Conserved Protein Domain Family
Sperm_Ag_HE2
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pfam05324: Sperm_Ag_HE2 
Sperm antigen HE2
This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins.The EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages. The translated putative protein variants differ significantly from each other. Some of these putative proteins have similarity to beta-defensins, a family of antimicrobial peptides.
Links
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Statistics
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PSSM-Id: 461622
Aligned: 9 rows
Threshold Bit Score: 88.3999
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002929982   4 SLSLFISLLLVALMPP-GQSRAGNVNHQGTEGlrePRESREESPGQGKngsplfHHQEKRQLL-PRTPPYPEPE 75 
XP_003803643   5 FLPPFTSLLLVVLLFS-GLSGTQYVDHSSTEG---PRELGEQSPGHSS------HQQVKRYVLpPRTPPYQEPE 68 
XP_002818835  49 LLLSVASLLLVALLLP-GSSQARHVNHSATDA---LGELRERAPGQGTnrfqllRHPVKRDLLpPRTPPYQGDV 118
NP_001291353   5 LLPSFVSLLLAALLLP-GSSSASSINHLVTEP---PSSPQDEFPAQGGngsgllHHRVKR--FpPRTPPYHEPG 72 
ABI24142       5 LAPS--TLLFVVLLFP-GLSRVTHANRQDPKG---PRK-QEESLGRGTnrshplHHQVKRYLV-PRKPPFPDTD 70 
Q30KR3         4 PLSPLVSFLLVALMFP-GPSRARNINHQGTEG---PREPWEESPGQGKneshllHHREKRRLL-PRTPPYLEPE 72  dog
2_pfamImport   1 FFSAFVSLLLVALMFP-GRSRAGSVHHPDAERlraLRESGEASPGQEKigsplpHHQEKRYLL-PRTPPFPEPE 72 
NP_001030077   5 LLPFFASLLFAALLFPaGLSNASSINHLVTEP---PSFPKDEFPARGVngsqllHHRVKR--LpPRTPPYHGKS 73  house mouse
XP_030664984   5 LLPFVASLLLVALLFP-GSSQARHVNHSATEA---LRELGEGAPEQGTngsqllHHPVKQDLLpPRTPPYQEPA 74  northern white-cheeke...
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