Conserved Protein Domain Family
AAA_10
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pfam12846: AAA_10 
AAA-like domain
This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins, including VirB4 components of the Type IV secretory pathway and conjugal transfer protein TrbE. This entry includes the arcaheal Vir4/HerA homolog CedB, a membrane-bound protein that is highly induced upon UV treatment and essential for DNA transfer between Sulfolobus cells.
Links
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Statistics
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PSSM-Id: 315512
Aligned: 11 rows
Threshold Bit Score: 406.012
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q82YT2   443 KI-VWFFPNLTK-KAIEGAQYTNGNT-LIIGPPGQGKSVLVKYIFLWLTFLG---------QKILYIDPKNE-TVLfF-- 507 Enterococcus faecalis
Q180M9   443 RN-VYLQPSLAS-QGVKGTVTNALAS-AFVGSLGGGKSFCNNLLVYYAVLFG---------GQAVILDPKAE-RGN-W-- 506 Clostridioides diff...
Q833R2   443 RN-VYLKPALAS-QGVKGSVTNALAA-AFLGSLGGGKSFSNNLLVYYAVLFG---------GQAVIVDPKGE-RGG-W-- 506 Enterococcus faecalis
Q832F0   443 RN-VYLKPALAS-QGVKGSVTNALAA-AFLGSLGGGKSFSNNLLVYYAVLFG---------GQAVIVDPKGE-RGG-W-- 506 Enterococcus faecalis
Q8Y813   444 KN-VYLKPALAS-QGVKGSVTNALAS-AFIGSLGGGKSFSNNMLVYYAVLFG---------GQAVIVDPKAE-RGK-W-- 507 Listeria monocytogenes
AAO80352 443 KI-VWFFPNLTK-KAIEGAQYTNGNT-LIIGPPGQGKSVLVKYIFLWLTFLG---------QKILYIDPKNE-TVLfF-- 507
P96642   442 RDfVLFHPFLAN-QQLKGSKTRSPHC-LITGDTGNGKSYLAKLIFNYISMLN---------IKSLYIDPKKE-MRK-Wiq 508 Bacillus subtilis s...
Q839K7   443 KNiVYMNLLLANkQNIEGKKTNNPHW-LVSGDTGNGKSVFSKWLFLYSSLLD---------VKVLYIDPKKEvRQQ-F-- 509 Enterococcus faecalis
Q831J1   444 KNlIFMNMLLANkEGVDGKKTNNPHW-ALTGDTGNGKSVTAKTLFMQMALLK---------DRVLYIDPKKEmRKQ-F-- 510 Enterococcus faecalis
Q2RLP7   425 AP-VWWRPGYAA-RELGR--SNAV---FITGGLGGGKSMTIKTMGHFIRLAG---------GVLFVIDPKKN-EYR-A-- 484 Moorella thermoacet...
Q9AD04   447 RP-VLIDP-------TRGPRENASGSmAFIGELGAGKSVGMKTAVYNVLARGhqpgrphsrGRAVIVDRTKE--EE-W-- 513 Streptomyces coelic...

Q82YT2   508 --------KRALdkfghiPEfk-------aLYQ--R----------INFVSL-S-SE-ERYRGMLDPLLFLP--RE-EAI 554 Enterococcus faecalis
Q180M9   507 --------KETL------PE----------IAN--E----------INIVNL-T-SD-KDNAGLLDPFVIMK--NVkDAE 545 Clostridioides diff...
Q833R2   507 --------KENL------PE----------IAD--E----------INILNL-T-SK-PENQGLLDPYVIMK--KKkDSE 545 Enterococcus faecalis
Q832F0   507 --------KENL------PE----------IAD--E----------INILNL-T-SK-PENQGLLDPYVIMK--KKkDSE 545 Enterococcus faecalis
Q8Y813   508 --------KETL------PE----------IAH--E----------INIVNL-T-SD-DENKGLLDPYVILS--RKkDSE 546 Listeria monocytogenes
AAO80352 508 --------KRALdkfghiPEfk-------aLYQ--R----------INFVSL-S-SE-ERYRGMLDPLLFLP--RE-EAI 554
P96642   509 rvlndeyiRENF------PLy---------IAHleK----------YNYITL-D-HEnTHNWGALDPISFLP--PMkAKE 559 Bacillus subtilis s...
