Conserved Protein Domain Family
SGIII

?
pfam15467: SGIII 
Secretogranin-3
Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localization to secretory granules of neuroendocrine cells, two interesting characteriztics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.
Statistics
?
PSSM-Id: 464732
Aligned: 10 rows
Threshold Bit Score: 707.312
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_011486780  23 VYAFPTPsaSTDADKSVYNQQLTEERPVQQQI--AEADSVKaalQSAGGQHPAASKESd--QDSDDFTMLKSLADGQK-S 97 
XP_005799798  23 TSAFPTPt-ASADDKTVYNRQLTEERPLQEQI--AEADSVKaavQSAESKQPATSKDAe-sEQGDDFTMLKSLADGQK-S 97 
A3KQQ9        19 INAFPTP--AGPDDK--YNRELTEEKPLEQQI--AEADSIR---KTESKPTPPAEEETn--SEDDDITFLKALAEKSK-E 86  zebrafish
XP_015198349  22 LNAFPTP--DVTSDKAVYNRQLSEERPLQEQI--AEADSVS---KSVAKDNQSASTEPtidPDNDDFSLLRSLAETSK-D 93 
F7E728        18 VQGFPNP--GIKQDKAVHNRELSEERPLEEQI--AEADTVS---RGTSKENQEMLKND---SFADELGLLMSVAEKEGdV 87  tropical clawed...
XP_008116705  19 GHSFPKPe-GARSDKAIHNRELSVERPLEEQIaeAEADKMK---KATSKENKPEFRNY---SFAEDLNLLKSAVEKER-- 89 
AFE66458      17 IQAFPKP--GGSQDKSLHNRELSAERPLNEQIaeAEADKIK---KTYPLENKPGQSNY---SFVDNLNLLKAITEKEKmE 88 
XP_006001977  61 VFAFPVP--DGAKDKAVYDRELSVERPLQEQi--AEADWAS---KTVNTESKADSKNI---SDADNFNLHKNLKENKRnE 130 coelacanth
XP_018539130  23 ISAFPTPt-ATTDDKTVYNRQLTEERPLQEQI--AEADSVKaavQSAESRRPTASKDTeseQERDDLTVLKTLASGQK-S 98  barramundi perch
CAF99835      21 GSGFPTPt-PSSDDKTGYNRQLTEERPIQEQI--AEADSVKaaiQVAETKPAASSQDA---QDLDDLTVLKSLADGQK-P 93  spotted green p...
XP_011486780  98 KEPSVVPVKK-DDQYVPDESDSTKSRRLADDYDSTKKGMDY----DDPESFRQVDGTPLTAEDIVQKIANKIYEEDDRGV 172
XP_005799798  98 KEAPEGPVKKgDHQYVPDESDSTKSRRLADDYDSTKNGMDY----DDPESFRQVDGTPLTAEDIVQKIANKIYEEDDRGV 173
A3KQQ9        87 SNNETPISDSaNERLGADDTDSTKNRRLADDYDSTKNGMDYky-qDDPESFRQLDGTPLTAQDIVQKIANKIYEEDDRGV 165 zebrafish
XP_015198349  94 LGSKTPSSKSiNTHYFPDDADSTKNRRLVDDYDSTKNGMDYry-qDDPDGLHQLDGTPLTAEDIVQKIATRIYEEDDRGV 172
F7E728        88 KRSGSVRSSVgGHRGTLDDADSTKNLKPAEYFDSTKSMLDYky-eDDPDGLHQLDGTPLTAEDIVRKIATRIYEENDRGV 166 tropical clawed...
XP_008116705  90 KEKASVRSSLyDQQLALDDADSTKSRRLVDDYDSTKSGLDYky-qDDPDGLHQLDGTPLTAEDIVQKIATRIYEENDRGV 168
AFE66458      89 KERQSIRSTPlDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHkf-qDDPDGLHQLDGTPLTAEDIVHKIATRIYEENDRAV 167
XP_006001977 131 KKSGST-NKSfNDQSFFDDTDSTKNRRLVDDYDSTKSGSSYks-qDDPDGLRQLDGTPLTAEDIVEKIATRIYEENDRGV 208 coelacanth
XP_018539130  99 KETAEAPVRK-QDQYVPDESDSTKSRRLAEDYDSTKNGMDDgkyqDDPESFRQVDGTPLTAEDIVQKIANKIYEEDDRGV 177 barramundi perch
CAF99835      94 KEGAEKEKKEaEEQYVPDESDSTKSRRLVEDYDSTKNGMDDgkyqDDPESFRQVDGTPLTAEDIVQKIANKIYEEDDRGV 173 spotted green p...
