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFndpvhg--------gswirGAIYYFKIAVALAVA 305  rabbit
CAA76764      244 EVQDAakekseddDPLSKRLDEFGDKLAKYVTYICIICWVMNIGNFsdpay---------ggtimGALYYFKVAVALAVA 314  Paramecium te...
O23087        245 QIHEAsle--eseTPLKKKLDEFGSRLTTAICIVCVLVWMINYKNFvswdvvdgykpvnikfsfeKCTYYFKIAVALAVA 322  thale cress
CAB65295      236 SITAQis----epTPLKQKLNDFGDQLAKVITVICVLVWLINIPNFadpsh---------gnwtkGAIYYLKIAVSLGVA 302  Neurospora cr...
Q9SY55        235 SMLQTdd----eaTPLKKKLDEFGSFLAKVIAGICVLVWVVNIGHFsdpsh---------ggffkGAIHYFKIAVALAVA 301  thale cress
BAA37143      237 EMMETet----ekTPLQQKLDEFGTQLSKVITIICICVWAINIGHFndpahg--------gswmkGAIYYFKIAVALAVA 304  Yesso scallop
AAC72756      238 QMMDTep----dkTPLQQKLDEFGQQLSKVISIICVAVWAINIGHFndpahg--------gswlkGAIYYFKIAVALAVA 305  Schistosoma m...
EAL17724      241 SISKGdee--eekTPLKRKLDDFGDQLAKVISVICILVWLVNIRHFndpsh---------hgwlkGAIYYLKIAVALAVA 309  Cryptococcus ...
P54209        258 AMGVEed----vvTPLKAKLDEFGALLSKVIAGICVLVWVVNINRFndpal---------ggwfqGAIHYFKIAVALAVA 324  Dunaliella bi...
NP_001032719  239 EMVETet----ekTPLAQKLDEFGEQLSKVISVICVTVWAINIGHFsdpshg--------gswvkGAVYYFKIAVALAVA 306  purple urchin

Feature 1                                                      #######                            
1VFP_A        306 AIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTsVICSDKTGTLTTNQMSVCKMFIidkvdgdfcsLNEFSIT 385  rabbit
CAA76764      315 AIPEGLPAVITTCLALGARRMAKQKAIVRKLPKVQTLGCTtIICSDKTGTLTTNEMCVKELVLltgq--eassLQVFPVE 392  Paramecium te...
O23087        323 AIPEGLPAVITTCLALGTRKMAQKNAIVRKLPSVETLGCTtVICSDKTGTLTTNQMSATEFFTlggk---tttTRVFSVS 399  thale cress
CAB65295      303 AIPEGLAVVITTCLALGTRKMAAKNAVVRSLPSVETLGSCsVICSDKTGTLTTNQMSVNKIVHfnqd---gtdLEELDVE 379  Neurospora cr...
Q9SY55        302 AIPEGLPAVVTTCLALGTKKMARLNAIVRSLPSVETLGCTtVICSDKTGTLTTNMMSVSKICVvqsae-hgpmINEFTVS 380  thale cress
BAA37143      305 AIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTsVICSDKTGTLTTNQMSVCKMFVfnkvegadiqTQQFEIT 384  Yesso scallop
AAC72756      306 AIPEGLPAVITTCLALGTRRMAAKNAIVRSLPSVETLGCTsVICSDKTGTLTTNQMSVCRMFIfskaddkapeVHHFEIT 385  Schistosoma m...
EAL17724      310 AIPEGLAAVITACLALGTKKMAKRGAIVRNLPSVETLGCTnVICSDKTGTLTTNQMSVSRFVTcdd-----agFTEYQVG 384  Cryptococcus ...
P54209        325 AIPEGLPAVVTTCLALGTRKMARHNAIVRTLPSVETLGCTtVICSDKTGTLTTNQMSVIKVAAvqss---ssqLAEFDVT 401  Dunaliella bi...
NP_001032719  307 AIPEGLPTIITTCLALGTRRMAKKNAIVRSLPSVETLGCTsVICSDKTGTLTTNQMSASRFFLlkdvqgdtanFNEFSVS 386  purple urchin