Q839K7   510 --------MRTIn----dPE----------YQR--KypldvafiktFNFVTL-DvRK-KENHGVLDPIVLFD--ET-EAI 560 Enterococcus faecalis
Q831J1   511 --------MYTIn----dPEyqkkypldvdFVK--S----------FNFVTLdV-RD-TKNHGVLDPIVLFD--ETeAIA 562 Enterococcus faecalis
Q2RLP7   485 --------YERL------YP--------------------------IKRIDL-S-PG-GDQ--ELNPFMLAA--DErRSK 517 Moorella thermoacet...
Q9AD04   514 --------VRFA------KA----------CPG--T----------TQVIRI-D----QEAEVSLDPLRLFNadSPkIAA 552 Streptomyces coelic...

Q82YT2   555 QTARNVLENfgeVTTDS--HTASDKKTLILDS---VNAVM-K---GKGkKHLTKVIEVI---R---EK--DPKLANLI-- 615 Enterococcus faecalis
Q180M9   546 SLAIDILTF---LTGIS--SRDGEKFPVLRKA---VRSVT-Q---SET-RGLLHVIEEL---R---KE--DTAISRNI-- 602 Clostridioides diff...
Q833R2   546 SLAIDILTF---LTGIS--SRDGEKFPVLRKA---IRTVT-Q---SDQ-RGLLQVINEL---R---KE--NSPVAENI-- 602 Enterococcus faecalis
Q832F0   546 SLAIDILTF---LTGIS--SRDGEKFPVLRKA---IRTVT-Q---SDQ-RGLLQVINEL---R---KE--NSPVAENI-- 602 Enterococcus faecalis
Q8Y813   547 SLAIDILTF---LTGIS--SRDSDKFPVLRKA---IRNVT-Q---SEQ-RGLLLVIDEL---R---KE--DTSISNSI-- 603 Listeria monocytogenes
AAO80352 555 QTARNVLENfgeVTTDS--HTASDKKTLILDS---VNAVM-K---GKGkKHLTKVIEVI---R---EK--DPKLANLI-- 615
P96642   560 LV-QVIFEQ---VYDFK--GKDDINTAFLRATsevIDAKQ-K---GEQ-VGSLDIIRKM---Q---SH--PEEAVQKA-- 618 Bacillus subtilis s...
Q839K7   561 ATAKAMLNN---INEDK--WKMPHKTA-INET---VAEVVaErkaGKQ-VGFWHVIERL---I---SH--SEKDVHEM-- 620 Enterococcus faecalis
Q831J1   563 TTKAMLTNI---YEGTWnlKQKTEINEAIAKV---VLERK-E---GKK-VGFWHVIERL---V---ES--EISDVKDM-- 621 Enterococcus faecalis
Q2RLP7   518 GIALDFLSI---ALNLR--DDNDVRRVAVSQA---VERVA-Gr-pPAE-RNLEACLEEL---NmmaKEkaHPQVAREAgq 583 Moorella thermoacet...
Q9AD04   553 RFCESFLTL---LLGVK--PMELEGV-ALSEA---VEAVL-E---RPD-PSMTALVDELverG---RT--DDVAGRNL-- 611 Streptomyces coelic...

Q82YT2   616 -SGHN-----VGLGKILLGND-YSEPIRFENQINVLGTQGLKIP-T--Q-----AEIdSGRLNNEQIAGMSIMEVIMKMT 680 Enterococcus faecalis
Q180M9   603 -ADHIdsftdYDFAHLLFSDGtVENAISLDNQLNIIQVADLVLP-D--K-----DTT-FEEYTTIELLSVSMLIVISTFA 672 Clostridioides diff...