XP_011486780 173 FDRIVSKLLKLGLITESQADTLEYQVAEALQDLITKNAKNNEIDDIEsidQAAGGEQ-E---DQDSDTGTWEPPKRR--- 245
XP_005799798 174 FDRIVSKLLKLGLITENQADTLEYQVAEALQDLITKNAKNNEVEDMD---QESRGEQ-D---DLGPDTDAWETPRRR--- 243
A3KQQ9       166 FDRIVSKLLKLGLITDSQAETLEYEVAEALQDLITKNAKDNMIGDRSvdyPVSAAK------DTQDEED---RPSPR--- 233 zebrafish
XP_015198349 173 FDRIVSKLLNLGLITESQADTLEYEVAEALQQLIANQVKNNEIEDTSmdyPASSTE------DPGEKQEKSVSEKAS--- 243
F7E728       167 FDKIVSKLLNLGLITESQAYTLEDEVAEVLQQLIANEAKNREKEAGDldyAAVRSDV-Y---DDDKQEGKMETRNKN--- 239 tropical clawed...
XP_008116705 169 FDKIVSKLLNLGLITESQAYTLEDEVAEVLQQLIANEAKDREKAAEGldyLPSKTDM-N---TNQNLEEKMVPKAPE--- 241
AFE66458     168 FDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYE---EDlnkPTSRTE--N---QAGKIPEKVTPMAAI--- 236
XP_006001977 209 FDKIVSKLLSLGLITESQAYTLEDEVAEALQQLITNEAKNNERESESfdnHPIRTGG-D---LKEKQEEKMLLEKPH--- 281 coelacanth
XP_018539130 178 FDRIVSKLLKLGLITESQADTLEYQVAEALQDLITKNARNNEIEDMEsndQETRGEQdDqgsDANTdt---wEPPRRryd 254 barramundi perch
CAF99835     174 FDRIVSKLLKLGLITDSQADTLEYQVAEALQDLITKNAKNNEIEDTEsndRDVRGEQ-D---DQGSDTNVDTWEPPR--- 246 spotted green p...
XP_011486780 246 -----------------------Y---------------------------NEKEEDAAEadDEDVedeverea-eedvn 274
XP_005799798 244 -----------------------Y---------------------------DEEDHDEVAnnDDEIadevdr----dvee 269
A3KQQ9       234 -----------------------F---------------------------DEEDEVENEggDDANgdepqeeesrddtv 263 zebrafish
XP_015198349 244 -----------------------R---------------------------RYEDQHVSEdvDDTV-------------- 259
F7E728       240 -----------------------E---------------------------DRESSETKN--EDSF-------------- 253 tropical clawed...
XP_008116705 242 -----------------------Q---------------------------D-----------DTL-------------- 246
AFE66458     237 -----------------------Q---------------------------DGLTKGEN---DETV-------------- 249
XP_006001977 282 -----------------------K---------------------------DGQSELMNEdiDDTL-------------- 297 coelacanth
XP_018539130 255 dedeevdddetedevdrdaeedgG---------------------------DAA-------------------------- 281 barramundi perch
CAF99835     247 -----------------------GrynededegqeedeeeeevedevdrdvGEDERETA--------------------- 282 spotted green p...
XP_011486780 275 eaGDTWE--KGTEDGNEVSPEDGLQDLQYFPNFYRLLKSLNLEKDTQERETLITIMKTLIDFVKMMVKYGTITPEEGVSY 352
XP_005799798 270 dmDNSWD--KEKEEGNEVNPEDGLQDLQYFPNFYRLLKSLDSEQDAQERETLITIMKTLIDFVKMMVKYGTITPEEGVSY 347
A3KQQ9       264 rsDDSWDavSDGNDRNELNPEDGLQDLQFFPNFYRLLKSLDSEQDKEERETLITIMKTLIDFVKMMVKYGTITPEEGVTY 343 zebrafish
XP_015198349 260 --DNTWAppNEADQRNELSPEDSLQDLQYFPNFYNLLKSLNSEQDAKEKETLITIMKTLIDFVKMMVKYGTITPEEGVSY 337
F7E728       254 --SSK-------ERRNELSPEEDFDDLQYFPNFNRLIKSLNSENDAKEKKTLITIMKTLIDFVKMMVKYGTITPEEGVNY 324 tropical clawed...
