3RZ3


Conserved Protein Domain Family
UBCc_UBE2R
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cd23803: UBCc_UBE2R 
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 R1-R2 and related proteins
The E2R subfamily includes mammalian ubiquitin-conjugating enzymes E2 R1 (UBE2R1/UBCH3/CDC34, EC 2.3.2.23 and EC 2.3.2.24), and E2 R2 (UBE2R2/UBC3B/CDC34B, EC 2.3.2.23), which accept ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2R1 catalyzes 'Lys-48'-linked polyubiquitination. It also involved in the degradation of beta-catenin. In vitro, UBE2R2 catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. It may be involved in the degradation of katenin.
Links
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Statistics
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PSSM-Id: 467423
Aligned: 22 rows
Threshold Bit Score: 321.228
Created: 11-Aug-2017
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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active siteligand binding
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: active site cysteine [active site], 1 residue position
Conserved feature residue pattern:CClick to see conserved feature residue pattern help
Evidence:
  • Comment:forms a thioester with ubiquitin or ubiquitin-like proteins
  • Comment:serves as the point of attachment of ubiquitin prior to transfer to cellular target
  • Citation:PMID 9497353
  • Citation:PMID 9705497
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3RZ3_A        10 KALLLELKGLQEePVEGFRVTLVDegdlYNWEVAIFGPPNTYYEGGYFKARLKFPiDYPYSPPAFRFLT-KMWHPNIYET 88  human
NP_490882     13 RALTMELKNLQSqPVEGFTIDVNEdn-lFVWTVGIYGPPKTLYQGGYFKASIRFPsNYPYSPPSMKFTT-KVWHPNVYEN 90  Caenorhabditis ...
EEC00696      11 RALGLEFKGLQEePVEGFRVKLVNednlFEWEVAIFGPPDTLYEGGYFKAHMKFPpDYPYSPPTVRFLT-KVWHPNVYEN 89  black-legged tick
NP_730058     43 RALAMEYKSLQEePVEGFRVKLINddnlFEWEVAIFGPPDTLYQGGYFKAHMKFPhDYPYSPPSIRFLT-KVWHPNVYEN 121 fruit fly
CBY33400       8 KVLSTELNKLTKePVEGFSISLKSehnlYEWKVAIFGPPKTLYEGGYFKAEMTFPkDYPYSPPTFRFRT-EMWHPNIYEN 86  Oikopleura dioica
EFX85558      11 RALALEYKTIQDePVEGFRIKLTNddilFDWEVAIFGPPETLYQGGYFKAQLKFPpDYPYSPPSMRFVT-KVWHPNVYEN 89  common water flea
XP_003387723  10 QRLAGELKSLHQePVEGFLVTLPAeedlYTWHVAIFGPPDTPYQGGYFKAEMRFPqEYPYSPPRLKFLT-PLLHPNVYSD 88  Amphimedon quee...
KJE96668       4 KALASELTEYQKhPVDGFDVSLVDdsnlYDWRIGIFGPPKTPYAGGYFKARVNFPkDYPYSPPSIRFET-ELWHPNIFKT 82  Capsaspora owcz...
ODN00444      11 RALTSELKNLKDePLEGFRVGLVNddnlFDWEIAIFGAPGTLYEGGYFKARMHFPsDYPYSPPSLRFQNpSLFHPNVYES 90  Orchesella cincta
PAA50273      11 KVLQQEFKSLNDsPVEGFLVHLKNddniYDWNVVIFGPPGTLYEGGYLKADLKFPnDYPYSPPSMKFVT-KMWHPNIYED 89  Macrostomum lig...

Feature 1           #                                                                            
3RZ3_A        89 GDVCISILHPpvddpqsGELPSERWNPTQNVRTILLSVISLLNEPNtfSPANVDASVMYRKWkeskgkdREYTDIIRKQV 168 human
NP_490882     91 GDLCISILHSpiddpqsGELACERWNPTQSVRTILLSVISLLNEPNtsSPANVDASVMYRKWked--qdPEYAKIVTKQV 168 Caenorhabditis ...
EEC00696      90 GDLCISILHPpiddpqsGELPCERWNPTQNVRTILLSVISLLNEPNtfSPANVDASVMYRRWkdskgkdKEYENIIRKQV 169 black-legged tick
NP_730058    122 GDLCISILHPpvddpqsGELPCERWNPTQNVRTILLSVISLLNEPNtfSPANVDASVMYRRWrdsqgkdNEYPNIIRKQA 201 fruit fly
CBY33400      87 GDVCISILHPpvddpqsGELPSERWNPTQNVRTVLLSVISLLNEPNtfSPANVDASVMYRKFkesggseDEYKTIIVEQV 166 Oikopleura dioica
EFX85558      90 GDLCISILHPpvddpqsGELPCERWNPTQNVRTILLSVISLFNEPNtsSPANVDASVMYRRWkdskgkdAEYANIIKKQV 169 common water flea
XP_003387723  89 GELCVSILHSpgedmlsGELPQERWNPTQSVRTILLSVISLLNEPNtfSAANVDASVLYRKWrdsrgkdKQYTDIIKKQV 168 Amphimedon quee...
KJE96668      83 GELCISILHPpgddpmsGERPEERWNPTQNVRTILLSVISLLNEPNtsSPANIDASVMFMKNl------TEYRRIVSAQV 156 Capsaspora owcz...
ODN00444      91 GDLCISILHPpiedpqsGELPCERWNPTQNVRTILLSVISLLNEPNtsSPANVDASVMFRRWkdskgtdNEYEEVVKRQV 170 Orchesella cincta
PAA50273      90 GKVCISILHPpgedpvsGELPSERWNPTQNVRTVLLSVISLLNEPNtsSPANVDASVMYRKWkdg--anTEYFDIVRRQV 167 Macrostomum lig...

Feature 1                   
3RZ3_A       169 LGTKVDAERDG 179 human
NP_490882    169 EESKKVAQKDG 179 Caenorhabditis elegans
EEC00696     170 SATRLEADRDN 180 black-legged tick
NP_730058    202 LAANAEAKREG 212 fruit fly
CBY33400     167 KKSQKDAERDG 177 Oikopleura dioica
EFX85558     170 AGSRAEAEKDN 180 common water flea
XP_003387723 169 EASLKEAERDG 179 Amphimedon queenslandica
KJE96668     157 RASQEIARQEG 167 Capsaspora owczarzaki ATCC 30864
ODN00444     171 AQSRAEAEKDG 181 Orchesella cincta
PAA50273     168 EVTKQEAVADG 178 Macrostomum lignano

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