Conserved Protein Domain Family
ELAV_HUD_SF
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TIGR01661: ELAV_HUD_SF 
ELAV/HuD family splicing factor
This model describes the ELAV/HuD subfamily of splicing factors found in metazoa. HuD stands for the human paraneoplastic encephalomyelitis antigen D of which there are 4 variants in human. ELAV stnds for the Drosophila Embryonic lethal abnormal visual protein. ELAV-like splicing factors are also known in human as HuB (ELAV-like protein 2), HuC (ELAV-like protein 3, Paraneoplastic cerebellar degeneration-associated antigen) and HuR (ELAV-like protein 1). These genes are most closely related to the sex-lethal subfamily of splicing factors found in Dipteran insects (TIGR01659). These proteins contain 3 RNA-recognition motifs (rrm: pfam00076).
Links
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Statistics
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PSSM-Id: 273741
Aligned: 4 rows
Threshold Bit Score: 544.535
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P26378        43 DSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKIT-------------GQSLGYGFVNYIDPKDAEKAINTLNG 109 human
XP_002059614 179 ETRTNLIVNYLPQTMTEDEIRSLFSSVGEIESVKLIRDKSQvyidplnpqapskGQSLGYGFVNYVRPQDAEQAVNVLNG 258 Drosophila virilis
XP_002002597 121 DPKTNLIVNYLPQTMSQDEIRSLFVSFGEVESCKLIRDKVT-------------GQSLGYGFVNYVKQEDAEKAINALNG 187 Drosophila moja...
NP_496057     39 ESKTNLIINYLPQGMTQEEVRSLFTSIGEIESCKLVRDKVT-------------GQSLGYGFVNYVREEDALRAVSSFNG 105 Caenorhabditis ...

P26378       110 LRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTg-----VSRGVGFIRFDKRI 184 human
XP_002059614 259 LRLQNKTIKVSFARPSSDAIKGANLYVSGLPKTMTQQELEAIFAPFGAIITSRILQNAGNd----tQTKGVGFIRFDKRE 334 Drosophila virilis
XP_002002597 188 LRLQNKTIKVSIARPSSESIKGANLYVSGLPKNMTQSDLESLFSPYGKIITSRILCDNITdehaagLSKGVGFIRFDQRF 267 Drosophila moja...
NP_496057    106 LRLQNKTIKVSYARPSNDQIKGSNLYVSGIPKSMTLHELESIFRPFGQIITSRILSDNVTg-----LSKGVGFVRFDKKD 180 Caenorhabditis ...

P26378       185 EAEEAIKGLNGQKPSGATEPITVKFANNPSqKSSQALLSQLYQSPNRRYPG--------------------PLHHQ--AQ 242 human
XP_002059614 335 EATRAIIALNGTTPSSCTDPIVVKFSNTPG-STSKIIQPQLPAFLNPQLVRrigg------------amhtPVNKG--LA 399 Drosophila virilis
XP_002002597 268 EADRAIKELNGTTPKNSTEPITVKFANNPS-SNKNSMQP-LAAYIAPQNTRggrafpa-------naaagaAAAAA--AA 336 Drosophila moja...
NP_496057    181 EADVAIKTLNGSIPSGCSEQITVKFANNPAsNNPKGLLSDLEAVQQAATTLvplstilgaptlrataggigPMHHApiTS 260 Caenorhabditis ...

P26378       243 RFRLDNL---------------------------------------------LNMAYGvkrlmsgp-vppsacpPRFSPI 276 human
XP_002059614 400 RFSPMAG---------------------------------------------DMLDVM----------------LPNGLG 418 Drosophila virilis
XP_002002597 337 AIHPNAG---------------------------------------------RYSSVI----------------SRYSPL 355 Drosophila moja...
NP_496057    261 KYRYSPMgaitavsqptatlpadylttsallqmsqlnalaglnpfatatavpDFTASLiahqqqqhavaqqhaaQTASPP 340 Caenorhabditis ...

P26378       277 TIDGMT-SL-VGMNIPGh-----------TgtgwcIFVYNLSPDSDESVLwQLFGPFGAVNNVKVIRDFnTNKCKGFGFV 343 human
XP_002059614 419 AAAAAAtTLaSGPGGAY------------P-----IFIYNLAPETEEAALwQLFGPFGAVQSVKIVKDPtTNQCKGYGFV 481 Drosophila virilis
XP_002002597 356 TSDLITnGMiQGNTITS------------Sgw--cIFVYNLAPETEENVLwQLFGPFGAVQSVKVIRDLqSNKCKGFGFV 421 Drosophila moja...
NP_496057    341 ATNGQVaGLaAHAQLSAlsasvaatlppsDtagycLFVYNLSSDTDDTLLwQLFSQFGAIVNVKILRDL-TQQCKGYAFV 419 Caenorhabditis ...

P26378       344 TMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAH 378 human
XP_002059614 482 SMTNYDEAAMAIRALNGYTMGNRVLQVSFKTNKAK 516 Drosophila virilis
XP_002002597 422 TMTNYEEAVLAIQSLNGYTLGNRVLQLAAVVNANA 456 Drosophila mojavensis
NP_496057    420 SMSNYTEAYNAMLSLNGTNLAGKTLQVVFKSSTPY 454 Caenorhabditis elegans
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