XP_008116705 247 --DNTWAssNILERRNELPPEDNFEDLQYFPNFYELLKSLNSEKEAKEKETLITIMKTLIDFVKMMVKYGTITPEEGVSY 324
AFE66458     250 --SNTLTltNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSY 327
XP_006001977 298 --GNSWTfpNSMERRNDLSPEDDFEDLQYFPNFYNLLKSLNSEADKKEKKTLITIMKTLIDFVKTMVKYGTITPEEGVSY 375 coelacanth
XP_018539130 282 --DNTWD--KDTEEGNEVSPEDGLQDLQYFPNFYRLLRSLNSDQDTQERETLITIMKTLIDFVKMMVKYGTITPEEGVSY 357 barramundi perch
CAF99835     283 --GNSWD--KNMQQGNEVNGGDGLQDLQYFPNFYHLLRSLDSERDTQERETLITIMKTLIDFVKMMVKYGTITPEEGVSY 358 spotted green p...
XP_011486780 353 LENLDAMIAMQTKNKLGKALGLP-DVTAPSE--KDWDDDDNTKAEAAKMQKEYENLKDSTKEEQPPT--ETNQP----GK 423
XP_005799798 348 LENLDAMIAMQTKNKLGKSLVVP-DISGLTG--KNFDEDDNTKSETAKMQKEYENLKDSTKEEQTST--ETNQP----GK 418
A3KQQ9       344 LENLDAMIALQTKNKLGKSLVPL-SITPPTG--KAADDDDNTKTEAAKMQKEYESLKDSTKDVQTAA--EISHP----GK 414 zebrafish
XP_015198349 338 LENLDAMIALQTKNKLGKSLVTS-DIRAPTD--KTSEEEDNTKEEVAKMEKEYESLKDSTKEEQAVP--ESGSS----GK 408
F7E728       325 LENLDAMIAVQAKNKLGKSFG---SHKSILSedKNVDESDSTKQEAAKMEKEYEALKDSTKPEPKDAe-DKDKPk---GK 397 tropical clawed...
XP_008116705 325 LENLDAMIALQTRKKLEKP-----GTKAKLLsdKSTEESDSTKAAAAKMEKEYETLKDSTKIEEQNTe-NDEEPk---GK 395
AFE66458     328 LENLDEMIALQTKNKLEKNATDNiSKLFPAPseKSHEETDSTKEEAAKMEKEYGTLKDSTKDDNSNPggKTDEPk---GK 404
XP_006001977 376 LENVDAMIALQTKSKLGKPLAYP-TDKEPAe--WSNEETDSTKEEADLMEKDSESLKDSTKKEGQKIsvKDEEPkgslGK 452 coelacanth
XP_018539130 358 LENLDAMIAMQTKNKLGKSLGPP-DFTGPNG--KNLDEDDNTKAEAAKMQKEYENLKDSTKEE-QPSt-ETNQP----GK 428 barramundi perch
CAF99835     359 LENLDAMIAMQTKNKLGKSLGTT-DFMGPNG--RNLEEDDNTKAEAAKMQKEYENLKDSTKEEQPSTa-TTDQP----GR 430 spotted green p...
XP_011486780 424 SEAYLEAIRKNIEWLKKHNKEDGK--EDYDLSKLKDFMDQQLDSYIDKGIIAKEEGDTIKRIYSSL 487
XP_005799798 419 SESYLEAIRKNIEWLKKHNKDEGK--NDYDLSKLKDFMDQQVDSYIEKGIIAKDEGDTIKRIYSSL 482
A3KQQ9       415 SESYLEAIRKNIEWLKKHNKEGNK--EDYDLSKLRDFMDQQVDSYIDKGILEKDEGDVIKRIYGSL 478 zebrafish
XP_015198349 409 TETYLEAIRKNIEWLKKHNKQGNK--EDYDLSKLRDFMDQQVDSYIDKGILEKDEGEIIKRIYSSL 472
F7E728       398 AETYLEAIRKNIEWLKEHNKEGNKgvSDNDLSKLKDFINQQADSYVEKGILDKEEANVIKRIYSSL 463 tropical clawed frog
XP_008116705 396 AEAYLEAIRKNIEWLKKHNTQGNK--EDYDLSKLRDFIDQQADAYVDKGILDKEEADVIKRIYGSL 459
AFE66458     405 TEAYLEAIRKNIEWLKKHDKKGNK--EDYDLSKMRDFINQQADAYVEKGILDKEEAEAIKRIYSSL 468
XP_006001977 453 SESYLEAIRKNIEWLKKHNKQGNK--EDYDLSKLRDFIDQQADTYVEKGILEKEEADVIKRIYSSL 516 coelacanth
XP_018539130 429 SETYLEAIRKNIEWLKKHNKEEGK--DDYDLSKLKDFMDQQVDSYIEKGIIAKDEGDTIKRIYSSL 492 barramundi perch
CAF99835     431 SETYLEAIRKNIEWLRKHNKEESK--DDYDLSKLKDFMDQQVDAYIEKGIIAKEEGDTIKRIYSSL 494 spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap