2J0A


Conserved Protein Domain Family
Fringe

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pfam02434: Fringe 
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Fringe-like
The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands. FNG is localized to the Golgi apparatus (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homolog, lunatic fringe, has been implicated in a variety of functions.
Statistics
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PSSM-Id: 367085
Aligned: 28 rows
Threshold Bit Score: 258.017
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2J0A_A        10 LQLGD--IFIAVKTTWAFHRSRLDLLLDTWVSRIRQQTFIFTDSPDERLQERLGPHLVVTQCSAEHSHPALSCKMAAEFD 87 
Q4H3H4       113 TNLDD--IFISVKTSGKFHKTRLNVIIDTWFRDANQQTYFFTDTDDDGLSKKTDGHMVNTMCNSSHIRRDLSCKLGAEYD 190 vase tunicate
XP_001633422 216 ISSDD--IFFAVKTTKKYHGDRVPVVKKTLGQHAKHVVF-YSETEDPDVPTE---NIGVPNTDTGHCAKLKAIIDRSAVD 289
Q0P4I4       265 VQKED--MFVAIKTCRKFHKDRVPVVKKTWEKQATHYEY-YSDYADNTIPTA---DLRIPNVERGHCGKTFAIL-----E 333 tropical clawed...
Q6Y288       264 VKKKD--IFVAVKTCKKFHGDRIPIVKQTWESQASLIEY-YSDYTENSIPTV---DLGIPNTDRGHCGKTFAIL-----E 332 human
Q29PM7       259 TTGSH--IYFAIKTCAKFHKERIPIIERTWATDARHRRY-YSDVAEVGIPTI---STGIPNVQTGHCAKTLAILQLSLKD 332 Drosophila pseu...
Q9VMJ0       269 TTGSH--IYFAIKTCAKFHKERIPIIERTWAADARNRRY-YSDVADVGIPAI---GTGIPNVQTGHCAKTMAILQLSLKD 342 fruit fly
Q17AB4       174 TEMPSapILFAVKTCEKFHAERVPVLLHTWARYVQHLRL-YSDIGDASIPTI---ATTIPNTSIGHCAKTLEILHLVQEE 249 yellow fever mo...
Q4H3H0        57 STLDD--IYITVRTSRKFHESRVAPIVQTWFNLARKQTYIFTDGDDDKLNETTGGHIINTHCGQEYNRPHLSCKTGTVFD 134 vase tunicate
Q4H3H3        38 STLDD--IFISVRTSKKFHEPRIVPIVKTWFNLAKKQTYIFTDGEDDKLNETTGGHVINTNCGPTSSREHLSCKTGTVFD 115 vase tunicate
2J0A_A        88 AFLVSGL----RWFCHVDDDNYVNPKALLQLLKTFPQDRDVYVGKPSLNRPIHASELQskqrtKLVRFWFATGGAGFCIN 163
Q4H3H4       191 FYIKSNK----RWWCHFDDDNYVNVDQLVMLLRDYDHNMDFYIGKPSLNYPFTTTFKG-----EKVGFWFATGGAGVCIS 261 vase tunicate
XP_001633422 290 RRFSDK-----PWLVVIDDDTIMSVPRMQQLLACYDPQEPILLGERYGFGVATG-----------YGYEYVTGGGGMVLS 353
Q0P4I4       334 RFMELYVgr-mSWLIIVDDDTLISLPRLQKLLGCYNPHQAVFLGERYGYGLQAG------------GYNYITGGGGMVFS 400 tropical clawed...
Q6Y288       333 RFLNRSQdk-tAWLVIVDDDTLISISRLQHLLSCYDSGEPVFLGERYGYGLGTG------------GYSYITGGGGMVFS 399 human
Q29PM7       333 IIEQRDI----RWLMLVDDDTLLSVPRLSALLNGYNHTEHIYLGERYGYRLYAP-----------DGFNYHTGGAGIVLS 397 Drosophila pseu...