Q833R2   603 -ADHIesftdYDFAHLLFSDGsITQSISLDKQLNIIQVADLVLP-D--A-----ETT-FEEYTTMELLSVSMLIVISTFA 672 Enterococcus faecalis
Q832F0   603 -ADHIesftdYDFAHLLFSDGsITQSISLDKQLNIIQVADLVLP-D--A-----ETT-FEEYTTMELLSVSMLIVISTFA 672 Enterococcus faecalis
Q8Y813   604 -ADHIesfvdYDFAHLLFSDGnVTQSISLEKQLNIIQVADLVLP-D--A-----DTS-FEEYTTMELLSVAMLIVISTFA 673 Listeria monocytogenes
AAO80352 616 -SGHN-----VGLGKILLGND-YSEPIRFENQINVLGTQGLKIP-T--Q-----AEIdSGRLNNEQIAGMSIMEVIMKMT 680
P96642   619 -GDYLnevvsDSILKLCIHDGs-NPALSLEKRITILEVENMDLP-D--H-----AER-LENYTISQLKSSAVMFALGKFC 687 Bacillus subtilis s...
Q839K7   621 -GRFLlstikGSILELAFSHGeVEG-LSFEKKVTILEIEDLDLP-T--D-------R-HDELDENQRLSVTLMFALGTFC 687 Enterococcus faecalis
Q831J1   622 -GRFIlstvkGSVLELAFSHGdVEG-LSFDKKVTILEIEDLDLPtD--K-----NEN-LDEN---KRLSVTLMFALGTFC 688 Enterococcus faecalis
Q2RLP7   584 cALLLeslrdGSLGHLVFGKGrG-NEIS---PVTVVSLQGLPLP-RtaQ-----NLL-AGRITESERQGLGMLYLAAAMA 652 Moorella thermoacet...
Q9AD04   612 -ARKLkavarKDLAAVVFDDTl-PVVDTRRADTVVFAVNSLQLP-K--KaeltsDHR-IERLEFEKVLGRAVMYLIAAVA 685 Streptomyces coelic...

Q82YT2   681 TIF--ST-DKTEDAAIIFDEAKGFEDTAQGRFLIEGSLRQG-RANMTDIYLVTQAFMDY-DKED------KKELLSYKFA 749 Enterococcus faecalis
Q180M9   673 LDFi-HS-DRSIFKIVDLDEAWAFLNVAQGETLSNKLVRAG-RAMQAGVYFVTQSAYDV-SKES------LKNNIGLKFA 742 Clostridioides diff...
Q833R2   673 LDFi-HS-NREIFKIVDLDEAWSFLQVAQGKTLSNKLVRAG-RAMNAGVYFVTQNSDDL-LDER------LKNNIGLKFA 742 Enterococcus faecalis
Q832F0   673 LDFi-HS-NREIFKIVDLDEAWSFLQVAQGKTLSNKLVRAG-RAMNAGVYFVTQNSDDL-LDER------LKNNIGLKFA 742 Enterococcus faecalis
Q8Y813   674 LDFi-HT-DRSIFKIVDLDEAWSFLQVAQGKTLSMKLVRAG-RAMNAGVYFVTQNADDL-LDEK------MKNNIGLKFA 743 Listeria monocytogenes
AAO80352 681 TIF--ST-DKTEDAAIIFDEAKGFEDTAQGRFLIEGSLRQG-RANMTDIYLVTQAFMDY-DKED------KKELLSYKFA 749
P96642   688 ELFgmNQ-DEQTVE--FIDEAWIFTTSQQGKKVERQMRRIG-RSYNNAEYFISQSTKDA-LKEE------DSGNFGVAFA 756 Bacillus subtilis s...