Feature 1                                                                                         
1VFP_A        386 GsTYAPEGEVLKndkpi---rsgqfDGLVELATICa------LCNDSSLDFNETkgVYEKVGEATETALTTLVEKMNvfn 456  rabbit
CAA76764      393 GtSYHPEGKIDGleskl----lkgnDLSGNLKRLCqs---maLCNESKLYMDKG--RVQRSGLPTEAALKVLVEKIGkyd 463  Paramecium te...
O23087        400 GtTYDPKDGGIVdwgc-----nnmdANLQAVAEICs------ICNDAGVFYEGK--LFRATGLPTEAALKVLVEKMGipe 466  thale cress
CAB65295      380 GtTFEPKGAIMSqgk-------kvtDLAQNSATILqltevaaLCNDARLDYHPStgTFSNVGEATEGALRVLTEKIGpca 452  Neurospora cr...
Q9SY55        381 GtTYAPEGTVFDsngmql-dlpaqsPCLHHLAMCSs------LCNDSILQYNPDkdSYEKIGESTEVALRVLAEKVGlpg 453  thale cress
BAA37143      385 GsTYAPEGDVYLggkkv---ktcdyDGLEEMATICa------MCNDSSVDYNDTkgVYEKVGEATETALTVLCEKMNffn 455  Yesso scallop
AAC72756      386 GsKYAPEGEVFLngqkv---esgeyDGLVEVANICa------MCNDSAIDYNETkhVYEKVGEATETALCCLVEKMNvyk 456  Schistosoma m...
EAL17724      385 GtTFAPIGAVTRsdgqpldkstlitPIIRKLSEICa------ICNDAKVAYHPEseTYSNVGEPTEAALKVLVEKLGsdn 458  Cryptococcus ...
P54209        402 GtTFSPEGMVLGpggvvl-rqpadtPCLAHAAQCAa------LCNDSQVFVAQKtgTLQRIGESTEIALRVFAEKIGlps 474  Dunaliella bi...
NP_001032719  387 GvTYEPKGEVFIdgrra---dlgayAALPELATICa------VCNDSSSDYNDAkgFYEKVGETTETALTVLVEKMNimg 457  purple urchin

Feature 1                                                                                         
1VFP_A        457 tevrnlskver---------anacnsvirqlmkKEFTLEFSRDRKSMSVYCSpakss---------raavgNKMFVKGAP 518  rabbit
CAA76764      464 ksfngrpilda---------pqqyndkivnefaKRATLXFTRDRKSMSVLASsqn-------------ekgNVLFIKGAP 521  Paramecium te...
O23087        467 kknsenieevtnfsdngssvklaccdwwnkrskKVATLEFDRVRKSMSVIVSepn--------------gqNRLLVKGAA 532  thale cress
CAB65295      453 psdcppkdrv-----------hyasswyekqyqRLATYEFSRDRKSMSVLVErd---------------gqQKLLVKGAP 506  Neurospora cr...
Q9SY55        454 fdsmpsalnmlsk----herasycnhywenqfkKVYVLEFTRDRKMMSVLCShk---------------qmDVMFSKGAP 514  thale cress
BAA37143      456 tgrsglnlreq---------gtvcnhviqqmwsKEFTLEFSRDRKSMSVYCTpnkps---------kipggTNMFAKGAP 517  Yesso scallop
AAC72756      457 tsksglskkdl---------smvcnhqiqamwnKEFTLEFSRDRKSMSVYLQvkpafaskvpntagsgetgPRMFVKGAP 527  Schistosoma m...
EAL17724      459 dlfnsglatldpl-----aratavndyydsnvkRLLTFEFSRDRKSMSVLSQss---------------ngTSLLVKGAP 518  Cryptococcus ...
P54209        475 sirpdrpisrs---------qfgtnnfwqedveRLALLEFSRDRKMMSVLVKgsd--------------rqHNIWSKGAP 531  Dunaliella bi...
NP_001032719  458 tdlsrlsksql---------snacnqallsrynKDVTLEFSRDRKSMSVYCSpskts----------qekgNKMFVKGAP 518  purple urchin