Q9VMJ0       343 IGKQLDI----RWLMLVDDDTLLSVPRVSALLCRHNATELVYLGQRYGYRLHAP-----------DGFNYHTGGAGIVLS 407 fruit fly
Q17AB4       250 MFRNRALadviSWIMLVDDDTILSPSALTRFLSAFDPSQDVYIGERYGYHLLAE---------DGQGYNYVTGGGGIVIS 320 yellow fever mo...
Q4H3H0       135 KYLASGK----KWWCRFDDDNYVNPPRLVNLVNGYNWTQDICIGKLSVPSYTANYRG------RPEIYQFAHGGAGCCIS 204 vase tunicate
Q4H3H3       116 TYLASGK----KWWCRFDDDNYVNPPRLVHLVNGYNWTQNICIGKLSVPSFTTGYHG------HSETYQFAHGGAGCCIS 185 vase tunicate
2J0A_A       164 RQLALKMVPWASGSHFVDTSALIRLPDDCTVGYIIECKLGGRLQPSPLFHSHLETLQLLgaAQLPEQVTLSYGVFEGKLN 243
Q4H3H4       262 KALAQRMKPWCSNGGLYRTSEHLNAPDDCTLGFVVSNRLAVELTSSNLLHSHLETLGQLnpATLTEQVTLSYGLD-NRNN 340 vase tunicate
XP_001633422 354 RAGINML--RESGCGCWQDNS----PDDMWLGNCFRN-LNIPVTHSPAFHQARPV--EYvaSLLDHQSAVSFHKHY---- 420
Q0P4I4       401 REAVRRL--MNSKCRCYSNDA----PDDMVLGMCFSS-LGITITHSPLFHQARPT--DYakDYLAHQIPISFHKHW---- 467 tropical clawed...
Q6Y288       400 REAVRRL--LASKCRCYSNDA----PDDMVLGMCFSG-LGIPVTHSPLFHQARPV--DYpkDYLSHQVPISFHKHW---- 466 human
Q29PM7       398 LPLVRLV---LEHCSCPSANA----PDDMILGYCLQA-LGVVALPAAGLHQARPQ--DYarELLHLQPPISFHKFW---- 463 Drosophila pseu...
Q9VMJ0       408 LPLVRLI---VQRCSCPSASA----PDDMILGYCLQA-LGVPAIHVAGMHQARPQ--DYagELLQLHAPLTFHKFW---- 473 fruit fly
Q17AB4       321 VRILGAL---LRSCECPSASS----PDDMIIAACLYR-LGVRPIHSPLFHQARPS--DYppETLD-PASISFHKHW---- 385 yellow fever mo...
Q4H3H0       205 RPLALKMQPWCGREKLVETTEDVGRHEDCTLGFIITNRLKIDLTLTDLLHSTRESLRDLnpGTLHEQVSIGQGPG-NTVN 283 vase tunicate
Q4H3H3       186 RPLALKMKPWCGRKNLVVTTREAVMNEDCALGFIITNRLKVALTLTDLLHSTRERLKDLnvDTLHEQVTIGQGPG-NTVN 264 vase tunicate
2J0A_A       244 VIKLPGP---FSHEEDPSR 259
Q4H3H4       341 IIQLQESshnLPISKDPTR 359 vase tunicate
XP_001633422 421 -------------DIDPIA 426
Q0P4I4       468 -------------NIDPIK 473 tropical clawed frog
Q6Y288       467 -------------NIDPVK 472 human
Q29PM7       464 -------------NTEPEH 469 Drosophila pseudoobscura
Q9VMJ0       474 -------------NTDPEH 479 fruit fly
Q17AB4       386 -------------QIDPYQ 391 yellow fever mosquito
Q4H3H0       284 LDQAKNAk-iFSHDVDPTR 301 vase tunicate
Q4H3H3       265 LDKAKSGk-kFNPNVDPTR 282 vase tunicate
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