Q839K7   688 SKFg-SR-NRKEETVTFFDEAWIFQSSPEGQKILKSMKRIG-RSFNNFMVLITQSVNDV-LDNG------DGTGFGTVVC 757 Enterococcus faecalis
Q831J1   689 SKFg-SR-NPKEETVTFFDESWIFQSSPEGKAILKSMKRIG-RSFNNFLVLITQSTNDL-DDSE------DGTGFGTVIC 758 Enterococcus faecalis
Q2RLP7   653 REVa-FSlPAHIIKGQIFDEVWMLAGISEGARLLDELIRMGaRSYNAIPILATQNASDVaSMQT------IKNNVSYVLC 725 Moorella thermoacet...
Q9AD04   686 RETa-MA-SKDEFAVAVFDECWYLTSSDEGLELLLELMRDG-RKHNAAAYMGSHDPDDI-GPEGsekgaiLRGLIPHRLM 761 Streptomyces coelic...

Q82YT2   750 FRPNQKEAQKKVLEFFGMDTNPAN---------I----Q-L------INELKSGTCLFQDHRGRSQPIAIDVLFD-SWLM 808 Enterococcus faecalis
Q180M9   743 FRSTDINEIKQTLEFFGIDKDDEN---------N----QkR------LRDLENGQCLLQDLYGRVGVVQIHPVFE-ELLH 802 Clostridioides diff...
Q833R2   743 FRSTDIHEIKKTLEFFGLDQEDES---------N----QkR------LRDLENGQCLMQDLYGRVGVVQVHPVFE-ELFH 802 Enterococcus faecalis
Q832F0   743 FRSTDIHEIKKTLEFFGLDQEDES---------N----QkR------LRDLENGQCLMQDLYGRVGVVQVHPVFE-ELFH 802 Enterococcus faecalis
Q8Y813   744 FRSTDLVEIKKTLTFFGVDPEDEN---------N----QkR------LRELENGQCLISDLYGRVGVMQFHPIFE-ELLQ 803 Listeria monocytogenes
AAO80352 750 FRPNQKEAQKKVLEFFGMDTNPAN---------I----Q-L------INELKSGTCLFQDHRGRSQPIAIDVLFD-SWLM 808
P96642   757 FD--EPNEREEVLKWMNMEVT-KD---------N----KkM------MESMFQGQCLFKDYYGRTSKISIECLFE-EWQG 813 Bacillus subtilis s...
Q839K7   758 FDEVDNRE--GILRYLKLPV-NEI---------N----LkW------VSNMIQGQCLMKDMFNQVNRIVIDVIFE-EWLE 814 Enterococcus faecalis
Q831J1   759 FD--EVQNREGVLKYLNLPV-NEI---------N----MkW------VSNMVQGQCLMKDMFGQTNRIVVHVIFE-EWLE 815 Enterococcus faecalis
Q2RLP7   726 FRAQDKSEIRSNIELLGADVEEEE---------E----KkGaglanlFRSLESGWCLMKDALGRIGQVYIDPRPE-YLLQ 791 Moorella thermoacet...
Q9AD04   762 FRQTTRALAVRGLDFLGIDSNDPDlldlvtsglSpidlPeE------ERFARAGECLYRDLAGRVGLMKILIPFDtPVAR 835 Streptomyces coelic...

Q82YT2   809 AI 810 Enterococcus faecalis
Q180M9   803 AF 804 Clostridioides difficile 630
Q833R2   803 AF 804 Enterococcus faecalis
Q832F0   803 AF 804 Enterococcus faecalis
Q8Y813   804 AF 805 Listeria monocytogenes
AAO80352 809 AV 810
P96642   814 AL 815 Bacillus subtilis subsp. subtilis str. 168
Q839K7   815 LF 816 Enterococcus faecalis
Q831J1   816 LF 817 Enterococcus faecalis
Q2RLP7   792 VF 793 Moorella thermoacetica ATCC 39073
Q9AD04   836 AI 837 Streptomyces coelicolor
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