Feature 1                                                                                         
1VFP_A        519 EGVIDRCNYVRvg-tTRVPMTGPvkeKILSVIKEWGTGr--DTLRCLALAtrdtppkreem---------vlddssrfme 586  rabbit
CAA76764      522 DYLLEKSTMILns-dGVAVPLKAq-dKNQLLTIVKNLAe--KGLRTLAICvqrcgqlseydgpkh-pahnllvdtnnynh 596  Paramecium te...
O23087        533 ESILERSSFAQla-dGSLVALDEs-sREVILKKHSEMTs--KGLRCLGLAykdelgefsdysseehpshkklldpssysn 608  thale cress
CAB65295      507 ESLIERCTHALlgpdGKKVPLDSn-mSELLMKEVVEYGn--RGLRVIALAsldnvagnpllh--------takstaeyas 575  Neurospora cr...
Q9SY55        515 ESIIARCNKILcngdGSVVPLTAa-gRAELESRFYSFGd--ETLRCLALAfktvphgq----------------qtisyd 575  thale cress
BAA37143      518 EGLLDRCTHVRv--gKDKVPMSPa-iKNEILKYTKAYGtgrDTLRCLALAtidapprredm---------dledsrkfiq 585  Yesso scallop
AAC72756      528 EGVLDRCTFVRi--gNKKVPMTPp-lKAEIVKHVASYGtgrDTLRCLALAtcdapvnkaqm---------dledstkfvk 595  Schistosoma m...
EAL17724      519 ESVLERCSNVLl--pNGVKAFTPe-lRKKLEEKQLEYGh--KGLRTLALAyvdesdgdvshy--------ktdrsedyvk 585  Cryptococcus ...
P54209        532 EFVLRKCSHVLanngEGAVPLTDn-mRQAILSDMQAFGs-rQALRCLALAfksvpttt----------------tkldys 593  Dunaliella bi...
NP_001032719  519 EGILDRCNSVRi--gSTKVPLTPs-vKTQIIEKIQSYGtgrDALRCLGMAtvdnpikkeem---------dlensvnfgk 586  purple urchin

Feature 1                                                                                         
1VFP_A        587 yETDLTFVGVVGMLDPPRKEVMGSIQLCrdAGIRVIMITGDNKGTAIAICRRIGIFgenee--------vadrAYTGREF 658  rabbit
CAA76764      597 lESKPIIIGVVALQDPPRPEVKRSIEKCreAGISVIMITGDIKETAQSIAMQIGILhnqsq--------fpthSFTGMEF 668  Paramecium te...
O23087        609 iETNLIFVGVVGLRDPPREEVGRAIEDCrdAGIRVMVITGDNKSTAEAICCEIRLFsened--------lsqsSFTGKEF 680  thale cress
CAB65295      576 lEQNLTLIGLVGMLDPPRPEVAASIKKCkdAGIRVVVITGDNRNTAESICRQIGVFgsned--------ltgkSYTGREF 647  Neurospora cr...
Q9SY55        576 nENDLTFIGLVGMLDPPREEVRDAMLACmtAGIRVIVVTGDNKSTAESLCRKIGAFdnlvd--------fsgmSYTASEF 647  thale cress
BAA37143      586 yETNMTFVGVVGMLDPPRMEVFDSIKNCrkAGIRVIVITGDNKATAEAICRRIGVFgenes--------tegmSFTGREF 657  Yesso scallop
AAC72756      596 yEQNLTFVGVVGMLDPPRMEVFDSIARCrkSGIRVIMITGDNKATAEAICRRIGIFsedep--------ttgkSFTGREF 667  Schistosoma m...
EAL17724      586 fERDMTFVGLIGMLDPPRPEVRDAIAKCktAGIRTIVITGDNKNTAETICREIGVFghded--------ltgkSYTGREL 657  Cryptococcus ...
P54209        594 dESGLTFIGLLGMHDPPRPECRSALSTChnAGIKVIMVTGDNKGTAEAVARQVGALspstalagsddednlgiSYTGREF 673  Dunaliella bi...
NP_001032719  587 yESNMTFVGCVAMLDPPRAEVKSSIEECrlAGIRVIVITGDNKATAEAICRKIGVFgpdes--------teglSYSGREL 658  purple urchin

Feature 1                                                                                         
1VFP_A        659 Ddlplaeq------reacrrACCFARVEPSHKSKIVEYLQsy-dEITAMTGDGVNDAPALKKAEIGIAMGs-GTAVAKTA 730  rabbit
CAA76764      669 StmgeekqnkvleqvigrpsGLVFSRTDPSHKRELVKLLTgqlnQIAAMTGDGVNDAPALKQASIGIAMGisGTEVAKEA 748  Paramecium te...
O23087        681 Mslpasrrs----eilsksgGKVFSRAEPRHKQEIVRMLKem-gEIVAMTGDGVNDAPALKLADIGIAMGitGTEVAKEA 755  thale cress
CAB65295      648 Dnltpseq------leaaktASLFSRVEPTHKSKLVDLLQsl-gEVVAMTGDGVNDAPALKKADIGVAMGs-GTDVSKLA 719  Neurospora cr...
Q9SY55        648 Erlpavqq------tlalrrMTLFSRVEPSHKRMLVEALQkq-nEVVAMTGDGVNDAPALKKADIGIAMGs-GTAVAKSA 719  thale cress
BAA37143      658 Ddlsheeq------rlavtkSRLFARVEPAHKSKIVEYLQge-gEISAMTGDGVNDAPALKKAEIGIAMGs-GTAVAKSA 729  Yesso scallop
AAC72756      668 Dalpieeq------reacrrARLFARVEPMHKSKIVEFLQed-gEVSAMTGDGVNDAPALKKAEIGIAMGs-GTAVAKSA 739  Schistosoma m...
EAL17724      658 Dalsheek------iaavqrASLFSRTEPTHKSQLVDLLQgl-gLVVAMTGDGVNDAPALKKADIGIAMGt-GTDVAKLA 729  Cryptococcus ...
P54209        674 Eemgalgq------aaatrnLVVLSRVEPMHKLRLVELLKaq-gHVVAMTGDGVNDAPALLRADIGIAMGs-GTAVAKHA 745  Dunaliella bi...
NP_001032719  659 Ddlspaeq------kaaclrSRLFSRVEPSHKSKIVDYLQsd-gEITAMTGDGVNDAPALKKAEIGIAMGs-GTAVAKSA 730  purple urchin

Feature 1                                                                                         
1VFP_A        731 SEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEaLIPVQLLWVNLVTDGLPATALGFN 810  rabbit
CAA76764      749 SDMILADDNFATIVRAVEEGRAIYQNMKGFIRYMISSNIGEVVSIFTSSALGIPDgFNSIQLLWVNLVTDGLPATALSFN 828  Paramecium te...
O23087        756 SDMVLADDNFSTIVSAVAEGRSIYNNMKAFIRYMISSNVGEVISIFLTAALGIPEcMIPVQLLWVNLVTDGPPATALGFN 835  thale cress
CAB65295      720 ADMVLADDNFATIEVAIEEGRAIYNNTQQFIRYLISSNIGEVVSIFLTAALGMPEaLIPVQLLWVNLVTDGLPATALSFN 799  Neurospora cr...
Q9SY55        720 SDMVLADDNFASIVAAVAEGRAIYNNTKQFIRYMISSNIGEVVCIFVAAVLGIPDtLAPVQLLWVNLVTDGLPATAIGFN 799  thale cress
BAA37143      730 SEMVLADDNFATIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVCIFLTAALGIPEaLIPVQLLWVNLVTDGLPATALGFN 809  Yesso scallop
AAC72756      740 ADMVLADDNFNSIVLAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEaLIPVQLLWVNLVTDGLPATALGFN 819  Schistosoma m...
EAL17724      730 ADMVLANDNFATIEKAVEEGRAIYNNTKQFIRYLISSNIGEVVSIFLTVLLGMPEaLIPVQLLWVNLITDGLPATALGFN 809  Cryptococcus ...
P54209        746 ADMVLGDDNFATIVFAVAEGRVIFNNTKQFIRYMISSNIGEVVAIFLAALLGLPEvLTPVQLLWVNLVTDGLPATALGFN 825  Dunaliella bi...
NP_001032719  731 SEMVLADDNFSTIVTAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGMPEaLIPVQLLWVNLVTDGLPATALGFN 810  purple urchin

Feature 1                                                                                         
1VFP_A        811 PPDLDIMdrpPRspke-plisGWLFFRYMAIGGYVGAATVGAAAWWFmyaedg---------pgvtyhQLTHFMQCtedh 880  rabbit
CAA76764      829 PPDPDVMqkpPRkhde-piitEYVFVRYCVVGTYVGLATVFVFIYYYlgyewagd-----ghpvvtfhQLRNWAEChhwe 902  Paramecium te...
O23087        836 PADIDIMkkpPRksdd-clidSWVLIRYLVIGSYVGVATVGIFVLWYtqasflgislisdghtlvsftQLQNWSECsswg 914  thale cress
CAB65295      800 PPDHDIMrrnPRkrde-aligGWLFFRYLVIGTYVGLATVAGYAWWFmfyseg---------pqisfyQLSHFHRCstef 869  Neurospora cr...
Q9SY55        800 KQDSDVMkakPRkvge-avvtGWLFFRYLVIGVYVGLATVAGFIWWFvysdgg---------pkltysELMNFETCalre 869  thale cress
BAA37143      810 PPDMDIMkkpPRnake-glitGWLFFRYMAIGGYVGCATVGAAAWWFmvydkg---------pqlnyyQLTHHSQClaqd 879  Yesso scallop
AAC72756      820 PPDLDIMerpPRnikd-plisGWLFFRYVAIGVYVGCATVGAAAWWFslypkg---------pqlnyyQLTHHMQClaek 889  Schistosoma m...
EAL17724      810 PPDHQIMktpPRsgke-plvgGWLFFRYMVIGTYVGCATVFGYAWWFmfytgg---------pqisfyELTHFHQCssvf 879  Cryptococcus ...
P54209        826 RADKDMMargPRrvdd-pivnGWLFLRYLIIGMYVGIVTVYGFIWWYisfpeg---------gnmtwsQLTHFQACasqp 895  Dunaliella bi...
NP_001032719  811 GPDIDIMt-kPPgnsreplisGWLFFRYMAIGIYVGAATVGASAWWFmfyedg---------phlsfwQLTHHLQCplep 880  purple urchin

Feature 1                                                                                         
1VFP_A        881 phfegld------------------ceifeapepmTMALSVLVTIEMCNALNSLSENQSLMRMPPWvNIWLLGSICLSMS 942  rabbit
CAA76764      903 gfkvanfdkydf-------skdpclyfswgkqkasTLSLSVLVVIEMFNALNALSEDGSLLKVGVFaNPYLILAIFGTMT 975  Paramecium te...
O23087        915 tnftatpytvagglrtiafennpcdyftlgkvkpmTLSLTVLVAIEMFNSLNALSEDNSLLTMPPWrNPWLLVAMTVSFA 994  thale cress
CAB65295      870 peigcam------------------fsndmakagsTVSLSILVVIEMFNAMNALSSSESLLTLPVWkNMMLVYAIGLSMA 931  Neurospora cr...
Q9SY55        870 ttypc---------------------sifedrhpsTVAMTVLVVVEMFNALNNLSENQSLLVITPRsNLWLVGSIILTML 928  thale cress
BAA37143      880 erflgvd------------------ckvfdhpapmTMALSVLVVIEMLNALNSLSENQSLLVMPPWcNKWLLGAMALSMG 941  Yesso scallop
AAC72756      890 dnfhgid------------------chifenpkpmTMALSVLVLIEMFNALNSLSENQSLVAMPPWvNIWLVLAMIVSMS 951  Schistosoma m...
EAL17724      880 snldcsm------------------ftglpaqratTVSLSILVVIEMFNACNSLSENESLFVLPLWsNPYLVASIILSMA 941  Cryptococcus ...
P54209        896 ggakdc--------------------evfhskhptTISMSVLVVVEMFNALNNLSEDSSLLRIPPWdNKWLVGAIATSMA 955  Dunaliella bi...
NP_001032719  881 knfkkld------------------cdvfqdphsmTMALSVLVTIEMLNSLNSLSENQSLTVMPPWsNMWLLGAIALSMS 942  purple urchin

Feature 1                                                        
1VFP_A        943 LHFLILYVDplpmifklkaLDLTQWLMVLKISLPVIGLDEILKFIAR 989  rabbit
CAA76764      976 LHCMICYVPlfenifntvpLSLQDWILIIGVSAPVVLVDEVLKFFSR 1022 Paramecium tetraurelia
O23087        995 LHCVILYVPflanvfgivpLSFREWFVVILVSFPVILIDEALKFIGR 1041 thale cress
CAB65295      932 LHFALLYTPilqtlfsilpMNWAEWKAVIVISAPVVLLDELLKAVER 978  Neurospora crassa
Q9SY55        929 LHVLILYVHplavlfsvtpLSWAEWTAVLYLSFPVIIIDELLKFLSR 975  thale cress
BAA37143      942 LHFCILYIDvmstifqitpLGFEEWFAVLKISMPVILIDETLKFCAR 988  Yesso scallop
AAC72756      952 LHFLILEVEflskvfqitpLSLEEWFMVIKISAPVIFIDEILKLIAR 998  Schistosoma mansoni
EAL17724      942 LHFMILYVPffremfritaLNKEEWIAVIVISFPVIVIDEVLKFISM 988  Cryptococcus neoformans var. neoformans B-3501A
P54209        956 LHFGILYTGasamf-gvtgLSFAEWTMVIKLSAPVILVDEIMKAWSR 1001 Dunaliella bioculata
NP_001032719  943 LHFVILYVDvlstvfqitpLNLAEWMAVMKISLPVILLDEMLKFMAR 989  purple urchin

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